Stability vs flexibility: reshaping archaeal membranes in silico This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model. buff.ly/jCnRfkO

🛠️ August’s most-read Tools and Resources paper presents FLiSimBA, a new open tool that helps scientists test and improve fluorescence imaging experiments: buff.ly/2IISokl Learn more about publishing your tools or resources with us: buff.ly/UbGY69s

The gut-brain connection Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.

Magnetotactic bacteria swim along geomagnetic field lines to navigate sediments. Using microfluidics and simulations, this study shows their motility is optimised, revealing how evolution fine-tunes life for challenging environments.

A new #CryoET study shows that the protein ZapD helps organise FtsZ filaments into stable ring-like structures in building bacterial division machinery. buff.ly/saLPqJM

Written up in Nature News, this preprint finds that peer reviewers are more likely to approve articles that cite their own work. 🔗 Read the original #OpenAccess article in eLife for free: buff.ly/gmPDXMz Nature article: buff.ly/hJMcKH9

Frustrated with confusing or conflicting requests for revisions? At eLife, our consultative review process means editors and reviewers discuss their reviews with each other before sharing their recommendations. Learn more about peer review at eLife: buff.ly/jdaPive

1/ Starting next year, @hhmi.org will require all authors to share their research as preprints under a CC BY 4.0 license as part of its new Immediate Access to Research policy. buff.ly/NrHlEKD

🧠 New research presents a method that can automatically reconstruct complex axon pathways with far greater accuracy than before. buff.ly/o7QmH4B

C. elegans uses an "accept-reject" behavioural strategy, based on learned features of its environment, to make decisions about food. This research tackles a core problem in #neuroscience: how neural circuits mediate decision-making. buff.ly/AXcsRVX

Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination. buff.ly/pZZfIso

Capturing enzymes in motion The structure and dynamics of the ACE enzyme revealed by #CryoEM and molecular simulations.

Openness means more than access. We’re pleased to announce that we now publish Replication Studies, helping make science more reliable, transparent, and trustworthy. buff.ly/Gebypvq

Science thrives on migration and collaboration across borders. Eve Marder reflects on her family’s history of displacement and survival in the 1930s through the story of her grandmother’s rug, and how those same forces are shaping science today. buff.ly/smgHkJ1

Can neurons bounce back after damage? A new study in @elife.bsky.social reveals that surviving dopamine SN neurons can restore full firing flexibility—once thought lost—with Kv4.3-mediated changes. Happy to have contributed to this seminal work. elifesciences.org/articles/104...

Scientists are loving our latest study! 🎉 Thrilled that our @elife.bsky.social research article on RAD51 filament strand exchange is August’s most-read in Structural Biology. A landmark for understanding DNA repair. 🧬

🧪 August’s most-read Biochemistry paper presents an alternative platform for #nanobody discovery using phage-displayed synthetic libraries: buff.ly/cXOdjHd Have a paper people should see? See what our Editors look for: buff.ly/o2u0B4k

Using a new organoid-based #CRISPR screen to test genes one by one, researchers identify the genes that regulate closure of the neural tube in humans, shedding light on conditions like spina bifida. The latest research explained in eLife Insight Articles 👇

Blood testing for cell-free HPV DNA could be a better way of tracking cervical cancer progression and treatment effectiveness.

The HABITS system automates large-scale behavioural training for mice, enabling them to learn complex cognitive tasks in their home cage without human interference.

Sleep helps us turn unconscious pattern learning into knowledge we can actually use.

Wnt Signalling: Exploring the origins of a signalling pathway

⛓️ August’s most-read Structural Biology paper is a ‘landmark’ study, describing the structural mechanism of strand exchange by the RAD51 filament: buff.ly/CvSkF34 Have a paper people should see? See what our Editors look for: buff.ly/rr68suW

Out in @elife.bsky.social! Lora and the Roeper lab discovered a new mechanism by which surviving dopamine neurons recover their function in a model of Parkinson's - a key step for understanding this disease! @goetheuni.bsky.social @uabneuro.bsky.social elifesciences.org/articles/104...

In @elife.bsky.social: Membrane binding properties of the cytoskeletal protein bactofilin doi.org/10.7554/eLif...

