Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!

Now online! Gut microbiota promotes immune tolerance at the maternal-fetal interface

The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource

I'm very happy to share our latest manuscript published today in @nature.com !! ➡️ doi.org/10.1038/s415... We analyzed data from over 34,000 participants in the US and UK, revealing strong associations between specific gut bacteria and markers of cardiometabolic health and dietary habits.

Our study, now out in Nature Metabolism: 🔥 Microbial trimethylamine inhibits IRAK4, a key kinase in inflammation ➡ This blunts TLR-driven inflammation and decouples metabolic dysfunction from obesity ✅ This casts IRAK4 as a therapeutic target for metabolic diseases. Meet TMA, our unexpected hero ⬇️

📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

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I’ve released a tool to sketch and edit phylogenetic trees! yawak.jp/PhyloWeaver/ Load a Newick file and intuitively add/remove/resize branches. Useful for quick conceptual trees, extracting subtrees, or turning ideas into Newick.

Proud to share that three Sinai Genetics and Genomics faculty have been named Clarivate Highly Cited Researchers 2025: • José Clemente, PhD • Guo-Cheng Yuan, PhD • Bin Zhang, PhD Their work spans #microbiome science, systems #genomics, single-cell biology, and AI-enabled disease modeling.

My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...

Excellent work from @aroneys.bsky.social here. Free to read version at rdcu.be/ePJp4

🟠 SCIENCE | Don't forget it‼️ 6th IBiS-Winter International Symposium of External Young Investigators 2025! #IBiSWISE 🗓️10-11/12 ONLINE for PhD students & postdocs researching abroad, especially if consider joining Spanish research system. ⏳Deadline for abstracts 14/11! @unisevilla.bsky.social

Hi #GIsky and #GIresearch friends, who has had success culturing mouse small intestinal enteroid monolayers? We could use some wisdom!

Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs. @quadraminstitute.bsky.social rdcu.be/eMmcT

NEW publication from our lab: One of the first methodologies (FUGAsseM) for gene function prediction from microbial community multi-omics data! www.nature.com/articles/s41... 🧵⬇️ 1/8

1/5 Today we are introducing the Key-Cutting Machine (KCM) for protein and peptide design. Like cutting a key to fit a lock, KCM sculpts sequences to match a target backbone—on a single GPU. No retraining. No clusters. 🧬🔑

Excited to share our LongTrack study out in @natmicrobiol.nature.com today! Fecal microbiota transplant (FMT), donor 💩 => patients' gut, is an effective treatment for recurrent C. difficile infection & is being evaluated for Inflammatory Bowel Diseases (IBD) & other conditions 1/ 📄 rdcu.be/eL8mR

🟠SCIENCE | 6th IBiS-Winter International Symposium of External Young Investigators 2025 is coming! #IBiSWISE 10th-11th December ONLINE, for PhD students & postdocs researching abroad, especially if consider joining Spanish research system Deadline: 14th November @unisevilla.bsky.social

We recently got two papers published on the relation between microbiome and arthritis, in collaboration with the groups of Jose Scher (NYU), Frances Williams (King's College) and Monica Guma (UCSD). In both papers with Kevin Bu, postdoc extraordinaire in my lab, as first co-author!

Excited to share our preprint led by Carlos Voogdt et al We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera. www.biorxiv.org/content/10.1...

New paper out demonstrating how we can use strain-level analyses of soil metagenomes to investigate the biogeographical patterns exhibited by a dominant group of soil bacteria (Bradyrhizobium) academic.oup.com/ismej/advanc...

New respiratory 🫁 infection and microbiomes conference in Hinxton with stellar line up of speakers. 🚨 Submit your abstracts now! 🚨 Please RT coursesandconferences.wellcomeconnectingscience.org/event/air-20...

Many of you gave me so much encouragement when I posted here earlier about my 10 year long passion project to make a microbial map of the ocean. Pinch me because I can't believe I get to update you that today that research was published in the journal SCIENCE! @science.org

Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!

