In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1 - Challenges for SARM1 therapeutic inhibition - SARM1 in non-neuronal cells - SARM1 activation for selective peripheral neuroablation. www.cell.com/trends/pharm...

💉👀 Ozempic. What does the eye have to do with it? Let’s take a look at the latest evidence published in @jamanetworkopen.com Thank you to @aunz.theconversation.com for inviting me to write this piece. Was a pleasure to write with @petetheteapot.bsky.social from @ki.se

Dr Pete Williams @petetheteapot.bsky.social @ki.se will be our next webinar speaker! 'From bench to bedside and back again: Targeting NAD for neuroprotection in #glaucoma' Aug 11, 2025 10-11am ET Host: Dr Diane Bovenkamp @dianebovenkamp.bsky.social @brightfocus.bsky.social Register: bit.ly/4o6WrqY

Doing science today feels like playing a video game on legendary difficulty. With shrinking budgets, extreme publication fees, subjective rejections, and daily lab chaos, the path of a scientist is tougher than ever. At least we have Parafilm to hold it all together. Stay strong, scientists.

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy

'we define how mitochondrial gene expression is spatially organized at sub-organellar scales into regulatory hubs that are subject to stress-induced remodeling. We propose that this remodeling into mitochondrial stress bodies may serve to aid in recovery of mitochondrial proteome quality control'

“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”

Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution www.nature.com/articles/s41...

Remember to pick up your EyeVenture pins today. Collect 7 different ones during #ARVO2025, bring them to @arvoinfo.bsky.social Central by May 8 and you could win free registration to #ARVO2026 in Denver, Colo.! Check our website for today's collection locations. bit.ly/2GErnw4

The authors of a Comment article in Nature write that hopes are high that AI can accelerate scientific discovery but warn that the rush to adopt AI has consequences. “Establishing clear scientific guidelines on how to use these tools and techniques is urgent.” 🧪

Meta used at least 16 of my books, and numerous articles, to help train the AI it will use to make billions. Authors, search your name here: www.theatlantic.com/technology/a...

New publication out with Katharina C Bell, Vicki Chrysostomou, Markus Karlsson, myself, Pete A Williams @petetheteapot.bsky.social , and Jonathan G Crowston Excitatory and Inhibitory Neurotransmitter Alterations With Advancing Age and Injury in the Mouse Retina bryanwjones.com/2025/03/exci...

"What they have done is, frankly, destroy trust and good will within the university." @leightonandrews.bsky.social www.bbc.co.uk/news/article...

Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness academic.oup.com/brain/articl...

My favorite thing about journal editors in the upper echelons of impact is that they deem my manuscripts of not being of sufficient quality or impact for their journal, but within the same week they are very happy to have me as a reviewer to judge said quality...

What a fun review to write with @petetheteapot.bsky.social on metabolic dysfunction in glaucoma! It’s out today in Glaucoma Today 😆 enjoy the read at the link below🧪 #glaucoma glaucomatoday.com/articles/202...

Another success for gene therapy! From The Lancet: Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study www.thelancet.com/journals/lan... #ophthalmology #genetherapy @

Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA www.nature.com/articles/d41...

Nice opinion piece by @adamsobel.bsky.social about destruction of U.S. science. thebulletin.org/2025/02/how-...

Hate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally: absolutelymaybe.plos.org/2025/02/14/w... #medlibs

Hello Vision Science Peeps! Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025 iserbrightfocusglaucoma.org

The Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US

Super cool new review by @caromenard666.bsky.social’s team on neuro-glio-vascular alterations #cerebrovascular

** Phillips then said: “So no youth mobility scheme?” The home secretary said: “That’s not the right starting point for us at all because what we need to do is to bring net migration down.” ** Good times ahead for British science and academia /s www.huffingtonpost.co.uk/entry/yvette...

