Dr David Joffe MB BS(Hons), PhD, FRACP
@davidjoffe64.bsky.social
📤 12403
📥 516
📝 4276
Respiratory and Sleep Medicine Neurobiology and Long Cövid WHN Long Covid Working Group Vice Chair
🧠 Daily Feed of Brain Damage 🧠
doi.org/10.1186/s128...
about 8 hours ago
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Mood 😂😂😂
1 day ago
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@joho.bsky.social
You were saying? Podcast Jay... Now gun-for-hire doing the RWNJ circuit. Worst possible appointment for such a crucial role
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1 day ago
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🧠 Daily Feed of Brain Damage 🧠
doi.org/10.1093/cerc...
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Widespread structural and functional brain alterations in COVID-19: a systematic review of MRI studies
Abstract. The coronavirus disease 2019 (COVID-19) pandemic has not only challenged global public health but also generated interest in its neurological bas
https://doi.org/10.1093/cercor/bhag022
1 day ago
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🧠 Daily Feed of Brain Damage 🧠
www.cureus.com/articles/436...
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Baseline Clinician Attitudes and Practices Regarding Long-Term Neurological Follow-Up for COVID-19 Patients: Early Pandemic Insights With Contemporary Relevance
Objectives: This study aimed to investigate clinician opinions and practices regarding long-term neurological follow-up for COVID-19 patients during the early pandemic period (June-August 2020), befor...
https://www.cureus.com/articles/436614-baseline-clinician-attitudes-and-practices-regarding-long-term-neurological-follow-up-for-covid-19-patients-early-pandemic-insights-with-contemporary-relevance#!/
3 days ago
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🚨 Paging Dr
@njbbari3.bsky.social
🚨 Dear Noor, The receipts are failing due 👇🏻👇🏻
3 days ago
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Get you sleep, Peeps
www.pnas.org/cgi/doi/10.1...
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/cgi/doi/10.1073/pnas.1721694115
3 days ago
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Hmmmmm.... I'm guessing LC isn't psychosomatic after all... Well colour me shocked🔥
www.nature.com/articles/s41...
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Protein microarray-based profiling of salivary IgA antibodies against human proteins in COVID-19 patients with depressive symptoms - Scientific Reports
To understand the pathophysiology and etiology of COVID-19 patients with depressive symptoms, we investigated the presence of autoantibodies associated with neurological sequelae using salivary IgA an...
https://www.nature.com/articles/s41598-026-45180-2
4 days ago
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Some things are best avoided... Innate immunity is your first line of defence
doi.org/10.1016/j.cl...
4 days ago
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😊 🙏🏻
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4 days ago
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🙏🏻🙏🏻 The
#Leonardi_Effect
is not helpful in world full of pathogens.
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4 days ago
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🧠 Daily Feed of Brain Damage 🧠
link.springer.com/article/10.1...
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Integrating inflammation-oriented brain injury mechanisms in acute COVID-19 using multi-modality MRI and serum proteomics: a longitudinal study - European Journal of Medical Research
Background Neurological sequelae have been frequently reported among COVID-19 patients, which are still lacking of definite therapeutic targets. Previous studies linked structural and functional brain...
https://link.springer.com/article/10.1186/s40001-026-04032-5
4 days ago
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My mood hasn't improved... But the meme quality has lifted 😂😂 Australian's have a unique sense of humour
5 days ago
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Pregnancy and COVID are Bad JuJu
www.sciencedirect.com/science/arti...
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Bacterial superinfection in pregnant women with severe COVID-19: Prevalence, resistance patterns and outcomes
Pregnant women with severe COVID-19 are at high risk for intensive care unit (ICU) admission and adverse maternal outcomes. Evidence on the burden and…
https://www.sciencedirect.com/science/article/pii/S1876034126000560?via%3Dihub
5 days ago
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academic.oup.com/braincomms/a...
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Association of structural brain changes with cognitive deficits and fatigue in patients with post COVID-19 condition
Schwichtenberg et al. report that patients with post COVID-19 condition show cognitive deficits across multiple domains, fatigue, and reduced quality of li
https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcag099/8527078?login=false
5 days ago
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Warning.... This one publication bias
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5 days ago
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🧠 Daily Feed of Brain Damage 🧠
www.sciencedirect.com/science/arti...
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Executive functioning after COVID-19: Associations between self-report, informant-report, objective cognition, and psychological factors. A prospective cohort study
COVID-19 has been associated with cognitive sequelae, particularly in executive functions (EFs). However, the relationship between subjective executiv…
https://www.sciencedirect.com/science/article/pii/S0022399926001005?via%3Dihub
5 days ago
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🧠 Daily Feed of Brain Damage 🧠
academic.oup.com/braincomms/a...
