Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes. @nfrk92.bsky.social @narjournal.bsky.social academic.oup.com/nar/article/...

Can CRISPR-Cas systems target any phage? Yes, no, it depends? What does it depend on? The second paper from my PhD came out today in a special issue of Phil Trans B on the ecology and evolution of bacterial immune systems doi.org/10.1098/rstb...

There's still time to get your abstracts in for this year's International Conference on Microbiome Engineering conference in Antwerp! We extended the deadline to September 15th. #microsky #microbiomesky

Plasmids can be lost from a bacterial community even under positive environmental selection: doi.org/10.1101/2025...

Preprint: De-novo design of proteins that inhibit bacterial defenses Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications Congrats Jeremy Garb! tinyurl.com/Syttt 🧵

Our new paper is online in Genome Biology: "Plasmids, prophages, and defense systems are depleted from plant microbiota genomes" genomebiology.biomedcentral.com/articles/10....

SVbyEye: A visual tool to characterize structural variation among whole-genome assemblies. #StructuralVariants #SVs #Visualization #WholeGenome #Assemblies #Bioinformmatics academic.oup.com/bioinformati...

www.biorxiv.org/content/10.1... Autocycler, the automated successor to Trycycler from @rrwick.bsky.social has a pre-print out - overall, pretty awesome performance (and is very easy to use) github.com/rrwick/Autoc...

🚨 New publication: We describe a novel, cultivated #Archaea species from the human microbiome: #Methanobrevibacter intestini sp. nov. ! www.microbiologyresearch.org/content/jour... #Microbiome #GutMicrobiota #NewSpecies #archaeasky #microbiomesky

OUT NOW: Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice #microsky 🧪 www.nature.com/articles/s41...

Happy to share our genetic toolkit designed to make your gene editing (life) easier, faster and very efficient! Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms! www.biorxiv.org/content/10.1...

I've been waiting for someone to do this: Phase variation via DNA methylation enables gut bacteria to adapt to environmental changes by regulating gene expression and enhancing phenotypic diversity. #microbiome www.biorxiv.org/content/10.1...

(Part 4 of 5) Available PhD projects in Biology! Start your career in ground-breaking research with Gal Ofir & Christian Rödelsperger from the MPI Biology Tübingen. Apply by: 27 Jan. www.phd.tuebingen.mp... #imprs #graduateprogram #maxplanck #phd #phdlife #phdposition #phdpositiongermany #biology

Thanks to great colleagues including @jweir.bsky.social at the @maxplanckcampus.bsky.social 🦠🧫

In a great collaboration with @typaslab.bsky.social, @lisamaierlab.bsky.social and @biocs.bsky.social found that 24% of the tested human-targeted drugs inhibit the growth of gut commensal bacteria. "Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...

I'm recruiting! I'm looking for a motivated postdoctoral scientist to join my new team at SCELSE in Singapore. The role will explore various aspects of how #eDNA is produced and utilised in #Pseudomonas aeruginosa biofilms. #Microsky #phagesky #Science ntu.wd3.myworkdayjobs.com/Careers/job/...

Just landed here from Twitter/X! 🚀 Time to rebuild my followers/following list. If u’re into microbiome science like me, let’s connect and grow a refreshed community! 🔁 Please RT & ❤️ this post so we can gather all the microbiome enthusiasts and scientists in one place. #MicrobiomeScience #Networking

🚨 The Alker Lab is starting at the University of Rhode Island in early 2025 and we will be hiring! 🚨 If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊

Our brand-new paper in #GutMicrobes reveals how Bilophila wadsworthia and Bacteroides thetaiotaomicron interact in the gut, driving H₂S production & metabolic shifts with potential links to inflammation & disease. #GutHealth Check it out: doi.org/10.1080/1949...

#Methanogens dominate #methanotrophs and act as a #methane source in aquaculture pond sediments doi.org/10.1016/j.ec...

Interesting look at gut strain-level dynamics: The human gut has low strain variation compared to other environments and has a limited capacity for strain richness. #microbiome www.nature.com/articles/s41...

Why are some microbes are better (gastrointestinal) commensals? Join for a Postdoc 19+12 months to investigate bacterial & fungal evolution in the human gut in a novel family cohort, using 3rd gen seq, metagenomics. Application deadline is 1st Dec: t.co/FE8tyW3Q3K

A very cool app to compare a list of microbes with microbial signatures in BugSigDB and Bugphyzz 🧫 #microbiome

I wanted to share our beautiful synthetic gut community Com20, highlighting my favourites 🧪cutie little R. intestinalis shaped like a banana 🧫big boss C. perfringens needs privacy around its rods 🧪E. ramosum showing it’s spores @lisamaierlab.bsky.social #microbiome #MicrobiomeSky #microscopy

Today we publish an (in my opinion) important paper in @naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠 Fantastic work Procházková et al. 👏 www.nature.com/articles/s41...

www.nature.com/articles/s41... My friend @chrischirp.bsky.social pointed out I can't just lazily paste links to a paper of interest without any explanation! We all buy into gut microbiota shaping immune populations and programmes, but this study adds huge granularity, by anatomical region and subset

Congratulations to our most recent doctors: Veysi Piskobulu and Mikel Martinez. We wish you all the best in the next step of your career! 🎓 🎉 To find out more about our PhD Program, visit lnkd.in/eMNXc3_M

My friend & colleague @micsysecolab.bsky.social Matthias has written this extremely insightful and fascinating perspective on bacterial collective metabolism, out now in @naturemicrobiol.bsky.social. So happy to see this out & super excited for proteome allocation! www.nature.com/articles/s41...

