This review highlights the context-dependent role of #MEX3A in tissue homeostasis, stemness, immune regulation, and #tumor progression, revealing how its RNA-binding and #E3Ligase activities shape development and #cancer biology. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights how oncogenic pathways and immune evasion drive #NSCLC, emphasizing #biomarker-guided #Immunotherapy and ICI combinations integrating #TumorGenomics with immune profiling for precision #LungCancer treatment. #OpenAccess: doi.org/10.1016/j.ge...

Gain-of-function #LCP1 mutations cause a novel #Immunodeficiency syndrome with #Neutropenia and immune dysfunction, where hyper-bundled F-actin triggers VDAC1-mediated #MitochondrialApoptosis, highlighting #ActinDynamics as a therapeutic target. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights the role of #m6A #RNAmethylation in #PulmonaryDiseases, showing how #epigenetic regulation drives inflammation, immune responses, #LungInjury, and #cancer progression while offering promising therapeutic targets. #OpenAccess: doi.org/10.1016/j.ge...

#ADAR1 drives #HepatocellularCarcinoma progression by binding PPARγ mRNA and reprogramming #LipidMetabolism, while 8-Cl-Ado suppresses the ADAR1–PPARγ axis to inhibit #tumor growth, invasion, and metastasis, revealing a metabolic therapeutic strategy. Read: doi.org/10.1016/j.ge...

This review highlights the role of #Lgr6 in #TissueHomeostasis, regeneration, and disease, showing how Lgr6⁺ cells regulate repair, drive #cancer progression, #DiabeticCardiomyopathy, & organ dysfunction, positioning it as a therapeutic target. #OpenAccess: doi.org/10.1016/j.ge...

High IRP1/ARID3A expression suppresses #Ferroptosis in #PancreaticCancer by repressing CYGB through iron-dependent chromatin regulation, driving #chemoresistance & poor prognosis while revealing a target for combined ferroptosis-based therapies. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights the central role of #CellularSenescence in #IntervertebralDiscDegeneration, exploring its mechanisms, diagnostic approaches, and emerging anti-senescence therapies aimed at restoring disc homeostasis & alleviating low back pain. Read: doi.org/10.1016/j.ge...

Persistent #HBV replication impairs mitochondrial respiration and drives #ROS accumulation, activating the #Nrf2–IL6/IL8–Jak2/Stat3 axis to trigger #LiverInflammation, revealing a key mechanism underlying #ChronicHepatitisB progression. #OpenAccess: doi.org/10.1016/j.ge...

#YangheDecoction suppresses #Osteosarcoma progression by inducing #ROS-mediated mitochondrial dysfunction, inhibiting PI3K/AKT signaling, activating p38 MAPK, & enhancing #cisplatin sensitivity, highlighting its potential as an adjuvant #CancerTherapy. Read: doi.org/10.1016/j.ge...

Reduced #CLCA4 drives #ColorectalCancer stemness and #chemoresistance, while restoring CLCA4 suppresses CSC self‑renewal via vimentin–FAK signaling, boosts CD8⁺ T‑cell infiltration, and enhances anti‑PD‑1 efficacy, highlighting a promising CRC target. Read: doi.org/10.1016/j.ge...

This review highlights the role of the #Immunoproteasome in #Diabetes, revealing how it regulates β-cell apoptosis, glycolipid metabolism, #inflammation, and diabetic complications, while offering promising targets for precision #DiabetesManagement. Read: doi.org/10.1016/j.ge...

This review highlights #MitochondrialTransplantation as a strategy for treating #LungDiseases by restoring mitochondrial function, targeting cellular energy imbalance, and oxidative stress linked to mitochondrial dysfunction in #RespiratoryDisorders. Read: doi.org/10.1016/j.ge...

This review explores the dual role of the #cGAS #STING pathway in #IBD and #ColorectalCancer, showing how context‑dependent signaling, timing, and biased activation shape inflammation and the future of spatiotemporal STING‑targeted therapies. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights #Disulfidptosis as a distinct regulated cell death driven by disulfide stress, #NADPH depletion, and cytoskeletal collapse, revealing its role in #InflammatoryDiseases and therapeutic potential via #SLC7A11 & metabolic targeting. Read: doi.org/10.1016/j.ge...

How common are oral side effects in #lungcancer? 46-77% experience taste changes during treatment. 35% with NSCLC report taste changes before treatment even begins. > 1 in 5 who develop mouth sores need their treatment dose reduced or interrupted. www.lungcancereuropenews.eu/news/oral-he... #LCSM

Late registration for the #ESMOExamination 2026 is available until 21 July. Secure your seat. 📅 24 Oct | 13:00–15:30 CEST 📍 Main session onsite in Madrid (Spain) + parallel sessions in selected locations. 🔗 Register: https://ow.ly/Z7gR50Z031c#ESMOExamination #esmomeetings

The incidence of #colorectalcancer is rising among younger individuals, sometimes as early as their thirties. The #research also shows the challenge of late diagnoses and calls for increased awareness.

