Rachel Gottschalk
@gottschalklab.bsky.social
📤 1027
📥 587
📝 18
Systems Immunology and Macrophage Signaling Assistant Professor at U Pitt
reposted by
Rachel Gottschalk
J Magarian Blander
about 15 hours ago
#discovery
from my lab
@nature.com
. Three isoforms of caspase-5, long known for
#inflammation
&
#celldeath
, exist in human
#gut
. CASP5C uniquely amplifies Wnt to nurse transit-amplifying cells supporting
#homeostasis
&
#regeneration
. Implications for
#IBD
&
#CRC
www.nature.com/articles/s41...
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Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis - Nature
CASP5 expression is restricted to the human intestinal epithelium, and the CASP5C isoform has a key role in promoting Wnt signalling, which is required for epithelial homeostasis, through binding...
https://www.nature.com/articles/s41586-026-10343-8
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reposted by
Rachel Gottschalk
Pitt Department of Immunology
3 days ago
New research published in
@natimmunol.nature.com
by Pitt Immunology researchers sheds light on how the immune system balances B cell quality and diversity during infection or after vaccination, offering a potential new avenue to improve vaccines. Learn more:
www.immunology.pitt.edu/news/blimp1-...
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reposted by
Rachel Gottschalk
Pitt Department of Immunology
7 days ago
Tomorrow (April 17) is a busy day for the Pitt Department of Immunology at the @aai.org
#IMMUNOLOGY2026
meeting! Here’s where you’ll find us in the morning!
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Go chat with Sonia Kruszelnicki about how microbiota-dependent IGF-1 shapes alveolar macrophage function. AAI, tomorrow morning!
add a skeleton here at some point
8 days ago
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reposted by
Rachel Gottschalk
JCI insight
11 days ago
Rachel A. Gottschalk
@gottschalklab.bsky.social
, Satarupa Ganguly
@satarupa2025.bsky.social
& team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice:
doi.org/10.1172/jci....
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Excited for this! If you are in the area, would love to see you.
add a skeleton here at some point
29 days ago
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reposted by
Rachel Gottschalk
Pitt Department of Immunology
about 2 months ago
Good things come in threes! Please join us in congratulating
@gottschalklab.bsky.social
,
@rh-lab.bsky.social
, and
@meisellab.bsky.social
on promotion to associate professor! (1/2)
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Excited to share that our paper was accepted at
@insight.jci.org
! GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function
insight.jci.org/articles/vie...
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JCI Insight - GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function
https://insight.jci.org/articles/view/196246
2 months ago
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reposted by
Rachel Gottschalk
Waggoner Lab
2 months ago
GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function
@insight.jci.org
@gottschalklab.bsky.social
insight.jci.org/articles/vie...
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New preprint! TL;DR: Network analysis reveals that CEBP/β and PU.1 stabilize regulatory architecture in tissue-resident alveolar macrophages to constrain inflammatory responses
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.02.16.706134v1
2 months ago
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reposted by
Rachel Gottschalk
JCI insight
3 months ago
TNF is a driver of rheumatoid arthritis, but the pathway details remain incomplete
@SLG1717.bsky.social
& team now report Arid5a as an activator of TNF signaling elevated in human RA tissues. And its loss in mice results in resistance to arthritis:
doi.org/10.1172/jci....
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reposted by
Rachel Gottschalk
Arjun Raj
4 months ago
Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
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Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
https://open.substack.com/pub/arjunrajlab/p/just-quit?r=37ev25&utm_medium=ios
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Her training is almost complete
5 months ago
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reposted by
Rachel Gottschalk
Stephanie Flores
8 months ago
49 travel grants awarded! 🎉 These early-career scientists are going to absolutely crush it at Cytokines 2025. The future of cytokine biology is looking bright with talent like this! Check out all the recipients:
cytokinesociety.org/2025/08/29/2...
#CytokineSociety
#Cytokines2025
#NextGenScientists
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reposted by
Rachel Gottschalk
Pitt Department of Immunology
6 months ago
Do you know an undergrad at Pitt, Chatham University, or
@cmu.edu
who hasn't had opportunities for hands-on research? Please encourage them to apply for the Microbiology and Immunology Departments (MID) Scholars Program! Learn more and apply:
lnkd.in/eT-gYTqR
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reposted by
Rachel Gottschalk
Adrian Liston
6 months ago
Pre-print alert! And this one really is a must read for anyone that does spectral
#flowcytometry
. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
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reposted by
Rachel Gottschalk
Miriam B. Goodman, PhD
6 months ago
Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n
facultypositions.stanford.edu/en-us/job/49...
