Sex-resolved Plasma & Tissue Proteomics of 👤Calcified Aortic Valve Stenosis Tissue ♂️Fibrotic➡️Nucleotide & Cholesterol metab ♂️Calcified➡️Acute Inflamm, γ carboxyl ♀️Fibrotic➡️Platelet-Collagen Ad ♀️Calcified➡️Spectrin cytosk @markcblaser.bsky.social #ATVB 2025 www.ahajournals.org/doi/10.1161/...

I love this whole article so so much! Had no idea it's peak Canadian!

I'm delighted to have been appointed as a member of @ahajournals.bsky.social Circulation Research's Early Career Editorial Board for 2025-26! Thank you to @janefreedmanmd.bsky.social, @drkoupenova.bsky.social, & Gemma Bridges-Lyman for this selection. www.ahajournals.org/res/editoria...

Excited to have this work from Casey Clift & myself out in #ATVB! We leverage mass spectrometry proteomics of human plasma & aortic valve tissues to assess potential drivers of sexual dimorphism in #AS aortic valve stenosis. Mini-explainer thread below! www.ahajournals.org/eprint/MF7VI...

Member publication alert: Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis www.ahajournals.org/doi/10.1161/...

ISACB is searching for candidates to serve as new members of our Committees and Executive Council! We welcome applications from members at all career stages who wish to contribute to the growth of our society. Please apply now via: forms.gle/2E1eyPznNJXn...

Save-the-Date for #ISACB2026 in #Miami! We are excited to announce that the next Biennial @appliedcvb.bsky.social ISACB meeting will be held in beautiful #Miami from November 11-14, 2026. Be sure to save the date in your calendar! More details coming soon.

oh the irony...

You haven’t really written an academic paper until you’ve cut the paragraph you built the entire paper around.

Member publication alert: Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks www.ahajournals.org/doi/10.1161/...

How does EV–vascular cell communication drive dynamic changes in atherosclerotic plaques? www.ahajournals.org/doi/10.1161/...

Long-weekend vibes!

Join @ACHA_Heart and millions of patients with #CHD in asking Congress to fund the Congenital Heart Futures Reauthorization Act of 2024. This legislation is vital to fund CHD research👇 #ACHD #ACCACPC #cardiosky #medsky www.achaheart.org/get-involved...

I had a fantastic time at my first @us-hupo.org #USHUPO2025, sharing our work on multi-omics of aortic valve stenosis!

Cassandra Clift, postdoc in Elena Aikawa's lab, presents her poster full of exciting research on proteomics as it applies to cardiovascular biomaterials at #USHUPO2025

Dr. Taku Kasai of @toleafgirl.bsky.social ‘s Proteomics group shares new in-source CID HCD fragmentation technologies for ADPr in human primary macrophages with fellow proteomics enthusiasts at @us-hupo.bsky.social #USHUPO2025

We're so excited to share our science at #USHUPO2025! Tomorrow, @markcblaser.bsky.social and Taku Kasai will represent CICS at the Pre-clinical Proteomics and Lightning Talk 1/Poster session 1 events!

Blood forces are key drivers of cardiovascular disease, but mechanisms are difficult to study in humans. We're excited to share an ultrasound image velocimetry-based approach to enable non-invasive quantification of complex hemodynamics in small animal models: www.sciencedirect.com/science/arti...

not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities

Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks. Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible). 1/n

Like every MBTA commuter, I complain a lot. But the improvements made over the last two years in the subways under Phil Eng have been remarkable.

Early-career researchers describe to Nature Careers how they juggled workloads, emotions and finances after having children. #AcademicSky 🧪

Heads-up to all my Toronto peeps!

There are glaring sex disparities in the pathology & tx of aortic stenosis #AS. Here's a sneak peak at work led by Dr. Casey Clift & I, where we begin to unravel sexually-dimorphic molecular fingerprints associated with fibrocalcific disease progression: www.biorxiv.org/content/10.1...

Member publication alert: Calcific aortic stenosis: omics-based target discovery and therapy development academic.oup.com/eurheartj/ad...

