Y’all. They used dental floss on mice.... for vaccine delivery!!! Not kidding. This is the type of research that keeps me so excited about science and innovation and why we should not be defunding science. www.science.org/content/arti...

A great night Wednesday - our first Hub for Dementia in East London (HuDEL) get together. From basic science to psycho-social intervention research our team @qmul.bsky.social cover it all. Hopefully get the whole team together next time too. @qmulpsychiatry.bsky.social @qmul-wiph.bsky.social

Exciting Senior Scientist 👩‍🔬 👨‍🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025. Please Share @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social Full details here my.corehr.com/pls/uccrecru...

Today, Professor Donal Wall, @uofglasgow.bsky.social attended a pitch session as part of the Science, Innovation and Technology Committee's 'Under the Microscope' inquiry to explain why they should be interested in microbiomes.

Absolutely incredible turnout for Budapest Pride! So proud of all the organizers, including some old friends, who estimate hundreds of thousands— major embarrassment to Orban

It's #WorldMicrobiomeDay! 🦠 We are proud to be a part of this exciting research area through contributions by our amazing authors. To celebrate this occasion, here are some of our favourite microbiome papers. Do you have a favourite of yours? let us know in the replies. #MicroSky #MicrobiomeSky

This new review by Anne L McCartney and Lesley Hoyles examines the often overlooked role of Klebsiella bioactives in host-microbiota dynamics. 🔗 Access the full article here: doi.org/10.1530/MAH-24-0011

Nature awards and Yakult have announced another round of 'Global Grants for Gut Health'. An excellent opportunity for gut microbiota researchers, at any career stage, to win $100,000 for a year to cover their interesting research! #MicrobiomeSky #MicroSky www.nature.com/immersive/gu...

Great to see this review out on dietary glucuronides with @drsimonmcarthur.bsky.social, and our lovely colleagues in chemistry at the University of Liverpool. Often thought of as inert chemicals, these glucuronides have wide-ranging biological activity. #microbiomesky

Very happy to see this published, with @bugsinyourguts.bsky.social and our colleagues at the University of Liverpool Looking at the biological roles of what are often dismissed as waste - glucuronide conjugates of dietary and gut microbe-derived phenolic compounds pubs.rsc.org/en/content/a...

JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...

Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF

Very pleased to see this review out on host interactions of bioactive molecules produced by Klebsiella spp. #MicroSky

“Behind every statistic is a real child, and a real family doing their best to heal wounds that others inflicted”, writes Lib Dem MP @tomgordonld.bsky.social 🗣️ Adoption breakdown in the UK is a silent crisis demanding urgent reform www.politics.co.uk/mp-comment/2...

This has made @drsimonmcarthur.bsky.social and I laugh this morning (but in a good - and very middle class - way). #gutbrainaxis #IShopAtWaitroseBecause

Bravo, Society for Behavioral Neuroendocrinology! Thank you to the members who crafted this important statement. @drglitterbear.bsky.social sbn.org/news/news/wh...

From big data and experimental models to clinical trials: Iterative strategies in microbiome research: Cell www.cell.com/cell/fulltex...

So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳 Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI www.nature.com/articles/s41...

Tally heading towards 1500. Please keep going - share and sign.

One week left to get your applications in for this exciting PhD studentship fully-funded for students eligible for UK fees. Deadline: 31st January 2025 www.findaphd.com/phds/project...

Every week, I see a new study talking about this or that effect of GLP-1 receptor agonists like #ozempic. FINALLY, we have a study evaluating all the outcomes (good and bad) in one dataset. There are some... surprises. 🧵

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. Thread below: (1/11)

A fascinating 2023/24 study of publishing timelines over 140,000 academics in STEMM showing discipline & country-specific attrition of academic careers from the publication of first paper. The probability of continuing after 19y just 38-43%. Interactive maps at: public.tableau.com/app/profile/... 🧪

Nice review highlighting the associations between neuropsychiatric conditions and #cerebrovascular deficits doi.org/10.1111/eci.... #BloodBrainBarrier #Psychiatry

Dr Cara Croft @caracroft.bsky.social & Dr Sarah Morgan @qmul.ac.uk are seeking a PhD Student to use high-resolution spatial transcriptomics to understand selective vulnerability to LBD pathology in Parkinson’s. Closing date: 31 Jan #PhDposition www.dementiaresearcher.nihr.ac.uk/job/phd-high...

New study on the pathogenic role of hypoxia in #BloodBrainBarrier disruption, with implications for vascular dementia #cerebrovascular academic.oup.com/braincomms/a...