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Association of structural brain changes with cognitive deficits and fatigue in patients with post COVID-19 condition
Schwichtenberg et al. report that patients with post COVID-19 condition show cognitive deficits across multiple domains, fatigue, and reduced quality of li
https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcag099/8527078?login=false
6 days ago
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Current Mood
6 days ago
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Remind me why Cövid is considered safe for Kids?? 🤬🤬
link.springer.com/article/10.1...
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Neutrophil-to-lymphocyte ratio as a correlative factor of severe SARS-CoV−2 infection in neonates: associations with lymphocyte subsets alterations - BMC Infectious Diseases
Background The SARS-CoV-2 remains prevalent, and neonates remain susceptible. This study aims to explore the potential of the Neutrophil-to-Lymphocyte Ratio (NLR) as a valuable tool for assessing the ...
https://link.springer.com/article/10.1186/s12879-026-12713-z
7 days ago
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Well, Esther, Here's a reality check meme... Our world in an image 🎯🙏🏻
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7 days ago
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Because the GBD Arsehats couldn't understand the terms "NOVEL" and "Airborne" Because making money out of petrochemicals and confining people to offices was their urgency The people who start wars never turn up... Their kids don't go either
doi.org/10.3201/eid3...
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Functional Limitations and Illness-Related Absenteeism among School-Aged Children with and without Long COVID, United States, 2022–2023
Limitations among Children with Long COVID
https://doi.org/10.3201/eid3114.251035
7 days ago
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Better late than never
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7 days ago
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🧠 Daily Feed of Brain Damage 🧠
www.frontiersin.org/journals/hum...
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Frontiers | Factors associated with severe neurological sequelae of COVID-19: findings from the multicenter COVID-BRAIN imaging cohort
IntroductionNeurological post-acute sequelae of COVID-19 (neuroPASC) are associated with persistent cognitive dysfunction and quality-of-life decline. We aim...
https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2026.1754342/full
8 days ago
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THIS 🔥🔥🔥 👇🏻👇🏻👇🏻👇🏻
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8 days ago
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Thank you,
@jonathanconp.bsky.social
Hope people find it helpful 🤞🏻🤞🏻
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9 days ago
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No organ it cannot bigger. Your skin is your largest organ
doi.org/10.1136/bmj....
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How does covid-19 affect the skin?
Unexpected chilblains, unusual rashes, and flareups of existing conditions— Katharine Lang asks experts how the skin can react to covid infection “Covid toes”—swollen and itchy red or purple toes, or...
https://doi.org/10.1136/bmj.s264
10 days ago
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North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder
academic.oup.com/sleepadvance...
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Validate User
https://academic.oup.com/sleepadvances/article/7/1/zpag007/8429593
10 days ago
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With thanks to Prof. Raina McIntyre. Shared via email. All Australians with kids should read this carefully... Perhaps Kelly CMO would like to see his handiwork?
doi.org/10.1016/j.va...
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Redirecting
https://doi.org/10.1016/j.vaccine.2026.128442
10 days ago
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WFH is not an option for me. But my hybrid is good value and my e-bike has been serviced 👍🏻
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10 days ago
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🧠 Daily Feed of Brain Damage 🧠
www.mdpi.com/2571-6980/7/...
11 days ago
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🧠 Daily Feed of Brain Damage 🧠 Part 2
doi.org/10.1002/nbm....
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Spatial Coefficient of Variation (sCOV) From ASL MRI Reveals Global Cerebrovascular Dysfunction in Long COVID
Arterial spin labeling (ASL) MRI was used to assess global and regional cerebral perfusion in individuals with long COVID with persistent neurological symptoms from an Argentine cohort. Long COVID pa....
https://doi.org/10.1002/nbm.70264
12 days ago
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🧠 Daily Feed of Brain Damage 🧠
doi.org/10.1111/ene....
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Neurocardiac Autonomic Dysfunction in Patients With Post‐COVID‐19 Condition: A Systematic Review and Meta‐Analysis
Our systematic review and meta-analysis of 11 studies, involving a total of 1162 participants, revealed that post-COVID patients exhibited lower heart rate variability compared to the control group. ...
https://doi.org/10.1111/ene.70561
12 days ago
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Everything in a single meme
12 days ago
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🧠 Daily Feed of Brain Damage 🧠
doi.org/10.1080/0022...
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Unveiling the Intricacies of Implicit Motor Learning in Adults Recovered from COVID-19
COVID-19 is primarily a respiratory illness, but it has been linked to persistent neurocognitive deficits. Given the prefrontal cortex’s role in cognitive-motor processing and implicit motor learni...
https://doi.org/10.1080/00222895.2026.2637940
13 days ago
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🧠 Daily Feed of Brain Damage 🧠
www.tandfonline.com/doi/full/10....
