Here are my four GWAS lectures of ~20 minutes each for the International Statistical Genetics Workshop 2026. They're part of the broader workshop curriculum but also work as standalone lectures covering the basics of GWAS from the ground up. Videos are below 👇🏽

Combining strong variant effects (e.g. protein-altering variation) with intermediate pleiotropy (2–5 TAs) nearly doubles the predictive power: OR 10.3, 4.8× clinical success. Led by Yakov Tsepilov + @opentargets.org www.biorxiv.org/content/10.6...

I’m so glad to see more attention being paid to the data being used to train AI models. The results will only be as good as the data going in.

Absolutely stunned that the Society for Epidemiologic Research chose John Ioannidis to deliver the conference keynote in the Year of Our Lord 2026.

Discover @revojoe.bsky.social's picks for top #RStats CRAN pkgs released in February, including ✅ quallmer v0.3.0: Tools for AI-assisted qualitative data coding 🏥 nhanesdata v4.1.0: Access to NHANES data 📏 ggInterval v0.2.4: Visualize intervals w/ ggplot2 Read the post: rworks.dev/posts/Feb-20...

Did a series of videos with Markus Brunnermeier on Claude Code (more to come) Video 1: Getting Started with CC open.substack.com/pub/paulgp/p...

I build a feed for european grant funding that's updated daily and (IMO) far more transparent then the official EU fundign website: michelnivard.github.io/eu-grants-fe... (inspired by the NIH equivalent @sashagusevposts.bsky.social build yesterday)

Still manually merging UK Biobank-linked health data? Faffing with Swiss Army Knife to extract variants or create polygenic scores? 🧬 I built {ukbrapR} so we could spend more time on science and less on data plumbing If it helps you, please cite! 📊 citation('ukbrapR') github.com/lcpilling/uk...

Really awesome stuff.

A single course of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure) nature.com/articles/s41...

Our work in NEJM www.nejm.org/doi/pdf/10.1...

www.biorxiv.org/content/10.6... Glad to see this paper out. I attended Prof. Gürsoy's talk during last year's probgen and the claims were scary. You can literally reverse-engineer GWAS summary statistics and public single-cell RNA-seq data to identify subjects.

How to draw propensity scores (PS) in DAGs? Some (me also) claim it is like "treatment -> PS <- covariates", since in order to compute PS we need both treatment and covariates. This view has confused me for so long, and now I think I was wrong. My letter here: track.smtpsendmail.com/9032119/c?p=...

”Most of the applications of clustering are not well thought out, not even considering whether observation clustering aligns with clinical goals.” YES. Clustering has become a huge fad in psychology as well, I see it everywhere.

As an editor I often see authors fall into a trap of stressing some fancy statistical technique for estimating causal effects. Often neglected are the necessary assumptions to map the data to the estimand. @pausalz.bsky.social and I wrote about it here www.bmj.com/content/391/... #EpiSky

I'm so excited to announce the first release of my newest #Rstats package, {adrftools}! This package facilitates estimation, visualization, and testing for the causal effect of a continuous (i.e., non-discrete) treatment. 🧵 1/10 #statssky #episky #causalinference

"An online sample size calculator for designing partially clustered trials" (@klange-au.bsky.social et al) has now been published in Clinical Trials! doi.org/10.1177/1740... This free and user-friendly online calculator makes it easier to ensure a trial is appropriately powered ✅

New paper "Variant selection to maximize variance explained in cis-Mendelian randomization" led by @AngZhou3 and published at @HGGAdvances: pubmed.ncbi.nlm.nih.gov/41548043/, with contribution from @vkarhune.bsky.social, Haodong, Janne, Ash, and Eric. Brief thread:

New article @bmj.com reviews procedures for eligibility and treatment assignment for #targettrial emulation. "Starting right: aligning eligibility and treatment assignment at time zero when emulating a target trial" Authors include @miguelhernan.org. Read the article: www.bmj.com/content/392/...

Two new preprints on the efx of GLP-1s just dropped. They use different samples, data, & designs. But they come to the same conclusion on one point: GLP-1s do not generate meaningful short- to medium-run reductions in non-GLP-1 medical spending, despite clear health benefits.

Have you seen George Davey Smith telling him the smoking findings were completely implausible at a seminar in Edinburgh 1994? youtu.be/K9pyS7EGCV8?...