🔬 Elizabeth Kaweesa studies plant-derived compounds that could help combat chemotherapy resistance in ovarian cancer. On #WorldOvarianCancerDay, her story highlights the power of perseverance, mentorship & cancer research. ➡️ www.asbmb.org/asbmb-today/... #WomenInSTEM #CancerResearch #OvarianCancer

Teaching, for Fatahiya Kashif, began with a question: “Why are so many students afraid of biochemistry?” Determined to change that, she transformed her classroom with handmade interactive learning tools that helped students move from fear to curiosity. 🔬 www.asbmb.org/asbmb-today/... #STEMEducation

Submit an abstract by July 8 for the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (November 18-20; Barcelona, Spain), chaired by Elena Garralda, Ryan Corcoran, and Tim Greten. Learn more: buff.ly/yGE9ODf

This review highlights PIWI/piRNA pathways as emerging #EpigeneticRegulators with therapeutic potential in #StemCellTherapies, influencing #DNAmethylation and disease regulation while requiring improved delivery systems and clinical validation. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights Nrf2’s dual role in #ColorectalCancer: sustaining redox balance yet fostering #chemoresistance, while its interplay with ROS‑driven #apoptosis, ferroptosis, and autophagy positions #Nrf2 as a target for redox‑based CRC therapies. Read: doi.org/10.1016/j.ge...

This review highlights #ACSL4 as a central regulator of #ferroptosis, oxidative stress, and #neuroinflammation in #AlzheimersDisease, emphasizing ACSL4 inhibition as a promising therapeutic strategy for reducing #neurodegeneration & #CognitiveDecline. Read: doi.org/10.1016/j.ge...

This review highlights miR-23b as a versatile post-transcriptional regulator in #cancer, influencing #oncogenic and #TumorSuppressive pathways, affecting prognosis across multiple tumor types, and emerging as a promising therapeutic target. #OpenAccess: doi.org/10.1016/j.ge...

Gal-1 promotes #HepatocellularCarcinoma progression under #hypoxia through m6A-dependent regulation, where HIF-mediated ALKBH5 and YTHDF2 signaling alters Gal-1 stability, driving malignancy and #EpithelialMesenchymalTransition. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights #eQTL as a critical bridge between genetic variation and disease mechanisms, emphasizing #multiomics, #SpatialTranscriptomics, and single-cell integration to advance genomics, #biomarker discovery, and #PrecisionMedicine. #OpenAccess: doi.org/10.1016/j.ge...

#FXYD proteins regulate the Na⁺/K⁺-ATPase pump and #IonTransport in tissue-specific ways, while contributing to #Cancer, #Cardiovascular, renal, and #NeurologicalDiseases, making them promising therapeutic targets. Read this review here: doi.org/10.1016/j.ge...

This review highlights the mitochondrial–metabolic–calcium triad as a key driver of #AlzheimersDisease, emphasizing multi-omics, #AI-guided #PrecisionMedicine, and #biomarker-based therapies for early intervention. #OpenAccess: doi.org/10.1016/j.ge...

SIK1 protects against EV-D68-induced #asthma by enhancing #AntiviralImmunity, regulating T cell responses, and suppressing IL-17A-driven #AirwayInflammation, reducing #ViralLoad and asthma severity. #OpenAccess: doi.org/10.1016/j.ge...

Dlc1 regulates #cardiac lineage specification by controlling #Wntβcatenin signaling, where its loss enhances mesoderm and cardiac progenitor accumulation but disrupts later #cardiomyocyte differentiation and #HeartContractility. #OpenAccess: doi.org/10.1016/j.ge...

The CBFA2T3-GLIS2 fusion reshapes chromatin & #DNAmethylation landscapes in #PediatricAML via DNMT3B-driven enhancer activation, promoting #oncogenic signaling & #chemoresistance, while #DNMT3B inhibition enhances sensitivity to #BCL2-targeted therapy. Read: doi.org/10.1016/j.ge...

This review highlights #SUMOylation as a critical driver of #glioblastoma progression through regulation of cell cycle, AKT signaling, and #tumor proliferation, while identifying #Ubc9, SAE1, and CDK6 as promising therapeutic targets. #OpenAccess: doi.org/10.1016/j.ge...