Great to see a) stunning tomography and b) eLife’s newish publication model working well with big hitters like @cellarchlab.com and @profmattjohnson.bsky.social using it

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

This just awesome - having started the basics of cryoET, I am doubly appreciative of the work and effort - spinach thylakoids at the molecular level

The protein KIF7 plays a crucial role in shaping the brain’s cortex. By fine-tuning Sonic Hedgehog signalling, it guides neuron development and connectivity. When KIF7 is missing, brain wiring is disrupted. #Neuroscience buff.ly/ZHSAeIE

The environment of the thymus plays a big role in how T cells grow and in how cancers like #leukemia can take hold. Using #medaka embryos and simulations like these, the study uncovers how thymic cells help shape health and disease. buff.ly/lGwWG1F

Magnetotactic bacteria swim along geomagnetic field lines to navigate sediments. Using microfluidics and simulations, this study shows their motility is optimised, revealing how evolution fine-tunes life for challenging environments.

A new #CryoET study shows that the protein ZapD helps organise FtsZ filaments into stable ring-like structures in building bacterial division machinery. buff.ly/saLPqJM

Reviewed as a ‘fundamental’ discovery, this study identifies lymphatic muscle cells as innate pacemakers driving lymphatic pumping. buff.ly/kWvdl5i

🔬 August's most-read #cancer biology paper highlights a little-known genetic "switch," called crotonylation, that helps tumours become more aggressive: buff.ly/Eg0QGGj Have a paper people should see? See what our Editors look for: buff.ly/B0dSNwI

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture. buff.ly/j3TSIkn

C. elegans uses an "accept-reject" behavioural strategy, based on learned features of its environment, to make decisions about food. This research tackles a core problem in #neuroscience: how neural circuits mediate decision-making. buff.ly/AXcsRVX

🧠New research presents a method that can automatically reconstruct complex axon pathways with far greater accuracy than before. buff.ly/o7QmH4B

Why do we act differently when we’re watched? We might change our opinions in group settings or take more risks around our friends. Turns out, our choices are shaped by what we *think* the people around us would do.

Reconstructing long-range axons from dense brain images is tough. This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections. buff.ly/o7QmH4B

Dorsal Vagal Complex: A cell atlas to guide research into appetite control buff.ly/QY7ev03

Removing Drp1 in mouse zygotes disrupts mitochondrial distribution, spindle formation & embryo development, revealing how vital this protein is for early life. buff.ly/9GxSdBM

🧬 August’s most-read #genetics paper shows how a new zebrafish tool (mitfa:Cas9) can reveal the genes driving melanocyte and melanoma development: buff.ly/oABwvaN #CRISPR Have a paper people should see? See what our Editors look for: buff.ly/4JvRtM3

« Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells. » A fundamental study now published @elife.bsky.social elifesciences.org/reviewed-pre...

Now published as a "version of record" at @elife.bsky.social elifesciences.org/articles/105...

Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination. buff.ly/pZZfIso

Research from macaques shows that brains recognise objects first with a rough picture, with neurons filling in details later. These fine detail neurons are important for recognising faces. buff.ly/8mOMh8A

Preserving knowledge is a shared responsibility. That’s why we are delighted that eLife partners with CLOCKSS to protect open scholarship for the future. Details here 👉 elifesciences.org/inside-elife... #DigitalPreservation #OpenAccess #AcademicPublishing @elife.bsky.social

Check out the final version of this insightful work by Claire Masson and our long-lasting collaborators #EFS #UMR1255. Very glad to be part of it with @naelosmani.bsky.social and kudos to @elife.bsky.social for a very transparent publishing process. doi.org/10.7554/eLif...

Our paper on central complex evolution in Heliconiini butterflies is now available as reviewed preprint at @elife.bsky.social 🎉🎉. Please check out the helpful and constructive reviews which we are going to address in the next weeks 🤗 elifesciences.org/reviewed-pre... @ebablab.bsky.social

Are you unsure what preprint peer review is? Or how to get started reviewing preprints? Wonder no more! Our latest 5 min video explains all 📽️ youtu.be/bd8QRNm69P4 Subscribe to our newsletter for more: bit.ly/RIsub #scicomm #preprints