Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy aacrjournals.org/cancerdisco...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

🚨 1/ Preprint Alert! Sex determination outcome is conserved across vertebrates (i.e. generating 2 compatible sexes) ♀️♂️ But are the cell types and gene programs behind them conserved too? 🧬 Spoiler: not really 👀 Find out in our new preprint ⬇️ www.biorxiv.org/content/10.6...

Not something you see in textbooks very often: tripolar mitosis.

A near-complete map of human cytosolic degrons and their relevance for disease We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence Led by @vvouts.bsky.social in @rhp-lab.bsky.social doi.org/10.1126/scia...

Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point. matsen.group/general/2025...

A study from @danmucida.bsky.social and @victora.bsky.social showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of #foodallergies. #RockefellerScience #YearInReview 🔗: https://bit.ly/4hyS18b

A quick story on how we matched genes across two datasets with different Ensembl versions. 1. There must be a tool out there. Ensembl ID History converter ofc! 2. Doesn't match Ensembl search outcomes due to a bug 3. Lesson: use this client instead github.com/Ensembl/ense... !

Revealing a coherent cell-state landscape across single-cell datasets with CONCORD - @zevgartner.bsky.social @ucsanfrancisco.bsky.social go.nature.com/4jsNxSL

I was invited by @focalplane.bsky.social to write a short description about it: focalplane.biologists.com/2025/12/12/a...

Have you heard about the Night Science Podcast, where we talk about the creative process of doing science? We explore this with discussions with brilliant scientists & philosophers and artists, to figure out the tricks of the creative scientific trade. podcasts.apple.com/us/podcast/n...

GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:

What's stopping the science community from abandoning the term 'basic science' and replacing it with 'fundamental science' across all forms of comms and publishing? "Basic" implies "simple" to the public, when it should be perceived as the foundational bedrock of all innovation.

A bit late to the party on this @science.org piece. I've always been intrigued by how TEs, are so specifically regulated. Mammalian cancers, for instance, often co-opt L1 activity as a potential mutational escape route from stressful environments. www.science.org/content/arti...

ICYMI 🚨 Neurotoxicity impacting the central & peripheral nervous systems is an adverse effect of cancer therapies. In this #Review, Karschnia et al. outline the mechanisms that underlie the clinical symptoms & the need for interventions to treat it. 👇

Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein #condensates #chromatin www.nature.com/articles/s41...

People who fund "disruptors" in biotech and health need to be as discerning and thoughtful as what Max showed here, if not more. #biotech #health #genomics #GWAS #IVF

PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️

A huge step for systematically mapping IDRs across the protein universe in different contexts www.cell.com/cell/fulltex...

Structural basis of regulated N-glycosylation at the secretory translocon #glycotime www.nature.com/articles/s41...

Mind-blowing discovery in Fanconi anemia. A rare embryonic event of incorporating a second polar body in late oogenesis created blood stem cells with a functional FA pathway. These "corrected" cells naturally expanded, rescuing the bone marrow. www.medrxiv.org/content/10.1...

Also, here’s an accessible video intro:

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

This is awesome! CellWhisperer AI enables chat-based analysis of single-cell RNA-seq data. It lets you directly query your datasets, making complex hypothesis testing on sc-transcriptomes intuitive and code-free.

Free up a time of your weekend for this and also watch www.pictureascientist.com

GWAS and burden tests diverge because one ranks trait-specific variants, the other trait-specific genes, not because one is right and the other wrong. So if you see a top GWAS hit, you might just be looking at a lucky allele that drifted to high frequency. www.nature.com/articles/s41...

New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬 An amazing set of resources for all scientists working on the brain! 🧠 Immersive feature: www.nature.com/immersive/d4... 🧠 Perspective: www.nature.com/articles/s41...

