Our work was highlighted by @jguerriero.bsky.social at #SITC25 today, session "Cellular Therapies for Solid Tumors, Cell Therapies beyond CAR T Cells." Check out the pre-print on BioRxiv! @sitcancer.bsky.social @sgholamin.bsky.social @nebanovich.bsky.social

Excited to be attending my first SITC Annual Meeting! On Friday, Brandon Fischer from @nebanovich.bsky.social will present a poster on some of our work on Chlorotoxin CAR T cells. Check it out! #SITC25

#SITC25 Science Preview: Examine immune regulatory subsets in tumors with Jennifer Guerriero, PhD, Sergio Quezada, PhD, UCL News, @bcellbruno.bsky.social, Florent Ginhoux, PhD and Aurélien Marabelle, MD, PhD Gustave Roussy 🏥 View session details: https://ow.ly/TqBo50XgUsp

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

The use of dichotomized labels for traits that are actually continuous has bothered me ever since I started working on complex trait genetics. Sasha's blog post provides an excellent explanation of why this matters in the context of polygenic risk and embryo selection.

Genetics is transforming lives—but communication is key. Join our webinar to explore how to engage communities, promote understanding, and advocate for justice in genomics. 📅November 12 Register now: learning.ashg.org/products/mee... #ASHG

Bulk of the lab are presenting posters today!

WOW! Our survey of scientists who stopped using Twitter and started using Bluesky is now the #1 most-shared on social media article in the history of the journal Integrative and Comparative Biology! Thanks for reading it, everyone! @sicbjournals.bsky.social doi.org/10.1093/icb/... 🧪

Hurts seeing so many of these notices during #ASHG25, but even sadder to see one with a Reviewer's Choice Award

The council is deciding your faith… #ashg25 @pacbio.bsky.social

Really hope someone posts from the Engaging Communities session this morning! I'm bummed it's at the same exact time as the sex & gender session 😭 #ASHG25

For those interested in #Indigenous #Genomics and #ASHG25 in Boston, here are some interested posters/talks/events coming out of the Tsosie Lab, @nativebio.bsky.social, and @d4itdr.bsky.social. For those looking for Friday plans, attend our Ancillary Event, debuting a #Tribal #data repository!

After a short *3 hour* flight delay excited to be in the air on the way to Boston for #ASHG25. Looking forward to sharing the lab's work.

Getting ready for our 8:30 session in room 252ABC. Join us to discuss genes, traits and identities, and navigating sex, gender, and sexuality in genomics. #ASHG25

Related: If any other trans or nonbinary folk are attending #ASHG25, I would love to connect! Especially students who haven't had a chance to meet an older trans scientist. I wish I had that kind of mentor, but I'm happy to try to be that for others 💖🏳️‍⚧️🧬

Vaccines are safe and effective. Autism isn't caused by vaccines, and autistic people and their families deserve our support. When you want information, ask your doctor. It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.

I want to invite the speakers and moderators of the session “Autism Spectrum Disorder: From Genetic Variation to Neurobiology” to attend my talk on community engagement and the following Q&A, with highlights from autism genetics. Wednesday 8:30, room 253ABC, level 2. 🙂#ASHG25

I'm looking forward to attending #ASHG25 next week in Boston! I have the honor and privilege to be presenting at the Featured Symposium "Genes, Traits, and Identities: Navigating Sex, Gender, and Sexuality in Modern Research" on Wed, Oct 15, 8:30-10am. 1/5

jamanetwork.com/journals/jam.... Acetaminophen (Tylenol) does not cause autism in this very large study 🧪 #medsky

Some thoughts about today’s announcement on Tylenol, “the autism epidemic”, and the $50M NIH initiative ADSI. 1/

Why do so many disease risk variants show no regulatory effects in GTEx and/or other standard eQTL studies? What do we mean when we say a regulatory effect is "context-specific" and how do we define the context? We explored these questions using brain organoids and oxygen stress.

It’s so gross to demand proof that someone “matters” for them to deserve health care. We are a rich country and *everyone* matters

Here we go again… techcrunch.com/2025/06/06/g... Genetics testing startup Nucleus Genomics criticized for its embryo product: 'Makes me so nauseous' | TechCrunch

Great piece and highlights what we need to be making clearer.

The phase II clinical trial in China tested CAR T cells in people with advanced gastric cancer or gastro-oesophageal junction cancer - one of the first times this therapy has worked against solid tumours 🧪 #MedSky www.nature.com/articles/d41...

