#discovery from my lab @nature.com. Three isoforms of caspase-5, long known for #inflammation & #celldeath, exist in human #gut. CASP5C uniquely amplifies Wnt to nurse transit-amplifying cells supporting #homeostasis & #regeneration. Implications for #IBD & #CRC www.nature.com/articles/s41...

New research published in @natimmunol.nature.com by Pitt Immunology researchers sheds light on how the immune system balances B cell quality and diversity during infection or after vaccination, offering a potential new avenue to improve vaccines. Learn more: www.immunology.pitt.edu/news/blimp1-...

Tomorrow (April 17) is a busy day for the Pitt Department of Immunology at the @aai.org #IMMUNOLOGY2026 meeting! Here’s where you’ll find us in the morning!

Go chat with Sonia Kruszelnicki about how microbiota-dependent IGF-1 shapes alveolar macrophage function. AAI, tomorrow morning!

Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....

Excited for this! If you are in the area, would love to see you.

Good things come in threes! Please join us in congratulating @gottschalklab.bsky.social, @rh-lab.bsky.social, and @meisellab.bsky.social on promotion to associate professor! (1/2)

Excited to share that our paper was accepted at @insight.jci.org ! GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function insight.jci.org/articles/vie...

GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function @insight.jci.org @gottschalklab.bsky.social insight.jci.org/articles/vie...

New preprint! TL;DR: Network analysis reveals that CEBP/β and PU.1 stabilize regulatory architecture in tissue-resident alveolar macrophages to constrain inflammatory responses www.biorxiv.org/content/10.6...

TNF is a driver of rheumatoid arthritis, but the pathway details remain incomplete @SLG1717.bsky.social & team now report Arid5a as an activator of TNF signaling elevated in human RA tissues. And its loss in mice results in resistance to arthritis: doi.org/10.1172/jci....

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

Her training is almost complete

49 travel grants awarded! 🎉 These early-career scientists are going to absolutely crush it at Cytokines 2025. The future of cytokine biology is looking bright with talent like this! Check out all the recipients: cytokinesociety.org/2025/08/29/2... #CytokineSociety #Cytokines2025 #NextGenScientists

Do you know an undergrad at Pitt, Chatham University, or @cmu.edu who hasn't had opportunities for hands-on research? Please encourage them to apply for the Microbiology and Immunology Departments (MID) Scholars Program! Learn more and apply: lnkd.in/eT-gYTqR

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n facultypositions.stanford.edu/en-us/job/49...

My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15. www.mskcc.org/research/ski...

🚨 Faculty position alert! 🚨The Center for Systems Immunology (CSI) and @pitt-immunology.bsky.social are seeking to appoint a tenure-stream Assistant Professor. Learn more and apply: bit.ly/3L42cGS

The Center for Systems Immunology at the University of Pittsburgh is recruiting at the Assistant Professor level. See below for more information. Please repost! cfopitt.taleo.net/careersectio...

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756

Congratulations to Morgan Jackson-Strong from the @gottschalklab.bsky.social who will defend her thesis in a few weeks! 👏

Reposting, submit soon!

UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu Apply here apply.interfolio.com/174404

Great minds think unalike: Learn how a team of immunologists, cancer researchers, telomere experts, and an organic chemist brought their different expertise together to reveal new insights into how damage to #telomeres can shut down #cancer -fighting T cells. buff.ly/gICm1SL (1/2)

We are currently in the process of recruiting a technician. 🥼🐭🔬 If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!

If you are somehow still compelled to be a PI in the world in which we find ourselves, we'd love to have you as a colleague! Two positions in Biochemistry at Vanderbilt University. www.nature.com/naturecareer... www.nature.com/naturecareer...

👋 Hello Bluesky! We are the Pitt Department of Immunology. From autoimmune disease and cancer immunotherapy to vaccine development to infectious disease, our work spans the spectrum of immunological science. Follow along for updates on the latest publications and other news!

Excellent opportunity - the Kueh lab will be recruiting at the Yale Center for Systems and Engineering Immunology this fall.

🛡️How do macrophages tailor their defenses to different pathogens? Our new paper in @cp-cellsystems.bsky.social combines dense multi-omics time series with high‐content CRISPR screens (CROP-seq) to map the regulatory landscape underlying macrophage immune responses: www.cell.com/cell-systems... (1/9)

AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity @sciimmunology.bsky.social www.science.org/doi/10.1126/...

MSA Pairformer efficiently extracts structure, protein-protein interactions, and mutation effects from MSAs by decomposing the effects of phylogeny and structural contacts. @yoakiyama.bsky.social Zhidian Zhang @milot.bsky.social @martinsteinegger.bsky.social @sokrypton.org

Good news for NIH MIRA applicants. Grants.gov recently published the forecast notice for the reissuance of the EI/NI MIRA notice of funding opportunity. As indicated at the link, the estimated post date for the NOFO is Nov 3. www.grants.gov/search-resul...

ICYMI: Parsing the STING in pulmonary hypertension— Andrew J. Bryant & team report on opposing roles for STING in PH—a paradigm shifting mechanism suggesting we refocus on treatments that target cell-specific inflammatory activation: buff.ly/DWmLPLp

NIH is already feeling the effects of LLMs. A new policy was posted yesterday that limits the number of proposals that can be submitted by any one investigator. grants.nih.gov/grants/guide...

The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more. recruit.ap.uci.edu/JPF09601

This is such a cool paper and dataset from lab of @arjunraj.bsky.social. There are [ahem] a lot of spatial transcriptomics papers out there. Here's a [rare?] example of one from which we can truly learn some interesting things... www.biorxiv.org/content/10.1...

Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...

'In the present study, we found evidence that the brain and immune system may be central regulators of aging and longevity in humans, as aged brains are most strongly predictive of earlier mortality, and youthful brains and immune systems are uniquely predictive of longevity.'

My NIH diversity supplement was reinstated! 🥳 This is not the time to keep quiet or feel defeated by this administration. This is the time to raise hell 🔥 and be heard ✊🏽

#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy. www.cell.com/cell/fulltex...

Thrilled to re-share our tweetorial on Bluesky: now out in @cp-cell.bsky.social (🔗 tinyurl.com/3a55tsky) - we present a framework to accelerate variant classification, diagnosis & treatment of inborn errors of immunity. A dream MD/PhD project, which has already led to the treatment of a patient.

@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!

This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...

New powerful article up in the New York Times on cancelled and delayed grants www.nytimes.com/interactive/...

Super cool new paper from the O'Shea lab. STAT interactions and consequences for inflammatory responses during viral infection. www.science.org/doi/10.1126/...

@jclinical-invest.bsky.social preview: IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis www.jci.org/articles/vie... article www.jci.org/articles/vie...