Latest preprint from us

To say that "the data show these vaccines fail" in regards to the mRNA plaform is unforgivable. For those of you that don't remember - this is the data from a SINGLE dose. In December 2020. So good I cried in grateful tears.

JUST IN: HHS shuts down BARDA mRNA vaccine program Scrapping the fastest platform we have is a reckless move rooted in a fundamental misunderstanding of vaccinology. No respiratory vaccine blocks all infections. mRNA vaccines have saved millions of lives. www.hhs.gov/press-room/h...

We knew this deeply misguided man was bad news, but now his actions threaten us all. RNA-based vaccines are safe, effective at preventing disease, and can be rapidly manufactured at scale. Just as the threat of infectious disease increases, we remove our best defence. www.bbc.co.uk/news/article...

Former Mossad, Shin Bet and IDF leaders join most of the world in demanding an immediate end to the Gaza war, saying it’s now an unjust, immoral and futile war of destruction guided by 'messianic and extremist goals' and threatening ‘the loss of Israel's security and freedom.’ It must end now.

Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

A more personal substack post today about the first refugee I hosted through @refugeesathome.bsky.social . It's not something I talk about much but I felt I needed to write something in response to the increasingly hostile environment for refugees. christinapagel.substack.com/p/the-path-t...

Pres, Gagliardi, of the 🇺🇸 Federation of Musicians: “We will not remain silent as 2 of our members Bruce Springsteen & Taylor Swift r singled out & personally attacked by the POTUS. S&S r not just brilliant musicians, they r role models & inspirations 2 millions of ppl in the US & across the🌍” 👏🏼👏🏼👏🏼👏🏼👏🏼

My daughter receives world-class care from the paediatric T1D team at @LeedsHospitals It's not a service to be cut. It's the standard of care that the entire #NHS should be aiming for This is not the way forward @wesstreeting.bsky.social @rachelclarke.bsky.social www.bbc.co.uk/news/article...

"Masked security forces captured an opposition leader in the coastal province of New Jersey as regime officials continue their months-long crack-down against pro-democracy elements in the embattled United States. The arrest comes as the regime issued calls for summary detentions without trial."

Increase in productivity since 1979: 86% Increase in hourly pay since 1979: 31% Just so happens that ~25% of workers were unionized in 1979. Today? 10%. As unions declined, the super-rich have taken a larger share of wealth generated by labor. We must build back union power.

Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells www.annualreviews.org/content/jour...

Congrats @lindavsinclair.bsky.social on your (and Doreen’s) Annual Review. A must read. www.annualreviews.org/content/jour...

Did you know that there are eosinophils in the thymus? Are you curious about what they might be doing there? If so please have a read of our latest review, where Dominique Gatti has summarized the status of the field and outstanding questions on this topic! :) academic.oup.com/jleukbio/art...

Thank you, Neil, for your support. Keep on Rockin’ in the Free World. tinyurl.com/yzmj52yj

Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out! We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections! www.nature.com/articles/s41...

Stand up with ASH and #Fight4Hematology! 🩸💪 As executive orders threaten hematologic research and care of patients, ASH has created a new #Fight4Hematology Action Hub to keep you informed and involved. Learn how to protect #hematology: www.hematology.org/a...#Fight4Hematology!#Fight4Hematology#hematology:#HemeSky #MedSky

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Exciting new paper from Linda Sinclair and colleagues. Check it out!

Pass it on. #StandWithUkraine

Your dignity honors the bravery of the Ukrainian people. Be strong, be brave, be fearless. You are never alone, dear President Zelenskyy. We will continue working with you for a just and lasting peace.

He is not just appeasing Putin, he is aligned with him. And every single client journalist, political shill & public/online cheerleader on both sides of the Atlantic is too. Against Zelensky. Against Ukraine. Against freedom. Against the most basic tenets of decency.

