ISACB
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International Society For Applied Cardiovascular Biology ISACB.org
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ABSTRACT DEADLINE EXTENDED! Abstracts due May 8th, 2026, by 11:59pm (ET)
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17 days ago
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Member publication alert: Restoration of structural organization in engineered cardiac microtissues is promoted by cardiomyocyte beating
www.nature.com/articles/s42...
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Restoration of structural organization in engineered cardiac microtissues is promoted by cardiomyocyte beating - Communications Biology
Engineered cardiac microtissues and modeling reveal that cardiomyocyte contraction prestretches collagen to drive tissue anisotropy, improving sarcomere development and contractility and informing car...
https://www.nature.com/articles/s42003-026-10121-2
2 days ago
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Member publication alert: Effect of Valved Versus Non-valved Conduits on Ventricular Size and Function in Stage I Palliation for Hypoplastic Left Heart Syndrome
link.springer.com/article/10.1...
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Effect of Valved Versus Non-valved Conduits on Ventricular Size and Function in Stage I Palliation for Hypoplastic Left Heart Syndrome - Pediatric Cardiology
Pediatric Cardiology - Interstage mortality remains high after introduction of right ventricle (RV) to pulmonary artery conduits to stage I palliation for hypoplastic left heart syndrome (HLHS)....
https://link.springer.com/article/10.1007/s00246-026-04249-5
2 days ago
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Member publication alert: Integrating Uncertainty Quantification into Computational Fluid Dynamics Models of Coronary Arteries Under Steady Flow
asmedigitalcollection.asme.org/biomechanica...
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Integrating Uncertainty Quantification into Computational Fluid Dynamics Models of Coronary Arteries Under Steady Flow
Abstract. Computational fluid dynamics simulations are increasingly being integrated into clinical medicine, where they have the potential to support clinicians in disease diagnosis, prognosis, and tr...
https://asmedigitalcollection.asme.org/biomechanical/article-abstract/doi/10.1115/1.4071773/1232738/Integrating-Uncertainty-Quantification-into?redirectedFrom=fulltext
2 days ago
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Member publication alert: Integrated Strain-Flow Analysis for Early Assessment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
link.springer.com/article/10.1...
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Integrated Strain–Flow Analysis for Early Assessment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension - Annals of Biomedical Engineering
Purpose Early detection of right ventricular (RV) dysfunction is essential in pulmonary arterial hypertension (PAH) but remains challenging using conventional echocardiography. This study investigates...
https://link.springer.com/article/10.1007/s10439-026-04153-2
2 days ago
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Member publication alert: In silico modeling of transcatheter heart valve oversizing and ellipticity, Part I: Establishing credibility of an advanced model
www.sciencedirect.com/science/arti...
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In silico modeling of transcatheter heart valve oversizing and ellipticity, Part I: Establishing credibility of an advanced model
Transcatheter aortic valve implantation (TAVI) is the most common modality of treatment for aortic stenosis. However, transcatheter heart valves (THVs…
https://www.sciencedirect.com/science/article/pii/S0169260726001598?via%3Dihub
2 days ago
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Member publication alert: Dual Quantification of Skeletal Muscle Perfusion and Metabolism in a Porcine Model of Peripheral Artery Disease Using Multiparametric 18F-FDG PET Imaging
link.springer.com/article/10.1...
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Dual Quantification of Skeletal Muscle Perfusion and Metabolism in a Porcine Model of Peripheral Artery Disease Using Multiparametric 18F-FDG PET Imaging - Molecular Imaging and Biology
Background A standard imaging strategy for quantifying skeletal muscle perfusion in peripheral artery disease (PAD) does not exist, and the widespread use of PET imaging for this purpose has tradition...
https://link.springer.com/article/10.1007/s11307-026-02106-8
2 days ago
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Member publication alert: In silico modeling of transcatheter heart valve oversizing and ellipticity, Part II: Effects on leaflet mechanics, hemodynamics, and stent deflection contributing to thrombogenic risk and structural degeneration
www.sciencedirect.com/science/arti...
