Douglas Kell
@dbkell.bsky.social
📤 1719
📥 1912
📝 139
Research Scientist who prefers facts to lies. Focus on Long COVID. Free book:
http://osf.io/pnxcs/
.
If folk are interested, I am giving a @BiochemSoc talk on our work with
@resiapretorius.bsky.social
on Fibrinaloid Microclot Complexes in Long Covid and ME/CFS on June 17 at 2pm. Registration needed but free
register.gotowebinar.com/register/226...
#TeamClots
#pwLC
#pwME
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https://register.gotowebinar.com/register/2264822884875568991
18 days ago
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A SECOND review with
@resiapretorius.bsky.social
also published today Kell, D. B. and Pretorius, E. (2026) Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging. J Biophotonics. 19, e70270.
doi.org/10.1002/jbio...
#TeamClots
@livuni-ismib.bsky.social
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Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging
We review the techniques of thermal imaging for assessing the functional consequences of lowered blood flow in the microcirculation that accompanies many chronic, inflammatory diseases. A comparison ...
https://doi.org/10.1002/jbio.70270
25 days ago
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New review with
@resiapretorius.bsky.social
Kell, D. B., Zhao, H. and Pretorius, E. (2026) Fibrinaloid Microclots-Induced Microcirculation Dysfunction: Mechanism and Laser-Based Haemodynamic Validation. Cardiovasc Sci. 3, 10005.
doi.org/10.70322/cvs...
#TeamClots
@livuni-ismib.bsky.social
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Fibrinaloid Microclots-Induced Microcirculation Dysfunction: Mechanism and Laser-Based Haemodynamic Validation
The microcirculation typically refers to those capillaries less than 100 μm in diameter. We have shown that blood can clot into an anomalous amyloid form, manifesting as microclots of typically 2–200 ...
https://doi.org/10.70322/cvs.2026.10005
25 days ago
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New review: Kell, D. B. and Roberts, I. (2026) How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution. Chem Soc Rev, in press.
doi.org/10.1039/d5cs...
@livuni-ismib.bsky.social
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How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution
The number of possible variants representing the landscape of a protein sequence of length N residues, made of the standard unmodified proteinogenic amino acids, is 20N; its exhaustive experimental an...
https://doi.org/10.1039/d5cs01387a
25 days ago
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reposted by
Douglas Kell
Institute of Systems, Molecular and Integrative Biology
25 days ago
From dirt to discovery! In our latest blog, Dr Rachel Floyd and Dr Amy Wedley discuss how research-connected teaching can build the skills, confidence and scientific curiosity the next generation of bioscientists need. 🔗
bit.ly/43avzwV
#TeamLivUni
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reposted by
Douglas Kell
Elly Brosius, MS
3 months ago
I love that the paper mentions PPAR agonists! Maybe we'll hear more at Roundtable with
@dbkell.bsky.social
&
@resiapretorius.bsky.social
(+ Dr. Vaughn + Dr. Schofield) + some very awesome panelists. Fri MAR 13 1 pm EDT US by
@renegaderesearch.bsky.social
us06web.zoom.us/webinar/regi...
add a skeleton here at some point
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reposted by
Douglas Kell
Renegade Research
3 months ago
What great presentations and illustrative slides. What a valuable discussion! Thank you to panelists
@resiapretorius.bsky.social
@dbkell.bsky.social
Jordan Vaughn and Jill Schofield. We'll post recording link soon. We were about to wrap at 2 hr 50 min when webinar accidentally ended. Sorry.
add a skeleton here at some point
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reposted by
Douglas Kell
🤜❤️🔥🤛 Challenger 🧪 Sourcecontrol.bsky.social. 🦋
3 months ago
March 13 at 1 pm ET (US) for a Research Roundtable with
@resiapretorius.bsky.social
of
@livunipress.bsky.social
@dbkell.bsky.social
@jfvaughnmd09 discussing: Hypercoagulability, Clotting and Microclotting, and Blood Issues in ME/CFS and Long Covid 👇
youtu.be/FygtEROEqXE?...
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Research & Clinician's roundtable on Hypercoagulability, and Blood Issues in MECFS and Long Covid
YouTube video by Renegade Research
https://youtu.be/FygtEROEqXE?si=ftP3_Hm3wzgAn7fX
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reposted by
Douglas Kell
Renegade Research
3 months ago
What great presentations, illustrative slides, and a valuable discussion! Thanks to our panelists
@resiapretorius.bsky.social
@dbkell.bsky.social
and Drs. Jordan Vaughn and Jill Schofield Thanks to our audience for your questions! The link to the YouTube recording is in the final post on this 🧵⬇️
add a skeleton here at some point
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mastodon.social/@We_Own_It/1...