>7000 miles away from NYC but we can feel the positive swarm of hopes and dreams. Here's the Autumn-Winter scene at KAIST in Daejeon🇰🇷 to let you in with the vibe

Required reading for cell biologists to get a sense of basic statistical principles! www.nature.com/articles/s41...

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This is interesting for a number of reasons. www.nature.com/articles/s41...

The new Wiley journal review system is an absolute nightmare. Editorial assistants have been replaced by a clunky, AI-enabled website that makes it harder to find and invite reviewers. Associate editor workloads have increased. I'm not convinced the invitations to reviewers are even going through.

Here's a first collection of great life science institutes worldwide you can follow to help you get back in the loop. 🌍🔬 Did we miss any? Let us know, and we'll add them! go.bsky.app/A5Jrf8N

🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...

The Laoui Lab will be well represented at the Tumor Heterogeneity, Plasticity and Therapy (3rd edition) conference #THPT25! Join us to hear more about therapy resistence in #cancer from Anna Obenauf @obenaufa.bsky.social Submit your abstract by the 8th of October on vibbio.tech/THPT25

Acidosis is not just a byproduct of an altere Metabolism - it drives cancer cells‘ stress resilience mechanisms. Big congratulations to our friends from the @johanneszuber.bsky.social lab as well as the team around @wilhelmpalm.bsky.social on this wonderful story now out in Science.

This is going to be one of the biggest, most important features of AlphaFold @alphafold.bsky.social if further improved! Glycobiochemistry needs this bestfriend! #glycotime academic.oup.com/glycob/artic...

Really important work that integrates long-read WGS, MEI-targeted enrichment, haplotype-resolved donor-specific assemblies, and internal L1 sequence variation to detect ultra-rare somatic mobile element insertions (sMEIs) with high precision! www.biorxiv.org/content/10.1...

Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profilingelifesciences.org/reviewed-pr...

Shout out for @johanneszuber.bsky.social and team ! Beautiful work with new biology !

Comment🚨 Large biobank projects like #FinnGen help in uncovering genetic factors that influence cancer risk and outcomes, enhancing risk prediction & biomarker and drug target discovery. @finngen.bsky.social @dalygene.bsky.social @aoxing2.bsky.social#FinnGen 📖 👇

Dogs as naturally evolved models for human cancers! Similar human driver architecture, hotspot usage, and mutational processes across histologies, not just within breed-associated cancer types. 🐶👨#Dogs #Cancer #Breed #Genomics www.biorxiv.org/content/10.1...

This week’s round-up spans species from birds to sheep, and now, fittingly, to dogs! We dive into a new study from Japanese researchers, who have successfully established culture conditions for #canine iPSCs. 🐕 Article: https://bit.ly/4gA5zkC 🐩 Discussion: https://bit.ly/4qfiME4

This is so cool and a severely overlooked aspect of the TME and stroma: spatially disordered geometries of the microenvironment promote invasion shifts from collective to single mode. #cancer #TME #stroma #invasion www.biorxiv.org/content/10.1...

The "pivot penalty". Such a great concept for capturing a nuanced idea. Larger pivots = lower citations, publication rates & market value. Yet, novelty rises with bold moves! Tough call for early-career scientists navigating expertise vs. exploration. www.nature.com/articles/s41...

Excited our paper is out in Cell @cp-cell.bsky.social! 🧬⚡ DNA photo-crosslinking proteomics in living cells 🎯 Pinpoints protein-DNA interactions to single amino acids 🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes 🔗 www.cell.com/cell/fulltex... 🧵

In love with the anterior-posterior double reporter system! Awesome work as usual from Elly Tanaka's group @imbavienna.bsky.social Molecular basis of positional memory in limb regeneration www.nature.com/articles/s41...

A bold step toward precision oncology, but the non-recurrent enhancer mutations highlight the messy complexity of translating these insights into universal therapies. www.nature.com/articles/s41...

This is such a thoughtful thread about the learning curve in bioinformatics and why small habits make the big difference.