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Nuclear pore permeability and fluid flow are modulated by its dilation state Hoffmann et al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings, they propose a hydrodynamics model and quantify fluid flow across nuclear pore complexes under conditions when nuclei change their volume rapidly. https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00993-6