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In silico modeling of transcatheter heart valve oversizing and ellipticity, Part II: Effects on leaflet mechanics, hemodynamics, and stent deflection contributing to thrombogenic risk and structural d...
Transcatheter aortic valve implantation (TAVI) is the leading treatment for aortic stenosis. Self-expanding transcatheter heart valves (THVs) are over…
https://www.sciencedirect.com/science/article/pii/S0169260726001264?via%3Dihub
9 days ago
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Member publication alert: Pericardial Fluid-Derived Small Extracellular Vesicles from Patients with Coronary Disease Alter the Lipidome of Human Coronary Artery Endothelium
www.cjcopen.ca/article/S258...
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Pericardial Fluid–Derived Small Extracellular Vesicles from Patients with Coronary Disease Alter the Lipidome of Human Coronary Artery Endothelium
To date, we have lacked an understanding of how factors in the pericardial fluid (PF) of patients with coronary artery disease (CAD) can influence the lipidome of coronary artery endothelium. This stu...
https://www.cjcopen.ca/article/S2589-790X(25)00768-1/fulltext
9 days ago
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Member publication alert: Diabetes-induced TREM2-endothelial cell signaling impairs ischemic vascular repair
www.science.org/doi/10.1126/...
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Diabetes-induced TREM2–endothelial cell signaling impairs ischemic vascular repair
Diabetes-driven TREM2-endothelial cross-talk impairs vascular repair in peripheral arterial disease.
https://www.science.org/doi/10.1126/scitranslmed.adu3761
9 days ago
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Member publication alert: Engineered Development: Directed Morphogenesis of an Embryonic Heart Tube
advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Engineered Development: Directed Morphogenesis of an Embryonic Heart Tube
Morphogenesis shapes organs through coordinated mechanical deformations, yet remains difficult to study in vitro. Here, a human tissue–engineered heart tube is guided through looping using a controll...
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202522459
9 days ago
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Member publication alert: Phosphatidylserine-everted erythrocyte membrane vesicles enhance efferocytosis and remodeling of vascular grafts
www.nature.com/articles/s41...
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Phosphatidylserine-everted erythrocyte membrane vesicles enhance efferocytosis and remodeling of vascular grafts - Nature Communications
Erythrocyte membrane vesicles (EMVs) are promising for drug delivery but their role in immune-mediated regeneration is unclear. Here the authors show that phosphatidylserine-everted EMVs trigger effer...
https://www.nature.com/articles/s41467-026-71975-y
9 days ago
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Register for our next ISACB Webinar via
isacb.wildapricot.org/event-6666190
!
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15 days ago
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Member publication alert: Novel biodegradable device for transcatheter closure of atrial septal defects
www.nature.com/articles/s41...
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Novel biodegradable device for transcatheter closure of atrial septal defects - Scientific Reports
The long-term safety of transcatheter atrial septal defect (ASD) closure devices remains a concern, despite favorable short- and mid-term outcomes. We developed a fully biodegradable atrial septal occ...
https://www.nature.com/articles/s41598-026-48868-7
16 days ago
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Member publication alert: Comparative Proteomic Analysis of Lipoprotein(a): Method-Dependent Profiles and Disease Pathways
www.mdpi.com/2077-0383/15...
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https://www.mdpi.com/2077-0383/15/7/2559
16 days ago
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Member publication alert: A Molecular Imaging Strategy for In Vivo Monitoring of Vascular Remodeling in a Porcine Model of Femoral Artery Overdilation
link.springer.com/article/10.1...
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A Molecular Imaging Strategy for In Vivo Monitoring of Vascular Remodeling in a Porcine Model of Femoral Artery Overdilation - Annals of Biomedical Engineering
Purpose Clinical use of endovascular interventions has increased in recent decades for treatment of peripheral artery disease (PAD); however, molecular imaging paradigms for monitoring inflammatory re...
https://link.springer.com/article/10.1007/s10439-026-04141-6
16 days ago
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Member publication alert: Editorial: Proteomics in atherosclerosis
www.frontiersin.org/journals/car...
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Frontiers | Editorial: Proteomics in atherosclerosis
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality worldwide and continues to impose a substantial burden of morbidity des...
