How do cells orchestrate themselves to achieve a directional movement as a group? Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.

Fresh pre-print: our all-human, innervated & vascularized oral cancer-on-chip, all done with fully defined extracellular matrices with controlled enrichment and degradability! 🔥 www.biorxiv.org/content/10.6...

#SpatialTranscriptomics Visium + scRNAseq Oral Squamous Cell Carcinoma vs paired Oral Leukoplakia vs normal tissues Inhibin A+ monocyte enriched in premalignant OLK lesions 1⃣Mesenchymal CAF 2⃣APOE+NRG1+ Mφ 3⃣TNFRSF4+ Treg ⬆️with tumor progression #CellDiscov 2023 www.nature.com/articles/s41...

In press: our brief review about the efforts to emulate the dental pulp using organ-on-a-chip approaches ”Dental Pulp-On-Chip” Microfluidic Devices for Emulating Human Dental Pulp Tissue Physiology and Pathology - Journal of Endodontics www.jendodon.com/article/S009...

A majestic tour-de-force by @szczotml.bsky.social lab at @liu.se - beautiful combination of function & transcriptional identity to understand how pain is encoded across the body 👇🏼👇🏼

Mapping genome-wide binding AND protein partners of virtually any gene regulator , simultaneously, without transgenesis? YES 👇🏼👇🏼👇🏼👇🏼 Look at what @annanordin.bsky.social & @claudiocantu81.bsky.social cooked!!

Please please read this.

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/47zrzYZ

Tomorrow Wednesday 29th at 11am, lesson #3 of @neilshubin.bsky.social guest Professor @college-de-france.fr on ‘The evolutionary origin of bones and teeth’. The second lesson is available @ www.youtube.com/watch?v=0B6y... . No registration, Free access, dentures accepted.

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence www.nature.com/articles/s43...

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se Details in the link - please help me spreading the announcement! liu.se/en/organisat...

SOX2 and NR2F1 cooperate to make #neurons in the #Thalamus for visual input from the #retina #DevBio journals.biologists.com/bio/article/... ‪ @biologyopen.bsky.social In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social Driven by Linda Serra and @annanordin.bsky.social

We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se Details in the link - please help me spreading the announcement! liu.se/en/organisat...

Glad to share the latest effort to emulate dental tissues on-chip: an organ-on-chip design including human dental pulp stem cells & HUVECs, odontoblasts, and a dentin powder-containing compartment, all innervated by mouse trigeminal ganglia! 👇🏼 advanced.onlinelibrary.wiley.com/doi/10.1002/...

If we lose our inner ear hair cells, we lose our hearing.. but reptiles can repair their sensory organs 🐊🤩 Tune in to Vetenskapspodden on Swedish radio P1, Sun 07:03, Mon 18:33, or bit.ly/4oCDHzP from Sunday, to hear me & Helge Rask-Andersen discuss crocodiles & regeneration with Lena Nordlund!

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Can using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷‍♀️🔧 If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology royalsociety.org/science-even...

Always a great pleasure to see high-level work on tooth 🦷& craniofacial development!

Closed up the Wnt Signaling GRS/GRC - honoured for the possibility of serving as co-chair in this amazing event!

Incredibly useful thread! Thank you @juliaeckert.bsky.social !!

What is buckling, and why is it relevant in understanding epithelial morphogenesis? 🧐 I am @onenimesa.bsky.social and I will share some papers to understand this aspect of #EpithelialMechanics

Modular integration of epithelial, microbial, and immune components to study human intestinal biology. Amazing team project with Rubén López-Sandoval, Marius F. Harter, Qianhui Yu, Matthias Lütolf, Mikhail Nikolaev, and Nikolche Gjorevski! biorxiv.org/content/10.1...

Always amazed by the sheer amount of e-mail traffic wasted by hopeless academic spam: this time, "dear Prof. [NAME]", "any contribution", from a "MEGA Journal of Case Reports" - waiting for Giga, Tera, and more!

Cannot thank you enough @neilshubin.bsky.social for such an amazing contribution 🦷!!

YAP, a protein known to help #cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, highlighting the importance of mimicking tumour architecture to guide better drug strategies. buff.ly/KQ9bkLg

Thank you @shuntaroyamada.bsky.social and @unibergen.bsky.social for inviting me to give a talk at such a stimulating event - MRCRM 3rd International Meeting on Regenerative Medicine 2025 in Bergen, Norway! www.helse-bergen.no/en/arrangeme... Looking forward to our continued collaboration!

Fresh out of press: our new chapter on the TBX3/WNT liaison, and how it drives metastasis-related genes expression in colorectal cancer, out on @pnas.org Enjoy the “bluetorial” by @claudiocantu81.bsky.social below! 👇🏼 #WNT #CRC @liu.se www.pnas.org/doi/10.1073/...

Registration is still open for our upcoming Gordon Research Conference (GRC, June 22-27) and Seminar (GRS, June 21 -22) on Wnt Signaling in Maine, US PhD students and postdocs, the GRS is for you, still possible to get selected for a talk - apply here! 👇🏼👇🏼 lnkd.in/d6ii4vDE lnkd.in/dfZ_v3Qk

The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics. gimm.pt/jobs/open-ca...

Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!

EGFR signalling in amygdala astrocytes mediates neuroimmune interactions associated with FEAR 😨 www.nature.com/articles/s41...

Registration is still open for our upcoming Gordon Research Conference (GRC, June 22-27) and Seminar (GRS, June 21 -22) on Wnt Signaling in Maine, US We have slots for short talks to be filled at both the main conference and the seminar - apply here! 👇🏼👇🏼 lnkd.in/d6ii4vDE lnkd.in/dfZ_v3Qk

😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social

Registration is still open for our upcoming Gordon Research Conference (GRC, June 22-27) and Seminar (GRS, June 21 -22) on Wnt Signaling in Maine, US We have slots for short talks to be filled at both the main conference and the seminar - apply here! 👇🏼👇🏼 lnkd.in/d6ii4vDE lnkd.in/dfZ_v3Qk

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

Thrilled to share our new review article! “The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44... #ECM #Mechanobiology #DevelopmentalBiology

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

With a little help from my friends… New cool story from @mucosalimmunology.bsky.social labs show that oral vaccines work way better when friendly microbes step in to outcompete gut pathogens. Teamwork makes the immune dream work! 🦠🫂 www.science.org/doi/10.1126/...

Hot off the press! 🧬🔬 We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ: doi.org/10.1126/scie...

'The Institute of Molecular Biotechnology (IMBA), one of Europe’s leading institutes for basic research in the life sciences, is seeking outstanding candidates for a faculty position.' #ScienceJobs in Vienna. www.oeaw.ac.at/imba/career-...

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

Cholinergic enteric neurons expressing Piezo1 sense mechanical forces to regulate gut motility and modulate intestinal inflammation. #MechanoSensing www.cell.com/cell/abstrac...

Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....

www.nature.com/articles/d41... There’s plenty to discover in every corner!

Read our collaborative paper @longchrom.bsky.social and @molinalab.bsky.social showing that disruption of NuA4 and ATAC coactivator complexes cause gene-specific transcript buffering, suggesting that cells dynamically adjust RNA export/degradation to sustain cellular homeostasis.