📚🩺Nuestro académico y virólogo Luis Enjuanes ha colaborado en este libro "La expedición Balmis. Primer modelo de lucha global contra las pandemias" 🦠 [...] Hoy podemos afirmar que el modelo de lucha contra la covid-19 tiene su germen en esta epopeya médica pionera @cnb-csic.bsky.social #geoplaneta

The gut microbiota is essential for maintaining female fertility go.nature.com/46OM03J

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine. 1) MMG (my dept): fundamental research in med micro 2) Peds ID / I4Kids institute 3) Center for Vaccine Research 🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

If you made it this far, thanks for reading. I hope you enjoyed it. I am currently looking for my next research adventure. If you have insights on the microbiome/microbial genomics job market in Europe (academia & industry), or want to chat about this work, please reach out.

Re-upping this: For those of you having new students in the lab, I have curated a YouTube playlist on molecular biology: www.youtube.com/playlist?lis... I usually have my students watch it before I show them how to do it in the lab.

Tenure-track Assistant Professor in Computational Ecology and/or Evolution @columbiauniversity.bsky.social. Deadline to apply September 30. Reach out if you have questions. apply.interfolio.com/172496

Now online! Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

A new paper is out from our research team at the @ueamedical.bsky.social at @uniofeastanglia.bsky.social titled "The landscape of microbial associations in human cancer" available from doi.org/10.1126/scit.... Led by @abrahamgihawi.bsky.social 🧬🖥️ @cancerinnorwich.bsky.social

Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.

Now online! Ancient host-associated microbes obtained from mammoth remains

The microbial composition of metagenomes is identified in seconds by profiling against large databases go.nature.com/3BBVqDC rdcu.be/eCbj4

Finally online! Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections. rdcu.be/ewwrG

🧬🖥️ Postdoc positions available SOON!! Looking for researchers with strong computational skills (programming essential) to work on microbiome & phylogenetics projects. 📅 Start on Nov 1, 2025 (flexible) 📍 Trento, Italy DM me for details or share! #postdocjobs #microbiome #metagenomics #phylogenetics

Hi folks, we had a last minute cancellation at MBL STAMPS, the microbiome data analysis course in Woods Hole that runs from July 14th to July 24th. We can provide housing space for a woman. If you or anyone you know is interested, pls drop me an e-mail at [email protected]. Thx!

Our lab is hiring! Based out of @rcsi.bsky.social Beaumont Hospital we are looking for a research assistant to work on an exciting project looking at early signatures associated with early stage #lungcancer. Feel free to share/reach out. #microbiome #cancer #omics my.corehr.com/pls/rcsirecr...

Our latest preprint is online @medrxivpreprint.bsky.social: "‪Metabolic modeling reveals determinants of synbiotic efficacy in a human intervention trial." www.medrxiv.org/content/10.1... Amazing work here by postdoc Nick Quinn-Bohmann @isbscience.org 🧵...

I am delighted that our manuscript 'Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut' is now published. www.tandfonline.com/doi/full/10.... Big thank you to all co-authors, particularly @lisalamberte.bsky.social and @halllab.bsky.social

‼️I'm looking for a postdoc‼️ Come join effort in using metagenomes to quantify microbial catabolic potential and carbon substrate availability at the ecosystem level. We seek to understand evolutionary forces shaping the carbon cycle. Part of ccomp-stc.org careers.peopleclick.com/careerscp/cl...

Apply now! Applications will be closing soon.

If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...

We are recruiting a tenure-track assistant professor in molecular microbiology in our department in Lausanne! Do consider appyling!!

We have two new positions, a PhD and a Post doc at #InstituteofBiologyLeiden within our @microclockerc.bsky.social #ERCSyG project to discover interaction of #circadianclocks between Bacillus subtilis and Arabidopsis please share these with your network! 🙏 links below👇 [1/3]

Probiotics in pregnancy: Where do we stand? Our new Gut Microbes review zooms in on the real-world potential of probiotics to support maternal health. #Spoiler: there’s promise—but also plenty of caveats. www.tandfonline.com/doi/full/10....

🥁NEW publication from our lab: the largest meta-analysis of gut microbiome associations with CRC! www.nature.com/articles/s41... 🧵⬇️ 1/6

I interviewed for a postdoc position in Howard's lab many eons ago. Although I ended up working in another (fantastic) lab, I always felt working with Howard & Nancy would have been an incredible opportunity. Highly recommended.