Photographs by the now late Sebastião Salgado www.theguardian.com/global-devel...

A month ago I adopted a one eyed hamster from my local animal shelter

I have a shocking idea where rather than continually trying to find a “good representative” for certain people We start looking at why they can’t / won’t/ aren’t respected when they try to live their lives and stop looking at them as things to manipulate What if we tried that

you know if it wasn’t for Disney it wouldn’t take ninety six fucking years for something to enter the public domain

A police officer is generating a transcript of an arrest and now it contains the phrase "throbbing essence of grizzly bear lust" Oh no, you've removed all the *most* likely outputs so it's now it's skimming the weird parts of AO3 that you stole while literally stealing the entire internet.

i have very serious thoughts about corporate insistence on forcing people to stand at retail jobs and the downstream effects of this

They're going to *throw out* one-of-a-kind NASA archives?! Not even a year since the Inauguration & we're already at the 2nd-time-as-farce version of the burning of the Library of Alexandria.

all meaning has collapsed in our post-literate society and i wrote a bunch of useless, useless words about it. read it if you, like me, are one of a diminishing minority who still reads www.theverge.com/policy/84960...

These things need to be banned. Full stop. They are dangerous in so many different ways.

With alt text

Happy New Year!

Zuckerberg, and every single other one of these fashy billionaire freaks, they can't understand why "make me richer and more powerful" isn't a compelling salespitch. They can't even fucking describe in concrete terms what their products are, or do. It just doesn't seem an important detail to them

Like, even snake oil salesmen had to promise their customers a benefit. This snake oil will heal your ailments. It will benefit you. You get something out of buying my snake oil. These fash tech dipshits can't even do that. It's just "if you buy my snake oil I get to have more money."

Newly unsealed docs show DOJ moved to prosecute Kilmar Abrego Garcia for smuggling only after it became clear Trump might not be able to deport him. Sure looks driven by a desire to punish him for fighting back against Trump/Miller lawlessness. Trump had to be right. www.cbsnews.com/news/abrego-...

Huh, I guess you could actually make it worse. Who knew?!

losing my mind thinking about these people being taken off a sanctions list while even more icc judges get sanctioned

Do I need to say anything else?

You can read all this and more here: • www.cell.com/cell-reports... • case.edu/news/new-stu... • www.eurekalert.org/news-release... • neurosciencenews.com/alzheimers-r... • www.sciencedaily.com/releases/202... • medicalresearch.com/case-western... • www.psypost.org/scientists-a...

This suggests the brain regained its ability to clear toxic proteins. Tau phosphorylation, a damaging chemical change, also declined. The blood-brain barrier, which normally shields the brain from harmful substances, showed clear repair. Structural gaps closed. Leaky blood proteins stopped entering

normalized after treatment. Restoring the brain's energy balance successfully achieved pathological and functional recovery in both lines of mice with advanced Alzheimer's. The recovery went beyond behavior. Amyloid plaques were reduced, even though amyloid production itself did not change.

blood-brain barrier breakdown, nerve damage, and behavioral changes similar to those seen in people. When P7C3-A20 was given before symptoms began, it prevented disease features. More striking was what happened when treatment started later. Mice with advanced disease REGAINED normal NAD+ balance.

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well). • case.edu/news/new-stu... The study has been published in Cell. YES, it is PEER-REVIEWED. • www.cell.com/cell-reports... 🧪🧵⬇️

GOOD NEWS! Researchers have shown Alzheimer’s disease can be REVERSED- not just prevented. Using a potent neuroprotective compound called P7C3-A20, they found RESTORING balance to a central cellular energy molecule (NAD+) not only PREVENTED disease features but REVERSED them, EVEN at late stages.

This whole story rips lol just a man going fuck I got rained on because I didn't know what side of the car the fuel filler was on I am a fucking car UI designer will submit a memo to make sure it never happens to anyone ever again and then forget about it Moreover, ICE must be destroyed

See this is why you have to just accept gatekeeping and target a goddamn audience. If those philistines can't even appreciate hivemind sex then they don't deserve a sci fi TV show

merry Christmas one and all abcnews.go.com/Internationa...

Sending love to those that are hurting today as well 🫂

It’s not “losing money” any more than air traffic controllers or public highways or street lights or fire departments are “losing money.” It is a government service. It’s not SUPPOSED to make money. It’s supposed to reliably deliver to anywhere in the US, even the unprofitable places.