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We Own It (@
[email protected]
)
BlackRock, one of the world’s largest asset managers, already owns 65 NHS GP surgeries. Now it wants to expand its UK empire by buying more NHS property, in a new venture with Greater Manchester Pen...
https://mastodon.social/@We_Own_It/116330100596397212
2 months ago
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reposted by
Douglas Kell
Tania J. Spencer
4 months ago
10/ This comprehensive study of treatment outcomes in 3,925 patients with
#ME/CFS
&
#LongCOVID
, examined over 150 supplements,
#OTC
medications, prescription medications -
www.pnas.org/doi/10.1073/...
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2426874122
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reposted by
Douglas Kell
Tania J. Spencer
4 months ago
8/ "In the early era of HIV, we tried single-drug therapies, but nothing worked. Two drugs, that didn’t really work. Three drugs – boom":
www.ucsf.edu/news/2026/01...
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Solving Long COVID: How Decades of HIV Research Paved the Way
Discover how UCSF is leading the charge in Long COVID research, uncovering key findings that advance our understanding of the condition. UCSF researchers have adapted innovative tools and methodologie...
https://www.ucsf.edu/news/2026/01/431346/solving-long-covid-how-decades-hiv-research-paved-way
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reposted by
Douglas Kell
Tania J. Spencer
4 months ago
7/ Pay attention to this - ⚠️ "...there's going to be a number of Trials done on single drug therapy and they will fail I can predict it now..."
#DrJacoLaubscher
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reposted by
Douglas Kell
Tania J. Spencer
4 months ago
4/ "How soon do most people notice benefits from proteolytic enzymes? The vast majority (3/4) reported benefits in under 2 weeks, and 42% noticed benefits within just 1 week":
open.substack.com/pub/pharmd/p...
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TREAT ME Survey: Individual Treatment Results
Proteolytic Enzymes (Nattokinase, Lumbrokinase, Serrapeptase)
https://open.substack.com/pub/pharmd/p/treat-me-survey-individual-treatment?r=auyzv&utm_medium=ios&shareImageVariant=overlay
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reposted by
Douglas Kell
Tania J. Spencer
4 months ago
1/ I rarely repost any advice on apparent silver bullets for
#LongCOVID
, because I don't want to raise false hope. However, I make any exception for the
#Microclot
hypothesis. Anecdotally, it appeared to significantly help my son & I -
@resiapretorius.bsky.social
@dbkell.bsky.social
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reposted by
Douglas Kell
Congresswoman Ayanna Pressley
4 months ago
There's no ICE accountability without ending qualified immunity. They're murdering people. There won't be justice for the lives they've stolen, but there must be accountability. My bill with
@markey.senate.gov
would ensure families can sue the agents murdering their loved ones.
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Douglas Kell
NBC News
4 months ago
BREAKING: Two Republican senators, Thom Tillis and Lisa Murkowski, call for DHS Secretary Kristi Noem to resign.
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Two Republican senators call for Kristi Noem to resign as DHS secretary
Sens. Lisa Murkowski and Thom Tillis are the first GOP members of Congress to call for Noem to step down as secretary of the Department of Homeland Security.
https://www.nbcnews.com/politics/congress/thom-tillis-lisa-murkowski-call-kristi-noem-resign-dhs-secretary-rcna256233
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reposted by
Douglas Kell
Caroline Lucas
4 months ago
Writing with
@rupertread.bsky.social
about just how devastating the Government- suppressed security report is, particularly its conclusions about our food insecurity. Ministers should be helping to build our resilience to these threats, not burying the report that contains them 👇
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It's ecological breakdown that should put us on a war-footing: official
Admissions of extreme, eco-caused national security threats foreground importance of climate adaptation to bring much needed urgency and agency.
https://www.resilience.org/stories/2026-01-27/its-ecological-breakdown-that-should-put-us-on-a-war-footing-official/
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reposted by
Douglas Kell
Jenoco 🇨🇦
4 months ago
Ongoing genocide by terrorist russia. 🤬
add a skeleton here at some point
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reposted by
Douglas Kell
Truthout
4 months ago
Amid growing calls for the abolition of ICE, Rep. Delia Ramirez is calling for the entire DHS to be dismantled. Highlighting how much experience the officers who killed Renee Good and Alex Pretti had, Ramirez said, “DHS was built to violate our rights and has been empowered to act with impunity.”
