First day of AACR: spatial and pups.

@hggadvances.bsky.social's latest article provides systematic evidence that sex-differentiated somatic regulation underlies tumor-intrinsic mechanisms in multiple myeloma, reinforcing the need for sex-aware molecular analyses in precision medicine: https://bit.ly/4s6j2VE #ASH #HumanGenetics

New publication! Lead by Lori Hogencamp, we present the Evolutionary Stress Framework, a complexity-based model that reframes neurodevelopmental variation as the emergent outcome of stress–energy regulation and predictive processing over time. 1/3

Should biology put complexity first? www.sciencedirect.com/science/arti... - excellent essay by @philipcball.bsky.social. I would add epistasis to polygenicity and pleiotropy as a ubiquitous and fundamental phenomenon, not some optional complication that we can try to account for afterwards

Important and alarming autism news from @rosebroderick.bsky.social at @statnews.com www.statnews.com/2026/01/23/k...

I would appreciate if the members of the committee could elaborate and clarify if their goal is truly to “fight against autism”

The idea that America needs to occupy Greenland because we actually care enough about native people and want to build oncology centers is enough to make your head fully explode

I'm happy to share that I will be serving in an ASHG @geneticssociety.bsky.social professional guidance writing group on the participation of people with disabilities in genomics and precision medicine research. 1/2

Join our January #ELSIFridayForum: how genetic embryo selection is being shaped by commercial incentives, regulatory gaps, and shifting cultural expectations of parenthood. January 9th, 2026; 12pm ET/9am PT Register: www.addevent.com/event/kct18q...

Why are more young adults getting appendix cancer? In the latest Cancerwise podcast episode, our experts explain why this rare cancer is often missed and share the latest treatment advances. Listen now: spr.ly/6014COB7p #EndCancer

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

One journal editor in chief called the results “concerning,” while another thought the analysis was looking for problems on purpose.

New pathway discovered!

What Other Diagnoses Could Learn From Autism’s Diagnostic Appeal The role of cognitive-perceptual mechanistic explanations A response by Riva Stoudt to my autism differential diagnosis post www.psychiatrymargins.com/p/what-other...

💯🙌

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

New preprint alert! Drawing from our experiences and observations on two initiatives with participatory aspirations, we have identified challenges, strategies, and recommendations for better and neurodiversity-affirming autism research. 10.13140/RG.2.2.27146.12481 1/

Someone get me (genetic epidemiologist) & my husband (school psychologist) on a podcast bc our rants on these people are...fiery. We spent 5y in the bay around these folks and oh boy. I'm also so sick of these puff pieces that avoid saying plainly what this actually is. Shoddy science for eugenics.

I'm excited to share that I will be participating in the @sitcancer.bsky.social Sparkathon program, class of 2026. I'm looking forward to connecting with the class and the organizers at the Spring Scientific in Tucson! @tgenresearch.bsky.social

A #ScienceSignaling study examines the activities of ligand-based #CARTcells and shows they induce proliferative signaling events within target cells, a finding that has implications for the design and application of future CAR T cells in the clinic. https://scim.ag/47CxSMB

I was interviewed for an article about autism and the gut microbiome published yesterday in @science.org. Check it out! www.science.org/content/arti...

What a great webinar featuring @drmbothapsych.bsky.social. An important reminder: dehumanization of autistic people and moral disengagement motivate remediation. pmc.ncbi.nlm.nih.gov/articles/PMC...

