I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

Friends and Colleagues! I am SO excited to catch up with you all this week at #AABA2026! Here is a quick 🧵summarizing what our 🧪🧬👩🏽‍💻👨🏿‍🔬👩🏼‍🔬🧑‍💻lab will be presenting at the meetings (1/n) @umncla.bsky.social @umnanth.bsky.social www.nievescolonlab.org

Excited to share new preprint with NVIDIA on GPU-accelerated single-cell analysis 🚀 rapids-singlecell brings native GPU support to scverse/AnnData: hours → seconds (1M cells: ~52m → ~25s), scaling to 100M cells. Huge thanks to Severin Dicks 🙌 📄 arxiv.org/abs/2603.02402

See thread from @jeremymberg.bsky.social from today that takes a whack at estimating FY2025 success rates by IC.

@ee-reh-neh.bsky.social capturing the difficulty of carrying out any sort of projects with a field component. So grateful to have been a part of this study.

Very excited to see this work be the first to use the quasar method for eQTL mapping!

Register now for March 2nd @agbt.bsky.social Recap! Inside AGBT: Big Announcements and Bigger Implications www.genengnews.com/multimedia/i... Featuring @jlemieux.bsky.social @biomath.bsky.social @jasmineplummer.bsky.social @nebanovich.bsky.social Catherine Aquino

Hi yes I will have more to say about this in a few hours but please enjoy this paper. It's been a huge labour of love and effort for the last four years, and a significant part of our research efforts, and I'm so so so thrilled it's finally ready to share. Tldr: scRNA-seq in Indonesia hard but fun

So excited to have this study live! Lead by @ee-reh-neh.bsky.social's teram and in collaboration with an incredible team at MRIN in Indonesia. This is the culmination of ~5 years of work including a ton of effort in the field. Really proud of how this came together! www.biorxiv.org/content/10.6...

Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign. (1) $48.7 billion for NIH (2) Full IDC recovery (3) No more multi-year funding (4) No NIH reorganization, maintaining the current IC structure.

The fact of the matter is: a severe #IceStorm is developing across much of the country at this very moment, with potentially devastating and far-reaching consequences extending far beyond the region of maximum #ice concentration. Watch out for the #ice, and help your neighbors weather the storm.

My (now) weekly update on 2026 NIH funding. New and competitive renewal awards. 3 new awards (compared to ~100 expected based on recent years). No new ICs... still just NIA, NINDS, NIDCD, and NIDCR. 1/2

Use of SNPs in a low diversity system for genetic monitoring and identifying a successful translocation event in the Paiute Cutthroat Trout (O. henshawi seleniris) https://www.biorxiv.org/content/10.64898/2026.01.07.697447v1

A fun little project. We were curious if you could prep a single sample using both 10X Genomics Xenium V1 probes and Prime probes – allowing users to profile 480 genes at high sensitivity and 5,000 genes at lower sensitivity inline. www.biorxiv.org/content/10.6...

Great new work led by Aaron Kwok from @davisjmcc.bsky.social’s group. A tool to “denoise” contaminating transcripts from image based spatial data. www.biorxiv.org/content/10.1...

🚀 We’re thrilled to announce our new partnership with SOPHiAGENETICS! Together, we’re redefining what’s possible in #sequencing—delivering richer insights, faster results, and greater accessibility for labs everywhere. 🔗 Learn more: https://bit.ly/4nNmOks #Genomics #Genetics

8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM). Only open for 2 weeks (applications due November 21). Application materials include a) CV b) vision statement c) a photocopy of doctoral degree. hr.nih.gov/careers/open...

Excited to be attending my first SITC Annual Meeting! On Friday, Brandon Fischer from @nebanovich.bsky.social will present a poster on some of our work on Chlorotoxin CAR T cells. Check it out! #SITC25

reminder that my (wonderful, diverse, interdisciplinary) department at the University of Oregon is seeking applications for an Associate/Full Professor of Data Science -- deadline 10/31 and only cover letter/CV needed to apply academicjobsonline.org/ajo/jobs/30328

My science 💜 is full as I reflect on a great week at #ASHG25! 5 posters from the lab, symposium on #epilepsy 🧠 #genetics 🧬, catching up with so many friends and colleagues. Already excited for #ASHG26 in Montreal - see you there!

Thank you! I am so honored and had such a wonderful time at #ASHG. What an amazing and inspiring society!

Great presentations from the lab this week at #ashg25.

Bulk of the lab are presenting posters today!

I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!

After a short *3 hour* flight delay excited to be in the air on the way to Boston for #ASHG25. Looking forward to sharing the lab's work.

Great new work from the Barthel lab!

Happy to share that this work together with @opentargets.org is now out at Nature Communications.

Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/

Interesting @nebanovich.bsky.social @florisbarthel.bsky.social glad we just installed an @elembio.bsky.social Aviti24 @tgenresearch.bsky.social. @aphillippy.bsky.social is this with standard cloudbreak chemistry or the high accuracy ultraQ chemistry

"We’re currently at about 54% of last year’s total [of funded R01s]...Another way to look at this is that we’re missing 1,809 new R01s."

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Our paper identifying evidence of off-target probe binding in the 10x Genomics Xenium Breast Gene Panel is now available as a reviewed preprint at #eLife elifesciences.org/reviewed-pre... We look forward to revising the paper to incorporate reviewer recommendations and other updates 🧵👇

Gotcha. I just did the math for NIGMS, and they're still short ~200 R01 equivalents compared to last year, with only 7 MYF'd. MYF funding for other mechs could contribute to fewer grants, but it still doesn't seem like the math works out. Maybe more will show up Reporter to reduce the shortfall.

🚨 New @10xgenomics.bsky.social eBook out now! Hear from Dr @saskiafreytag.bsky.social, @wehi-research.bsky.social on how spatial biology is helping identify therapeutic cancer targets. Plus, insights from other leading researchers worldwide. 📖 Download here: pages.10xgenomics.com/web-2025-08-...

So proud of @saahimall.bsky.social for crushing her comps today. She's a force in the lab and seeing her present her plan for the next few years was awesome. #nocrumbs

Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...

Just to give the TL;DR on this one: *The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.

In my small corner of biology, I’m constantly reassured by how frequently we confirm main findings. And then when differences do show up, they very rarely end up being fraud, but instead tell us something important about differences in experimental design.

Great summary

One critical lesson here for future republics. institutions, foundations or agencies of national importance should be placed clearly outside the controls, oversight, or influence of the executive, or anyone appointed by the executive!

Well, this is a huge Executive Order power grab... www.whitehouse.gov/presidential... 1/3

Whoa! 👀

So excited to share @saahimall.bsky.social just had her her first 1st author publication published in AJP lung! Huge accomplishment!!! This study wouldn't have been possible without the amazing @jensucre.bsky.social! journals.physiology.org/doi/abs/10.1...

👀👀👀 @elembio.bsky.social

Yesterday was the last day of @tgenresearch.bsky.social's summer internship supported by the Helios foundation. Bittersweet to say goodbye but happy to see them presenting their great work. Special congrats to Francesca, Lauren, and Yafnelt who were recognized for their outstanding presentations.

BIG NEWS: “Senate appropriators on Thursday approved an FY26 Labor-HHS bill that included a slight bump in funding for the NIH, with a strong 26–3 bipartisan vote.” Thank you to members of the Senate Appropriations Committee on both sides of the aisle! www.axios.com/pro/health-c...

Whoa!

Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!

I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!

Check out @saahimall.bsky.social's #skysplain of our latest work! Very proud of all her hard work on this study and REALLY excited for what she's got planned next! #bpd #lungdevelopment #genomics #science