You can send donations yourself direct to ukraine here: war.ukraine.ua/donate/ #SlavaUkraïni

This pair of absolute thugs berating, bullying & humiliating President Zelensky because he won’t roll over for a dictator whose forces have invaded his country, raped & murdered his people, bombed hospitals, killed children & filled mass graves in the forests. What a vile, venal pair they are.

I think this is the closest many of us have ever got to seeing the real Trump. The only consistent thread in his entire unhinged rant was the love & praise for Vladimir Putin. Zelensky has more courage & dignity in his little finger than every member of Trump's regime & fan club combined.

Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n

We have to fight now for research that we know benefits all of humanity, we have to stand up for our colleagues at the NIH, we can’t lie down and take it, we stand against this madness #standupforscience2025

Nature covers @scurry.bsky.social open letter to @royalsociety.org "which calls for the society to stand up for the science community and “the values it claims to believe in”" ⬇️ www.nature.com/articles/d41...

Hi Y’all-this paper out in print now sheds new light on how nutrients can affect histone acetylation in a locus-specific manner…in other words “you are what you eat”!

Hello, Bluesky👋 We’re the Faculty of Biological Sciences @universityofleeds.bsky.social. Follow this account to keep updated on the latest news and research stories from our community.

It was a pleasure to write a review for @mucosalimmunol.bsky.social "Emerging Leaders" series, with lab members @lukeocyte.bsky.social and Alanna Kelly. Always a pleasure working with this journal. More below 👇🏻

This week's editorial and cover at @thelancet.bsky.social www.thelancet.com/journals/lan... "The past 3 weeks have generated much anger, fear, and sorrow—but it is no time for panic. The medical and scientific communities must come together and stand up for this vision."

A new issue of Cell is out, featuring the 4 winners of the Rising Black Scientists Awards. Their essays bring hope, inspiration and reinforce the importance of equity in science. Do take a moment to check them out: www.cell.com/cell/current @cp-cell.bsky.social

Nature research paper: IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control https://go.nature.com/4guUvnp

Are you interested in a postdoc with our group studying cancer immunometabolism? If you’re at #KSTcells25 @keystonesymposia.bsky.social DM me and let’s chat!

*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...

This is just a reminder that the #cancermetabolism and #mitochondrialbiology community is ever-growing, and the third starter pack is becoming very juicy. Starter pack 1: go.bsky.app/VavECSX Starter pack 2: go.bsky.app/CH1MctZ Starter pack 3: go.bsky.app/7Uwa6fb

Hello Friends, I created a 5th #immunology Starter Pack. If you're an immunologist and you don't see yourself on the lists, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS go.bsky.app/QSEPDoj go.bsky.app/Mdbpk7h

Online now! Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components. 👇 www.nature.com/articles/s43...

The world’s richest man is promoting the far right in Europe. Don’t buy a Tesla . Location: Tesla Gigafactory, Berlin www.youtube.com/watch?v=NjWl...

Online now, our latest manuscript reporting findings on the metabolic basis of cytokine-driven CD4+ T cell expansion, assessed in vitro and during T cell proliferation following autologous stem cell transplantation. www.sciencedirect.com/science/arti...

Live forever is book of the day in @theguardian.com Thanks for a great review www.theguardian.com/books/2025/j...

I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪

Huh. There are flowers in Ethiopia that native nectar-foraging wolves pollinate! 🦊😋🌻🍊 🧪 "Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa" by Lai et al. (2024, Ecology) esajournals.onlinelibrary.wiley.com/doi/10.1002/...

Happy New Year! I am a newly-arrived refugee from the other platform. Looking forward to (re-)connecting with friends and colleagues in this community!

Foxp3 negative CTLA4 positive suppressor cells! rdcu.be/d5p6s

Interesting new research from Antoine Marçais’ lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells. #immunology #NKcells #Immunometabolism doi.org/10.1038/s422... See our commentary article here: www.nature.com/articles/s42...

Finally deleted Twitter. What an utter cesspit it became

We've just joined Bluesky 🎉 Follow us for research, news, comment and opinion from Nature journal 🧪