Only a few days remaining to apply for a #PhD with me at the #EPSRC funded QMUL #CDT. The project involves working on the host-microbe interactions in the human mouth using novel #3D #organotypics / #organchip models #metabolomics Deadline is Monday, January 6th, 9am.

🚨Deadline is 6th Jan to apply for a PhD with me and @drsimonmcarthur.bsky.social, at the EPSRC funded QMUL CDT. Come and work on the host-microbe interactions in the human mouth with us at the @qmul-coirm.bsky.social group based in the Blizard Institute! #PhD #3D #organotypics #metabolomics

The researchers also found that a class of ‘inhibitor’ type drugs – which can block chemical reactions in the body – showed promising results in being able to prevent this damage from occurring. Find out more: www.tandfonline.com/doi/full/10....

P-cresol sulfate is a molecule produced by the gut microbiome and has been seen to accumulate in the blood of patients with CKD. The study found that the toxin triggers a process which damages the critically protective blood–brain barrier, increasing the risks of strokes and other issues.

New research by @drsimonmcarthur.bsky.social and colleagues at Nottingham Trent University has found that a toxin found in the blood of patients with chronic kidney disease (#CKD) damages the body’s protective blood–brain barrier, likely contributing to the risk of #stroke.

Bit of commentary on fantastic exciting area using antibodies in Dentistry. Prof Takahashi group in Japan leading the way. Will follow this research closely. Immunotechnology in Dentistry coming of age. One day maybe even collaborate? www.france24.com/en/live-news...

Immunologists, time to embrace your inner neuroscientist 🧠🧪 Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology www.nature.com/articles/s41...

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)

Monoclonal antibodies in #Alzheimers clear amyloid plaques and increase Aβ42. High Aβ42 levels improve cognition. Removing amyloid comes with risks: brain edema ('ARIA') and faster brain atrophy. The trade-off is not worth it. A nice summary @psypost.bsky.social www.psypost.org/neuroscienti...

#microbiomesky - please pass on to any potential PhD students interested in a (fully funded) project studying host-microbe interactions in the mouth

🎓 PhD Opportunity with me! 🚀 📢 Calling for aspiring bioengineers to join us! Develop organotypic models to explore host-microbe dynamics due to metabolic signals. Work with tissue systems, biofilms, imaging, and mass spectrometry. 💡Get in touch, and apply here: www.cpm.qmul.ac.uk/cdt/applicat...

Welcome to the European Microglia Webinar Series! Here you will find the information and link to every webinar, so dont forget to follow us

Over 7M people in the UK are estimated to live with #CKD. Researchers at #COIRM found a #gut #microbiome toxin in #CKD patients, p-cresol sulfate, damages the blood-brain barrier risking stroke & cognitive decline, but promising drugs may block this. More here: www.tandfonline.com/doi/full/10....

Nice write-up of our work from NTU's press office. @drsimonmcarthur.bsky.social @dvauzour.bsky.social

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)

@astephen.bsky.social - seen this?

📢Utmost importance the #food we eat & the #GutMicrobiota we have‼️ 👉#Gut #physiology & #environment explain variations in human gut #microbiome🦠 composition & #metabolism🆕🔥 @naturemicrobiol.bsky.social 🔍Zoom in to uncover the insights within 👉https://www.nature.com/articles/s41564-024-01856-x

New translational study from @bugsinyourguts.bsky.social and @drsimonmcarthur.bsky.social (at QMUL) showing how a microbiome-associated metabolite implicated in chronic kidney disease affects the blood–brain barrier. #microbiomesky

Brand new paper from our group! www.tandfonline.com/doi/full/10.... with @bugsinyourguts.bsky.social, looking at the role of the #gutbrainaxis and the #bloodbrainbarrier in #chronickidneydisease, and how we could protect it. Only started the work in 2016 - I blame (hand waves) everything... 1/5

Huge thank you to David Vauzour at UEA for quantifying pCS in patient samples, and colleagues from The William Harvey Research Institute for providing us with patient samples. Systems-level microbiome research only works when it's collaborative.

🧵 on our (@drsimonmcarthur.bsky.social) work showing the mechanism through which the microbiome-associated metabolite p-cresol sulfate damages the blood-brain barrier in chronic kidney disease (CKD). #microbiomesky #gutbrainaxis

Delighted to see this out, after a 2-year-long review process that left @drsimonmcarthur.bsky.social and I wondering what we'd done to upset the reviewing gods. #microbiomesky #gutbrainaxis www.tandfonline.com/doi/full/10....