1/5 Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body. www.biorxiv.org/content/10.6...

Pedestrianizing the Financial District would be another one of those projects where as soon as it went into effect people would wonder why New York didn't do it earlier and, before too long, even more people would forget it was ever any different.

New family of generative DNA language models trained on 1T 6-mer DNA tokens in long genomic contexts. Open weights, open source, open training data... h/t @mmitchell.bsky.social huggingface.co/spaces/Huggi...

Attention all #RNA26 Montreal @rnasociety.bsky.social attendees! Get your special edition @rnacanada.ca RNEh? tshirt to celebrate your Canadian RNA pride. Order here: gametime.gearware.com/stores/rna thru Friday, May 29th. Delivery ONLY to RNA2026 in MTL/no shipping. Image design by Jasmine Tsang.

#MLCB2026 will be November 16-17 at (once again) @nygenome.org, NYC! Paper/abstract deadline is July 1st, more deets at mlcb.org. We'll be opening in-person registration alongside paper decisions. Mailing list to stay in the loop: groups.google.com/g/mlcb. Keynotes TBA! Please RP!

Orthus: an RNA foundation model pretrained via contrastive learning based on splicing isoforms and orthologous transcripts. @phil-fradkin.bsky.social @heyitsmeianshi.bsky.social @taykhoomdalal.bsky.social @bowang87.bsky.social @quaidmorris.bsky.social www.nature.com/articles/s41...

Small Model, Big Insight: RNA Structure Rules Emerge from Minimal Data 🧬 #AcademicSky #higherEd #RNA www.mcb.harvard.edu/department/n... @rachellegaudet.bsky.social @naoshigeuchida.bsky.social @nature.com @harvard.edu

New research from MSK, led by Dr. Scott Lowe, Dr. Dana Pe'er, & colleagues, shows how pancreatic cells can shift from a benign state to cancer — revealing a key “switch” in this process. The study, published in @cellpress.bsky.social, identifies a critical window for early detection and prevention.

Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...

The Donnelly Centre is hiring a new Research and Communications Officer! As a vital part of our administration team, this role covers the external and internal communications of our community. Learn more about the role and apply at the link below: jobs.utoronto.ca/job/Toronto-...

We’re hiring: Research Group Leader in computational biology. Are you generating more research ideas than you can explore? Lead cutting-edge AI & biology research at EMBL-EBI. Apply by 11 April 2026: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ScienceCareers @ewaldlab.org @embl.org

In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...

AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

Now with a bioinformatics/genomics label 🖥️🧬

In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...

Join @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...

SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the @simonsfoundation.org. Details to follow. Please RT.

We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—

New Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/... Redesigned Angular interface ReacFoam & entity-level visualizations Multi-omics analysis tools React-to-Me chatbot FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized 🖥️🧬

True

It's always exciting when the latest edition of JASPAR comes out. Great leadership by @amathelier.bsky.social and pleased to welcome @anshulkundaje.bsky.social to the journey. #Jaspar2026 academic.oup.com/nar/advance-...

Fifteen Years xkcd.com/3172/

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)

Great collaboration with @gingraslab.bsky.social & congrats to lead author Vesal. Paper: www.nature.com/articles/s41... Thanks to @sinaihealth.bsky.social

new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0q

Good morning to all the puppies not observing the time change

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15. www.mskcc.org/research/ski...

The most important paper in evolutionary biology I'd never heard of: 1/ www.sciencedirect.com/science/arti...

Finalized my 2025 book tour! Coming through New York, DC, Chicago, Toronto, San Francisco, Los Angeles, London, Oxford and Cambridge. Click here for details: timwu.net#booktour

I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...

Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget. “Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me. www.nature.com/articles/d41...

www.biorxiv.org/content/10.1... Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.

This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...

Hi @npr.org! We worked late tonight putting together this handy pocket guide! It doesn't address road design issues, but if we're going to educate road users, we should include drivers. It's the size of a folded business card. Print it, fold it, put it in your wallet!

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails. Not an easy job under the best of circumstances and right now it's the pits. Thank you!

YouTube link for MLCB2025 is up! Starting in 30 min. www.youtube.com/live/19I7xTh...

2025 Machine Learning in Computational Biology (#MLCB) meeting starts TODAY (9/10) at 9:30a (EST) at the NY Genome Center in NYC! We have a great lineup of keynotes, contributed talks, and posters today and tomorrow Schedule: mlcb.org/schedule Join for free via livestream: m.youtube.com/@mlcbconf

FYI, if your code is written in MATLAB, your 2025 manuscript will not be read by me

If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXB

RNA is far more than a messenger. Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot. But predicting #RNA structure from sequence is still extremely difficult. In our recently published paper in @narjournal.bsky.social we present a way forward. 🧵 ⤵️

Thrilled to see my postdoctoral work published in @cellpress.bsky.social OncoGAN generates simulated genomes to train genomic analysis tools —without the confidentiality risks of real genomes. News story: t.co/J9QJZInPOE Paper: t.co/ygEjM5vuGZ #Genomics #Cancer #AI #Bioinformatics

Interested in #RNA research in the Asia-Pacific region? Join us at the first Asia RNA Club Symposium 2025! 🗓️ Nov 3-5, 2025 📍Seoul National University, Seoul, 🇰🇷 Submit your abstract by Aug 22nd Register by Oct 10th More info: asiarnaclub.org #AsiaRNA2025 #RNASky @rnasociety.bsky.social 🔄🙏🏽

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Meet Jernej Ule (@ulelab.bsky.social) and Ben Blencowe, who set up the Brain RNA Regulatory Networks satellite lab here at the Crick. We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy. www.crick.ac.uk/news/2025-07...

An excellent systematic analysis of RBPs by @quaidmorris.bsky.social and colleagues (with a tiny contribution from us) #RNAsky #RNAbiology

New in @natbiotech.nature.com: a team led by scientists at MSK and ‪University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.

Please welcome @nickymcgranahan.bsky.social to Bluesky! I'm excited that he is here