Our work was highlighted by @jguerriero.bsky.social at #SITC25 today, session "Cellular Therapies for Solid Tumors, Cell Therapies beyond CAR T Cells." Check out the pre-print on BioRxiv! @sitcancer.bsky.social @sgholamin.bsky.social @nebanovich.bsky.social

Excited to be attending my first SITC Annual Meeting! On Friday, Brandon Fischer from @nebanovich.bsky.social will present a poster on some of our work on Chlorotoxin CAR T cells. Check it out! #SITC25

#SITC25 Science Preview: Examine immune regulatory subsets in tumors with Jennifer Guerriero, PhD, Sergio Quezada, PhD, UCL News, @bcellbruno.bsky.social, Florent Ginhoux, PhD and Aurélien Marabelle, MD, PhD Gustave Roussy 🏥 View session details: https://ow.ly/TqBo50XgUsp

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

The use of dichotomized labels for traits that are actually continuous has bothered me ever since I started working on complex trait genetics. Sasha's blog post provides an excellent explanation of why this matters in the context of polygenic risk and embryo selection.

Genetics is transforming lives—but communication is key. Join our webinar to explore how to engage communities, promote understanding, and advocate for justice in genomics. 📅November 12 Register now: learning.ashg.org/products/mee... #ASHG

Bulk of the lab are presenting posters today!

WOW! Our survey of scientists who stopped using Twitter and started using Bluesky is now the #1 most-shared on social media article in the history of the journal Integrative and Comparative Biology! Thanks for reading it, everyone! @sicbjournals.bsky.social doi.org/10.1093/icb/... 🧪

Hurts seeing so many of these notices during #ASHG25, but even sadder to see one with a Reviewer's Choice Award

The council is deciding your faith… #ashg25 @pacbio.bsky.social

Really hope someone posts from the Engaging Communities session this morning! I'm bummed it's at the same exact time as the sex & gender session 😭 #ASHG25

For those interested in #Indigenous #Genomics and #ASHG25 in Boston, here are some interested posters/talks/events coming out of the Tsosie Lab, @nativebio.bsky.social, and @d4itdr.bsky.social. For those looking for Friday plans, attend our Ancillary Event, debuting a #Tribal #data repository!

After a short *3 hour* flight delay excited to be in the air on the way to Boston for #ASHG25. Looking forward to sharing the lab's work.

Getting ready for our 8:30 session in room 252ABC. Join us to discuss genes, traits and identities, and navigating sex, gender, and sexuality in genomics. #ASHG25

Related: If any other trans or nonbinary folk are attending #ASHG25, I would love to connect! Especially students who haven't had a chance to meet an older trans scientist. I wish I had that kind of mentor, but I'm happy to try to be that for others 💖🏳️‍⚧️🧬

Vaccines are safe and effective. Autism isn't caused by vaccines, and autistic people and their families deserve our support. When you want information, ask your doctor. It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.

I want to invite the speakers and moderators of the session “Autism Spectrum Disorder: From Genetic Variation to Neurobiology” to attend my talk on community engagement and the following Q&A, with highlights from autism genetics. Wednesday 8:30, room 253ABC, level 2. 🙂#ASHG25

I'm looking forward to attending #ASHG25 next week in Boston! I have the honor and privilege to be presenting at the Featured Symposium "Genes, Traits, and Identities: Navigating Sex, Gender, and Sexuality in Modern Research" on Wed, Oct 15, 8:30-10am. 1/5

jamanetwork.com/journals/jam.... Acetaminophen (Tylenol) does not cause autism in this very large study 🧪 #medsky

Some thoughts about today’s announcement on Tylenol, “the autism epidemic”, and the $50M NIH initiative ADSI. 1/

Why do so many disease risk variants show no regulatory effects in GTEx and/or other standard eQTL studies? What do we mean when we say a regulatory effect is "context-specific" and how do we define the context? We explored these questions using brain organoids and oxygen stress.

It’s so gross to demand proof that someone “matters” for them to deserve health care. We are a rich country and *everyone* matters

Here we go again… techcrunch.com/2025/06/06/g... Genetics testing startup Nucleus Genomics criticized for its embryo product: 'Makes me so nauseous' | TechCrunch

Great piece and highlights what we need to be making clearer.

The phase II clinical trial in China tested CAR T cells in people with advanced gastric cancer or gastro-oesophageal junction cancer - one of the first times this therapy has worked against solid tumours 🧪 #MedSky www.nature.com/articles/d41...