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Stanford | Faculty Positions: Details - Assistant Professor of Molecular and Cellular Physiology
https://facultypositions.stanford.edu/en-us/job/494922
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reposted by
Rachel Gottschalk
John Chodera
6 months ago
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
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Faculty Positions
The Sloan Kettering Institute is seeking innovative scientists to join our faculty.
https://www.mskcc.org/research/ski/positions/faculty-positions
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reposted by
Rachel Gottschalk
Pitt Department of Immunology
6 months ago
🚨 Faculty position alert! 🚨The Center for Systems Immunology (CSI) and
@pitt-immunology.bsky.social
are seeking to appoint a tenure-stream Assistant Professor. Learn more and apply:
bit.ly/3L42cGS
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The Center for Systems Immunology at the University of Pittsburgh is recruiting at the Assistant Professor level. See below for more information. Please repost!
cfopitt.taleo.net/careersectio...
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Assistant Professor - CSI
Click the link provided to see the complete job description.
https://cfopitt.taleo.net/careersection/pitt_faculty_external/jobdetail.ftl?job=24007498&tz=GMT-04%3A00&tzname=America%2FNew_York
6 months ago
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reposted by
Rachel Gottschalk
Ardem Patapoutian
6 months ago
During these uncertain times, I’m very happy to see that my institution,
@scripps.edu
has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/174756
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reposted by
Rachel Gottschalk
Pitt Program in Microbiology & Immunology
6 months ago
Congratulations to Morgan Jackson-Strong from the
@gottschalklab.bsky.social
who will defend her thesis in a few weeks! 👏
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reposted by
Rachel Gottschalk
Vaughn Cooper
7 months ago
Reposting, submit soon!
add a skeleton here at some point
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reposted by
Rachel Gottschalk
Shabaana Khader
7 months ago
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department!
microbiology.uchicago.edu
Apply here
apply.interfolio.com/174404
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/174404
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reposted by
Rachel Gottschalk
Pitt Department of Immunology
7 months ago
Great minds think unalike: Learn how a team of immunologists, cancer researchers, telomere experts, and an organic chemist brought their different expertise together to reveal new insights into how damage to
#telomeres
can shut down
#cancer
-fighting T cells.
buff.ly/gICm1SL
(1/2)
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reposted by
Rachel Gottschalk
Adriana Forero
7 months ago
We are currently in the process of recruiting a technician. 🥼🐭🔬 If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!
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reposted by
Rachel Gottschalk
ThePatrick&WatsonLabs
7 months ago
If you are somehow still compelled to be a PI in the world in which we find ourselves, we'd love to have you as a colleague! Two positions in Biochemistry at Vanderbilt University.
www.nature.com/naturecareer...
www.nature.com/naturecareer...
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Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515
Department of Biochemistry, School of Medicine—Basic Sciences
https://www.nature.com/naturecareers/job/12843515/assistant-professor-of-biochemistry-at-vanderbilt-university/
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reposted by
Rachel Gottschalk
Pitt Department of Immunology
7 months ago
👋 Hello Bluesky! We are the Pitt Department of Immunology. From autoimmune disease and cancer immunotherapy to vaccine development to infectious disease, our work spans the spectrum of immunological science. Follow along for updates on the latest publications and other news!
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Excellent opportunity - the Kueh lab will be recruiting at the Yale Center for Systems and Engineering Immunology this fall.
add a skeleton here at some point
8 months ago
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reposted by
Rachel Gottschalk
Christoph Bock Lab @ CeMM & MedUni Vienna
8 months ago
🛡️How do macrophages tailor their defenses to different pathogens? Our new paper in
@cp-cellsystems.bsky.social
combines dense multi-omics time series with high‐content CRISPR screens (CROP-seq) to map the regulatory landscape underlying macrophage immune responses:
www.cell.com/cell-systems...
(1/9)
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reposted by
Rachel Gottschalk
Waggoner Lab
9 months ago
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
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GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity.
https://www.science.org/doi/10.1126/sciimmunol.adt0688
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reposted by
Rachel Gottschalk
Kevin K. Yang 楊凱筌
9 months ago
MSA Pairformer efficiently extracts structure, protein-protein interactions, and mutation effects from MSAs by decomposing the effects of phylogeny and structural contacts.
@yoakiyama.bsky.social
Zhidian Zhang
@milot.bsky.social
@martinsteinegger.bsky.social
@sokrypton.org
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reposted by
Rachel Gottschalk
Pam Ronald
9 months ago
Good news for NIH MIRA applicants.
Grants.gov
recently published the forecast notice for the reissuance of the EI/NI MIRA notice of funding opportunity. As indicated at the link, the estimated post date for the NOFO is Nov 3.
www.grants.gov/search-resul...
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Lock
https://www.grants.gov/search-results-detail/359862
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reposted by
Rachel Gottschalk
JCI insight
9 months ago
ICYMI: Parsing the STING in pulmonary hypertension— Andrew J. Bryant & team report on opposing roles for STING in PH—a paradigm shifting mechanism suggesting we refocus on treatments that target cell-specific inflammatory activation:
buff.ly/DWmLPLp
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reposted by
Rachel Gottschalk
Jevin D. West
9 months ago
NIH is already feeling the effects of LLMs. A new policy was posted yesterday that limits the number of proposals that can be submitted by any one investigator.
grants.nih.gov/grants/guide...
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NOT-OD-25-132: Supporting Fairness and Originality in NIH Research Applications
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supporting Fairness and Originality in NIH Research Applications NOT-OD-25-132. NIH
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-132.html
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reposted by
Rachel Gottschalk
Katherine Xue
9 months ago
The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601
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Junior, Assistant, or Associate Specialist – Xue Lab
University of California, Irvine is hiring. Apply now!
https://recruit.ap.uci.edu/JPF09601
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reposted by
Rachel Gottschalk
Adam MacLean
9 months ago
This is such a cool paper and dataset from lab of
@arjunraj.bsky.social
. There are [ahem] a lot of spatial transcriptomics papers out there. Here's a [rare?] example of one from which we can truly learn some interesting things...
www.biorxiv.org/content/10.1...
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Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids
Gastruloids are three-dimensional stem-cell-based models that recapitulate key aspects of mammalian gastrulation, including formation of an anterior-posterior (AP) axis. However, we do not have detail...
https://www.biorxiv.org/content/10.1101/2025.07.14.664617v1
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reposted by
Rachel Gottschalk
Ruth Franklin
9 months ago
Exciting week! Congrats to
@xuzhoulab.bsky.social
, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉
www.sciencedirect.com/science/arti...
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Regulation of inflammatory responses by pH-dependent transcriptional condensates
Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…
https://www.sciencedirect.com/science/article/pii/S0092867425007354
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reposted by
Rachel Gottschalk
Thiago Carvalho
9 months ago
'In the present study, we found evidence that the brain and immune system may be central regulators of aging and longevity in humans, as aged brains are most strongly predictive of earlier mortality, and youthful brains and immune systems are uniquely predictive of longevity.'
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Plasma proteomics links brain and immune system aging with healthspan and longevity - Nature Medicine
In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...
https://www.nature.com/articles/s41591-025-03798-1#Sec7
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reposted by
Rachel Gottschalk
Juan Del Toro, PhD
9 months ago
My NIH diversity supplement was reinstated! 🥳 This is not the time to keep quiet or feel defeated by this administration. This is the time to raise hell 🔥 and be heard ✊🏽
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reposted by
Rachel Gottschalk
Ivan Zanoni
10 months ago
#WeekendRead
!
#InterferonsFriendsOrFoes
?!
@ruthfranklinlab.bsky.social
, Medzhitov, Hoagland, Rodriguez-Morales &co show
@science.org
that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
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Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
https://www.science.org/doi/10.1126/science.adi8828
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reposted by
Rachel Gottschalk
10 months ago
Our lab just completed a +6 year
#marathon
, describing for the first time that the
#microbiome
is critical for
#exercise
- induced increases in antitumor CD8 T cell immunity and improved of
#cancer
#immunotherapy
.
www.cell.com/cell/fulltex...
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900684-1
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reposted by
Rachel Gottschalk
Zach Walsh
10 months ago
Thrilled to re-share our tweetorial on Bluesky: now out in
@cp-cell.bsky.social
(🔗
tinyurl.com/3a55tsky
) - we present a framework to accelerate variant classification, diagnosis & treatment of inborn errors of immunity. A dream MD/PhD project, which has already led to the treatment of a patient.
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reposted by
Rachel Gottschalk
Anshul Kundaje
10 months ago
@saramostafavi.bsky.social
(@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
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Rachel Gottschalk
Mathew Kiang
10 months ago
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
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Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
https://ki.se/en/about-ki/jobs-at-ki/join-a-global-community-of-excellence
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Rachel Gottschalk
Ardem Patapoutian
10 months ago
So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!
add a skeleton here at some point
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Rachel Gottschalk
Adam Gracz
11 months ago
This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...
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reposted by
Rachel Gottschalk
Jeremy Berg
11 months ago
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
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Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
https://www.nytimes.com/interactive/2025/06/04/health/trump-cuts-nih-grants-research.html?unlocked_article_code=1.MU8.U2JL.z3BXY3hj-08t&smid=url-share
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Super cool new paper from the O'Shea lab. STAT interactions and consequences for inflammatory responses during viral infection.
www.science.org/doi/10.1126/...
11 months ago
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reposted by
Rachel Gottschalk
Waggoner Lab
11 months ago
@jclinical-invest.bsky.social
preview: IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
www.jci.org/articles/vie...
article
www.jci.org/articles/vie...
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