@uhnresearch.ca @uoftmedicine.bsky.social @myelomacanada.bsky.social @mayoclinic.org

Love hearing these cases, such huge changes in therapy now that are providing patients with the best response they have seen to date. And the plus for MM patients doing well after CAR-T, it is often the first time they are off therapy, hope things go well and you are now planning a vacation instead

Are 'unexpected' early relapses really unexpected in #myeloma ? Or a sign for need for wider implementation of and access to already diagnostic tests? Challenging the concept of functional high-risk myeloma through transcriptional and genetic profiling url: ashpublications.org/blood/articl...

@medrxivpreprint.bsky.social on early access data generated by Baylor College of Medicine scientists with Illumina Constellation Mapped Read Technology. #genomics #VariantCalling #DRAGEN #Constellation bit.ly/48wm3I3

Wow, two myeloma talks as late breaking abstracts at #ASH2025, one on in vivo CAR-T and another on teclistamab+daratumumab versus DPd or DVd

I missed it but as of November 12 the @thermofishersci.bsky.social and Binding Site Maldi-TOF assay got FDA 510(k) clearance. Big milestone in moving the myeloma field forward. Many thanks to the Mayo Clinic team for putting in years of hard work to bring this transformative approach forward

Vaccines work wonders, need thing like this more than ever with the stupidity on the CDC website

VACCINES DO NOT CAUSE AUTISM, YOU FLAMING SHITBIRDS. WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

@epicypher.bsky.social's is new Fiber-seq Kit works with PacBio long-read sequencing to reveal chromatin accessibility, DNA methylation, and protein footprints on single molecules, expanding access to powerful multiomic analysis. Learn more: bit.ly/4qSMa3d

Very important work from a great Canadian team. Building an important part of how we will monitor myeloma patients in the future and maybe define a cure

Common diseases can be misdiagnosed as actually being due to rare, disease-causing genome variants. DNA and RNA sequencing can make the true diagnosis, which affects response to therapy @nejm.org www.nejm.org/doi/full/10....

Transcriptional interferences ensure one olfactory receptor per ant neuron www.nature.com/articles/s41... Caviar for RNA-Seq nerds! Check this out

@cityofhope.bsky.social multiple myeloma leader Dr. Amrita Krishnan is now the SWOG multiple myeloma chair.

Way to go Blue Jays

Vaccines are safe and effective. Autism isn't caused by vaccines, and autistic people and their families deserve our support. When you want information, ask your doctor. It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.

@sci-bri.bsky.social moving from 2 weeks of sunshine to a year of it, great line

Bridging therapy with #talquetamab enabled patients with high-risk #myeloma #MMsm to successfully transition to #BCMA #CARTcell therapy, with 88% experiencing rapid disease control and proceeding to treatment with ide-cel or cilta-cel: ow.ly/7JkM50X8KYa #HemeSky #MyelomaSky #MultipleMyeloma

What an amazing assay. DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform: www.biorxiv.org/content/10.1... This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.

How old is this plane, don’t remember the last time I saw volume and channel controls in the arm rest

Interesting work on genes that regulate anti-BCMA CAR-T efficacy in myeloma.

Awesome to see a 🇨🇦 in the rainbow jersey

I am excited to share my first work in @schapirolab.bsky.social on Multiple Myeloma (MM) in collaboration with the Standal Lab from NTNU Norway. We use Imaging Mass Cytometry (IMC) on bone marrow biopsies from MM and precursor patients (details below): www.biorxiv.org/content/10.1...

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

Interesting @nebanovich.bsky.social @florisbarthel.bsky.social glad we just installed an @elembio.bsky.social Aviti24 @tgenresearch.bsky.social. @aphillippy.bsky.social is this with standard cloudbreak chemistry or the high accuracy ultraQ chemistry

The latest human GENCODE releases for Human (49) and Mouse (M38), have just been released. They're available via gencodegenes.org and visible in @ensembl genome browser as part of Ensembl 115 ensembl.org

Asking for a friend, to my pathology colleagues, please ensure ISCN sections are on your FISH reports

Thank you Tommy! The link you gave is good but points to a 2yr old rendering. This one uses recent versions of R and all packages and has all the latest typo fixes: www.huber.embl.de/msmb/

Pleased to say that our preprint benchmarking Nanopore data for MLST, cgMLST, cgSNP & AMR typing from bacterial isolates is out! TL;DR you can get almost perfect results from 50x depth using live SUP basecalling with a GPU in under 20 hours #microsky#IDsky 🦠🧬🖥️ /1 www.medrxiv.org/content/10.1...

