Health officials are investigating whether the mosquito-borne virus chikungunya is circulating in New York after a woman tested positive on Long Island in a preliminary screening. The last time the debilitating disease was known to have been transmitted locally in the U.S. was about a decade ago.

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture. buff.ly/j3TSIkn

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

You’ve heard of #Lymedisease, but have you ever seen the bacteria that causes it? 🦠 Borrelia burgdorferi, the spiral-shaped culprit transmitted by ticks, swims with a creepy wriggling motion and uses #chemotaxis to navigate. Both fascinating... and disgusting #Microsky 🧪 #IDsky @shawlab.bsky.social

RFdiffusion3 is here: www.biorxiv.org/content/10.1...

❄️ NEW PRE-PRINT ❄️ Happy to see our latest work online. Here we present a super simple solution to the preferred orientation problem in single particle cryo-EM: the use of ultrasonic excitation during vitrification! Details in the 🧵 below... #cryoEM #structuralbiology

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching! Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv! www.biorxiv.org/content/10.1...

Sometimes it's nice to remember that even Marcus Aurelius was like "you don't have to comment on everything bro"

I just find everything feels a bit better when I watch this.

Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress #ribosome #rnasky www.biorxiv.org/content/10.1...

Sunrise from Thacher Park

I got yer timeline cleanse right here, folks. A whole clutch of teeny tiny snapping turtle behbehs emerged one at a time from their underground nest and crossed the gravel road while I and a couple other humans watched and made sure they were safe from anyone else coming along.

Golden trumpet in Panshet, India

Check out our new paper: a review of translational coupling, the phenomenon where translation of one prokaryotic gene can promote translation of the gene downstream. We cover the history, and delve into the mechanism, which is still not fully understood. journals.asm.org/doi/10.1128/...

One of my favorite things right now is when my 10-yo tells me something he learned at school, I act like I’m not really familiar, and then he teaches it to me. He just gave me a great lesson on prime vs composite numbers. At some point he’s going to wonder how I can possibly be a science professor.

Here, have some birds perched on appropriate/delightful signage. You're welcome. 🧵 ⤵️ 1. Black Vulture (Coragyps atratus) by tysmith on iNaturalist

Did you know your MacBook has a sensor that knows the exact angle of the screen hinge? It’s not exposed as a public API, but I figured out a way to read it and make it sound like an old wooden door.

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

7 meter high Shiva sculpture with three faces at Elephanta caves

Comprehensive nucleoside analysis of archaeal RNA modification profiles reveals an m7G in the conserved P loop of 23S rRNA #rnasky #microsky 🦠💫 www.cell.com/cell-reports...

Structural studies by Ahmad Jomaa and colleagues @jomaalab.bsky.social show how NAC on translating #ribosomes couples protein synthesis to N-myristoylation of nascent polypeptides by NMT2 www.embopress.org/doi/full/10....

Bald eagle at the edge of Thomson’s Lake, NY (Sep 1, 2025)

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

How can you find consistent biological 3D structures in heavily contaminated electron microscopy data sets without using any prior knowledge? #CryoEM #SingleParticle #Reconstruction doi.org/10.1107/S205...

This is one of the most beautiful things I have witnessed, the craft here is impeccable.

New ABCF article from @balikovalab.bsky.social group! Even though ABCF proteins have the same shape and act on the ribosome E-site, they have very different role in bacteria physiology level. What an interesting topic!🤩 doi.org/10.1128/mbio...

These exciting new results therefore have important implications for recoding of the genetic code for synthetic biology purposes and in the use of suppressor tRNAs for premature stop codon readthrough in human diseases. Congrats everyone! rdcu.be/eAcLz

Stunning! A pigeon doing backflips.

Afternoon haze over the Albany dock at the Hudson River due to Canadian wildfires.

the scenario we all feared

This is the most intense tsunami footage I've ever seen. It purportedly shows the tsunami from the 29 July Mw 8.8 quake in Kamchatka, Russia, filmed in that same region. Source: seismic.kiwi on TikTok, although I've seen this video all over the internet and may originally be from VK or Telegram.

this is how it starts and then before you know it we have to live in a society

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

Enjoyed a wonderful visit and scientific discussion with Dr. Prem Kaushal and his colleagues at the Regional Center for Biotechnology in Faridabad!

Excited to contribute to the Mitoribosome collaborative study led by @wredenberglab.bsky.social in @natcomms.nature.com🎉 "The mitochondrial methylation potential gates mitoribosome assembly" The assembly starts before the completion of the rRNA gene cluster processing🧵 www.nature.com/articles/s41...

Had a fabulous day at the Wadsworth Center in Albany yesterday 🤩 Very impressive place to do science plus everybody is so kind 🤗 Thanks so much Sian @sianowen.bsky.social and Tom Bartlett for the kind invitation 🤩. Glad to see your new labs started so well.

The cecropia moth is North America's largest native moth. Credit: mackattack_zoology/ig

CryoDRGN-AI: neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets pubmed.ncbi.nlm.nih.gov/40571741/ #cryoem

I'm excited to share our new preprint: PocketVina — a fast, scalable, and accurate multi-pocket molecular docking method. Docking remains essential in early-stage drug discovery, but recent deep learning–based approaches still face limitations in generating... Thread - (1/n)

Researchers at the University of Edinburgh have engineered a strain of Escherichia coli that relies on small molecules from waste polyethylene terephthalate (PET) plastic bottles to survive. cen.acs.org/biological-c... #chemsky 🧪

With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF

Amazingly, this gave us a high-confidence transmembrane channel for both mouse and human NS3, with oleic acids forming a bilayer-like pattern. Our group now call this the “fatty acid hack.” The #alphafold predictions with and without fatty acids shown below 👇

Register for a Workshop on PDB Deposition at ACA Become proficient in leveraging various OneDep features and tools, including ORCiD management, validating data, submitting batches of structures, and completing depositions with minimal manual input. pdb101.rcsb.org/news...

Structure suggests alternate mechanism of peptidyl-tRNA hydrolysis on the ribosome. www.science.org/doi/10.1126/...

Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation. It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology

This is what happens if you map the latitude of European cities onto North America & vice versa. Some realizations: Most European cities are north of the US-Canadian border. London shares latitudes with an Alaskan island chain. Houston is further south than Cairo. (🧑‍🎨: 7LeagueBoots)

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...