EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬 The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!

Another wild paper from Jan Burian et al! Modern day gold mining w/ cutting edge sequencing tech! ⛏️ @rockefelleruniv.bsky.social www.nature.com/articles/s41...

📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun! With #CIHR & other 💰: 1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169 2) #Immunology PhD student 3) Postdoctoral fellow Please see our Google lab website + dept website 😀

In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science. Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024. Send a letter: win.newmode.net/canadianasso...

Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

‼️ Notice of upcoming funding opportunity! Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October. Learn more: cihr-irsc.gc.ca/e/54442.html

Wow. Check this out. Politicians actually trying to solve problems can achieve a lot! www.washingtonpost.com/climate-solu...

Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social www.nature.com/articles/s41...

🇨🇦🚨Job alert🚨🇨🇦 We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children

🚨 Two weeks left to apply! 🚨 #facultyjobs

Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...

Sharing some of my PhD work that just came out today. TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5) www.nature.com/articles/s41... (1/5)

Our friends in Pharmacology + Toxicology at the @uoftmedicine.bsky.social @uoft.bsky.social are looking for an assistant professor! The successful candidate will also become a member of the Acceleration Consortium. Apply now: jobs.utoronto.ca/job/Toronto-...

Excited to share that our department at UofT is hiring! We are looking for someone working on "Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology". jobs.utoronto.ca/job/Toronto-...

Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild. Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story. www.biorxiv.org/content/10.1...

🇨🇦🚨Job Alert🚨🇨🇦 Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget) U Toronto, Dept of Biochem/LabMedPath *Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?) Are you an established PI ready to move to 🇨🇦? research.utoronto.ca/funding-oppo...

Very excited for the “Machines acting on DNA and RNA, a molecular mechanistic perspective” - CNIO-CaixaResearch Frontiers Meeting! Getting started with the introduction by @oscarllorca.bsky.social @cniostopcancer.bsky.social

Thrilled to announce my first PhD publication in Nature Comms! We determined structures of the Tad pilus ATPase CpaF from Caulobacter. We use these structures to propose how CpaF employs a rotary mechanism of catalysis to drive Tad pilus assembly. www.nature.com/articles/s41...

Recruiting scientists from the US has to be coupled with increases to tricouncil funding, else we will fail both the recruits, & of course Canadian scientists, who are struggling with insufficient funds. Discovery & biomedical research funding (NSERC, CIHR) in Canada is among the lowest in the G7.

🚨 We’re hiring! 🚨 Exciting opportunity for a Cryo-EM Senior Research Associate at the University of Toronto! Join a cutting-edge facility supporting groundbreaking, cross-disciplinary research. 🧬🦠🔬 📍 Toronto 🔗 jobs.utoronto.ca/job/Toronto-... #CryoEM #ElectronMicroscopy #Hiring #UofT #AcademicJobs

There is an exciting opportunity available to work in the vibrant cryoEM community here in Toronto! 🇨🇦 Happy to field informal inquiries about the position or about uprooting and moving to Toronto as a recent Torontonian myself! Please share widely. jobs.utoronto.ca/job/Toronto-...

www.nature.com/naturecareer... UBC LSI Job!!

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years. Contact me if you are interested. www.nature.com/naturecareer...

Right spirit but grant application length is not a problem (lack of face to face review is) and there is no benefit to showering a few with short term $ if the ecosystem is incapable of supporting them when the $ run out. Making that ecosystem fertile for science would make a long term difference.

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree... Montreal is an amazing city and the Lady Davis is a great institute to work at!

Come work with us in Vancouver! UBC’s Department of Medical Genetics, in collaboration with The Life Sciences Institute, seeks an Assistant Professor working in chromatin regulation or genetic regulatory mechanisms. ubc.wd10.myworkdayjobs.com/en-US/ubcfac...

Tenure track position in pharmacology or toxicology at McGill, in Montreal!!! www.nature.com/naturecareer...

