Really enjoyed Project Hail Mary except the two tubes SIDE BY SIDE in the centrifuge instead of opposite each other 😵😵‍💫

Today in @nature.com we introduce INSTALL, which bypasses mammalian DNA immune sensing to enable non-viral DNA integration with recombinases—a step toward safe, and mutation-agnostic genome editing. 🧬 🧵 (1/13) www.nature.com/articles/s41... @harvardmed.bsky.social @mgbresearch.bsky.social

CRUK goes green [OA] news.cancerresearchuk.org/2026/04/01/w...

Thank you @senguptalab.bsky.social.

Sh*t happens. Despite your best efforts and intentions. Super stressful for all involved. But a masterclass from @scottishwaddell.bsky.social and Gaby Maimon in how to deal with this with scientific integrity and mutual respect. They'll work out the neuronal mechanisms at some point.

Thank you @ribeirocarlitos.bsky.social

Immense respect for handling this situation with this level of integrity. Mistakes happen. Science is a process.

The New York Times rolling up its sleeves to do the hard work of normalizing the idea that women should not have the right to vote.

A measured story about our new pet, the digital sphinx, in @thetransmitter.bsky.social. www.thetransmitter.org/systems-neur...

The Greens have now overtaken both the Conservatives and Labour, according to the latest polling average

This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.

🥄🥄🥄🥄🥄🕵️‍♂️🕵️‍♂️🕵️‍♂️🕵️‍♂️🕵️‍♂️

🌤️  Good morning Edinburgh. Today’s headlines: Uni probes Mathieson 'harassment', MP @drscottarthurmp.bsky.social says students' Sheriffhall 'throughabout' idea 'blew me away' + the mystery of disappearing teaspoons in offices ⏰ Edinburgh’s ad-free local news: www.edinburghminute.com/the-edinburg...

Based on traffic levels 10% higher than today’s: 💷 Cost • Scot Gov option: £155 million • Students: 74% cheaper 🚗 Congestion • Scot Gov 32% reduction in delays • Students: 48% reduction 💡 Scot Gov (cost per 1% delay reduction) • Scottish Government: £4.8 million • Students: £1.2 million 3/3

They’ve been re‑designing Sheriffhall Roundabout using a layout known as a “throughabout” (See pic of one in South Gloucestershire). They didn’t just sketch ideas… they fully modelled the junction and compared their design with the £155 million option currently being considered by the Scot Gov. 2/3

A better Sheriffhall Roundabout. Today, I had the absolute pleasure of catching up with some of my former Civil Engineering students at Heriot-Watt University, and what they’ve achieved genuinely blew me away. 1/3 @edinreporter.bsky.social @edinburghminute.com

The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."

I nearly died when @tspiresjones.bsky.social and @janetulloch.bsky.social surprised us with this complete *YEAR LONG* study at our lab meeting. academic.oup.com/braincomms/a...

Breaking new ground in this landmark, staggering work of discovery science, the Spires-Jones lab have today published this seminal work on one the greatest mysteries of their scientific careers: academic.oup.com/braincomms/a...

Many thanks to our collaborators @clairedurrant1.bsky.social, @sorayam.bsky.social, Davide Gobbo, and Colin Smith; special thanks to our funders @ukdri.ac.uk and Alzheimer Scotland for the brain and tissue bank. #EJN

New paper out this week with amazing synapse imaging! With the amazing @tspiresjones.bsky.social and our team we found that astrocyte processes protect synapses from amyloid beta-induced degeneration in an ex vivo slice model. onlinelibrary.wiley.com/share/GHTFFB...

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

Churches to lecture theatres! @Scotfly26 in Glasgow, Sir Charles Wilson Building

Great to be kicking off the 36th @camneuro.bsky.social Seminar with our first speaker @colemanlab.bsky.social #neuroslyence

Just hatched: the first egg-cellent paper from @carvalhosantosz.bsky.social lab! 🥚🪰 A beautiful ovaries-to-behavior axis: Stalled egg production = a drop in Dilp8. This releases the protein appetite brake, driving the fly to eat yeast to unblock the system. biorxiv.org/content/10.6...

🆕 New paper out with Jean-Luc Imler and Rune Hartmann in EMBO journal. We dissect mechanisms of antiviral immunity and how STING is activated by FADD and DREDD during viral infection in Drosophila melanogaster. link.springer.com/article/10.1...

