Got an optimistic dumpster fire pen today

Nature research paper: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome go.nature.com/3RMNwPW

Extended Shine-Dalgarno motifs govern translation initiation in Staphylococcus aureus www.nature.com/articles/s41... 🦠

🚨 New in @natcomms.nature.com 🚨 Excited to share our paper on how proline-rich antimicrobial peptides interact with the bacterial ribosome. Using cryo-EM, we found that tiny sequence changes cause these peptides to "flip" orientation in the exit tunnel! 🔄🧫 Read: www.nature.com/articles/s41...

Ribosome heterogeneity in E. coli : ribosomal RNA (rRNA) sequence and modifications, r-protein stoichiometry and PTMs, and ribosome-associated proteins pubs.acs.org/doi/10.1021/... 🦠

Online Now: Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes Online now:

New streptogramin analogs binding to the nascent peptide exit tunnel in the ribosome (from Fraser and Seiple groups) www.sciencedirect.com/science/arti...

Close up of a daisy from the backyard

Precision in RNA degradation: helicases, ribosome and RNA polymerase stalling, and RNA modifications: Trends in Cell Biology www.cell.com/trends/cell-...

Structural investigation suggests Elongation Factor-G1 is the bona fide canonical translation factor for ribosome recycling in mycobacteria www.biorxiv.org/content/10.64898/2026.05.25.727771v1 #cryoem

CryoARC: Atomic-resolution conformational landscapes of protein assemblies from cryo-EM single particles with evolutionary priors www.biorxiv.org/content/10.64898/2026.05.25.727696v1 #cryoem

WebCalEM: a browser-based tool for routine and accurate pixel size calibration in cryo-EM www.biorxiv.org/content/10.64898/2026.05.26.726020v1 #cryoem

Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...

1/8 🚨 New preprint from the @sternberglab.bsky.social & @martinjinek.bsky.social labs! CRISPR-associated transposases (CASTs) insert large DNA cargoes at precise genomic locations — no double-strand breaks needed.

If you haven't been using Bioicons, you should check it out: bioicons.com You can find so many high quality vector arts for science that is also open source/free! If you made vector arts for your papers, I urge you to contribute them on Bioicons too. I have shared several icons I made as well.

Check this fantastic, first-of-its-kind method to reversibly deplete proteins exclusively from mature ribosomes by @mbarnalab.bsky.social and colleagues: www.sciencedirect.com/science/arti...

Structural modification of oxazolidinone antibiotics alters nascent peptide stalling preference and peptide trajectory through the ribosome www.biorxiv.org/content/10.6...

Dual site targeting of the bacterial 70S ribosome by tetracyclines pubmed.ncbi.nlm.nih.gov/42156748/ #cryoem

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity. Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it. Paper: www.nature.com/articles/s41...

How can we examine higher energy states of proteins experimentally? Answer: Published in Nature, multiplexed hydrogen–deuterium exchange mass spectrometry (mHDX-MS) studies of 5,778 protein domains. They can both analyse protein energy landscapes and change them by design. doi.org/10.1038/s415...

Fifteen uncoupled simple pendulums of monotonically increasing lengths dance together to produce visual traveling waves, standing waves, beating, and seemingly random motion. 📽: Harvard Natural Sciences Lecture Demonstrations

So, as translation control is getting popular, please note the newly unified nomenclatures: Translons: a single term for translated regions www.nature.com/articles/s41... Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status www.nature.com/articles/s41...

Inside the Tomb of Ramesses VI there's a painted relief of the goddess Nut, believed by many scholars to be an ancient celestial depiction of the Milky Way. via James Lucas

Sometimes what the setting sun illuminates is as beautiful as the sunset.

#caturday #cats

I feel I should alert Bluesky to the baby foxes in our yard

“Neurodivergent people have a hard time understanding humor.” Or maybe we understand it perfectly and you’re just not funny.

If you missed the preprint, now is a good time to read the journal version of @grocklin.bsky.social et al’s fantastic paper on multiplexed HDX measurements Large-scale discovery, analysis and design of protein energy landscapes doi.org/10.1038/s415...

Please share widely. The new (simpler) MIRA R35 for Early Stage Investigators (ESI) NOFO is published. First due date is 10/2/2026. files.simpler.grants.gov/opportunitie...

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

Now published in NSMB! Paper: doi.org/10.1038/s415... Full PDF: rdcu.be/fhBtI Overview of additions since the preprint👇 (1/5)

Surely they've suffered enough?

Small molecule binding to proteins is broadly affected by post-translational modifications www.nature.com/articles/s41...

Measurement of atomic scattering factors by cryoelectron microscopy pubmed.ncbi.nlm.nih.gov/42101996/ #cryoem

While I'm nerding about birds, everyone should get to know the Black-and-Chestnut Eagle, an endangered raptor from South American mountain forests. One of the Most Birds Ever.

This Is Just To Say We have desk-rejected the manuscript that you submitted and which you were probably hoping would be sent for peer-review Forgive us it represents an insufficient advance so incremental and so much better suited for a specialist journal

In two separate Science studies, researchers report strategies to transform carbocycles into nitrogen heterocycles. These approaches could diversify the library of pharmaceutically relevant molecules and contribute to drug discovery. Learn more in a new #SciencePerspective: https://scim.ag/4esmcQe

Tremendous scholarship on display by our students @albany.edu, including Hannah from the Ciota Lab in our Department of Biomedical Sciences! www.albany.edu/news-center/...

A Science paper with 140 authors – and it's not physics, it's organic chemistry/chemical biology! #chemsky doi.org/10.1126/scie...

Not to victim blame but this balloon does feel like it's asking for trouble

Spiralling global temperatures (1850-2026) It is exactly 10 years since I first put this animated graphic of changes in global temperature online. #ClimateSpiral It instantly went viral. People watched it over and over again. It still offers the power to shock a decade on.

How do mitochondrial ribosomes keep pace with membrane insertion? Now out in NSMB: We show that mitoribosomes slow down at defined positions linked to membrane insertion and protein topology: rdcu.be/fhqIT #Mitochondria #Ribosome #CryoEM

Ribosome collisions trigger tmRNA-mediated rescue through mRNA disengagement www.biorxiv.org/content/10.6... 🦠

not the methanobody?

Nature research paper: Expanding the human proteome with microproteins and peptideins go.nature.com/4ttILbi