Top ten news stories in 2025 www.nature.com/articles/s41...

📢 How does #epigenetics fuel #chromosome #instability in #cancer? Together with @IlioVitale and @deadoc80.bsky.social, we highlighted two recent papers from @NatGen and @CD_AACR in our newly published @cp-trendscancer.bsky.social Spotlight! Check it out here 👉 www.sciencedirect.com/science/arti...

A review on m6A methylation regulation & its biological functions in the #ImmuneSystem, detailing its critical role in the #Pathogenesis of #AutoimmuneDiseases, identifying potential #Biomarkers & targets for their prevention & treatment. #OpenAccess: doi.org/10.1016/j.ge...

and the Research Briefing to go with it www.nature.com/articles/d41...

plinkQC: An Integrated Tool for Ancestry Inference, Sample Selection, and Quality Control in Population Genetics www.biorxiv.org/content/10.1... 🧬🖥️🧪 R package meyer-lab-cshl.github.io/plinkQC/ #Rstats

Snappy: fast identification of DNA methylation motifs based on Oxford Nanopore reads. #DNAmethylation #BacterialDNA @nanoporetech.com #Sequencing #Bioinformatics #Genomics @bioinfoadv.bsky.social academic.oup.com/bioinformati...

new out in Nature www.nature.com/articles/s41...

ICYMI: New online! Establishing cancer registries in Africa — focus on hepatopancreatobiliary cancers

A systematic review highlights that many pathogenic DDR gene variants arose in recent #HumanEvolution, suggesting today’s cancer risks linked to DDR PVs are the by-product of human evolution. #medsky #OpenAccess: www.sciencedirect.com/science/arti...

Circular DNA has a ticket to ride chromosomes www.nature.com/articles/d41...

A vaccine targeting mutant IDH1 induces antitumour immunity www.nature.com/articles/nat...

A new pre-print with some cool results from my PhD! www.medrxiv.org/content/10.1...

Thank you @natrevcancer.nature.com for the invitation to talk about this really cool study by Lu and collaborators! www.nature.com/articles/s41... Thank you as well to my coauthor @pbasurto.bsky.social 😄

📍 Latest OmniPath paper is out now! ➡️ academic.oup.com/nar/advance-...

Our paper is out in @nature.com! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 www.nature.com/articles/s41...

Review: Linking tumour angiogenesis and tumour immunity

SigRescueR: A Pan-System Framework for Noise Correction and Mutational Signature Identification Across Sequencing Platforms https://www.biorxiv.org/content/10.1101/2025.11.14.688578v1

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions www.sciencedirect.com/science/arti... #genomics #dna #biochemistry #biophysics

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

New online! Decoding the regulatory genome with large-scale deep learning

PhD training needs a reboot in an AI world www.nature.com/articles/d41... 🧬🖥️🧪

This review highlights the dual nature of R-loops in #GeneRegulation and #GenomeInstability, emphasizing their impact on #DNADamage responses and potential as #therapeutic targets. #medsky #OpenAccess: www.sciencedirect.com/science/arti...

Now online in Cancer Discovery @aacrjournals.bsky.social: A Prognostic Signature for Lung Adenocarcinoma in Patients Who Have Never Smoked - by Wei Zhao, Maria Teresa Landi, and colleagues doi.org/10.1158/2159...

The first time I saw this approach was this post by @fabiocrameri.ch: x.com/fcrameri/sta... Some more serious examples are featured in his paper "The misuse of colour in science communication" 👉 www.nature.com/articles/s41...

Reproducible processing of TCGA regulatory networks academic.oup.com/gigascience/... 🧬🖥️🧪

What makes PhD students happy? Good supervision - Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research www.nature.com/articles/d41... #mentoring #phd #gradschool #commonsense #true #education #meded

GraphComm predicts cell cell communication using a graph based deep learning method in single cell RNA sequencing data www.nature.com/articles/s41... 🧬🖥️🧪 github.com/bhklab/Graph...

A telomere-to-telomere map of somatic mutation burden and functional impact in cancer. #T2T #SomaticMutations #CancerGenetics #Genomics @biorxiv-genomic.bsky.social www.biorxiv.org/content/10.1...

New online! Revisiting the somatic mutation theory of cancer pathogenesis

APOBEC3A-Induced DNA Damage Drives Polymerase Theta Dependency and Synthetic Lethality in Cancer https://www.biorxiv.org/content/10.1101/2025.10.21.682588v1

Beyond Cox models: Assessing the performance of machine-learning methods in non-proportional hazards and non-linear survival analysis 🧬🖥️ www.sciencedirect.com/science/arti...

Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers. #SomaticAlterations #PopulationDiversity #Genomics @natgenet.nature.com 🧬 www.nature.com/articles/s41...

FYI: New online! Advances in haplotype phasing and genotype imputation

Choose your human genome reference wisely. #HumanGenome #ReferenceGenome @natmethods.nature.com #TechnologyFeature www.nature.com/articles/s41...

Proud to share our latest work in Science Advances!!! p21 rules 😎! Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses | Science Advances www.science.org/doi/10.1126/...

Your ggplot2 charts work fine, but are they memorable? Real color engineering: brightness first (strongest differentiator), then hue, finally saturation. Most people get this backwards and wonder why their viz falls flat. www.chartography.net/p/color-engi...

An improved epigenetic age estimation with TFMethyl Clock reveals DNA methylation changes during aging in transcription factor binding sites https://www.biorxiv.org/content/10.1101/2025.10.07.680024v1

Transcription Factor-Dependent Cancers: Targeting chromatin remodelling complexes to treat uveal melanoma. buff.ly/ALwM42Y

Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social

A HEROIC Prostate Cancer Precision Health (PCaPH) Africa1K and Pan Prostate Cancer Group (PPCG) collaborative paper where through whole genome interrogation we reveal African specific candidate genes for prostate cancer germline testing, has gone live in @natcomms.nature.com. doi.org/10.1038/s414...

Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase - by Yang Bai, Samuel Bakhoum, Vivek Mittal, and colleagues doi.org/10.1158/2159... @weillcornell.bsky.social

📢ONLINE @natgenet.nature.com 📰DNA methylation influences human centromere positioning and function. By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution www.nature.com/articles/s4...

Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance. #SingleCell #MultiOmics #DNAmethylation #Epigenomics @natmethods.nature.com www.nature.com/articles/s41...

From @jdrakephd.bsky.social & @bahanbug.bsky.social in @plos.org #Computational #Biology | How to write a scientific paper in fifteen steps | #Education #Science 🧪 🔓 #GoodReadingForAll CC/ @ppalagi.bsky.social ⬇️ journals.plos.org/ploscompbiol...

This review highlights the role of #Mitochondrial dynamics in influencing #Cancer progression and highlights recent advances in targeting mitochondria for #Tumour therapy, which could reshape future treatment strategies. #medsky #OpenAccess: www.sciencedirect.com/science/arti...

ICYMI: New online! Regulatory genomics at biobank scales

ICYMI: New online! Is enhancer-driven gene regulation all wrapped up?