Celebrating this fantastic work lead by Kristýna Kárová (with some EvaLab contribution!), its new home in Molecular Therapy. Spinal cord axon regeneration with improvements in paw reaching, grip strength, and ladder walking using a gene therapy approach. Delta is the way! tinyurl.com/55en9z6d

For many of the early modern thinkers who laid the foundations of modern science, the world teemed with the uncanny: witches, unicorns, mermaids, metals that could be distilled into elixirs of eternal life. 🧪

For new followers! A pack on professional journal editors in the life sciences. go.bsky.app/Lj5TDXn

Our global study on the state of trust in scientists is now out in Nature Human Behaviour! 🥳 With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5

“One thing that struck me is the visibility of people with smaller followings and early-career researchers,” say @jbakcoleman.bsky.social. That is particularly true in the feeds Bluesky lets users build themselves and that can include all posts related to a certain research field'

Features of Adulthood xkcd.com/3034

Do you work with human donor eye tissues to study glaucoma? Or, rely on histology of human tissues to understand molecular underpinnings of ocular diseases? Check out our latest paper actaneurocomms.biomedcentral.com/articles/10....

Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice www.science.org/doi/10.1126/... Cool #mitochondria and #aging paper in @science.org

🍵🧪 Teabags Release Nanoplastics Researchers found teabags release billions of micro- & nanoplastics during preparation. These particles were absorbed by human intestinal cells in lab tests, raising concerns about health effects 🔗 www.sciencedirect.com/science/arti... #Plastics #Health #SciComm 🧪

The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals: https://www.jci.org/articles/view/185054 Taylor Peach and Mattia Quattrocelli comment on Ancel et al. (https://www.jci.org/articles/view/163648)

It’s out! Third (and last) article for the Conversation this year! This time about sunglasses 😎 eye protection is important year round, but definitely more so during summer 🌺 Thanks for reaching out @aunz.theconversation.com 😎🌞🧪

Writing for @nejm.org, our colleagues and co-creators of the world's first #AI foundation model in #ophthalmology, assess progress in the field. Mark Chia, Yukun Zhou, @pearsekeane.bsky.social of @ucleye.bsky.social and Moorfields Eye Hospital @moorfieldsbrc.bsky.social ai.nejm.org/doi/full/10....

The mitochondrial NAD+ pool buffers the overall decline in cellular NAD+. Fascinating! Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+ www.nature.com/articles/s42...

Aanandita Kothurkar, @colinchulab.bsky.social, Ryan MacDonald and colleagues @ucleye.bsky.social apply IBEX to simultaneously identify all the major retinal cell types. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

HHMI says the round hopes to “broaden institutional representation by encouraging applications from scientists in geographic regions where HHMI is not currently supporting scientists” we talked to economists, researchers & ppl who have researched funding inequities👇 www.statnews.com/2024/12/13/h...

🌟 ICYMI: Altmetric now tracks Bluesky mentions! ✔️ Comprehensive social media coverage 📊 Mentions reflected in your Altmetric score 🌐 Stay ahead in tracking research discussions Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl... #AcademicSky

Honest conversation Interesting piece in @natureportfolio.bsky.social re: management vs. bench work for the scientist building their career. www.nature.com/articles/d41...

Assad Returns To Ophthalmology At Moscow LensCrafters.

Are you living with an eye disease or vision loss- or supporting someone who is? Your experiences and insights can shape the future of eye research. CERA is looking for consumer advisors. Click the link below to learn more and apply. www.cera.org.au/consumer-pro...

Updated, with over 90 global health organizations go.bsky.app/Df5hsLV

This week in Science Without Anguish: Loneliness and the long distance researcher. Overcoming isolation for science and wellbeing. www.sciencewithoutanguish.com/blog/overcom... This is the last post in Series 2. Stay tuned for webinar announcements, plans for a coaching programme and Series 3.

🧨 Systematic reviews are in peril ! AI will be soon (if not already) massively be used to generate tons of fake and/or replicated papers; this wave will becomes a tsunami 🌊 ... There really is a need for falsification/copy control in science now! 🧪🌐🌍🦤 www.science.org/content/arti...

Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!

You made it @richardevalab.bsky.social! Let the neuro-regenerative biology roll 🍾

Promoting a positive research culture is so important to support each other - and to ultimately enable great science! @colemanlab.bsky.social has put together an array of scientists who are striving for this in many different ways ⤵️ #research #culture 🧪

Who is driving the bus in your research career: you, your emotions or other people? www.sciencewithoutanguish.com/blog/who-is-...