How to use LLMs in research work - a really nice introduction to coding with LLMs for research by Kohei Kawaguchi. Code and docs available in a github repo #linkoftheday note.com/mixingale/n/...

I've had this on my reading list for awhile, but I finally got around to it and it is excellent It is a great introduction to bounds for missing data (that I wish I read much earlier when I was first learning about them!!) www.sciencedirect.com/science/arti...

Paul Goldsmith-Pinkham, Peter Hull, Michal Koles\'ar: Leniency Designs: An Operator's Manual https://arxiv.org/abs/2511.03572 https://arxiv.org/pdf/2511.03572 https://arxiv.org/html/2511.03572

We wrote an article explaining why you shouldn't put several variables into a regression model and report which are statistically significant - even as exploratory research. bmjmedicine.bmj.com/content/4/1/.... How did we do?

Dismantling the Institutional Review Board (IRB), that oversees all human subjects research, is bad. Really bad.

Though it’s traumatic for me to bring this up, I was targeted by a group allied with Turning Point USA in 2018, with the help of Tucker Carlson on Fox. My home address circulated online and I got death threats. 1/

I wrote something about statistics under authoritarianism

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...

Jana Christofer and I wrote a piece on #papermills for Laborjournal. We discuss challenges of paper mills and AI for scientific publishing. Science needs immediate solutions to correct it and prevent it from massively produced fraud. @image-integrity.bsky.social www.laborjournal.de/rubric/essay...

🚨ICYMI 🫀🧬 from @mariosgeorgakis.bsky.social & co 📄Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease

I probably won't have time to make a video out of this. But the materials are available online, and should be pretty self-explanatory. Hope this is useful to some people. privefl.github.io/statgen-cour...

Due both to federal research cuts and lack of funds in state govs., a number of universities are facing hard financial times. Indiana University is handling this in part by canceling or suspending 116 academic programs, tinyurl.com/28x2cysu. 🧵 1/

🎉(1/4) Excited to share that our latest paper is now published! We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP. www.nature.com/articles/s41...

about that: www.sciencedirect.com/science/arti...

Thanks @timpmorris.bsky.social et al - a wonderful course at UCL on Simulation - highly recommend. And huge congratulations to my colleague Ryan for completing this complex methodological review - will be so important for #DIAMOND going forward. 🎉👏🏼

Harvard today, your institution tomorrow. It's all part of the Project 2025 plan to destroy high education in America. All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.

🎫Registration open for 1-day hybrid event: “Target trial emulation and other frameworks: The role and potential of observational data for evaluating effects of interventions”. 📆26th June. tinyurl.com/dash-tte. Hosted by LSHTM Centre for Data & Statistical Science for Health. @lshtm-dash.bsky.social

Watching Scott Zimmerman and Erin Ferguson lead a workshop on reproducible research and multiverse analysis. It's their practice for a workshop at #EpiResearch #SER 2025. epiresearch.org/annual-meeti... Drawing on Erin's paper: link.springer.com/article/10.1... So cool.

📣📣 Thrilled to see this cool work finally out in the wild! "Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology & prediction" www.nature.com/articles/s41... Loads of cool findings including MR for alcohol usage -> increased variance in BC traits

I have been in biomedical science for over a decade & I independent of that have followed @joshtpm.bsky.social and @talkingpointsmemo.com for political commentary. Those worlds now converge as Josh is one of the key political reporters with relentless focus on what is happening at NIH/NSF.

Happy to share our new (open access) article in the Canadian Journal of Economics on people’s willingness to donate DNA for science and its relationship with economic incentives and preferences. A brief thread on what we learned (1/4): doi.org/10.1111/caje...

Big news for health data research and population diversity: The Mexico City Prospective Study data are now available securely to approved researchers worldwide. www.ndph.ox.ac.uk/news/latin-a... Cohort description: www.ctsu.ox.ac.uk/research/pro...

Cool story! Fun fact: The original SARS-CoV-2 strain was uncovered using metagenomics in Jan 2020 (www.nature.com/articles/s41...) which was pivotal for vaccine development efforts. Metagenomics has arguably saved many millions of lives already.

Very excited to give a virtual talk as part of the @eshg.bsky.social webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...

How many NIH supported "life-changing" studies have been or will be terminated? This one on the Diabetes Prevention Program Outcomes Study, by @dhruvkhullar.bsky.social @newyorker.com www.newyorker.com/news/the-led...