Also worth noting that the path from international postdoc (any nationality) to Canadian Permanent Resident is usually pretty straightforward. I believe most postdocs successfully obtain PR status after 2 years. Canada values and wants highly skilled people to immigrate here.

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See lnkd.in/dVVk4N3s. #microsky

Exciting new work from Barna Lab @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...

My alma mater, the University of British Columbia, Dept of Medical Genetics, is hiring for a tenure track junior faculty position specializing in chromatin regulation / gene regulatory mechanisms. Beautiful city and vibrant epigenetics research. Please share! medgen.med.ubc.ca/assistant-pr...

It’s pretty easy to “apply” for a PhD in Canada, and a little different from most US places, just send a cover letter, CV and undergrad transcript to a PI you’d like to work with. Put some effort into it, make sure you convey what you’re applying for and why.

The graph that shows why Ontario is f***ed: NDP 19% of vote and 20% of the seats, liberals with 30% of the vote and 10% of the seats. So they can never agree who should lead on any vote-sharing deal - both will claim ‘we are the second biggest’ and on the mad corrupt rotten circus goes.

Because of the alarmingly quick dismantling of our federal funding agencies I imagine some academic scientists are considering a stint in (or fulltime switch to) industry R&D. As someone who recently made this switch I thought it could be useful to share some advice (1/7)

If there are any Canadian Universities looking to recruit a Full Professor Endowed Chair who works on Infectious Disease and technology-driven tool development, hit me up. Seriously.

In @justinditrani.bsky.social final postdoc paper (with contributions from many others) we show that forming/purifying vesicles (here from M. smegmatis) allows structure det'n of *endogenous* membrane proteins in their *native lipid bilayer* 🧵 on methods & TB biology... www.pnas.org/doi/full/10....

Yes some important distinctions! Having been in US vs Canada as well, another important difference for many earlier labs is that post docs are more rare & grad students are ⬆️ here vs US. We also keep telling our potential 🇨🇦 post docs to consider 🇺🇲 although that may change now in short term!

I’m not sure if someone has made this thread yet, but I figure there may be some postdocs in the states that are now thinking more seriously about trying to get a PI position in Canada. 🇨🇦 (1/n)

We are hiring - if you are a computational biologist or a molecular biologist with strong nucleic acid skills, please get in touch. I know many of you are in precarious positions right now - Canada is friendly, it’s close. Come and help this project move forwards! www.nature.com/articles/s41...

With recent 💰, we are recruiting a postdoctoral fellow & an #immunology PhD student to start this year! We have 1 summer undergrad position open too. Sadly, our university is not reviewing international student apps due to permit cuts. See here for the current team: sites.google.com/view/thesant...

Biomedical Discovery Research - Assistant Professors @uoft.bsky.social Temerty School Of Medicine Lab Medicine and Pathology universityaffairs.ca/search-job/?...

We are hosting a cryo-EM grid nanofabrication workshop on 28 April 2025, as part of the Canadian Cryo-EM Nexus (ccemn.ca). Learn how to make holey gold or holey carbon grids in your own laboratory! Space is limited, so please apply at web.cvent.com/event/ee88ac...

Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2

The Institut Pasteur is recruiting group leaders! Pasteur is an absolute incredible environment to start your lab. Surrounded by so many great scientists, in the beautiful city of Paris. Come eat 🥐 and conduct awesome science. Contact me if you want info ! research.pasteur.fr/en/call/call...

Dear academics We could dramatically reduce our administrative workload if we all just agreed not to ask for reference letters until we made our list of finalists. This is massive collective action problem has already been solved by… *checks notes* …every other industry on earth.

1/ Keen to share the story of my postdoc research out in @natureportfolio.bsky.social! We built a massive resource characterizing the spatial landscape of the gut—and yes, we dug deep into the biology too. If you’ve got a minute, let me walk you through the story. 🧵👇 www.nature.com/articles/s41...