Woohoo! Go Foldit!

GOOD NEWS! Researchers have discovered a powerful antibody, known as 04_A06, that is able to neutralize 98.5% of MORE THAN 300 different HIV strains AND permanently reduce HIV viral load to undetectable levels, making it one of the broadest-acting antibodies against HIV identified to date.

Laughter is medicine. G’night all

Optogenetic construction of de novo integrin-adhesion complexes reveals role for biocondensation in adhesion nucleation https://www.biorxiv.org/content/10.1101/2025.10.08.681107v1

Viral AlphaFold Database (VAD) is live in Science Advances ~27,000 predicted viral protein monomers & homodimers Conserved folds across bacteria, archaea & eukaryotic viruses New toxin–antitoxin system KreTA uncovered Vast “functional darkness” remains uncharted www.science.org/doi/10.1126/...

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

GOOD NEWS! Researchers have developed a new mRNA vaccine that has been shown to suppress abnormal blood vessel growth in the retina, offering hope to MILLIONS of patients with age-related vision loss. The vaccine triggered strong antibody responses that REDUCED retinal damage by UP TO 85%.

I'm a transgender Genomics PhD with 15 years of science communication experience who just launched an educational campaign to fight anti-trans propaganda that claims to be rooted in "biology" Resources and advocacy campaigns to come soon. Follow at @beyondxandy.bsky.social beyondxandy.org

I'm excited to report that a species has been named after my son Ze Frank, "in recognition of his outstanding contributions to science communication, which have inspired curiosity, wonder, and deeper public engagement with the natural world"

1. 4 months ago, The Supreme Court gave families a right to opt out of LGBTQ+ education in schools. Now, in Montgomery County, Maryland, where the case originated, the results are in. Only 43 families out of 160,000 students have exercised that new right. Subscribe to support our journalism.

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link: apply.interfolio.com/174360 PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10

✨My first science feature is out in Chemical & Engineering News!✨ I interviewed and wrote about Dr. Shana V. Stoddard, a brilliant disabled scientist changing STEM. Disabled scientists deserve visibility and celebration. cen.acs.org/synthesis/me... #DisabledInSTEM #SciComm #RepresentationMatters

Our lab is moving to a new building, so I brought home the #origami capsids that normally sit above my desk - they're camping on my #Lego table for now

Go home spell check, you're drunk

The Trump administration has completely ended all pathways to seek asylum, a legal right for more than half a century. We took the government to court and won, and they're now appealing. We won't abandon our commitment to people fleeing danger.

Autistic inertia = difficulty with starting, stopping and switching tasks It can happen even when: - you want to do the task - the task is important or urgent - you have a clear understanding of what needs to be done - it’s something as “simple” as getting out of bed or the shower

The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars

GOOD NEWS! Researchers have made a HUGE breakthrough towards a UNIVERSAL antiviral. By targeting sugar molecules found on the surface of many viruses that SHARE structural similarities, they identified FOUR compounds that successfully BLOCKED infections from SEVEN different viruses.

GOOD NEWS! Researchers have unveiled a promising new vaccine that generates a powerful immune response against HIV and other viruses including SARS-CoV-2 and influenza with just ONE dose. By combining immune-boosting adjuvants, the vaccine encourages the body to generate more antibody variations.

A Conserved Motif as an Evolutionary Kernel for β-Sheet Oligomerization Revealed by Divergence Analysis of Helix-to-Sheet Transitions in EAA1 Isoforms https://www.biorxiv.org/content/10.1101/2025.10.02.679742v1

🚨GRFP DEADLINE ALERT!🚨 I missed this in my original solicitation read-through, so FYI 📣LETTERS ARE DUE BEFORE PROPOSALS📣 this year! "Reference letters are due Friday, November 7 at 5:00 p.m. Eastern Time (ET)." www.nsf.gov/funding/oppo...

rAAV-Delivered Bicistronic Artificial microRNAs for Allele-Specific Silencing Improve Motor and Molecular Outcomes in Spinocerebellar Ataxia Type 3 https://www.biorxiv.org/content/10.1101/2025.10.02.680011v1

Check out our latest, where we investigate the molecular origin of differences between Lys and Arg and their roles in biomolecular #condensates @dipcehu.bsky.social www.biorxiv.org/content/10.1...

The last block…👏🏼👏🏼👏🏼👏🏼👏🏼 There is no LGB without the TQ.

Are viruses capable of regulating protein synthesis in the nuanced way of cellular organisms? Kinda! I’m excited to share some of my postdoc work that leveraged giant DNA viruses to address this question.