Excited to share “Bin Chicken”, substantially improving genome recovery through rational metagenomic assembly. Applied to public 🌍 metagenomes, it recovered 24,000 novel species 🦠, including 6 novel phyla. doi.org/10.1101/2024... @wwood @rhysnewell @CMR_QUT 🧵1/6

Hi all, I am back again on blue sky after some time of dwindling Twitter engagement. My group studies #microbiomes of wild animals, we have exciting projects in mammals, birds, reptiles, amphibians. We are based at Uppsala University, Sweden. @animecol-uu.bsky.social www.videvall.com

Sign of the times, no more bluebird on the biorxiv engagement tab..

📢 Interested in chromosomes and microbes thriving at the edge of life?PhD project in York-UK on chromosome segregation in #Archaea. Supervised by me, @Steve Quinn & @georgerheath.bsky.social www.findaphd.com/phds/project... Open to Applicants Worldwide! 📅 January 6, 2025 #microsky #archaeasky

The PLSDB 2025 update: enhanced annotations and improved functionality for comprehensive #plasmid research #plasmidLovers academic.oup.com/nar/advance-...

I am hiring a Research Assistant microbiologist! We are new, expanding research group in the School of Microbiology, UCC and APC Microbiome Ireland in Cork studying anaerobic gut bacteria. Deadline for applications 29th November. Apply here: ore.ucc.ie Job ID: 081111

🚨 New paper alert! 🚨 MinD is famously known for positioning FtsZ at mid-cell in bacteria In our study, myself and @iduggin.bsky.social found that MinD homologues in Haloferax volcanii influence the localisation of CetZ1, a homologue of FtsZ and tubulin #Archaeasky #Microsky

Honored to be part of a collaborative team receiving funding to genetically engineer methanogens in ruminants for reducing carbon emissions. We're now seeking multiple postdocs in the USA, Germany, and New Zealand - apply via the link! docs.google.com/forms/d/e/1F... 🧫🧪 #ArchaeaSky #MicrobiomeSky

Tidyplots empowers life scientists with easy code-based data visualization https://www.biorxiv.org/content/10.1101/2024.11.08.621836v1 #rstats

Hello and welcome to all of you who ditched Twitter! Well done! Introductions: I work with @jmarsh.bsky.social and other awesome researchers from all over the world at @maxplanckcampus.bsky.social where we do curiosity driven microbiome research! Join us! @leylab.com 🧫🦠

I've updated the wording to be clearer that this is an international grant open to global applicants, barring any OFAC sanctioned countries. International researchers outside the USA please feel free to apply!

Another function for the agr quorum sensing system of Staph aureus. Linked to cytosine methylation and regulation of type I RM enhancing HGT. Exciting stuff! www.nature.com/articles/s41...

Anymore archaea peeps out there keen to be part of the ‘kingdom’? #archaeasky go.bsky.app/PEx7P9v

Repurposing endogenous type I-E CRISPR-Cas systems for natural product discovery in Streptomyces www.nature.com/articles/s41...

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

New GPU-based MMseqs2: 20x faster searches on a single L40S (approx. as fast as a RTX 4090) vs. a 128-core CPU. This work enables to set up a very cost-efficient ColabFold MSA GPU server. 🧵🧵 📄 www.biorxiv.org/content/10.1... 💾 mmseqs.com 🗞️ developer.nvidia.com/blog/boost-a...

Another day, another cool recent preprint on bacterial immunity. #Phagesky This one is on an super cool regulation of Restriction-Modification systems. Post-translational modifications that are temperature dependent AND inherited over 60 generations. www.biorxiv.org/content/10.1...

ArchaeaCast: A podcast about the coolest domain of life: Archaea. rss.com/podcasts/arc...

Should've done this a long time ago, but here's my first post on #Bluesky. Check out my postdoc paper on a bacterial ubiquitin-like defense system that we recently published! www.nature.com/articles/s41...

Mobile Elements Starter Pack on BlueSky! Interested in plasmids, phages, ICEs, transposons, integrons, and all things accessory genome? Follow this curated list of researchers and labs doing exciting work in mobile elements.

We discovered the first alternative genetic code in Archaea! www.biorxiv.org/content/10.1...