Shoegaze is just mumble rap for guitarists

New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...

A colonial Fallout Shelter Sign. Faneuil Hall, Boston. 11/23/25.

Last week: Invent universe. This week: Apple pie.

Happy anniversary to the Max Headroom incident, the greatest example of signal hijacking. en.wikipedia.org/wiki/Max_Hea...

I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵

they're saying there's a spectre haunting europe and it's very nice, we're looking into it strongly, it's beautiful, we love it and we think it means well

If I were him I would change my last name to Power and Associates

This is a most excellent read. Reducing Rosalind Franklin to simply a victim in the discovery of the DNA double helix inadvertently strips her of her very real contributions.

If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...

new NoVA winemom yard sign just dropped In This House We Believe: -Black Lives Matter -No Human Is Illegal -Women's Rights Are Human Rights -Science Is Real -[redacted due to 18 U.S. Code § 871] -Love Is Love

Welp time for bed

BRING IT BACK - dashare.zone ADMIN

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

Statement on Removal of NMB Member Deirdre E. Hamilton The abrupt removal of a member under those conditions raises serious questions about respect for the rule of law and the independence of the mediation process. Follow this link to contiue reading: www.brs.org?zone=/uniona...

Statistics without calculus is also an atrocity

Do you know ~60% of human SVs fall in ~1% of GRCh38? See our new preprint: arxiv.org/abs/2509.23057 and the companion blog post on how we started this project and longdust: lh3.github.io/2025/09/29/o.... Work with Alvin Qin

Sweet plums, I'm takin' these Who am I to ask mercy I raid the icebox to find some sweets Everybody's looking for breakfast

Does anyone have access to the full text of this / could I get a copy of the PDF from anyone?

The gallery has more crazy things

Now this is Content

Pärting the Internet www.youtube.com/watch?v=TJ6M...

Well don't I feel stupid

*day 356 of learning German* This is where I'm at right now.

George Smoot, explorateur de la soupe cosmique primordiale et Nobel de physique, est mort

Yanni - Optimystique (1989 release)

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation https://www.biorxiv.org/content/10.1101/2025.09.18.677100v1

Where the separate divisions of ANTIFA landed on the beaches of Normandy on June 6, 1944:

Very cool find. www.nature.com/articles/s41...

There is something so cute and appealing about Nordic coastal defense ships.

Dina Hashem has left dead bodies in her wake before: www.youtube.com/watch?v=l7K3...

Born #OnThisDay in 1887 was Arctic explorer Louise Arner Boyd, the first woman to fly over the North Pole. She won a medal for her efforts to find lost explorer Roald Amundsen, and her photography of Greenland is still being used by glaciologists: #WomenInSTEM https://bit.ly/44USH18

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

The Bandit

The

Note the carpet #vcfmidwest

But who is aligning the AI alignment aligners?

I think it’s less we are completely fucked and more it turns out a lot of these people are wishcasting us being completely fucked. Including a bunch of alleged liberals.

Denouncing political violence is a cooked take when fascists are actively taking over and enacting violence on civilians. Wake the fuck up Fascists are presenting themselves as existential threats. Taking an imaginary moral high ground won’t protect those already being rounded up

Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.

I am recruiting a Ph.D. student in microbial ecology, evolution, and systems biology for fall 2026. Please share! Details: qevomicrolab.org/Documents/Gr... Apply by October 1 here: forms.gle/38pPS1Ky84HB...

Figure 5 in some genomics papers

Excited / nervous to share the “magnum opus” of my postdoc in Andreas Wagner’s lab! "De-novo promoters emerge more readily from random DNA than from genomic DNA" This project is the accumulation of 4 years of work, and lays the foundation for my future group. In short, we… (1/4)

Related but cool combo of cytogenetics and phenotype. Know when the first QTL was mapped? Sax, K. 1923. The association of size differences with seed coat pattern and pigmentation in Phaseolus vulgaris. Genetics 8:552-560.

How many hobbies just got shut down because no one will ship to the US anymore? Is this the thing that might make normies finally wake the fuck up?