Tumour heterogeneity comes at different length scales.This article classifies regulators of cancer into tumour-cell-intrinsic, tissue-microenvironment and organism-level sources, describing engineering strategies to measure and analyse these factors:

Had a great time working with @natrevbioeng.nature.com to put this review together! Biophysical cues integrate across length scales (molecular, cellular, tissue level, organismal) to drive cancer outcomes. Bioengineers have the tools to measure and model these factors in isolation 🛠️🔬

Preprint alert! Excited to share this manuscript from my PhD which aims to answer an age-old question. Does size matter? For fat cells, or adipocytes, the answer seems to be yes. We found that larger adipocytes promote aggressive behavior in breast cancer cells. 1/5 www.biorxiv.org/content/10.1...