Physicists' perspective on the future direction of condensates in Cell Biology. arxiv.org/abs/2601.03677

Really don’t understand why loads of people are advocating delegation of paper reading and reference searching to AI, and even paper-writing using AI. It’s like volunteering to be left out of the discovery process and intellectual works, happily living as a slave to the “transformers”.

Experimental structures provide valuable hypotheses and accelerate but do not replace evolutionary and statistical analyses of protein sequences

Very exciting project! Trafficking, IDRs, and structural biology!

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics With @dariagusew.bsky.social & Carl G. Henning Hansen doi.org/10.1016/j.sb...

I found a tiny octopus on the tide pool🐙✨️ Small as it is, it’s every bit an octopus ... and absolutely adorable!! It even shoots ink🫧 ͛.*

I agree. I think protein folding is evidence that one can form specific structures that are thermodynamically driven by non-specific, dynamic interactions, with additional contributions to specificity from h-bonds etc (that probably contribute less to the "driving" force).

The structure of most folded proteins are stabilised by the hydrophobic effect which in some sense is quite fuzzy. And the hydrophobic cores of proteins can be quite dynamic.

Now published in @cp-cellsystems.bsky.social - we look at the chemical features that make proteins tolerant to dehydration, and the functions these proteins fill. 🏜️🚱 tinyurl.com/bsfy56yt

yep, this is very concerning. Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved... www.cell.com/patterns/ful...

Language models cannot reliably distinguish belief from knowledge and fact #AI Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation. www.nature.com/articles/s42...

If you’re into protein evolution, molecular innovation, or just good scientific detective work — we hope you enjoy reading this story as much as we loved uncovering it. Link: www.nature.com/articles/s41... Happy Halloween 👻🌿

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale See preprint for: — Ensembles of >12000 full-length human proteins — Analysis of IDRs in >1500 TFs 📜 doi.org/10.1101/2025... 💾 github.com/KULL-Centre/...

If you are interested in membrane trafficking and IDPRs, please join us!

Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data Data imputation/normalization Batch correction Data visualization Statistical models Instrumental handbook, adoptable for other omics #NatComms 2025 www.nature.com/articles/s41...

🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝 📅 June 21-26, 2026 | Les Diablerets, Switzerland 👉 Details & registration: grc.org/intrinsicall...

Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together! Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays! biophysics transcription protein:DNA interactions my.corehr.com/pls/uoxrecru...

I'm hiring for a PhD position at Malmö University, Sweden! The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes. More details and application form: tinyurl.com/4zm92365 Please feel free to share! @vetenskapsradet.bsky.social | @mau.se

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41... The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

Is it just my feeling that the Bluesky community has suddenly grown dynamic and “real” (i.e, much less boring political statements to dilute interesting people and stuff on my timeline) in the past 3 months… oh Yay!

I wish 7-11 can come to the UK as well. So tired of “meal deals” when you don’t have time to cook… I mean, it is indeed a deal, but not really a meal…

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

This isn't how birding is supposed to work!

New #preprint from talented graduate student for a workflow we have been using for a while into a formal usage www.biorxiv.org/content/10.1...

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

🚨Interdisciplinary perspectives needed🚨 Have you worked across disciplines in research? We want to hear from you! Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments. app.onlinesurveys.jisc.ac.uk/s/edinburgh/... Please RT.

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

Join us for the first Scottish Cell Biology Meeting in Dundee! 🔥 Free registration and lots of opportunities for oral, poster presentations, and networking opportunities! #SCBM2025 Abstract submission until June 6th, general registration until July. All cell biologists are welcome!

How did life on Earth begin? 🌍🧬 New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social‬‬ @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.‬ Read more: www.ucl.ac.uk/news/2025/ma...

Really great to see this out!

"De novo prediction of protein structural dynamics" I'll be presenting an overview of the field tomorrow at a workshop. Link to a PDF copy of the presentation: delalamo.xyz/assets/post_...

AlphaFold is amazing but gives you static structures 🧊 In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃 Code: github.com/KULL-Centre/... Colab: github.com/matteo-cagia...

Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!

A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...

Long-term studies provide unique insights into evolution 🧪 www.nature.com/articles/s41... Showcasing groundbreaking discoveries of long-term evolutionary studies underscoring their crucial role in advancing our understanding of the complex nature of evolution across multiple systems and timescales.

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com. Check it out here! rdcu.be/eeY1J #COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…

Attending #biologists100 in Liverpool and just finished the ECR session — really inspiring career keynote talk and invaluable experience talking to established figures in all fields related to biology for advice! Greatly enjoyed it!

Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology! You will be supported by core funding, excellent facilities & enthusiastic colleagues. Apply by 18 MAR www.nature.com/naturecareer...

I am exporting a tiff stack (top) to avi video (bottom) in Fiji. However there is a huge loss of resolution, especially for the overlay text. I was wondering if there is a workaround? Thank you so much in advance!! Please RT!

Have you looked in the mirror recently? We took a good look at stereochemistry and how D- and L-ligands bind ... its all about disorder! Exited to share a true REPIN collaborative work led by @estellaan.bsky.social, A. Due and J. Olsen. Thanks for support NNF and DFF. rdcu.be/d1F6q

RT if you wouldn't mind!! Any endoplasmic reticulum aficionados out there? Are there ad hoc pharmacological ways to reliably block ER vesicle export (e.g. COP-II mediated etc.) or ER secretion more generally?

So excited this work is out! A super comprehensive mechanistic study by my colleague Julija on SURF4, surely opens new door for us to think about cargo receptors and why they are so important (complex but fun😆). Really happy to be part of the team and huge thanks to Liz for her support and guidance!

As a completely new comer, my experience on academic bluesky is like numerous nucleation and droplet fusion events—the nucleation takes quite a while but now they are fast maturing lol.

Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list! go.bsky.app/SinqoJU

And here's a biotech starter pack for you go.bsky.app/36QCKD2

I’m creating a drug development starter pack, reach out to join or suggest additions: go.bsky.app/B2pzQm2

I have made a ChemSky starter pack and am posting here to help boost visibility. This list is not exhaustive, but should hopefully help newcomers or rejoiners find some accounts and feeds to follow go.bsky.app/C9BtrLj