It was great opportunity to participate in the 2025 international long COVID pathogenesis workshop hosted by Yale University. There was highly engaged discourse in forward looking topics followed by a public session to communicate our ideas! @virusesimmunity.bsky.social @jtmatamalas.bsky.social

This morning our co-Director and global leader in the field of cardiovascular calcification, Dr. Elena Aikawa, enlightened #USHUPO2025 attendees at the new Biofluids, Secretomes, and Extracellular Vesicles session created by @toleafgirl.bsky.social .

Dr. Taku Kasai of @toleafgirl.bsky.social ‘s Proteomics group shares new in-source CID HCD fragmentation technologies for ADPr in human primary macrophages with fellow proteomics enthusiasts at @us-hupo.bsky.social #USHUPO2025

Thank you @us-hupo.bsky.social for a great day of amazing science! But wait — there’s more: CICS has three exciting sessions tomorrow! Mark your calendars and see you there! #USHUPO2025

Such an honor to be recognized by my peers!!!

Exciting seminar in the vascular biology seminar series by Craig Goergen from Purdue University about the use of high resolution imaging to understand etiologies of vascular disease!!!

Immunologists, time to embrace your inner neuroscientist 🧠🧪 Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology www.nature.com/articles/s41...

On this day in 1981, a landmark paper in NEJM described four patients with evidence of immunodeficiency associated with PJP pneumonia, disseminated CMV, and Kaposi sarcoma. The disease would come to be known as HIV/AIDS. Revisit the paper: nej.md/41iekKD #MedSky #IDSky

📅 Mark your calendar fo#BCVS2525, the global meeting dedicated to bridging cardiovascular discovery and practice. Network with top researchers and dive into the latest discoveries for the treatment and management of CVD. Don’t miss this career-essential event!

I'm excited to publish our State of the Art Review on #multiomics & #pharmacotherapy in #aorticstenosis #AS with Magnus Bäck, Thomas Lüscher, & Elena Aikawa in the European Heart Journal! academic.oup.com/eurheartj/ad...

Saw Wicked last night. Child Elphaba and adult Elphaba wear the same eyeglass frames, despite head growth over time. Did the frames magically grow with her or did she find a manufacturer that sells identical frames in child and adult sizes? Many people are asking this.

“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.” www.researchamerica.org/2023-oped-us...

The NIH is one of the glittering jewels of health research (I have many friends & colleagues who work there or who are grantees) This piece does a terrific job of exploring all the ways that RFK Jr & his colleague Jay Bhattacharya could destroy it (gift link) 😢 1/2 www.nytimes.com/2024/12/01/h...

How to recover biological signal removed from batch effect correction? See www.nature.com/articles/s41...

Viewpoint: To safely integrate #AI into healthcare, healthcare organizations (HCOs) and clinicians must proactively mitigate risks through pre-implementation quality checks, ongoing monitoring, and patient/clinician engagement. https://ja.ma/419xF0h

2024 Albert Lasker Basic Medical Research Award winner Zhijian Chen describes his discovery of cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS), a DNA-sensing enzyme that triggers inflammation. https://ja.ma/4ibukUD

NEW research shows: • SARS-CoV-2 spike protein accumulates and persists in the body for years after COVID infection, especially in the skull-meninges-brain axis. • Its presence may contribute to #LongCovid neurological issues. • The mRNA vaccines help but can’t stop it. www.cell.com/cell-host-mi...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

New paper from our lab @erturklab.bsky.social www.cell.com/cell-host-mi...

Call to action/study/investment. #endothelial #covid

Endothelial inflammation in COVID-19 | Science www.science.org/doi/10.1126/...

When the mask mandate was lifted from Mass General Brigham in May '23, hospital transmission of resp virus went up. When the mandate was re-instituted in Jan '24, infection rates went down. www.news-medical.net/news/2024052...

Not sure which side of the argument I am on but it’s an interesting topic !

Eight ways to show gratitude to lab mates at the end of year. #Nature "Alongside secret Santas and seasonal parties, many laboratories develop traditions to show appreciation to colleagues — from sweets and mulled wine to quizzes and ice-skating trips." Read more www.nature.com/articles/d41...