New prognostic systems for multiple myeloma in the context of contemporary therapies url: ashpublications.org/blood/articl...

Sarcastic me: Ah I feel so bad for him… Honest me: please don’t give this piece of shit a platform, hope no one hires him as it just helps is platform of spewing crap appear academic in origin

This is yet another amazing outcome of large public datasets like the UK bio bank. Suspect having a high serum BAFF level means you don’t have many plasma cells, wonder if those people have frequent infections

Dysregulated immune proteins in plasma in the UK Biobank predict multiple myeloma 12 years before clinical diagnosis, regardless of MGUS status, amazing work!: ashpublications.org/bloodadvance...

Sauber only had two bottles of champagne, both Mercedes and Aston Martin sent them all of theirs so the team could celebrate properly! A very hard fought well deserved podium for both team and driver #BritishGP

Yesterday the FDA approved the third T-cell engager against BCMA, Lynozyfic (linvoseltamab) from Regeneron, following on the earlier EMA approval this spring. This is the 20th drug approved to treat #myeloma in just over 20 years. For those that are interested here is the updated approval timeline.

Interesting paper #myelomasky The bone marrow NK-cell profile predicts MRD negativity in patients with multiple myeloma treated with daratumumab-based therapy url:https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2024026455/535791/The-bone-marrow-NK-cell-profile-predicts-MRD

Congrats to @dantipov.bsky.social et al. on the publication of Verkko2! The team put a ton of work into this making it the first assembler that deals with the complexity of human acrocentric chromosomes. Lots of interesting discoveries to come! genome.cshlp.org/content/earl...

Preprint on "Improving spliced alignment by modeling splice sites with deep learning". It describes minisplice for modeling splice signals. Minimap2 and miniprot now optionally use the predicted scores to improve spliced alignment. arxiv.org/abs/2506.12986

We are proud to announce that the International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma has been published by the Journal of Clinical Oncology! ascopubs.org/doi/10.1200/...

ascopubs.org/doi/10.1200/... considering the patient population this is extremely impressive, 1/3 of patients progression free at 5 years, glad to have @cityofhope.bsky.social physician Dr. Myo Htut as one of the coauthors. I for one believe cures are possible in #myeloma @tgenresearch.bsky.social

Using sequencing replicates of the normal cell line COLO829BL, we found that SAVANA shows 13- and 82-times higher specificity than the second and third-best performing algorithms (391x higher than the worse performing one). In practice, this means 10s-1000s less false positives..

Release of DeepVariant and DeepSomatic v1.9 DV: Now train on HG002 T2T-Q100. Error reduction of 12% for Illumina and 30% for PacBio on this truth set. 25% faster. DeepTrio is 5x faster (20h -> 4h). DS: New models FFPE_TUMOR_ONLY for {WGS, WES}. Much improved WGS models. github.com/google/deepv...

Excited to share our first study using nanopore direct RNA seq to comprehensively characterize RNA features. We believe that our deep and high coverage datasets should be a nice resource for the field! www.cell.com/cell-genomic...

Exercise your right to vote today, Canadians! Own your democracy! 🇨🇦🗳️

The Allen Institute for Immunology is at #AACR25 conference! Come see my poster to preview our open data and tools for Multiple Myeloma. 2 PM, Section 46, Board 11 More details and where to find us at tinyurl.com/allen-aacr-2... @alleninstitute.bsky.social @theaacr.bsky.social

Kinda crazy to see the full structure of complex immunoglobulin translocations in #myeloma with some nice clean @pacbio.bsky.social HiFi reads and assembly with hifiasm

This is everything you need to know about Pope Francis. If only we could all abide by his teachings.

Unexpected fun of a proper limit of detection study, discover the “normal” blood cells of the #myeloma patient clearly has a BCR::ABL1 clone, CML?, that increases as the percent normal increases, oddly totally gone 6 years later with just anti-myeloma therapy.

Great work on whole genome assembly using @nanoporetech.com and @pacbio.bsky.social sequencing @tgenresearch.bsky.social part of @cityofhope.bsky.social