As a martini simulator, lipid enthusiast, and map nerd, I absolutely love this one! 🌎

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

May lipid scramblases be selective after all?! New @pnas.org paper showing that TMEM16F prefers PS and PC over PE in the complex context of a real plasma membrane. www.pnas.org/doi/10.1073/...

Evo-MD strikes again! Unraveling the physics of cholesterol attraction by transmembrane proteins. @natcomms.nature.com www.nature.com/articles/s41...

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Thanks to @snsf.ch, we are hiring two PhD students to investigate frontier topics in lipid biology using a combination of MD simulations and experiments. Preferred starting date: ASAP. Fribourg - and Switzerland - are quite nice, for both work and private life! Please spread the word!

Now published as a "version of record" at @elife.bsky.social elifesciences.org/articles/105...

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Looking forward to this one!

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow. www.biorxiv.org/content/10.1...

Wrapped up #BPS2025 with a scenic bike ride to Griffith observatory. This week was a blast! See you next year in SF 🌁 @biophysicalsoc.bsky.social

So much cool science at #bps2025! I’ll present my work on designing lipid scramblases tomorrow at 11 am.

✅ Arrived in #LA ✅ Funded 20 bicycles for World Bicycle Relief Now refocus on some awesome science at #bps2025 @biophysicalsoc.bsky.social I will keep the fundraiser open for another week, so donations are still welcome 🙏🏼

Day 4 ✅ Tough day of riding in the rain. Happy to take a rest day tomorrow. #santabarbara has awesome #bike infrastructure! Donations 🙏🏼 www.powerofbicycles.org/fundraisers/niekvanhilten

Day 3 ✅ Making the most of the sunny weather. Getting closer to LA and #bps2025! Donations 🙏🏼: www.powerofbicycles.org/fundraisers/...

Day 2 ✅ Getting closer to #bps2025 with every pedal stroke. Donations to World Bicycle Relief ➡️ www.powerofbicycles.org/fundraisers/...

On my way to #bps2025 @biophysicalsoc.bsky.social I’m biking from SF to LA to promote low-emission transportation and raise money for World Bicycle Relief. Donations: 🙏🏼 www.powerofbicycles.org/fundraisers/niekvanhilten

Our paper is now out in @elife.bsky.social! We performed @cg-martini.bsky.social MD simulations to capture >700 lipid scrambling events in 27 TMEM16 structures to systematically study their lipid scrambling rates and mechanisms. 📃 doi.org/10.7554/eLife.105111.1

From 9 to 14 February 2025, I embark on a 550 mile (900 km) bike adventure from San Francisco to Los Angeles to attend the annual BPS meeting @biophysicalsoc.bsky.social. On this trip, I strive to (1) raise money for World Bicycle Relief, and (2), to promote low-emission travel. A thread 🧵: