With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes. Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc

Once upon a time I just admired nudis and sea slugs. But it was not enough. Now apparently I'm creating an R package to celebrate their colour palettes? 😅 First up, my Sydney fave, Hypselodoris bennetti. #rstats #nudibranch #dataviz 🦑🐙🧪 #marinelife #invertebrates

"i have two Microsoft Outlooks, and neither one of those are working." The Astronauts truly representing us all up there.

Pleased to share our latest research where we investigated a potential new drug for type 1 diabetes in slices of living human pancreas tissue from nPOD donors #industrycollaboration with Immunocore @bruskolab.bsky.social @ufbme.bsky.social @ufresearch.bsky.social www.science.org/doi/10.1126/...

My main gripe with the alphafold example is how it shows you need decades and decades of high quality data, well structured, open and accessible to train a model -- and yet they always gloss over it and pretend it's just AI and magic. No, we need to continuously invest in real data and FAIR data.

PSA: Do not take your plasmids for granted. Sequence EVERYTHING. Trust no one.

Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...

Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira www.sciencedirect.com/science/arti...

New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky

Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD www.cell.com/cell-reports...

I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social www.cell.com/cell-reports...

Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org www.nejm.org/doi/pdf/10.1...

First ADA 5k in the bag. #ADAChicago

What an amazing time to be a biomedical scientist. www.nejm.org/doi/abs/10.1...

Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress. link.springer.com/article/10.1... 🔓

When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday

How academics imagine their lives would look like if they decide to work in tech

I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.

Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this! www.biorxiv.org/content/10.1...

Great session on biomaterials for beta cell replacement in T1D at #SFB2025. Thanks to all the speakers and co-organizer Jess Weaver.

Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI 🍸 as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social www.biorxiv.org/content/10.1... #CalciumImaging #Diabetes

Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!

We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...

New aquarium denizens

Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too! bme.ufl.edu/events/uf-bi...

Exiting the microscopy room

Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

Leading the pack: Glucokinase reinforces Ca2+-waves #PancSky #BetaCellSky elifesciences.org/articles/103...

I love @journeytomicro.bsky.social but they don't seem active on here, so I'm going to post my favorite videos of theirs here to spread their chill science vibes

Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...

AIMBE has posted a public statement on the impact of federal policy changes on biomedical research: aimbe.org/advocate/wri... Above, we have also developed an advocacy letter for members of the medical & biological engineering community to send to their congressional representatives on this matter.

When the visiting speaker asks me about things the last couple weeks .

Timeline cleanse. Please meet Lucy the giant schnauzer puppy. Age 11 weeks. Hobbies include ambush attacking her family from under the coffee table and shredding dress shirts with her shark teeth.

Sana Biotechnology's first-in-human study of hypoimmune-engineered deceased donor islets shows insulin production & immune evasion without immunosuppression #Diabetes #T1D #CellTherapy ir.sana.com/news-release...

Early career vs. mid-career investigators 😉 Happy New Year to all who are returning to the trenches of academia for the winter semester!

It’s never a good sign when I have an opportunity to post this exceptional public health graphic.

Nice findings on Beta cell dysfunction studied in human pancreatic slices during type 1 diabetes progression, interesting findings on calcium dynamics #BetaSky @eaphelps.bsky.social www.biorxiv.org/content/10.1...

Check out our new preprint "Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis" featuring Ca2+ imaging and timelapse imaging of human T1D insulitis. Very proud of this massive effort by first-author @molliehuber.bsky.social www.biorxiv.org/content/10.1...

Checkout out these two bombshell papers from @possuhuanglab.bsky.social @stanfordmedicine.bsky.social, computational design of antigen-specific binders to MHC-I or -II, with applications to next gen targeted therapeutics 🤯

UF Biomedical Engineering is HIRING! Join a vibrant team that's shaping the future of biomedical engineering education!We're seeking instructional faculty (non-tenure-track) to teach our lab-based cell and tissue engineering course. explore.jobs.ufl.edu/en-us/job/53...

One of the most surprising lessons for me during my 30 years of doing science is how it's essentially impossible predict what major scientific breakthroughs will emerge or where they will emerge from. But the way we fund science is mostly based on the assumption that we can make such predictions.

Dear NIH, No, I do not want to read the summary statement of my rejected grant on Thanksgiving. Sincerely, boundaries.

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

Laboratory Manager position available in my group. We are a fun, dynamic lab focused on cellular and biomaterials engineering for type 1 diabetes. explore.jobs.ufl.edu/en-us/job/53...

Photosynthetic CHO cells. www.jstage.jst.go.jp/article/pjab...