A short video of a global heat map of real time pings to FlyBase website from one of our talented developers (not sped up) @flybase.bsky.social @iubiology.bsky.social

Can we predict health, Or when flies drop like fall leaves? Yes, chemotypes can! www.biorxiv.org/content/10.6... #Drosophila #AgingResearch #sciku @thescikuproject.bsky.social

A viral dog rescue from 2016 is now immortalized with a statue in Kazakhstan. When a dog fell into the Sayran reservoir, bystanders formed a human chain to pull him to safety. The statue is a reminder of the value of unity, solidarity and collective action. 14/10 for all

Explore “Brainstorming,” @thetransmitter.bsky.social’s new LinkedIn newsletter that looks at how neuroscientists are solving research challenges. The first edition features nontraditional model organisms that are well suited for studying certain behaviors or neurological conditions. bit.ly/4v6x506

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

This confirms all my prejudices, and I will not be critically evaluating its claims or evidence at this time.

PhD at the University of Edinburgh exploring small vessel disease using imaging, AI and metabolic profiling to understand brain cell dysfunction and test therapies. www.dementiaresearcher.nihr.ac.uk/job/phd-meta...

🚨 New preprint 11,000+ human brain microvessels in cSVD. Key findings: • Early, bimodal pericyte loss • Endothelial activation comes later • Venous-like microvascular shift • Capillary density ↑ 💡 Suggests a sequential vascular pathology, not parallel. 🔗 www.biorxiv.org/content/10.6...

50 years ago today, Star Wars began filming

🚨 We've hit a record 10,000 members! All over Scotland people are demanding bold change, and the Scottish Greens are he only party delivering it. With the election in May there's never been a better time to get involved and help us build a fairer, greener future. 👉 www.greens.scot/join

Sometimes failed experiments reveal gaps in how we are thinking about a problem, and digging into why an experiment didn't work can lead to discovery. This new preprint by Anne Sustar, in collaboration with Dion Dickman's lab, is one of those gratifying instances.🧵 www.biorxiv.org/content/10.6...

Here's the programme-by-programme dossier in which the @thenewworldmag.bsky.social reviewers tracked the breaches of broadcasting codes which Ofcom seems happy to ignore www.thenewworld.co.uk/the-gb-news-...

I despise when tech execs describe resistance to a new tech product or paradigm as "being scared" i.e. "I understand why musicians are scared but.." it's so condescending. being politically against something or exercising your right to opt out can come from many places other than "being scared"

Great work from Claire, Ravi, and the whole team– the initial lifelong continuous screen of behaving vertebrates provided a wealth of ideas on progression/staging of brain function across lifespan. Behavior is unmatched as a noninvasive quantitative readout of brain function (and, one that matters).

Happy to announce I've launched a new service for the fly community: flyRoom, a web-based comprehensive stock manager for all your fly pushing needs. Organise all your stocks, maps all your genotypes, plan your crosses, print and scan your labels. Give it a try and let your colleagues know!

One of the things I do to decompress - cross stitch. I’ve been making pieces that are related to my research. This is the first one I completed (a while ago) of a germarium of the #drosophila ovary.

Academic life used to mean suffering through 10 rounds of editing a grant. Now ChatGPT can do it in 10 seconds. Progress or problem? @dryvonnecouch.bsky.social explores www.dementiaresearcher.nihr.ac.uk/blog-chatgpt...

My first-author review ‘Determinants of individual navigation ability’ is out in Nature Reviews Psychology, co-authored with the inspiring @hugospiers.bsky.social!!!! 🎉🧠 ➡️ rdcu.be/e7KxG #Neuroscience #Navigation @nature.com @natrevpsychol.nature.com @sfn.org @fens.org @ucl.ac.uk

The number of cancer deaths worldwide has more than doubled since the 1980s. Does that mean we're losing the fight against cancer? Not necessarily, because it depends on how you measure it. On this chart, you can see three ways to look at the same data. 🧵

Here we go! Four days, 750 miles, one mission: a world free of MND. Doddie's Triple Crown has officially kicked off. Donate now: www.justgiving.com/campaign/tri...

I would like to vote for a party that said: "we keep being buffeted by forces outside our control. This is because we've allowed our capabilities to degrade. We're going to build them up again so some moron can't just bankrupt us with a stupid idea. It will take a while but here's the plan".

Love is in the air at Edinburgh zoo. Pebbling marks the start of the breeding season for Gentoo penguins. Kids at Edinburgh Children's Hospital Charity painted pebbles for the penguins to choose from and present to their mates.

Dear Shabana, Let's clear some things up around migration and remember we're talking about people's lives.