Can someone create a company to generate protein specific recognizing aptamers and retire antibodies already.

this right here!

I'm excited to publish our State of the Art Review on #multiomics & #pharmacotherapy in #aorticstenosis #AS with Magnus Bäck, Thomas Lüscher, & Elena Aikawa in the European Heart Journal! academic.oup.com/eurheartj/ad...

What. The. Fuck.

What cell types drive congenital heart defects (CHD)? Some new answers in our latest preprint, where we explored: 1). Key cell types contributing to CHD genetics 2). Impact of noncoding variants on CHD risk https://www.medrxiv.org/content/10.1101/2024.11.20.24317557v1

Athero Researchers! Anyone make the move here yet? Let me know if you want to be added to this Athero Starter Pack! #AHA24 #ATVB #BCVS #CardioSky go.bsky.app/NwLNGxy

Pleased to share my editorial w/ Elena Aikawa in JAMA Cardiology, where we tackle disease drivers of #aorticstenosis #AS vs #CAD in the context of an elegant new GWAS of #AS -specific risk loci by Trenkwalder et al. Article: jamanetwork.com/journals/jam... Editorial: jamanetwork.com/journals/jam...

I was grateful to receive the 2024 Joseph Loscalzo Award from #Circulation for best basic/translational science paper of the year! Tune in to Circulation on the Run, where I chat abt our work on #EV multi-omics in #athero & #AS: circulation.libsyn.com/circulation-...

I'm honored to have contributed to this #ATVB #AHACentennialCollection article w/ Elena Aikawa, Sasha Singh, Robert Levine, & Sir Magdi Yacoub. We offer a perspective on future challenges & therapeutic opportunities in valvular heart disease! www.ahajournals.org/doi/10.1161/...

In an effort co-led by Casey Clift & myself, in collab w/ David Mooney & Robert Langer, we explore how #3Dbioengineered model systems recapitulate human disease. Using #proteomics & network analyses, we benchmark #3Dbioprinted valve #organoids against traditional 2D cell culture & native tissues.

I employed proteomics to identify unique drivers of human #atherosclerosis vs #aorticstenosis, isolated #extracellularvesicles from diseased human tissue, & integrated multi-omics to reveal that cardiovascular tissue #EV cargoes include potent modulators of smooth muscle/valve cell calcification.

In collaboration with Sneha Raju, Jason Fish, & Kathryn Howe, I contributed #extracellularvesicle #EV #proteomics expertise to very exciting work that dissects the basis of polarized EV cargo loading & directional secretion by the inflamed proatherogenic endothelium.

With Florian Schlotter, we generated spatiotemporal multi-omics maps of human #aorticstenosis to dissect layer-specific, side-specific, & disease stage-specific molecular interaction networks to identify novel drug targets & pathogenic disease drivers.

In Elena Aikawa’s lab, Dewy van der Valk & I worked with Robert Langer’s lab to measure layer-specific mechanical props of the human aortic valve, tune bioprinted hydrogels to mimic those biomechanics, then induce pathogenesis of valve cells in hydrogels that match disease-prone valves.

During my #biomedeng PhD in Craig Simmons’ lab at U. Toronto, I ID’d natriuretic peptide signaling as a novel regulator of embryonic aortic valve development & #aorticvalvestenosis, #aorticaneurysm, & #heartfailure in adults.

Hi Bluesky! In an effort to start to develop a profile & network over here, I’d like to share some of my past & present work in #aorticstenosis, #cardiovascularcalcification, #multiomics, #extracellularvesicles, #drugdiscovery, #cardiovascularbiology, & #bioengineering!

❤️

Two @haoyin.bsky.social paper highlights in one week is a nice little victory heading into the weekend! Thank you!

Thank you @haoyin.bsky.social for highlighting our work on #EVs, vesiculomics, and #multiomics drug target discovery in cardiovascular fibro-calcification!

No Frontiers, contrary to the emails you just spammed me with, I promise you that I didn't "successfully register [my] interest" to submit to 4 different special editions between 3-5am last night....