People with HIV will be able to receive kidney or liver transplants from donors who also have HIV, federal health officials announced Tuesday. The landmark move, which takes effect Wednesday, is expected to shorten wait times for organs for all patients.

High-resolution profiling reveals coupled transcriptional and translational regulation of transgenes www.biorxiv.org/content/10.1...

Happy to share our recent publication led by @jtmatamalas.bsky.social in @pnasnexus.bsky.social showing how obesity impacts susceptibility to COVID-19 infection upon comparable exposure. academic.oup.com/pnasnexus/ar...

www.nytimes.com/2024/11/26/u... Change at the NIH leadership with the new administration

DNA copy number variation is strongly buffered at the protein level. The buffering is much stronger than at the RNA level.

Our recent review on S1PR targeted therapeutic approaches in autoimmune pubmed.ncbi.nlm.nih.gov/35508810/

Such an incredible experience to have front row seats to hearing the legendary Eugene Braunwald presenting about the origins of the TIMI clinical trial group and hear about the game changing discoveries in recent trials from Marc Sabatine. Over 450,000 patients in 84 clinical trials!

Want to know more about special types of #astrocytes in #primates? Give a read to our latest review on interlaminar astrocytes and varicose-projection astrocytes, led by our postdoc Dr. Caterina Ciani 😍 Thanks to @humantechnopole.bsky.social funding for the support! 👇👇👇 shorturl.at/aiz0j

Scientists who study sex variables ("differences")- now more than ever you need to be extremely specific and careful when you discuss sex in your work and with the public. Our language can be weaponized against sex and gender minorities, and justify policy trying to restrict them from public space.

PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity www.cell.com/cell-reports...

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

I took biochem in 2001, and for nearly 20 years read amino acid sequences daily… and I never knew Dayhoff named them or even the logic behind things like Q until last Friday (h/t Mike Janech). Also, this is another big Dayhoff moment for me. She was incredible! #proteomics #bioinformatics

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity www.cell.com/cancer-cell/...

Bacterial single-cell RNA sequencing captures biofilm transcriptional heterogeneity and differential responses to immune pressure www.nature.com/articles/s41... BaSSSh-seq

Optimist: The cup is half full Pessimist: The cup is half empty Reviewer 2: Do one more single cell RNA seq experiment, validate it by qPCR, make sure your UMAP fits my expectations

'Our method provides subcellular half-life information of the relative contributions of each step of the mRNA life cycle to transcript steady-state levels. We provide evidence that nuclear retention of mRNAs is the rate-limiting step in the life cycle of protein-coding transcripts'

Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability www.nature.com/articles/s41...

MAT2a and AHCY Inhibition Disrupts Antioxidant Metabolism and Reduces Glioblastoma Cell Survival https://www.biorxiv.org/content/10.1101/2024.11.23.624981v1

Single CAR-Dual target: Intracranial Delivery of Anti-PD-L1 CAR T Cells Effectively Eradicates Glioma and Immunosuppressive Cells in the Tumor Microenvironment. https://www.biorxiv.org/content/10.1101/2024.11.22.624897v1

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening www.sciencedirect.com/science/arti... by @nefzgerlab.bsky.social

Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With #Alirocumab #Circulation #CardioSky #MedSky @ahascience.bsky.social @ahajournals.bsky.social @erinmichos.bsky.social @drmarthagulati.bsky.social www.ahajournals.org/doi/10.1161/...

I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:

"It takes time to find a good problem, and every week spent in choosing one can save months on years later on" My favourite advice

The origin story of Parafilm

Hello to everyone [email protected] 👋.Follow along for all things #kidney #diabetes & #cardiovascular 👩‍🔬🧪🥼....oh & a bit of wine, interiors & all things a little bit boujee 🥂🕯🏡. The other half of team @UoLRenal with @paulsquires.bsky.social #cardiosky #NephSky #Diabetes #cardiorenal #cardiovascular