Evidence for a detrimental causal effect of social isolation on cognitive function in older adults academic.oup.com/psychsocgero...

Optimism is currently unfashionable. The newly published Community Life Survey asks, "do you agree or disagree that this local area is a place where people from different backgrounds get on well together?" I wondered if we might see a sharp decline this year; it has gone down 1%, to 80% agreement.

Absolutely amazing chart from @peterkellner.bsky.social's piece in @thenewworldmag.bsky.social today: www.thenewworld.co.uk/peter-kellne...

Multiple large natural experiments have documented Shingles vaccine is linked with ~20-25% reduced risk of dementia and Alzheimer's disease. A new report today adds to that and extends the to slowing the progression of dementia @cellcellpress.bsky.social www.cell.com/cell/fulltex...

This is how the Mail has covered a 70% fall in net migration. The Government should stop kidding itself it will ever get credit for being anti-migration. They could cut numbers to zero and there would still be front pages blasting them for making the UK a socialist wasteland no one wants to come to

Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials novonordisk.com/content/nnco...

Turnout in the NYC mayoral election is the highest since 1993.

We in the UK will work out far too late that this is a bad thing.

The fun thing about having a small team working with you is you can say "hey you're spending this week digging for stolen mobile phones in London flowerbeds, I promise you it's a thing". www.londoncentric.media/p/london-pho...

Your daily reminder that the government continues to commercially support an individual who wants to destroy it through fascist violence.

"While public concern often focuses on youth violence, today, a man aged 31 to 50 is more likely to be admitted to hospital with a violence-related injury than a boy aged 11 to 17." observer.co.uk/news/nationa... London: safer than ever. Because we all need reminding of good news!

Exposure to sugar early in life: a natural experiment among >63,000 @uk_biobank participants: rationing of sugar was associated with less cardiovascular risk in adulthood www.bmj.com/content/391/...

"They need us more than we need them"

Some really fun evolution to the Dorothy dementia app x.com/dorothy_app/... pls rt😀

This is my flag.

Brexit:

open.substack.com/pub/rorycell... Wrote about my first trip to a tech event in a while where I found some fascinating tech on the @alzheimerssoc.bsky.social stand. I found the show hard to navigate and exhausting which perhaps explains why I accidentally posted this last night not this morning!

🎉 I am thrilled to launch the Dementia Journeys website - a new digital platform sharing powerful stories from carers, & exploring what better end-of-life dementia care looks like based on research from the UCL/KCL EMBED-Care programme 👉 www.dementia-journeys.com #DementiaActionWeek 1/8

I think about this comic at least once a week

Amazing result from Canada. It looks like the world can continue to thrive with centrist liberal democracies. www.ft.com/content/5f9a... Mark Carney’s Liberals win pivotal Canadian election

Why are we not doing this? Never seen a more "no brainer" policy. Even people who are the most strongly opposed to immigration tend not to object to top scientists coming here.

Britain, a trading nation, now has a vital choice to make about its priority trading partners: - the EU, where agreements are made, kept, reciprocal, based on international norms, & enforced by a court - the USA, where agreements are made, broken, changed & broken again at a whim, with no recourse

Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors. Here’s (almost) everything we know about it erictopol.substack.com/p/the-breakt...

Use of digital technology and reduced risk of cognitive impairment, results of a meta-analysis of over 410,000 adults average age 69 years, from 57 studies www.nature.com/articles/s41...

@sameihuda.bsky.social @dranniehickox.bsky.social @jonathanstea.bsky.social #depression #suicide

Three minutes from me on why the Trump tariff “Brexit dividend” idea is the weirdest take of the year. www.youtube.com/watch?v=c98A...

Great talk about how EPR satisfaction is not EPR dependent rather approach and training. Poor implementation a major factor for #physicianburnout @thmswebb.bsky.social 🩺🖥️ #rcpsychdata25

Excellent talk by Ian McCafferty from Hampshire and Isle of Wight NHS Foundation Turst creating safe remote doctor roles- zero applicants to eleven, one consultant funded to three ! 🩺🖥️ #rcpsychdata25

Have written about JD Vance’s Munich speech. In what may prove to be the biggest week for European security since 1991, it’s time Europe listened to what Trump and his Vice President are telling us. open.substack.com/pub/goodalla...

EU medicines agency quits X & moves to Bluesky "EMA will no longer post updates and content on X. We believe the X platform no longer suits our communication needs” the agency said in a statement www.reuters.com/world/europe...

"Just 3% of people in the organisation or system typically influence 85% of the other people." Super blog (with lots of great links!) by @hayleylever.bsky.social of @gmmoving.co.uk on understanding systems & how relationships can best effect change. hayleyleverblog.wordpress.com/2023/05/17/f...

The perfect Monday #RecipeOfTheDay: Spaghetti with Marmite! And I’ll have you know that this is no Anglo act of appropriation but the invention of that great Italian foodwriter, Anna del Conte www.nigella.com/recipes/spag...

open.substack.com/pub/rorycell... My latest Substack post is about a young Indian health tech entrepreneur who has chosen London rather than Silicon Valley as the base for his AI startup and asks whether more will follow

Great to see @wikipedia.org on here and using their own domain (yes yes I’m going to do it for myself soon)

Have you ever wondered how @wikipedia.bsky.social really works? Or who are the people who edit and improve its articles? This video is for you. This is #AWikiMinute! A series of videos that answer frequent questions about Wikipedia and the Wikimedia universe in only a minute.

This years @gerisoc.bsky.social Dhole-Eddlestone prize went to a paper on deprescribing BP meds for people with dementia in care homes. Really interesting study with unexpected results! www.bgs.org.uk/policy-and-m....

It's very funny that Musk has apparently been working with Cummings. Makes perfect sense.

Back in the office

Sure it was shit. Yeah it cost billions and achieved sweet FA. But at least they owned the "wokes". (AM I DOING THIS RIGHT?)

Will the real @pboyle.bsky.social @pboylebskysocial.bsky.social please stand up?

This article discusses clinical use of biomarker tests for Alzheimer's disease pathology, including indications for testing, review of biomarker modalities (PET, CSF, blood), selection of modality based on individual factors, and interpretation and return of results. #ENDALZ doi.org/10.1002/alz....

After nearly three decades, a Minnesota summer camp for kids with HIV/AIDS is closing and up for sale... because retroviral drugs are so effective that there aren't enough campers. Science works, y'all. www.startribune.com/closure-of-n...

Brilliant analysis and worth looking at From a UK perspective our lack of efficiency ironically stems from being too lean on the things that matter - beds, diagnostics, not enough admin/managers. We apparently have the money but not the tools to leverage it.

Amazing news but not early enough for the two bags of random collected cables I disposed of today. www.theverge.com/24330106/usb...

Researchers used AI to generate 288 complete academic finance papers predicting stock returns, complete with plausible theoretical frameworks & citations. Each paper looks and reads as legit. They did this to show how easy it now is to mass produce "credible" research. Academia isn't ready.

Really great profile of my local MP, lots of things about her I didn’t know, what motivates her, and the reasons we are where we are post Brexit.

This is amazing UK company develops AI Granny to keep phone scammers occupied www.androidtrends.com/news/ai-gran...

Comparing the Commonwealth report on healthcare system rankings with cost rankings is pretty telling. We pay the most and get the least. So much for the efficiency of for-profit endeavors.

🧪 New review in The Lancet highlights a gap between AI's potential and actual patient benefits in health care (only 18 RCTs). Many systems lack external validation and harm assessments, raising safety concerns. While psychiatry shows promise, other specialties report mixed results. 🩺🖥️ #MLSky