The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes www.nature.com/articles/s41... @natcomms.nature.com

Thrilled to see this out. What started out as a chat several years back with @drfejzo.bsky.social about leveraging publicly available data on hyperemesis gravidarum GWAS turned into a wonderful collaboration with April Shu, @mvaudel.bsky.social, @xwww.bsky.social and many others! rdcu.be/fdl9k

Happy to share our latest work out now in Immunity @cp-immunity.bsky.social. doi.org/10.1016/j.im.... We provide insight into how influenza infections detrimentally impact cardiovascular health. Building on clinical observations, we show that influenza damages the heart and lowers its function.

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart: Immunity www.cell.com/immunity/ful...

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social

Exciting updates!! (1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated) (2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week! (3) Learn more at stroberlab.com

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

yet, I constantly find myself having to explain this in most spaces where important conversations and decisions (regulatory, policy, higher education, etc) take place

It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ

Staff scientist position (computational): I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record. #sciencejobs

ICE just arrested Brad Lander, the NYC Comptroller and one of the leading candidates for Mayor, without grounds. He was conducting routine immigration court work, escorting individuals from hearings. He asked ICE for their warrant - well within his legal rights. This is political intimidation.

what the actual fuck

If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again: www.biorxiv.org/content/10.1...

Delighted to share that one of my major PhD projects has been published today in Current Biology. In this paper, we look into the genetic population structure and demographic histories of two populations in Sri Lanka: the Sinhalese and Adivasi [1/n]. www.cell.com/current-biol...

Now published in PNAS: www.pnas.org/doi/10.1073/...

I didn't have much hope that we'd find genetic determinants of long-COVID, but after years of work, Vilma Aho, Tomoko Nakanisha, Hugo Zeberg and Hanna Ollila made it happen! (Among a few others :-)) www.nature.com/articles/s41...

“Should AI be allowed to review papers or grant proposals” always reveals a thing I think people don’t understand about algorithmic bias 🧵

PIs who think their research isn’t political: yes it is, it always is

📣Online now from Fu et al! 📄Role of X chromosome and dosage-compensation mechanisms in complex trait genetics

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics https://go.nature.com/4jGqiUc

They are coming for every university, if you think you’re safe because it hasn’t been yours yet I don’t know what to tell you. Join AAUP, refuse to comply, organize your colleagues

Biomedical value of studying human diversity spotlighted by 5-nation asian Immune Diversity Atlas (AIDA) of circulating immune cells from healthy donors www.cell.com/cell/fulltex... @cellcellpress.bsky.social @jayshin.bsky.social

The @nytimes.com just discovered parallel computing.

How do you study gene-environment (GxE) interactions in humans? Well, there's probably no way to avoid studying each exposure individually, but what about the cellular context? If you choose directed differentiation, you have to study GxE one cell type at a time. If you choose an organoid system -

for Sasha & his family www.gofundme.com/f/rememberin...

absolutely devastating — i feel incredibly grateful to have had you as a coach and you will be missed dearly, Sasha 🤍

Here’s what’s what at UChicago. Not good.

The sword has now been brandished over civil society, including scientists, universities, and other NGOs. Who, including university presidents, will have any backbone in defending their jnstitutions’ missions? Or will they take on the Zuckerberg/ Bezos pose? www.nytimes.com/live/2025/01...

Very excited about this new work from our lab! Explainer thread coming soon @minetoota.bsky.social

Innate Immune Memory is Stimulus Specific https://www.biorxiv.org/content/10.1101/2025.01.22.634275v1

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen

I am in R dependency hell

#WeekendRead! #MysterySolved! Why people with the same mutation present or not a pathology? @bogunoviclab.bsky.social &co show @Nature that epigenetic controls the random expression of 1 allele in 5% of all genes, explaining incomplete penetrance for monogenic inborn error of immunity #IEI diseases!

Human embryo editing against disease is unsafe and unproven despite rosy predictions @shaicarmi.bsky.social @wiringthebrain.bsky.social www.nature.com/articles/d41... Heritable polygenic editing: the next frontier in genomic medicine? @juliansavulescu.bsky.social www.nature.com/articles/s41...

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼

one unanticipated downside of grad school was that it took the fun out of reading for me. this year, i started picking up books again and fell back in love 🥹 #booksky

Women leave academia at higher rates than men at every career stage, and attrition is especially high among three groups: tenured faculty, women in non-STEM fields, and women employed at less prestigious institutions, a #ScienceAdvances analysis finds.

🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We're excited to bring PhD students together with an all-star list of leaders in human genetics. 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at www.lpshg.com

What do GWAS and rare variant burden tests discover, and why? Do these studies find the most IMPORTANT genes? If not, how DO they rank genes? Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬) www.biorxiv.org/content/10.1...

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts https://www.medrxiv.org/content/10.1101/2024.12.05.24318552v1

very excited to share the last chunk of my PhD work, now available on @biorxivpreprint.bsky.social! in this work, we explore how cis-regulatory variation and gene-environment (GxE) interactions influence immune response diversity directly in a cohort of hospitalized COVID-19 patients 1/n

Top 10 Hill-Robertsons to Die On

1/ Keen to share the story of my postdoc research out in @natureportfolio.bsky.social! We built a massive resource characterizing the spatial landscape of the gut—and yes, we dug deep into the biology too. If you’ve got a minute, let me walk you through the story. 🧵👇 www.nature.com/articles/s41...