🚨 EARLY REGISTRATION DEADLINE: 27 MAY 🚨 ⏳ Only 2 weeks left to secure your reduced fee for the 4th Joint FARO-ESTRO Congress @ #ESTROmeetsAsia 2026! 📍 Singapore | 28–30 Aug 2026 https://bit.ly/43au95z #FARO #ESTRO #Radiotherapy

Early Bird registration closes 15 May. Register for the 2026 World Congress on Pain, 26 – 30 October in Bangkok, Thailand today and save: bit.ly/4e0fErL

Degraders in Lymphoma: Shannon Buckley, Francesco Bertoni, and Justin Taylor will address this topic in a plenary session at the AACR Conference on Advances in Malignant Lymphoma (June 24-27; Philadelphia). Learn more: buff.ly/XH3lbfr #AACRlymphoma26 @frbertoni.bsky.social

This review highlights how genomic advances are transforming genetic #KidneyDisease through molecular classification, improved therapeutic decisions, and the development of targeted mechanism-based therapies in #PrecisionNephrology. @pku1898.bsky.social Read: doi.org/10.1016/j.ge...

miR-101a suppresses #ChondrocyteHypertrophy and #osteoarthritis by targeting #Cox2 and reducing Col10a1 and #MMP13, with in vivo delivery limiting #cartilage damage, highlighting its therapeutic potential in OA. @uchicagocancer.bsky.social #OpenAccess: doi.org/10.1016/j.ge...

This review highlights #BCL6 overexpression in #GlioblastomaMultiforme as a driver of proliferation and poor prognosis; its inhibition induces #apoptosis, and YK01 suppresses GBM growth and synergizes with temozolomide as a promising therapy. #OpenAccess: doi.org/10.1016/j.ge...

#RAB26 drives #ProstateCancer progression by promoting proliferation, invasion, stemness, and #EpithelialMesenchymalTransition via MAPK/ERK signaling and #TWIST1 activation, with high expression linked to advanced stage and poor prognosis. #OpenAccess: doi.org/10.1016/j.ge...

This review explores #TumorAngiogenesis by examining #EndothelialCell origins & highlights advances in #AntiAngiogenic therapies, while addressing resistance & emphasizing the need for deeper mechanistic insights to improve #CancerTreatment strategies. Read: doi.org/10.1016/j.ge...

This review highlights in vivo #CARTCellTherapy as a cost-effective alternative to ex vivo methods, preserving #Tcell function and showing strong preclinical efficacy while addressing challenges in clinical translation for #HematologicalMalignancies. Read: doi.org/10.1016/j.ge...

#OncolyticViruses show potent tumor killing with minimal toxicity, and combining them with #immunotherapies like checkpoint inhibitors, CAR-T, #vaccines, #cytokines, and #BispecificTcellEngagers enhances efficacy, offering strategies for #cancer. Read: doi.org/10.1016/j.ge...

Register by May 11 to get the lowest rates for the AACR Conference on Advances in Malignant Lymphoma (June 24-27; Philadelphia), organized in cooperation with the ICML and chaired by Michael R. Green. Learn more: buff.ly/hA2t3nu

📣 #ESMO26: Abstract submission closes tomorrow! Last chance to submit your abstract and make a lasting impact. Contribute to a leading international programme focused on practice-changing advances in oncology ⏰ Abstract deadline 12 May 2026 🔗 https://ow.ly/SI0t50YWoIs#ESMO26 #esmomeetings

🖥️Free webinar w/Silvia Sookoian: Multi-omics architecture of MASLD 🗓️May 13 at 12:15 p.m. ET Don't miss the next installment of ASBMB Breakthroughs on understanding the integrated biological networks that drive metabolic dysfunction-associated steatotic liver disease. www.asbmb.org/meetings-eve...

#SOX2 drives #ProstateCancer progression by regulating #CancerStemCell fate, promoting proliferation, #metastasis, and therapy resistance, with elevated expression linked to aggressive disease & poor prognosis, highlighting its potential as a target. Read: doi.org/10.1016/j.ge...

#CHI3L1 acts as both a #biomarker and regulator in #LiverDiseases, predicting #fibrosis, #steatohepatitis, and #cancer progression while modulating inflammation, fibrosis, and tumorigenesis, highlighting its diagnostic and therapeutic potential. #OpenAccess: doi.org/10.1016/j.ge...

Targeting #MitochondrialBiogenesis offers promise in treating #AcuteKidneyInjury, as MB suppression drives mitochondrial dysfunction and #RenalDamage; small molecules like resveratrol, ZLN005, and PQQ enhance MB, improving outcomes. #OpenAccess: doi.org/10.1016/j.ge...

Aberrant #fucosylation drives ligand–receptor interactions, adhesion, and signaling, promoting inflammation and #cancer in digestive organs, while mutations, #biomarkers, and targeted therapies underscore its clinical relevance in #DigestiveDiseases. Read: doi.org/10.1016/j.ge...