🔬 We’re hiring again! Looking for 1 #PhD student to join the #MSCA-DN TRANSCEND network 🧬 Project on unconventional #Tcells in #MultipleSclerosis with research exchanges in 🇩🇰 Klaus Eyer’s lab, Aarhus 🇳🇴 Victor Greiff’s lab, Oslo ⏳ Deadline: May 10 👉 euraxess.ec.europa.eu/jobs/403235

I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...

Emma is an incredible mentor and scientist! Plus, Switzerland is a powerhouse of high-quality science. Don’t doubt to apply to this position.

1 week left to apply for a postdoc position in beautiful Switzerland doing awesome mucosal immunology. See below for details! Please re-post to spread the word!

We are hiring! 🧫 🧬 🚀 Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland. See here for details (Deadline: 7th November 2025): join.com/companies/im...

Introducing SLAE, our new framework to represent all-atom protein structures with residue local chemical environment tokens! SLAE reasons over atomic interactions to recover structures and residue pairwise energetics, yielding a generalizable, physics-informed latent space. (1/8)

Excitability as a Design Principle in the Immune System https://www.biorxiv.org/content/10.1101/2025.08.31.673412v1

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice https://www.biorxiv.org/content/10.1101/2025.08.28.672860v1

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Our new review article led by Jordan Kramer: Platforms for studying cell–cell recognition by immune cells onlinelibrary.wiley.com/doi/10.1111/...

As promised, a 'skeet' -orial on our paper published last week !

Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below! www.science.org/doi/10.1126/...

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/

1/ Ever wonder how a clearly brilliant person – someone great a math and engineering and company building – can display shockingly unintelligent thinking when it comes to politics? Neuroscience has the answer!

Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!

Our new work! The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination www.biorxiv.org/content/10.1...

Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection #Tpex www.nature.com/articles/s41...

Our work led by Anna Huhn is now published! The molecular reach of antibodies crucially underpins their viral neutralisation capacity lnkd.in/epe8YZPm Thank you to the reviewers for constructive feedback!

Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything. The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n) doi.org/10.1242/dev....

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

Prior antigen experience of CAR T cells determines functional attributes and amenability to transcription factor-mediated functional enhancement www.nature.com/articles/s41... @koledegolier.bsky.social www.nature.com/articles/s41...

Biologist, stop putting UMAP plots in papers! Blogpost here: simplystatistics.org/posts/2024-1...

'The TME of Long Term Survival cases was distinguished by coinfiltration of T cells, B cells & plasma cells, along with upregulation of the PD-1/PD-L1 pathway. Remarkably, these prognostic associations were almost entirely restricted to tumors with high-epithelial content & the C4/DIF mol. subtype'

"(...) reinforcing 41BB costimulation on the day of vaccination did not result in a substantial improvement in vaccine responses. However, reinforcing 41BB costimulation on day 4 after vaccination, when 41BB expression levels were highest, resulted in a profound improvement in CD8+ T cell responses"

🖐️ Hi Mam! - A superantigen (MAM) goes to the head of the class (II) to find alternatives to TCRs for specific peptide:MHC binders doi.org/10.1038/s415...

This is a clever way to use synthetic biology: taking a toxin that overactivate the immune system (superantigen), rationally modify its core components and transform it into a platform of immunotherapy agents. Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk

Out this week @science.org by first release: Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations. https://buff.ly/4gvqKTz From Shixin Ma, Sue Kaech @tcellogic.bsky.social and colleagues #Immunology #immunometabolism

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

In #biotech #celltherapy news, in vivo CAR T company #Esobiotec has dosed Patient 1 with their proprietary lentiviral therapy for rrMM finance.yahoo.com/news/esobiot... joining the top tier with Interius, Umoja etc. Disclosure: I'm an independent Board Member and wicked proud of the team.

Fascinating study where they label CAR T cells and follow their trafficking in patients! Immediate biodistribution is to the liver and spleen, and they can see whether the Car goes into extramedullary masses. What explains differences between patients?

NiCo is out! Our new algorithm for spatial transcriptomics data analysis predicts the crosstalk of cell types co-localized in tissue niches and sheds light on signalling mediators and downstream effects of cell-cell interactions by inferring covarying gene programs. www.nature.com/articles/s41...

Engineering cells as “live-drugs” is a promising therapeutic strategy, with applications that go beyond cancer. Congrats to Nishith and Milos! Great to see your work published!

Wowza! Lim lab drops bombs in 2s! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

After spending a week learning scRNAseq at SCALE @mskcancercenter.bsky.social, I think this thread below is a good reminder of: 1) the key importance of QC in sc data interpretation and 2) how QC is an iterative process that can be updated when new tools are available.

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

This is really horrific. These single cell reference atlases are widely used as is to train all kinds of models! This is one of the reasons I've constantly harping about uniform reprocessing & extremely careful QC of large atlases. 1/

What were the most inspiring 2024 discoveries in cancer? Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said aacrjournals.org/cancerdiscov...

"The identification of stem-like CD4+ T cells that replenished the autoimmune lesion mirrors earlier findings of islet-specific stem-like CD8+ T cells in both mice and humans with diabetes" #Immunology #Autoimmunity www.cell.com/trends/immun...

In lots of cell atlases the immune system seems to be the guest of honour - getting premier spots in the main figures (not the extended, or extended extended figures) - I have a theory about this...

Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!

IL-2 acts intrinsically on B cells to trigger a “vanguard” metabolic shift that activates mTOR, reprograms B cell metabolism, and drives their differentiation into extra-follicular plasma cell, diverting them from germinal center selection www.cell.com/immunity/ful...

Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social www.nature.com/articles/s41...

If you submit your grants last minute, you're in good company. For the 2005 NIH Pioneer grant, half of the applications were submitted in the last two days. The red bars indicate the awardees. One awardee submitted 8 minutes before the deadline. bsky.app/profile/jere... @jeremymberg.bsky.social

Cool preprint by ⁦Dustin and coworkers on how various T cell engager formats, w/varying geometries/rigidities, impact synapse structure and potency www.biorxiv.org/content/10.1...

In #celltherapy news, Roche to acquire Poseida for programs in blood cancers and autoimmunity/inflammation #bioblue #biotech www.globenewswire.com/news-release...

more #biosky news from @bymadeleinea.bsky.social on the ever-faltering targetTIGIT www.oncologypipeline.com/apexonco/roc...