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House Democrat Says Abolishing ICE Isn’t Enough — DHS Must Go, Too
“The problem isn’t ‘training.’ DHS was built to violate our rights,” said Rep. Delia C. Ramirez.
https://truthout.org/articles/house-democrat-says-abolishing-ice-isnt-enough-dhs-must-go-too/
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reposted by
Douglas Kell
Tania J. Spencer
5 months ago
20/ Next, I tried the same regimen on my then 23-year old son. And within weeks he noticed an improvement in multiple, unexplained severe pains in internal organs, & an amelioration of some of his
#LongCOVID
symptoms. More resources here, courtesy of
@dbkell.bsky.social
-
dbkgroup.org/longcovid/
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Long COVID and the role of fibrin amyloid (fibrinaloid) microclots « Bioanalytical Sciences Group
https://dbkgroup.org/longcovid/
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reposted by
Douglas Kell
Tania J. Spencer
5 months ago
13/ I can't tell you how many times I have spelled this word for health providers who feign mild interest but somehow never get around to looking it up. "But what exactly is
#Nattokinase
, and why does it work?":
@resiapretorius.bsky.social
@dbkell.bsky.social
youtu.be/6q2WS4NuiBQ?...
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Can Nattokinase Help Break Down 'Microclots'? | With Prof Resia Pretorius & Prof Doug Kell
YouTube video by Gez Medinger
https://youtu.be/6q2WS4NuiBQ?si=RaQ0AgRhwswg4OEt
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reposted by
Douglas Kell
5 months ago
Massimo Nunes, Loren Kell, Anouk Slaghekke, Rob CI Wüst, Burtram C. Fielding, Douglas B. Kell & Etheresia Pretorius
@resiapretorius.bsky.social
@dbkell.bsky.social
et al.
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reposted by
Douglas Kell
We Own It
5 months ago
🚨Thames Water is on the brink of collapse. 🙋We asked its customers what should happen next. 54% think the water regulator Ofwat should put it into special administration. And over two thirds (68%) believe that Thames Water should be run in the public sector. Read the full results here.
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New polling: majority of Thames Water customers want Ofwat to reject creditors’ proposal for the utility
New polling has revealed that 54% of Thames Water customers think Ofwat should reject a deal proposed by Thames Water's creditors, and put it into special administration.
https://weownit.org.uk/news/new-polling-majority-of-thames-water-customers-want-ofwat-to-reject-creditors-proposal-for-the-utility/
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reposted by
Douglas Kell
Tania J. Spencer
7 months ago
1/ Those of us who developed unexplained bruising, among other vascular symptoms during the early years of
#LongCOVID
, are not at all surprised by this -
@resiapretorius.bsky.social
@dbkell.bsky.social
add a skeleton here at some point
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reposted by
Douglas Kell
TRAstonDrs
6 months ago
@dbkell.bsky.social
et al
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
link.springer.com/article/10.1...
www.sciencedirect.com/science/chap...
www.sciencedirect.com/science/arti...
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Long COVID: pathophysiological factors and abnormalities of coagulation
Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten cases: known as Long COVID. The disease affects ~65 million ind…
https://www.sciencedirect.com/science/article/pii/S1043276023000553?userQuery=SARS-CoV-2%20Spike%20Protein%20Amyloid%20Fibrils%20Impair%20Fibrin%20Formation%20and%20Fibrinolysis%20in%20longcovid&optQuery=How%20do%20SARS-CoV-2%20spike%20protein%20amyloid%20fibrils%20affect%20fibrin%20formation%20and%20fibrinolysis%20in%20long%20COVID%3F§ion=Abnormalities%20of%20coagulation%20in%20Long%20COVID&_origin=sd_ai_core&_zone=rslt_list_item
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reposted by
Douglas Kell
Treaty of Westphalia
7 months ago
Veronica's poem will resonate with pts trapped in their ME cage, yearning to escape pain & to live a little.
@fatigatioev.bsky.social
@broadwaybabyto.bsky.social
@erinraeburn.bsky.social
@annabookwriter.bsky.social
@bettinagrande.bsky.social
@dbkell.bsky.social
@jefflubellc19.bsky.social
add a skeleton here at some point
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reposted by
Douglas Kell
Sarah Murphy
7 months ago
If *anyone* still thinks this grifting, piss-taking, moneyed spiv and his grifting, piss-taking, moneyed spiv mates are in this for them, then they need to be sent this. Every day. Farage is literally laughing his way to the bank and betraying this country as he goes.
