Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1. www.nature.com/articles/s41...

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

Inflammation, unfolded protein response, and secretory hormone processing create #T1D epitopes in human cytokine-treated #islets www.cell.com/cell-reports...

Really interesting www.nature.com/articles/s41...

Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication: Cell Metabolism www.cell.com/cell-metabol...

One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/... For more trending articles, visit ow.ly/Me2U50SkLRZ.

The combination of verapamil and low-dose mATG outperformed monotherapy in reversing recent-onset type 1 #diabetes in NOD mice #T1D @diabetologiajnl.bsky.social link.springer.com/article/10.1...

About 1 in 3 young people who are 12 to 17 years old have prediabetes, new national data show, putting them at risk not just for type 2 diabetes but also for heart disease and stroke. www.statnews.com/2025/07/09/p...

🎉Excited to share our latest paper, published in Nature Communications!🎉 "Enhancing autophagy by redox regulation extends lifespan in Drosophila" #redox #metabolism #ageing #Drosophila @natcomms.nature.com @mrc-lms.bsky.social doi.org/10.1038/s414...

New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇 www.biorxiv.org/content/10.1...

Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...

Be on the lookout for a new paper from the lab: "iCLAP: A high-plex immunostaining with high sensitivity for co-detection of low-abundance antigens". In this paper, we introduce ICLAP to detect and spatially map low-abundance proteins, such as senescence markers, in FFPE tissue sections.

Online Now: STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders Online now:

New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below. www.biorxiv.org/content/10.1...

Huo, Wang et al. reveal that #adipocytes experiencing endoplasmic reticulum stress secrete #ceramide in lipoprotein form to #hepatocytes, activating the unfolded protein response by reducing membrane fluidity. rupress.org/jcb/article/... #ER_literature

Beautiful work by my colleague and friend Maria Hatzoglou 🎉 rdcu.be/efdpL

Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social

Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo. elifesciences.org/reviewed-pre...

www.quantamagazine.org/how-metaboli... Seems like a good time to remind you of an upcoming meeting on this exact topic: www.keystonesymposia.org/conferences/...

Modulating the liberation of miR-503-322 which is secreted as small extracellular vesicles from senescent β-cells, to enter and damage exocrine acinar cells may provide preventive and therapeutic strategies for aging-associated pancreatitis @naturecomms.bsky.social www.nature.com/articles/s41...

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

From our latest issue: Åke Lernmark and colleagues provide their perspectives on what the TEDDY study has revealed about the environmental determinants of type 1 #diabetes mellitus (£) go.nature.com/4fpx27n #T1D #T1DM

▶️ Postdoctoral Fellow Position in Cell Stress/Senescence UNIVERSITY OF WISCONSIN-MADISON @EnginLaboratory jobrxiv.org/job/univ... ▶️ Post-doctoral Fellow in Leukemia Research Saint-Louis Research Institute, INSERM U944 @LabPuissant jobrxiv.org/job/sain... #Sciencejobs #AcademicSky 3/8

Endocrine dysfunction and #diabetes is promoted by β cell dedifferentiation and loss of cellular identity in people with Wolfram syndrome, and ameliorated by inhibition of TXNIP #islets #genetics www.science.org/doi/10.1126/...

Marie Sklodowska Curie was the first woman to receive a #NobelPrize and the first person to receive the honor twice. In 2017, #ScienceBooks explored the dynamics that established Curie as “the most iconic of all female scientists.” #WomenInScienceDay

Breaking news: 22 states are suing to block NIH’s cutting of indirect costs. See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...

If you are interested in studying senescence, immune surveillance, and the cell stress pathways multiple positions are open in my lab. jobs.wisc.edu/jobs/researc... jobs.wisc.edu/jobs/scienti...

Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @natureportfolio.bsky.social Huge effort by whole team and collaborators to work this out. www.nature.com/articles/s41...

🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking. Check out the program and register here 👇 events.faseb.org/event/endoplasmic-reticulum-function-disease

A Nature Aging paper identifies 13 proteins linked to brain aging. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old, and suggest that these ages may be important for potential interventions in the brain aging process. https://go.nature.com/3ZvGLSy 🧪

Registration is open for #METPHYS2025! www.sablesys.com/metphys2025-...

Here is a brief summary of academic journals and news account. Please help me add more accounts to this list! go.bsky.app/hCfhqn

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...

More than #proteostasis, less than proteotoxicity --- explore proteolethargy 🤩🤩 www.cell.com/cell/abstrac...

A @science.org First Release: @tommyz626.bsky.social, Wei Zhou, @junyuecao.bsky.social & colleagues present #PanSci, a #SingleCell #atlas profiling >20 million cells from 623 #mouse tissues across various #ages & #genotypes w/ a focus on regulatory roles of #ImmuneSystem on #aging !