What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ @landau.bsky.social Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇 Lets goooo!! rdcu.be/ehkUb

"Your AI can’t see gorillas!" A few years ago we found that students are more likely to see the gorilla in their data if they are not also asked to test a specific hypothesis. In his blog Chiraag Gohel now shows that Chat-GPT can’t help you to find it either. chiraaggohel.com/posts/llms-e...

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)

RNA molecule rejuvenates ageing mice by restoring old cells "Mice injected with a microRNA molecule lived longer and had fewer markers of ageing, but it’s not yet known if the treatment would work in people." www.sciencedirect.com/science/arti...

That’s what GZMK does! (You’ll have to read it 😅). www.nature.com/articles/s41...

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

So excited to have our new paper out now! Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3 #innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit www.cell.com/cell/fulltex...

SPATIAL PROTEOMICS is the Method of the Year 2024!!! 🤩🤩🤩 www.nature.com/articles/s41...

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. www.science.org/doi/10.1126/...

Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1

Timescales in Cell Biology #Cell PDF download: www.cell.com/cell/pdf/S00...

The complex effects of biomaterial and animal characteristics on wound healing and metastatic tumor formation in bone are revealed with single-cell RNA-seq in my most recent PhD work in #Biomaterials with @madhavmantri.bsky.social @fischbachlab.bsky.social & Iwijn De Vlaminck #cornellbme t.ly/WAjXZ

We ask students to write a research proposal, but we should also teach them about how the project will likely actually unfold.

The pSABER paper is now online! pSABER is a new method for amplifying in situ hybridization signals This work was driven by Sahar Attar and co-led by Ram Akliesh ([at] podocytes on the other app) with help from @shechnerlab.bsky.social @dschweppe.bsky.social doi.org/10.1038/s415... 🧵 1/12

Publication Alert! Happy to share our new work published in CellReports of a collaboration with the Zychlinsky Lab (Max Planck Institute for Infection Biology). "Histone H1 kills MRSA". cell.com/cell-reports.... Enjoy!

Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging - Nature Aging 🧪 www.nature.com/articles/s43...