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1792281/full
16 days ago
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Member publication alert: Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype
www.ahajournals.org/doi/10.1161/...
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Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype | Circulation Research
BACKGROUND: Atherosclerosis, an inflammatory driver of coronary artery disease, manifests as unstable atheromatous plaques and stable fibrous plaques. Although atheromatous plaques have been extensive...
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.125.326941
16 days ago
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Member publication alert: Eicosapentaenoic acid ethyl ester, cardiac metabolomic and lipidomic signatures, and cardioprotection in myocardial infarction
academic.oup.com/eurheartj/ad...
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Eicosapentaenoic acid ethyl ester, cardiac metabolomic and lipidomic signatures, and cardioprotection in myocardial infarction
AbstractBackground and Aims. The cardiovascular benefits of eicosapentaenoic acid ethyl ester (EPA-E) in MACE reduction might extend beyond its triglycerid
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag187/8658450
16 days ago
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Member publication alert: Primed for metabolic syndrome: evidence of cardiac mitochondrial dysfunction preceding disease
journals.physiology.org/doi/abs/10.1...
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Primed for metabolic syndrome: evidence of cardiac mitochondrial dysfunction preceding disease | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00248.2026
16 days ago
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Member publication alert: Small Diameter Vascular Grafts Made in Minutes
advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Small Diameter Vascular Grafts Made in Minutes
Vascular trauma requires immediate intervention to repair or replace injured blood vessels and restore normal circulation. With limited clinical options, this study presents a vascular graft manufact....
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202509353
16 days ago
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Member publication alert: Cardioprotection with intravenous statin administration during myocardial infarction vs. oral preloading: a preclinical study
academic.oup.com/eurheartj/ad...
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Cardioprotection with intravenous statin administration during myocardial infarction vs. oral preloading: a preclinical study
Infarct size is associated with all-cause mortality and heart failure hospitalization underscoring the need for effective cardioprotection beyond timely re
https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehag269/8654244?redirectedFrom=fulltext&login=false
16 days ago
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ABSTRACT DEADLINE EXTENDED! Abstracts due May 8th, 2026, by 11:59pm (ET)
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17 days ago
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**RESCHEDULED** ISACB Webinar: April 28th, 2026 Next up in our pre-ISACB Miami networking webinars for early-career scientists:
@mghnmrtn.bsky.social
5:00pm CET /11:00am EST / 8:00am PT / 4:00pm UTC
stanford.zoom.us/j/8351157509...
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20 days ago
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ISACB Webinar: April 20th, 2026 Next up in our pre-ISACB Miami networking webinars for early-career scientists:
@mghnmrtn.bsky.social
! 3:00pm CET / 9:00am EST / 6:00am PT / 2:00pm UTC
stanford.zoom.us/j/8351157509...
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Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise cloud communications.
https://stanford.zoom.us/j/8351157509?pwd=pVZ0S4MnHFRLf6o7cIdleVMnZuKlGN.1&omn=93043018773
about 1 month ago
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Member publication alert: First long-term preclinical evaluation of woven vascular grafts made from human cell-assembled extracellular matrix
www.sciencedirect.com/science/arti...
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First long-term preclinical evaluation of woven vascular grafts made from human cell-assembled extracellular matrix
To meet the clinical need for small-diameter vascular grafts, we propose a new generation of Tissue-Engineered Vascular Grafts (TEVGs) based on the te…
https://www.sciencedirect.com/science/article/pii/S0142961226001961?via%3Dihub
about 1 month ago
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Member publication alert: MRA and Doppler ultrasound of laryngeal blood flow under hormonal and hydration modulation
link.springer.com/article/10.1...
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MRA and Doppler ultrasound of laryngeal blood flow under hormonal and hydration modulation - BMC Research Notes
Objective Phonation is a complex process requiring an appropriate tissue environment of the vocal folds, with laryngeal blood flow serving as one factor that contributes to tissue homeostasis. Effects...
https://link.springer.com/article/10.1186/s13104-026-07817-3
about 1 month ago
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Member publication alert: Reinforced biotubes as readily available and regenerative vascular grafts
www.nature.com/articles/s41...