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reposted by
Douglas Kell
Led By Donkeys
7 months ago
Farage: epic grifter
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Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging. Preprint with @resiapretorius
www.preprints.org/manuscript/2...
#preprints
via @Preprints_org
#TeamClots
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https://www.preprints.org/manuscript/202510.1377/v1
8 months ago
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reposted by
Douglas Kell
We Own It
8 months ago
🚨Urgent: Thames Water want permission from Ofwat to ILLEGALLY pollute rivers and seas until 2040. 🤮They want your bills to fill their pockets with gold, while they fill your rivers with sewage. ✍️Sign now. Tell Ofwat to say NO to Thames Water before Tuesday 21st October.
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Thames Water want to pollute illegally until 2040. Ofwat must say NO.
Thames water want to make at deal with Ofwat, to pollute illegally for 15 years
https://weownit.org.uk/act-now/petition-ofwat-must-say-no-to-thames-water-creditors
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#tinnitus
is a frequent symptom for
#pwLC
,
#pwME
and others.
@resiapretorius.bsky.social
and I think the evidence is strong (and self-consistent) that it is often caused by
#microclots
and summarise it at
www.preprints.org/manuscript/2...
#TeamClots
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https://www.preprints.org/manuscript/202508.1557/v1
10 months ago
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May be of interest to
#pwLC
and
#pwME
www.youtube.com/watch?v=H-NX...
#TeamClots
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"Get rid of the microclots" | Will 2 Win: Overcoming Long COVID with Jillian Angeline
YouTube video by Jillian Angeline
https://www.youtube.com/watch?v=H-NXwKOPqyE
10 months ago
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reposted by
Douglas Kell
TRAstonDrs
10 months ago
#Medsky🧪
#IDsky
#Immunosky
#publichealth
Recent research has shown that human plasmacytoid dendritic cells (pDCs) have been altered by
#SARSCoV2
🦠This could have implications for both viral persistence and the development of
#LongCOVID
, with the Omicron subvariants having a more prominent effect.
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New preprint with
@resiapretorius.bsky.social
showing the amyloidogenic potential of the proteome of thrombi in various embolisms and atherosclerotic plaques.
#TeamClots
www.preprints.org/manuscript/2...
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https://www.preprints.org/manuscript/202508.1049/v1
10 months ago
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My chum reminds me: "The England India cricket series was a day longer than Liz Truss's premiership in duration (46 days from start to finish). Far more enjoyable, exciting, happy and socially more cohesive." Too right.
10 months ago
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reposted by
Douglas Kell
Tania J. Spencer
11 months ago
1/ Many of us who developed
#LongCOVID
in the first wave in 2020, noticed an abrupt change in our nails -
@resiapretorius.bsky.social
Via
@dbkell.bsky.social
www.preprints.org/manuscript/2...
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https://www.preprints.org/manuscript/202505.2356/v1
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reposted by
Douglas Kell
TRAstonDrs
10 months ago
Recap A Perspective on How Fibrinaloid Microclots and Platelet Pathology May be Applied in Clinical Investigations
@dbkell.bsky.social
et al
www.thieme-connect.com/products/ejo...
@davidjoffe64.bsky.social
et al
pmc.ncbi.nlm.nih.gov/articles/PMC...
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Pleased to see our paper on
#preeclampsia
and cell
#senescence
and seeming prevention by
#ergothioneine
is now published, with
@resiapretorius.bsky.social
@louiseckenny.bsky.social
@lorenkell.bsky.social
@themoorelab.bsky.social
and others
doi.org/10.1016/j.jr...
. Hope we can get RCTs done now.
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Redirecting
https://doi.org/10.1016/j.jri.2025.104621
10 months ago
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New preprint on the antibacterial mode of action of colistin
www.biorxiv.org/content/10.1...
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Rapid accumulation of fluorophores and fast kill identify drugs with bactericidal effects against Gram-negative bacteria
Antimicrobial resistance is a massive threat, but it can take decades to develop a new antibiotic. That time could be drastically reduced if we were able to anticipate desirable properties of a chemic...
https://www.biorxiv.org/content/10.1101/2025.07.10.664096v1
11 months ago
0
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New bioinformatics preprint w
bsky.app/profile/resi...
and others on the amyloid nature of the thrombus (clot) proteome in ischaemic stroke
www.biorxiv.org/content/10.1...