Georges Benjamin: For every dollar we put into research, we get 2.64 dollars back. This enterprise produces innovation and economic activity. #STATBreakthrough @statnews.com

A computational framework links transcriptomic analyses with mechanical signatures to study the interplay between cell mechanical forces and gene expression. www.nature.com/articles/s41...

Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma! doi.org/10.1093/neuo...

Our new contribution to the quest to find causal GWAS genes! Sam Ghatan from my lab at @nygenome.org led a systematic comparison of eQTLs and CRISPRi+scRNA-seq screens. TL;DR: they provide highly complementary insights, with ortogonal pros and cons. 🧵👇 www.biorxiv.org/content/10.1...

New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology. www.biorxiv.org/content/10.1...

US President Donald Trump’s proposed budget for fiscal year 2026 calls for unprecedented cuts to scientific agencies that, if enacted, would deal a devastating blow to US science, policy specialists say. https://go.nature.com/4jYv3IP

ASHG is concerned about the research cuts in the proposed U.S. FY26 budget, forecasting substantial reductions to the NIH and other agencies. We urge the U.S. Congress to reject this proposal and maintain support for life-saving biomedical research. Read More: www.ashg.org/publications... #ASHG

President Donald Trump today asked Congress to make massive and unprecedented cuts to the 2026 budgets of major federal science agencies. scim.ag/3Yszqnm

A recent #ScienceImmunology Review discusses the mechanisms through which dendritic cells influence cytotoxic CD8+ T cell responses against cancer. Learn more on #DayOfImmunology: scim.ag/3YRrBYk

Brilliant session focused entirely on spatial multiomics @theaacr.bsky.social #AUA25 Well said @tanevski.bsky.social "Cancer is a spatial disease-spatialomics is the future of cancer science"! Wonderful composite spatial data from Linghua Wang @mdanderson.bsky.social www.nature.com/articles/s41...

Cancel the poster session 🫠 #CanineSupport @theaacr.bsky.social #aacr2025

@johannajoyce.bsky.social giving a wonderful presentation about she and her team’s successful discoveries on immunosuppressive myeloid cell infiltration and their contribution to recurrence and progression of brain tumors and at the #aacr2025 Plenary Session

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics https://go.nature.com/42Zryw1

Impressive opening plenary presentation from @johannajoyce.bsky.social on Unraveling the complexity of cancer ecosystems. She highlighted the importance of the fibrotic niche and potential therapeutic approaches that target it #AACR25

PhD Timeline xkcd.com/3081

I wrote about how we must stand and fight against the threat of eugenics. Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent. This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.

Our 3D study of the tumor microenvironment is finally out! Play around with the data yourself at lung-3d-browser.mdc-berlin.de (Kudos to @danilexn.bsky.social👏 ) Many thanks to Nikolaus Rajewsky lab at @mdc-bimsb.bsky.social and everyone involved, it takes a village to raise a multimodal paper!

After freezing all grants to Columbia University last week, the National Institutes of Health is now stopping grant and contract payments to Harvard University and four other universities. scim.ag/4ikYp2T

ASAN, Autistic Women & Nonbinary Network, the Autistic People of Color Fund, Autism Society of America, Autism Speaks, The Arc, and others stand united: Autistic people deserve respect, support, and science-based policy, not dangerous disinformation. autisticadvocacy.org/2025/04/lead...

💡 "Good researchers and leaders figure out the right questions to ask." 💡Meet Dr. @heinimnatri.bsky.social, Research Assistant Professor. She shares insights on team science, mentorship, & her recent breakthrough in glioblastoma research—helping pave the way for new clinical trials in CAR T therapy.

I’m disappointed (but not surprised) to see that none of the major funders of autism research (INSAR, ASF, Autism $speaks…) are taking any stance on the current administrations plans re: autism research. ASAN and other self-advocacy groups, in contrast, are. Why? 1/2

How does tumor heterogeneity impair the immune response to cancer? Tanaka, Reeves @utah.edu and colleagues show tumor cells shape their microenvironment on a highly local level, using CX3CL1 to create spatial pockets of immunosuppression. rupress.org/jem/article/... @maxkrummel.bsky.social

This is so incredibly sad for cancer and specifically cell and gene therapy. I am profoundly grateful to Peter for his service, collaboration and dedication through an incredibly impactful career. CAR-T therapies would not be where they are without his efforts. www.wsj.com/politics/top...