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Reinforced biotubes as readily available and regenerative vascular grafts - Nature Communications
Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and dem...
https://www.nature.com/articles/s41467-026-70799-0
about 1 month ago
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Member publication alert: The Influence of Micropatterned Surfaces on Platelet Adhesion to Reduce the Risk of Thrombus Formation in Left Ventricular Assist Devices
link.springer.com/article/10.1...
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The Influence of Micropatterned Surfaces on Platelet Adhesion to Reduce the Risk of Thrombus Formation in Left Ventricular Assist Devices - Annals of Biomedical Engineering
Purpose Surface micropatterning is being explored as a strategy to mitigate thrombus formation and reduce long-term anticoagulation requirements in left ventricular assist devices (LVADs). This study ...
https://link.springer.com/article/10.1007/s10439-026-04108-7
about 1 month ago
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Member publication alert: Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication
www.nature.com/articles/s41...
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Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication - Nature Reviews Cardiology
In this Review, Emmert and colleagues provide an overview of the clinically available metallic and polymeric stents used to treat coronary artery disease and valvular heart disease, and discuss the ma...
https://www.nature.com/articles/s41569-026-01275-x
about 1 month ago
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Member publication alert: MSC Origin and Biomechanical Conditioning Determine ECM Maturation in Tissue-Engineered Matrix
www.mdpi.com/2227-9059/14...
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https://www.mdpi.com/2227-9059/14/3/560
about 1 month ago
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Member publication alert: Platelets: the first cellular responders in the foreign body response to blood-contacting biomaterials
www.frontiersin.org/journals/imm...
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Frontiers | Platelets: the first cellular responders in the foreign body response to blood-contacting biomaterials
Implanting biomaterials gives rise to the foreign body response (FBR), a complex cascade consisting of blood-material interactions, provisional matrix format...
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1758373/full
about 1 month ago
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Member publication alert: Focal Adhesion proteins confer smooth muscle anoikis resistance and protection against aortic aneurysm and dissection
insight.jci.org/articles/vie...
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JCI Insight - Focal Adhesion proteins confer smooth muscle anoikis resistance and protection against aortic aneurysm and dissection
https://insight.jci.org/articles/view/195291
about 1 month ago
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Member publication alert: A Novel Spatial Correlation Analysis of Peripheral Hemodynamics in a Murine Model of Vascular Calcification Using NIRS Imaging
link.springer.com/article/10.1...
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A Novel Spatial Correlation Analysis of Peripheral Hemodynamics in a Murine Model of Vascular Calcification Using NIRS Imaging - Annals of Biomedical Engineering
Vascular calcification (VC) is a major contributor to cardiovascular diseases (CVD) and progresses rapidly in patients with chronic kidney disease (CKD). Recently, we developed a low-cost, near-infrar...
https://link.springer.com/article/10.1007/s10439-026-04054-4
about 1 month ago
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Member publication alert: Editorial: Immunity, atherosclerosis, and cardiovascular disease: an interdisciplinary approach to cardiometabolic health
www.frontiersin.org/journals/car...
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Frontiers | Editorial: Immunity, atherosclerosis, and cardiovascular disease: an interdisciplinary approach to cardiometabolic health
This Research Topic entitled, "Immunity, Atherosclerosis and Cardiovascular Disease: An Interdisciplinary Approach to Cardiometabolic Health," co-o...
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1787241/full
about 1 month ago
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Member publication alert: Ex Vivo Hypothermic Perfusion Enables 48-Hour Heart Preservation and Bench-Top Functional Recovery via Normothermic Reperfusion in a Porcine Model
www.ahajournals.org/doi/10.1161/...
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Ex Vivo Hypothermic Perfusion Enables 48‐Hour Heart Preservation and Bench‐Top Functional Recovery via Normothermic Reperfusion in a Porcine Model | Journal of the American Heart Association
https://www.ahajournals.org/doi/10.1161/JAHA.125.045800
about 1 month ago
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Member publication alert: Impact of Variations in Commercial Standard Operating Procedure on Plasma Proteome Recovery
pubs.acs.org/doi/10.1021/...
