Proud to share that our first paper from the lab's new home at The Warren Alpert Medical School of Brown University and Brown University Health is now in press at @insight.jci.org! insight.jci.org/articles/vie...

The evolution of acute pulmonary embolism classification (including the recently published 2026AHA/ACC/ACCP/ACEP/CHEST/ SCAI/SHM/SIR/SVM/SVN Guideline): #foamed #foamcc #meded #Medsky #emimcc

Are you in the terminal a lot with Claude but work a lot with markdown files? I am using glow to see rendered markdown in the terminal. They have a great tagline, too. Anyone using anything else? github.com/charmbracele...

#PVRI2026 was incredible! Got to catch up with friends & colleagues, hear exciting science, share our own (PAEC biopsies & systems pharmacology for precision PAH care) and applaud @brownpvd.bsky.social colleagues @willoldham.bsky.social & Dr. Klinger who were recognized for their own stellar work!

📣 We are recruiting a post-doctoral fellow! Join an interdisciplinary, NIH-funded research program studying metabolic reprogramming in pulmonary fibrosis with strong translational focus and collaborative environment. Apply here: jobs.brownhealth.org/search/jobde...

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

When I ask a patient what medicines they take and they wave their hands and say “it’s in the chart” I need them to understand that “the patient’s chart” is a mythical concept, more akin to the scattered scribblings of the British constitution rather than a single, comprehensive document.

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !

Handed out, yet again, the basic #ScrawledGrantAdvice Aims page structure

some light teasing for an upcoming quarto revealjs plugin I have been working on

Looking for the hay bales at the base of the tower… #IYKYK #grclung2025

Woohoo! Latest preprint from the lab describing how fibroblasts can use alanine to bypass glutamine requirements for differentiation and ECM production. It's a lovely example of metabolic flexibility with implications for how we study cell metabolism. Shout out to Fei Li, who led this work! #cureipf

Still regretting the 4 month period 13 years ago when I went all in on the Mac office suite...

📢 Get ready to submit your abstract to PVRI 2026 Dublin — registrations & the abstract portal will open on 1 July! Stay tuned for full details on how to register and submit your abstract! pvrinstitute.org/pvri2026 #PVRI2026 #PulmonaryHypertension #GlobalScience #Congress

This JUST came up again and @ruben.the100.ci pointed me to the @malte.the100.ci blog explaining how to do it:

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

our lightsaber

Excited to announce that, In 26 days, I will be joining Brown University Health! Excited for new colleagues, new opportunities, and renewed energy to advance our work toward a cure for pulmonary fibrosis!

Such a great meeting! Looking forward to #PVRI2026 in Dublin!

#rstats folks: If you have a habit of updating your library after an R upgrade by copying the old one and run update.packages(). --> DON'T DO THAT <-- Especially not with 4.5.0. You will overwrite base packages with ones from a previous version and as these are not on CRAN, things go bad.

Thanks so much @navneetsinghmd.bsky.social @brownpvd.bsky.social for the opportunity to visit and hospitality! Wonderful to be able to see you all! @gauravchoudhury.bsky.social @willoldham.bsky.social

This helped me a lot: www.tidyverse.org/blog/2020/08...

#rstats folks! Does anyone have workflow tips on using ggplot2 in both manuscripts and slide presentations? Currently using targets to generate panels/figures themed for manuscript. These are not easy to port to slides given size of points, fonts, etc. Any advice appreciated!

Breaking in a new column today and, gosh, sometimes it’s nice to be able to SEE the science! #scienceincolor

I do not pay the kind of attention to college basketball that I once did but it is still important to take time out of my day to root against Duke

🏋️‍♀️ Strength training is vital for women entering #menopause - boosting metabolic, mental, & bone health. But like any intervention, it needs proper assessment & guidance. I started at 43, lifting heavy: no injuries. The secret? Good coaching, mobility, movement literacy, slow progression, and rest.

Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...

Happy to share our work on cold storage of pcls. Hoping this will be of interest to many and will help to store, share and expand the use of PCLS in #lungresearch. Kudoz to Camila and Fee who Share first authorship. @atscommunity.bsky.social respiratory-research.biomedcentral.com/articles/10....

Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!

Say what you will about the antiquity of beepers as a technology, but when that’s the only number anyone can reach you at, then the person holding the beeper is the only person who gets disturbed by the beeping.

How to snipe techie people of a certain age...

The Grover Conference Planning Committee is now inviting proposals for the 21st Grover Conference, to be held Sept. 3-7, 2025. Topic proposals should include a tentative schedule and speakers. All proposal submissions are due by 11:59 p.m., Friday, Jan. 31, 2025. Submit proposal here: bit.ly/4hbGr2V

Boosting for the weekend crowd...

We are interested in purchasing a system for primary cell electroporation. Any recommendations? We are looking for a "good enough" system at a low price. Thanks! 🧪

The flat one we made is here www.printables.com/model/45750-...

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress www.nature.com/articles/s41...

An unexpected and delightful consequence of growing up studying PAH before focusing on pulmonary fibrosis is being invited to think a little about the role of myofibroblasts in the heart! Grateful to write this editorial and to see it in print at the start of the New Year!

📌

I'm excited to share a new study out today in @bmj.com comparing the two single-inhaler triple therapies on the US market. Brief thread below! www.bmj.com/content/387/...

I made this over the break. Why would I do such a thing? Am I some sort of #phylogenetics dork? Well... yes, but that's not why. To fully explain I'll have to do one of those sewing-strings-wrapped-around-a-spool dealies. 1/ 🧪

I am honored to be listed there among so many brilliant and passionate researchers in the field of #PulmonaryFibrosis #ILD #Cure4IPF. If you're interested in the topic you should definitely follow those people 💥

The Blue Journal thanks Jonathan Rose, MD, MS, for his contribution to the December 15 issue Development, Progression, and Mortality of Suspected Interstitial Lung Disease in COPDGene www.atsjournals.org/doi/full/10....

Carolina hoops point differential by "quarter" or 10 minute segment through 11 games this season -25 in the 1st half +103 in the 2nd half -3 in overtime #Rstats #collegebasketball

@atspc.bsky.social what took y’all so long?! Nice to see you here! #pulmsky

Just discovered this #rstats package by @ethanbass.bsky.social for reproducible chromatogram analysis. Looking forward to trying it out. It was good timing as I was fixing to throw my Agilent ChemStation computer out of the window! ethanbass.github.io/chromatograp...

1/10 🔥 Hot off the press #RENOVATEtrial has been published on @jama.com. RENOVATE was an adaptive RCT testing the noninferiority of the HFNO vs NIV in 1,766 pts with ARF of different causes. HFNO was noninferior to NIV for some but not all causes of ARF jamanetwork.com/journals/jam...

I made it through the first week all by myself! I just completed "Bridge Repair" - Day 7 - Advent of Code 2024 #AdventOfCode adventofcode.com/2024/day/7

A very cool study that began by asking how circulating immune cell populations change following out-of-hospital cardiac arrest. A very challenging study to do with fascinating results! I'm delighted to have played a tiny part in the work and congratulations to @edykimlab.bsky.social and colleagues!