Happy to share that I just started a W2 professorship at the University of Bremen! Yay tenure! While I already start teaching now, the lab will stay in Freiburg until May while we get things ready. Super excited about this new chapter! We’re also hiring! Please get in touch if you’re interested!

🧠🧪 #Neurons can communicate via a hidden network of #nanotubes. Chang et al. (2025) show dendritic nanotubes as #actin-based conduits transferring Ca²⁺ + cargo, rising before plaque deposition in 🐁 #cortex. This overlooked pathway may expand views of neuronal communication beyond #synapses.

🚨 New paper in Nature Methods: HippoMaps: multiscale cartography of the human hippocampus Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG) Led by @jordandekraker.bsky.social docs: hippomaps.readthedocs.io paper: doi.org/10.1038/s415...

Our paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...

Many thanks to @sophiekb.bsky.social, @silviaviansilva.bsky.social and Maike Busson-Spielberger for organizing and @mbartos.bsky.social for enabling such a great meeting. This was a lot of fun and inspiring to meet all these power women.

Happy to share our new paper with Mathilde Nordlund and Julie Koenig out @currentbiology.bsky.social. We used virtual reality in mice to study hippocampal distance coding. Our results suggest a primary contribution of grid cells to distance over cue-dependent place cell coding. shorturl.at/63yFo

Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.

Voltage Imaging of CA1 Pyramidal Cells and SST+ Interneurons Reveals Stability and Plasticity Mechanisms of Spatial Firing https://www.biorxiv.org/content/10.1101/2025.08.20.671230v1

The main project from my PhD, in collaboration with Manuela Allegra and @schlab.bsky.social is now available as a preprint! We wondered how the hippocampus and the visual cortex may differ in the way they refine sensory inputs into internal representations

Congratulations Jake et al! Looks very interesting.

When neurons change, but behavior doesn’t: Excitability changes driving representational drift New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...

Really beautiful hippocampal connectomics from @zhihaozheng.bsky.social et al. Such high quality data shows many interesting circuit wiring surprises - an incredible resource to digest! Great also to see the parallels with our physiology work on neuronal heterogeneity www.biorxiv.org/content/10.1...

Our study is out in Nature! Using wireless Neuropixels we recorded hippocampal activity in freely flying bats and uncovered replay and theta(less) sweeps, revealing striking differences from classic rodent models. 👉 www.nature.com/articles/s41...

Your brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...

My latest Aronov lab paper is now published @Nature! When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️ The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar bit.ly/3HvWSum

It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵 www.nature.com/articles/s41...

Almost all Nobel Prizes are awarded for work that is exploratory, or absolutely basic science with no obvious commercial or medical benefit. You cannot predict where advancements come from, so you have to invest in science and scientists. Targeted (corporate) science investment will never do this.

I'm pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, out in @cp-cellreports.bsky.social ! With Demi Brizee & David Dupret, we track how oscillations and spiking behaviour map onto hippocampal layers using an LFP-based embedding. (1/13)

Oh wow. Starting grant 0-10 years post PhD from 2027, Consolidator 5-15

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week. www.nature.com/articles/s42...

A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab www.sciencedirect.com/science/arti...

Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social

Mice discriminate odour source distance via sub-sniff temporal features of odour plumes https://www.biorxiv.org/content/10.1101/2025.05.14.653752v1

🚨new paper alert Blind mice use stereo olfaction, comparing smells between nostrils, to maintain a stable sense of direction. Blocking this ability disrupts their internal compass. Kudos to @kasumbisa.bsky.social! Another cool chapter of the Trenholm-Peyrache collab😉 www.nature.com/articles/s41...

Enjoying the IN-Code retreat organized by @mbartos.bsky.social in beautiful Potsdam. Great talks about the impact of interneurons on the neural code. @uni-freiburg.de @biologyunifreiburg.bsky.social @uniklinik-fr.bsky.social #neuroscience #interneurons

Freiburg, Germany, Central Station Bookshop (right @the center of the shop‘s entryway): “This is a selection of books which are banned at schools in the US“. #UniteAgainstBookBans #FreedomToRead @ala-pla.bsky.social @librarypolicy.bsky.social

5th Summer School Advanced Tools for Data Analysis in Neuroscience, Sept 11th to Septh 20th, 2025 Analyse data and meet colleagues from european countries. No fees , and accomodation/lunches offered to all students Spread the word and/or register at shorturl.at/3xbiZ

Exciting collaboration including the first set of in vivo whole-cell data from the lab. Thanks a lot to @scimemia.bsky.social and the entire team. Feedback very welcome!

If you do multi-plane 2p imaging, you may see the same cells across planes. We built Suite3D exactly for this purpose! It removes duplicates, corrects axial movement, finds more cells with less noise, much faster than alternatives. github.com/alihaydarogl... Try on your data, and reach out!

All-optical electrophysiology reveals behavior-dependent dynamics of excitation and inhibition in the hippocampus https://www.biorxiv.org/content/10.1101/2025.03.20.644347v1

Why do adult-born DGCs in NHPs and Humans exhibit protracted maturation or neoteny. Perhaps to compensate for decline in neurogenesis? How? Because immature neurons exhibit distinct physiological properties and Inhibitory connectivity compared to that of mature neurons?

Exciting new paper from David Dupret's lab, showing that hippocampal CA1 ripples can be categorized in 2 types, either driven by CA3 or entorhinal inputs, & are associated with different replay content. The categorization only requires pyramidal layer recording. www.biorxiv.org/content/10.1...

A hippocampal population code for rapid generalization https://www.biorxiv.org/content/10.1101/2025.03.15.643456v1

Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’ by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer. www.biorxiv.org/content/10.1...

Visit our Symposium: ‚Dendritic inhibition - it’s role in network dynamics, memory & behavior, at Göttingen Meetings of the German Neuroscience Society, March 29, 2025, Hall 10. www.nwg-goettingen.de/2025/default... Talks by Johannes Letzkus, Matthew Larkum, Panayiota Poirazi, Marlene Bartos.

Congratulations 👏

New preprint about SWRs, this time in HUMANS! 🤩 With @anna-maslarova.bsky.social and @JiyunShin, from @NYU, we’ve (i) developed a pipeline to analyze SWRs in intracranial EEG, and (ii) created ripmap, an open-source toolbox that allows versatile inspection and curation of events 🧵

🚨 New lab paper!🚨 A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇 www.nature.com/articles/s41...

New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social

Slow life as a scientist

Want to hear more about hippocampus-to-cortex feedback circuit? Our paper with the Basu lab is out in Nat Neuro! rdcu.be/eak1k . Well done Tanvi Butola!

delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab www.nature.com/articles/s41...

Perfect periodicity in grid cells would make decoding locations degenerate in large spaces. Slight distortions in grid patterns, as observed in vivo, solve this problem, enabling precise spatial navigation. Final version of the manuscript is now available 👇 elifesciences.org/reviewed-pre...

Are you interested in drifting place cells and the paradox of stable spatial maps? We have uploaded a new preprint: We find coordinated drifting in CA1. Very happy about this collaboration w/ @olechsylte.bsky.social, Marlene Bartos and @jf-sauer.bsky.social 👇👇👇

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X https://go.nature.com/42tH8Ai

Exciting 🥳

Excited to share our Preprint led by talented PDFs, Yu-Tzu Shih PhD and Jason Alipio PhD describing our identification of Experience-dependent PV IN plasticity as a convergent mechanism for Neurodevelopmental Disorders (NDDs) 1/n www.researchsquare.com/article/rs-5...

🚨Highly recommended job opportunity.