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Impact of Variations in Commercial Standard Operating Procedure on Plasma Proteome Recovery
Advancements in mass spectrometry and complementary technologies now enable comprehensive, high-resolution plasma proteomics. Plasma is a key biofluid for clinical research, harboring potential diseas...
https://pubs.acs.org/doi/10.1021/acs.jproteome.5c01012
about 1 month ago
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Member publication alert: Deficiency of ZC3HC1 Modulates Vascular Smooth Muscle Cell Phenotype and Increases Neointima Formation
www.ahajournals.org/doi/10.1161/...
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Deficiency of ZC3HC1 Modulates Vascular Smooth Muscle Cell Phenotype and Increases Neointima Formation | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: The ZC3HC1 (zinc finger C3HC-type containing 1) gene has been linked to various cardiovascular traits, including coronary artery disease, blood pressure, and carotid intima-media thickness...
https://www.ahajournals.org/doi/10.1161/ATVBAHA.125.323659
about 2 months ago
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Member publication alert: Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress
www.frontiersin.org/journals/phy...
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Frontiers | Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress
IntroductionHutchinson-Gilford Progeria Syndrome (HGPS) is a fatal, accelerated-aging disease caused by a mutation in the nuclear envelope protein Lamin A. T...
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1599339/full
about 2 months ago
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reposted by
ISACB
Nominations are now open for the 2026 ISACB Elena Aikawa Trailblazer Award! A key part our ISACB 2026 meeting in Miami 🌴 See applications details at:
mailchi.mp/68414bc2fb5c...
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Applications Now Open: 2026 Elena Aikawa Trailblazer Award
https://mailchi.mp/68414bc2fb5c/isacb-ecirculator-2022-year-in-review-17240950
2 months ago
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reposted by
ISACB
ISACB x FCVM Research Topic #3: "Advances in Transplantation and Organ Preservation" Submit your research articles today!
www.frontiersin.org/research-top...
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Frontiers | Advances in Transplantation and Organ Preservation
This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. This collection will showcase cutting-edge advance...
https://www.frontiersin.org/research-topics/75702/advances-in-transplantation-and-organ-preservation
2 months ago
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reposted by
ISACB
ISACB x FCVM Research Topic #2: "Rheumatic Heart Disease: Global Trends and Emerging Mechanisms" Submit your research articles today!
www.frontiersin.org/research-top...
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Frontiers | Rheumatic Heart Disease: Global Trends and Emerging Mechanisms
This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. Despite significant advances in global health, Rhe...
https://www.frontiersin.org/research-topics/73536/rheumatic-heart-disease-global-trends-and-emerging-mechanisms
2 months ago
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reposted by
ISACB
ISACB x FCVM Research Topic #1: "Novel Mechanisms and Innovations in Calcific Aortic Valve Disease and Aortic Stenosis" Submit your research articles today!
www.frontiersin.org/research-top...
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Frontiers | Novel Mechanisms and Innovations in Calcific Aortic Valve Disease and Aortic Stenosis
This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. Aortic stenosis, largely driven by calcific aortic...
https://www.frontiersin.org/research-topics/73829/novel-mechanisms-and-innovations-in-calcific-aortic-valve-disease-and-aortic-stenosis
2 months ago
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reposted by
ISACB
ISACB Webinar: March 3rd, 2026 🚨 Calling all early-career researchers! 📢 Ahead of ISACB Miami, join us for an interactive webinar to get to know young research group leaders from our society! 5:00pm CET / 11:00am EST / 8:00am PT / 4:00pm UTC
us02web.zoom.us/j/2235938651...
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Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise cloud communications.
https://us02web.zoom.us/j/2235938651?omn=84342327081
2 months ago
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Member publication alert: Abnormal extracellular matrix deposition by fascial fibroblasts underlies the connective tissue pathology in the disease Radial Dysplasia
www.sciencedirect.com/science/arti...
