Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

Our latest review with @doctorpaf.bsky.social! We discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1. -Challenges for SARM1 inhibition for neuroprotection -Roles in non-neuronal cells -SARM1 activation for selective peripheral neuroablation dlvr.it/TNnCBh

In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1 - Challenges for SARM1 therapeutic inhibition - SARM1 in non-neuronal cells - SARM1 activation for selective peripheral neuroablation. www.cell.com/trends/pharm...

I’m excited to share that my PhD work is out in @jcb.org! Big thanks to my amazing mentor @stephgupton.bsky.social and inspiring collaborator @coronin.bsky.social!!!!

Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further! www.biorxiv.org/content/10.1... @denklab.bsky.social #fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal

The long and newly updated story of lithium and its potential role for helping to prevent Alzheimer's disease erictopol.substack.com/p/lithium-an...

A huge thank you to the Eva and Bradbury Lab members, @wolfsonsparc.bsky.social, and all the GRC CNS Injury and Repair attendees. So much fun, so much science and all top quality. A poster prize for Zahra to top it off! New ideas, collaborations, connections. As a great conference should be!

Love this. Who needs sheets!?

*New paper alert* - extracellular tau blocks synaptic plasticity in vivo via its microtubule-binding domain, which can be rescued by our Gen2 tau antibodies - all the product of a great collaboration with Michael Rowan and colleagues at @tcddublin.bsky.social link.springer.com/article/10.1...

What an interesting paper, such a huge amount of work! Great to see it cover the different CNS and PNS axon types. And thank you for the thread: enjoyed following the story, showing how many people were involved, how long it took, and how it all came together. A phenomenal community effort!

Researchers in the Reh Lab have produced the clearest evidence yet that AAV-delivered genes can stimulate regeneration in the mammalian retina. @tomreh.bsky.social Marina Pavlou. #retina #regeneration @uwmedicine.bsky.social shorturl.at/qVUKz

Our paper is finally out! Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function. www.pnas.org/doi/abs/10.1...

A fantastic place to work with brilliant colleagues in a vibrant part of London! Wolfson SPaRC is hiring for Lecturer and above-level roles. Come and be part of the exciting work happening here. Amazing people, meaningful impact, and a location that’s hard to beat.

Excellent story from the Woolf lab! www.nature.com/articles/s41...

Significant functional improvements in walking speed/endurance for people with spinal cord injury with combined 4-aminopyridine and paired associative stimulation. A great study by Dr. Monica Perez and an All Star group. #SCIrehab 🧪 #phySKYatry academic.oup.com/brain/advanc...

Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...

Some interesting findings for ribosomal populations in mature human neurons...

Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin @ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding. www.pnas.org/doi/10.1073/...

Ooh, that's very interesting...

An exciting paper demonstrating a complex integrin trafficking mechanism with potential implications for the machinery regulating axon growth and regeneration. Intriguing!

Masalmeh, RHA, et al. FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation. bioRxiv posted 20 February 2025 doi:10.1101/2024.12.11.627900. www.biorxiv.org/content/10.1...

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...

ICYMI our latest paper is now out officially in print (is there still such thing?). And since Dev Cell @cellpress.bsky.social did not select our submission for cover, I post it here. A really cool illustration from my son Zack. www.cell.com/developmenta...

Aged motor neurons display an impaired response to muscle BDNF, consistent with downregulation of TrkB at the neuromuscular junction.

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...

Welcome to Bluesky @taamslab.bsky.social! Everyone - follow them for amazing #ImmunoSky #neuroimmune 🧪 🧠 content on #Arthritis, #Tcells and many other things. And of course, don't forget to read our latest review: www.nature.com/articles/s41...

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

Since I've met many new people on @bsky.app, I wanted to re-share this paper we published earlier this year in @naturecomms.bsky.social! We found OXR1, which regulates #longevity and #brainaging through neuronal endocytic recycling. Read below for a summary 👇 www.nature.com/articles/s41... #GeroSky

Finally my first author preprint at Cullen's lab is out! Amazing collaboration with Kevin and @brettcollins.bsky.social where, by using dedicated proximity proteomics, Biochemistry, crystallography and structural prediction, we show new aspects of human Retromer complex acting as hub for RAB GTPases

Celebrating this fantastic work lead by Kristýna Kárová (with some EvaLab contribution!), its new home in Molecular Therapy. Spinal cord axon regeneration with improvements in paw reaching, grip strength, and ladder walking using a gene therapy approach. Delta is the way! tinyurl.com/55en9z6d