Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...

Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

We've got two exciting chromatin talks coming up on Wednesday next week: @epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social! register and join us: us06web.zoom.us/webinar/regi...

🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️ www.biorxiv.org/content/10.1... Structural model is already available in the PDB (9MLC).

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

The Vlaming lab continues to grow! It's an exciting time in the Vlaming lab: we've just had our 2nd PhD student join, and the 3rd is joining in February. Now, we're looking to recruit a postdoc!

International Genome Dynamics course in Institut Curie-Paris (April 8-15), experimental and computational methods in multiomics,with a #TE centered session. Free registration, until Jan 15th Don’t miss it! 👉https://training.institut-curie.org/courses/Genome-Dynamics-2026 @institutcurie.bsky.social

RESEARCH PAPER: The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons By Bergfort et al., and Karla Neugebauer ➡️ https://genesdev.cshlp.org/content/40/1-2/94.full Karla Neugebauer Alexandra Bergfort Yale Center for RNA Science and Medicine #splicing

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Happy New Year!🎉 We hope everyone has enjoyed the holidays! If you have an exciting chromatin/transcription story, or if you know someone with one, please fill out the form or get in contact with us! 😉 forms.gle/TBi38UgYxPAB...

Mahtab Dastpak, @camimoso.bsky.social, @adelmanlab.bsky.social and colleagues report that a SF3B1 mutation in human embryonic stem cells alters splicing and dysregulates immune-related gene expression, providing new insights into the role of SF3B1 in haematologic malignancies.

We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components! apply.interfolio.com/177120

Undergraduates who are interested in summer research please consider the HHMI Cech Fellows Program. There are many great HHMI labs to choose from including ours!

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg! Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ

"TOMORROW @yaleneuro.bsky.social @kavliatyale.bsky.social Yale present #SYNAPSES, our senior postdoc symposium! 🙌 Hear from four incredible researchers 👩‍🔬🥼 as they share their latest discoveries and insights! 🗣️ You won't want to miss it! 🗓️"

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳

Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...

Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵: www.cell.com/cell-genomic...

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word! academicjobsonline.org/ajo/jobs/30607

Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus! Deadline is October 1st danish-rna-society.nemtilmeld.dk/8/

As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday). If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...

Thrilled to be one of the ERC StG awardees this year! It will allow my team to further delve into the puzzle of what regulates the fate of RNA Polymerase II during early elongation: will it terminate early, or elongate happily ever after?

JUST IN: Harvard won summary judgment against the Trump administration with the court finding that the admin violated Harvard's 1st amend. rights. The court has vacated the funding freeze orders and termination letters and issued a permanent injunction. storage.courtlistener.com/recap/gov.us...

Gift link.

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...

shocking to read over and over the stories of close colleagues who can't run their lab anymore. I know Karen well and it's heartbreaking. Also #PIinthelab! www.washingtonpost.com/education/20...

NIH: After review, we note that you have a large unspent balance on your grant. Please explain immediately. me: well, uh, yeah, one reason we're not spending on that grant is because NIH terminated it in May along with all the rest of federal funding to Harvard, maybe you don't remember

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat... My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.

🧑‍🔬I am thrilled to share I am starting my lab as an asst. prof. in the Dept. of Molecular and Cellular Biosciences at the University of Cincinnati. 🔬We will be hiring soon, so if you're interested in Mechanisms of Transcription Termination, watch this space 👀 🥳 www.clarehall.cam.ac.uk/news/dr-juan...

📢 Save the Date! The 13th Yale RNA Center Annual Retreat returns this fall: 🗓️ November 7, 2025 Join us for a full day of cutting-edge RNA science and community. Stay tuned for details on speakers, sessions, and registration.

Final call for postdoc positions in Aarhus, Denmark. Sorting of gene expression and beyond. Please get in touch for further information or apply using this link: mbg.au.dk/en/news-and-...

There's just a few more days for RNA Society members to get your artistic entries in!! 🎨 🧁 Don't miss the chance at some nice cash prizes, sponsored by GenScript 🤩🤩🤩

Happy to have contributed to work by the Hildebrant lab @bostonchildrens.bsky.social $ @harvardmed.bsky.social on de novo variants in the splicing factor PRPF8 found in CAKUT (congenital abnormalities of the kidney and urinary tract) patients www.biorxiv.org/content/10.1...

Happy to share this paper! We uncovered that good 5' splice sites protect against ZC3H4/Restrictor's promiscuous role, and that its role is to suppress elongation and indirectly cause termination. Looking forward to learning more about this protein in the future!

We are seeking speakers for the upcoming academic year! Contact us if you are interested! @cambiochem.bsky.social #CambridgeRNAClub #RNAClub @rnasociety.bsky.social

Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!

NEW ISSUE ALERT!!! Check out the new Outlook, Review and Research Papers online now at Genes & Development. Click on the link for more: ➡️ genesdev.cshlp.org/content/curr...

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in. mcgill.wd3.myworkdayjobs.com/en-US/McGill...

This is an excellent article on the termination of all federal funding at Harvard. This visualization shows all of the terminated programs that were supposed to train the next generation of scientists. www.nytimes.com/interactive/...

Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall? Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬

FN is taking a summer vacation 🏖️, but we'll be back in September with more exciting talks on chromatin and transcription! If you've got a new story you'd like to share with the FN audience this fall, fill out the form here: docs.google.com/forms/d/e/1F...

Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series! In case you haven't joined any of the previous 2025 sessions, here is registration link: us06web.zoom.us/webinar/regi...