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Abnormal extracellular matrix deposition by fascial fibroblasts underlies the connective tissue pathology in the disease Radial Dysplasia
Fibroblast cells are broadly distributed throughout the body and play instructive roles in tissue development and homeostasis. Defects in fibroblast f…
https://www.sciencedirect.com/science/article/pii/S0945053X26000211?via%3Dihub
about 2 months ago
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Member publication alert: Biomechanical Characterization of Porcine Lower Limb Arteries for Preclinical Evaluation of Peripheral Vascular Devices
link.springer.com/article/10.1...
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Biomechanical Characterization of Porcine Lower Limb Arteries for Preclinical Evaluation of Peripheral Vascular Devices - Annals of Biomedical Engineering
Purpose Peripheral artery disease (PAD) predominantly affects the lower extremities, where complex biomechanical deformations during limb flexion contribute to disease progression and treatment failur...
https://link.springer.com/article/10.1007/s10439-026-04066-0
about 2 months ago
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Member publication alert: Wireless blood pressure sensor implantation in sheep: A detailed technique
onlinelibrary.wiley.com/doi/10.1002/...
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Wireless blood pressure sensor implantation in sheep: A detailed technique
Twelve adult sheep underwent wireless blood pressure sensor implantation. The procedure lasted an average of 36 min, with mean systolic and diastolic blood pressures of 93 ± 6 and 65 ± 5 mmHg, respec...
https://onlinelibrary.wiley.com/doi/10.1002/ame2.70159
about 2 months ago
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Member publication alert: Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities
academic.oup.com/eurheartj/ad...
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Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities: A scientific statement of the ESC Council on Basic Cardiovascular Science, the ESC Working Group on Atherosclerosis...
Abstract. Metabolic disorders such as obesity, type 2 diabetes, and dyslipidaemia are major drivers of cardiovascular risk and have reached epidemic levels
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag116/8509350
about 2 months ago
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Member publication alert: Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence
www.sciencedirect.com/science/arti...
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Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence
Human placental mesenchymal stem cell-derived extracellular vesicles (hPMSC-EVs) have demonstrated anti-senescence effects across various diseases. Ho…
https://www.sciencedirect.com/science/article/abs/pii/S014296122600133X?via%3Dihub
about 2 months ago
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Member publication alert: Serotonin transporter downregulation is associated with aortic stenosis, and early profibrotic remodeling is mitigated by pharmacological inhibition of HTR2B receptor
www.frontiersin.org/journals/car...
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Frontiers | Serotonin transporter downregulation is associated with aortic stenosis, and early profibrotic remodeling is mitigated by pharmacological inhibition of HTR2B receptor
BackgroundAortic Stenosis (AS) is a highly prevalent disease involving physiological and structural remodeling of aortic valve, yet lacks effective medical t...
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1729078/full
about 2 months ago
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Member publication alert: Reliable Identification of Cardiac Maturation Markers Using Robust and Flexible Label-Free Proteomic Quantitation by Spectral Counting on Relatively Abundant Proteins
pubs.acs.org/doi/10.1021/...
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Reliable Identification of Cardiac Maturation Markers Using Robust and Flexible Label-Free Proteomic Quantitation by Spectral Counting on Relatively Abundant Proteins
The identification of biomarkers has been one of the major applications in proteomics research. The high specificity and sensitivity of a good biomarker can be evaluated only in population studies, which is costly and a limited number of candidate proteins can be evaluated. However, high throughput proteomics usually identifies thousands of proteins from a biological sample and yields tens to hundreds of candidate biomarkers. We demonstrate the use of robust and flexible spectral counting, a label-free semiquantitative method, on relatively abundant proteins to integrate proteomic results from different samples obtained from different laboratories for reliable biological insights and high-quality biomarkers. Furthermore, this strategy can be easily tuned for one or a few biomarkers on demand. We illustrate the use of this strategy to reveal the biological differences between terminally differentiated myocardium and rapidly proliferating HEK293T cells, as well as the successful selection of both positive and negative maturation markers for cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs). The advantage of this strategy is the capacity to utilize the exponentially growing number of proteomic results deposited in the public repository for candidate biomarker selection and to derive biological insights.
https://pubs.acs.org/doi/10.1021/acs.jproteome.5c01224
about 2 months ago
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