#TeamClots
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AmyloGram Reveals Amyloidogenic Potential in Stroke Thrombus Proteomes
Background: Amyloidogenic proteins play a central role in a range of pathological conditions, yet their presence in thrombi has only recently been recognized. Whether computational prediction tools ca...
https://www.biorxiv.org/content/10.1101/2025.07.07.663482v1
11 months ago
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www.biorxiv.org/content/10.1...
New preprint on proteins involved in colistin sensitivity/resistance
#AMR
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Membrane proteins ClcB, PtsI and YcaM mediate the bactericidal effects of colistin in Escherichia coli
Bacteria can be killed very effectively by targeting their first line of protection. The cell membranes (outer and inner membranes) of Gram-negative bacteria are directly targeted by antibiotics, such as polymyxins, via electrostatic interactions with their lipopolysaccharide (LPS) fraction. The downstream effects - preceding the cell death - of the disruptions of the bacterial membranes upon the intercalation of these antibiotics are unknown. By screening a set of E. coli membrane protein knockouts, three membrane transporters were shown to mediate the growth-inhibitory effects of colistin. This was corroborated with growth assays on gain-of-function strains, cytotoxic assays and in vivo infections in an invertebrate animal model. This is first-time evidence that the disruption caused to membrane proteins, such as the chloride channel ClcB, the sugar transport system component PtsI and the hypothetical Glutamate:GABA antiporter YcaM, is part of the cytotoxic pathway that follows or is concomitant to the electrostatic intercalations of polymyxins with the Gram-negative bacteria membrane. ### Competing Interest Statement The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1101/2025.07.07.662571v1
11 months ago
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A new review with
@resiapretorius.bsky.social
on two more imaging methods for measuring effects of
#fibrinaloid
#microclots
on the
#microcirculation
and endothelial damage.
#TeamClots
#pwLC
#pwME
preprints.org/manuscript/2...
. Much pricier than
#nailfold
#capillaroscopy
but impactful.
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https://preprints.org/manuscript/202506.2239/v1
12 months ago
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johncrace right on the button when analysing these ghastly people who destroyed the UK
www.theguardian.com/books/2025/j...
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‘I could hear the Camerons sniggering at us’ – Sarah Vine’s How Not to Be a Political Wife, digested by John Crace
Michael Gove’s ex on her compassionate pieces for the Daily Mail, struggling to survive on an MP’s salary, doing Sam Cam’s ironing and becoming a laughing stock after Brexit
https://www.theguardian.com/books/2025/jun/13/sarah-vine-how-not-to-be-a-political-wife-digested-read-john-crace
12 months ago
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reposted by
Douglas Kell
sibylle dahrendorf
about 1 year ago
@resiapretorius.bsky.social
@dbkell.bsky.social
@ruhoy.bsky.social
@kaufmanmd.bsky.social
@putrinolab.bsky.social
@virusesimmunity.bsky.social
Documentary "Chronically Ignored", 92 min, now via online stream, just 14 days. Unfortunately with payment, but I'd be grateful for watching & sharing ♥️
add a skeleton here at some point
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reposted by
Douglas Kell
Firstname Lastname #FuckTrump
about 1 year ago
@dbkell.bsky.social
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More idiotic incompetence...
www.notus.org/health-scien...
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The MAHA Report Cites Studies That Don’t Exist
The Trump administration’s “Make America Healthy Again” report misinterprets some studies and cites others that don’t exist, according to the listed authors.
https://www.notus.org/health-science/make-america-healthy-again-report-citation-errors
about 1 year ago
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Another new preprint with
@resiapretorius.bsky.social
is available, on a technique called
#Nailfold
#Capillaroscopy
that we think will be an important complement to
#microclot
measurements.
preprints.org/manuscript/2...
#TeamClots
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https://preprints.org/manuscript/202505.2356/v1
about 1 year ago
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reposted by
Douglas Kell
Dr David Joffe MB BS(Hons), PhD, FRACP
about 1 year ago
🧠 Daily Feed of Brain Damage 🧠 Part 2 Sincerest thanks to
@resiapretorius.bsky.social
and
@dbkell.bsky.social
www.ahajournals.org/doi/10.1161/...
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Amyloid Presence in Acute Ischemic Stroke Thrombi: Observational Evidence for Fibrinolytic Resistance | Stroke
https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.050033
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reposted by
Douglas Kell
Renegade Research
about 1 year ago
ME/CFS Incidence Is Higher Following COVID-19 "Other studies have shown that many acute viral, bacterial, and protozoal illnesses can be followed by ME/CFS — including COVID-19. This study highlights the clinical similarity between
#MECFS
and
#longCOVID
— the two..."
www.jwatch.org/na58371/2025...
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