Amazon, a decade ago: "this stuff is expensive, we'll use FedEx & USPS." Amazon now: "wow, as long as we can get to city near remote spot, which is reasonably cheap, we can force USPS to go the last mile, which is expensive and USPS can't charge a profit for it!"

You can redescribe this in more pleasant ways, according to your preferred social theory. All I care about is the recognition that social relations don't reduce to some other more objective form of utility.

ironic christmas cards are great if you want to signal to your loved ones that you're embarrassed by sincerity but would be ashamed if you didn't fulfil the social ritual

Buy someone a cane. Get some compression socks from the pharmacy. Vitamins and supplements are so expensive!

You can use your FSA to buy allergy meds, wound care supplies, TENS units, massage guns … find out your balance and HELP SOMEBODY IN NEED

--who will happily listen to infodumps about the special interests of autistic people all day no matter what they are because autistic people are absolutely fucking FANTASTIC at knowing and communicating all the weird details I live for, I could listen to him for HOURS about his tactics

If they deny it, have your doctor ask, in writing: - the name, license number, and board specialty of the doctor who denied care; - copies of all materials they relied on to justify that denial; - the rate at which that doctor denies this treatment as compared to all doctors doing medical review

Remember: Ethical doctors who care about patients and practice competent medicine do not work for insurance companies doing "peer consults", because ethical doctors who practice competent medicine don't actually like denying care. The doctors doing this are the dregs of the dregs.

The lessons for heavy DIYers to take from this, btw: If your doctor says your insurance won't approve a newly-released drug you really want to try, don't despair. Ask them if they're willing to do a "peer to peer" if you draft the justification for them to edit to save time.

But the gatekeeping assholes keep arguing for requiring lab test confirmation! Except THEY USE THE TESTS WRONG. Mast cell episodes triggered by histamine exposure can be detected by lab testing! FOR TWENTY MINUTES TO TWO HOURS AFTER THE EXPOSURE ONLY.

Joke of a trial filled with portland police getting caught lying, but in the end @cozca.bsky.social was found not guilty on all 6 charges in this political prosecution 🥳 article soon. Live reporting on kolektiva until then

Just now, a national trans healthcare felony ban for youth has passed the US House, with 10 year prison terms. 3 Dems crossed party lines to vote to jail providers. 4 GOP crossed party lines to vote against. It is not expected to pass the Senate, where Dems hold filibuster power. Story to come.

Clay letters from ancient Mesopotamia are alive with idiom, sayings, and everyday language that I love. Here are just a few random ones so you can enjoy them too.

"artists do art for ~*the process*~" idk pal. I do art because the angels scream louder when I don't

BREAKING: Seattle Children's Hospital successfully fought this summer to get DOJ's invasive trans care subpoena quashed. The Seattle court partially unsealed the case this week. This was the fourth, previously sealed case mentioned in this recent Law Dork report: www.lawdork.com/p/judges-doj...

Deeply disappointed to hear that the BBC has pushed out one of the most brilliant presenters in all of science communication for speaking with integrity and honor in support of human rights and dignity.

"It’s also about the rather wholesome pleasure of seeing murderous bigots put quite literally on blast."

Everything in this thread was the motivation behind the GoogleX project i worked on: the idea = applying modern SW principles to HW design, and to do the full stack in a single team (instead of the HW standard of having separate teams for each phase, each one blaming the others whenever things fail)

Just a sample of the comments, all which have a hint of either PTSD, Stockholm Syndrome, or some other toolchain-induced trauma. I sometimes miss FPGA dev but I had to find an off the shelf solution for my quantum project since they were not ready to traverse the 9 levels of FPGA Development Hell

Love the threads on r/FPGA where software engineers get a peek behind the curtain and have to go 'damn girl, you live like this?' and all the comments are just... 'yup...' www.reddit.com/r/FPGA/comme...

Here's another idea: Fears of a demographic crunch are being fanned by those with power and money b/c the don't want to lose their ability to easily keep most of humanity under their control. 5/

I mean, the column mentions how many sectors from semiconductors to agriculture "now need vastly more researchers and R&D spending just to keep productivity and growth on the same old trend line." Here's an idea: How about a society where stability instead of constant growth is the goal? 2/