1/5 Lab's first manuscript 🎉 is out @biorxivpreprint.bsky.social today! Beautifully, it is performed by a senior undergraduate thesis student, Mohammed! We developed a 3-D printed #zebrafish embryo imaging chamber 🔬and connected it to syringe pumps to be able to perfuse drugs in a timely fashion. 🧪

Out today in @nature.com, a new paper from @doudna-lab.bsky.social lab, co-first authors @erinedoherty.bsky.social + @benadler.bsky.social and collaborators at @ucsandiego.bsky.social unveils a powerful new defense strategy in the arms war between viruses + microbes. Read here: ow.ly/mPQI50X5g68

"AlphaFold-Multimer’s prediction accuracy is sensitive to the defined boundaries of the interacting partners" #alphafold yep www.pnas.org/doi/10.1073/...

I said I will never work on phages, but having @micheleleroux.bsky.social next door made me change my mind. Here is Alexis's new paper showing how different phages deal with the capsular barrier to infect Acinetobacter! A great collaboration between our labs! journals.plos.org/plospathogen...

Wow! @mychal3ts.bsky.social is an incredibly kind and supportive person! I had a few brief conversations with him on Insta about my book and I couldn’t think of a better person to host such a seminal show as Reading Rainbow.

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture. buff.ly/j3TSIkn

I’m thrilled to share my latest published manuscript, which summarizes my work in the exciting fields of structural biology and amyloid research. A huge thank you to @meytallandau.bsky.social and the team at @landaulabcssb.bsky.social for their shared efforts doi.org/10.1002/advs...

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

Hey! Bluesky! Learn you about some Autism! I wrote this piece after a conversation with CNN's Sanjay Gupta, and it's received tremendous feedback from both Autistic people and from educators, doctors and journalists who have learned from it. Read it! coda.io/@mykola-bilo...

The Quakers issued this reply to a GC attack on their trans inclusion policy. It’s incredible in its care and certainty. Its examples of transphobia are spot on. And >98% of Quakers surveyed agree with the policy. Anyone implementing trans inclusion policies should take note. This is how to do it.

It’s NOT a communication “deficit”… It’s the Double Empathy Problem - and it changes everything 💬 Autistic people aren’t defective, uncaring, or unsociable 🧠 The real issue? Two different neurotypes trying to connect Communication is a two-way street, not a one-sided flaw (1/7)

And that's how you integrate digital elements into an exhibition. Part of the temporary "China's Dinosaur World" at the Shanghai Natural History Museum, China. Closing this November. Video source: Shanghai Let's Meet

(If we can try to support living authors, that would be especially neat btw)

Do not miss it! 1st Place 2025 Small World in Motion Competition "Self-pollination in a flower of thymeleaf speedwell (Veronica serpyllifolia)" Credit Jay McClellan 🧪 #Science #SciComm #Nature #Photography 1- www.nikonsmallworld.com 2- www.nikonsmallworld.com/galleries/20...

In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular: The joy. One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...

Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...

Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵 📑 Paper doi.org/10.1038/s443... 🔭 Explore virosphere viro3d.cvr.gla.ac.uk

Still boggles my mind that we can leave frameworks as-is and only edit CDRs and still reliably get nM binders. Complete opposite of what I would have expected given how hard it is to graft CDRs from one FW to another (such as humanizing mouse mAbs). First RFantibody and now this

Postdoc position available in the BioEmu team at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK. Looking for candidates with backgrounds in #MachineLearning #AI Biophysics or Bioinformatics jobs.careers.microsoft.com/global/en/jo...

This generic acetaminophen had an Amtrak ACS-64, four Amfleet 1 cars, a Conrail EMD GP15-1, and some Conrail rolling stock in it. The problem is more serious than I thought.

Trump/MAGA have made several critical blunders and one that I think has been underappreciated was the assumption that if they (illegally) fired THOUSANDS of career civil servants, those folks would go quietly into the industry night. LOL. Nah. They are going straight into activism.

Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing @computingcaitie.bsky.social, now at the @biozentrum.unibas.ch 🧪🧶🧬

YES! Gene therapy in the brain www.bbc.com/news/article...

Stay tuned for: ✊ Grassroots activism campaigns 🧬 Educational resources about the science behind sex, gender identity, and gender-affirming care 📰 Summaries & commentary about major news relating to trans health, research, and politics. 🫂 Community building for trans people in the field of biomed