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Unveiling the Intricacies of Implicit Motor Learning in Adults Recovered from COVID-19
COVID-19 is primarily a respiratory illness, but it has been linked to persistent neurocognitive deficits. Given the prefrontal cortex’s role in cognitive-motor processing and implicit motor learni...
https://www.tandfonline.com/doi/full/10.1080/00222895.2026.2637940?mi=4bgu58
14 days ago
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Sleep and circadian health in the UK Biobank: Report on the 2023 sleep questionnaire enhancement url:
academic.oup.com/sleep/articl...
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Sleep and circadian health in the UK Biobank: Report on the 2023 sleep questionnaire enhancement
AbstractStudy Objectives. Our study introduced the 2023 UK Biobank sleep questionnaire and described variation in sleep health dimensions and prevalence of
https://academic.oup.com/sleep/article/doi/10.1093/sleep/zsag068/8510814
14 days ago
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www.hhs.gov/longcovid/in...
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https://www.hhs.gov/longcovid/index.html
14 days ago
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Thanks, Mark My slide collection thanks you too😊
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14 days ago
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🧠 Daily Feed of Brain Damage 🧠
@atranscendedman.bsky.social
🙏🏻
link.springer.com/article/10.1...
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Receptor-mediated mechanisms underlying neurological complications in COVID-19: from viral entry to neuroinflammation - 3 Biotech
Neurological complications of COVID-19 encompass acute syndromes and persistent post-acute sequelae, yet their mechanistic basis remains incompletely defined. Integrated clinical, neuropathological, n...
https://link.springer.com/article/10.1007/s13205-026-04749-4
14 days ago
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I was waiting for you to knock on the door, My Friend 😂😂😂
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15 days ago
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Hmmmm.... I wonder if the: 🧠 Daily Feed of Brain Damage 🧠 Applies here: CMAJ 2026 March 9;198:E313-25. doi: 10.1503/cmaj.251065
15 days ago
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🧠 Daily Feed of Brain Damage 🧠
@atranscendedman.bsky.social
🙏🏻
doi.org/10.1093/brai...
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Validate User
https://doi.org/10.1093/braincomms/fcag045
15 days ago
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🧠 Daily Feed of Brain Damage 🧠
@atranscendedman.bsky.social
🙏🏻
www.nature.com/articles/s41...
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Intra and inter-network functional connectivity among long-Covid patients with ongoing disease duration - Scientific Reports
Long-Covid can cause neurological and cognitive dysfunctions. The impact of disease duration on these neurobiological changes remains underexplored. This study aims to investigate how long-Covid disea...
https://www.nature.com/articles/s41598-026-42000-5
17 days ago
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Reasons those with Long Covid should have a PSG. Could Positive Airway Pressure (PAP) Enhance Brain Waste Clearance and Modify Neurodegenerative Risk? A Perspective on Sleep-Dependent CSF–Lymphatic Pathways url:
academic.oup.com/sleep/articl...
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Could Positive Airway Pressure (PAP) Enhance Brain Waste Clearance and Modify Neurodegenerative Risk? A Perspective on Sleep-Dependent CSF–Lymphatic Pathways
Abstract. Obstructive sleep apnea (OSA) is linked to cognitive decline and is increasingly implicated in neurodegenerative trajectories. Continuous positiv
https://academic.oup.com/sleep/article/doi/10.1093/sleep/zsag065/8507967
17 days ago
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The
#Leonardi_Effect
are strong. Up your nose and away it goes. It would seem the depletion of NK Cells contributes to Long Cövid 🙏🏻
www.frontiersin.org/journals/imm...
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Frontiers | Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19
IntroductionLong-term COVID-19 syndrome (LTCS) or “long COVID” is a debilitating post-viral condition affecting approximately 2%–8% of individuals after SARS...
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1720551/full
18 days ago
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🤬🤬
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19 days ago
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Perhaps this explains the US's lacklustre performance at the military level.... The Hesgeth Factor is likely a huge confounder 🤬🤬
www.amjmedsci.org/article/S000...
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Prevalence and Symptoms of Post-COVID-19 Syndrome in Active-Duty Military Personnel
Post-acute COVID-19 is a syndrome characterized by the persistence of clinical symptoms beyond 4 weeks from the onset of acute symptoms. Over 250,000 Department of Defense service members have recover...
https://www.amjmedsci.org/article/S0002-9629(26)00103-5/fulltext
20 days ago
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Thank You, Jonathan.... It's was a lot of fun to chat 😊😊🙏🏻
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20 days ago
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From the other place.... Priceless 😂😂
20 days ago
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