Nuria Quiles
@quilesnuria.bsky.social
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Microbiologist and phage enthusiast. Researcher at UCH CEU University.
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Nuria Quiles
Andreas Haag
about 1 month ago
📢 Funded PhD in molecular microbiology & phage biology How do bacterial stress responses control prophage activation and horizontal gene transfer? Join us at St Andrews to dissect Clp protease–mediated regulation in Staphylococcus aureus. Apply:
www.findaphd.com/phds/project...
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Protease-Controlled Prophage Activation in Staphylococcus aureus: New Mechanisms Driving Antimicrobial Resistance and Virulence at University of St Andrews on FindAPhD.com
PhD Project - Protease-Controlled Prophage Activation in Staphylococcus aureus: New Mechanisms Driving Antimicrobial Resistance and Virulence at University of St Andrews, listed on FindAPhD.com
https://www.findaphd.com/phds/project/protease-controlled-prophage-activation-in-staphylococcus-aureus-new-mechanisms-driving-antimicrobial-resistance-and-virulence/?p195078
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Pedro Dorado-Morales
about 2 months ago
A short research stay in 2019 (back in the pre-COVID era) at José R. Penadés lab turned into the third chapter of my PhD and today it finally sees the light.
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Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems
https://www.nature.com/articles/s41522-026-00931-x
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Thomas Ipoutcha
about 2 months ago
On this fabulous day celebrating André Citroën's birthday 🥖🚗, I’m happy to share my main paper from my postdoc in
@jrpenades.bsky.social
Lab. If you want to hear about how plasmid evolution is driven by mobile genetic elements, please come and read this preprint!
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.01.09.696371v2
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Asaf Levy
2 months ago
A new paper from the lab on virus-like particles called eCISs
www.nature.com/articles/s41...
How bacteria evolved thousands of precision nanoinjectors? Some bacteria don’t secrete toxins — they inject them using phage-derived machines called extracellular contractile injection systems (eCISs).
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A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems - Nature Communications
Extracellular contractile injection systems (eCISs) are bacteriophage tail-derived toxin delivery complexes that are present in many prokaryotes. Here, the authors present an analysis of eCIS tail fib...
https://www.nature.com/articles/s41467-026-68710-y
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Ákos T Kovács
3 months ago
A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
#PLoSPathogen
from
@prsecor.bsky.social
journals.plos.org/plospathogen...
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A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
Author summary Prophages—viral genomes integrated into bacterial chromosomes—are common in enteric bacteria and can profoundly influence bacterial physiology and ecological fitness. Here we show that ...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013836
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3 months ago
[1/3] Is your favorite bacterial isolate hiding a surprise lytic virus with a VERY different lifestyle? Finally I can proudly say that our paper on persistent phages is out in Nature Microbiology.
rdcu.be/eWJEp
. Well done
@peterdoug.bsky.social
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Persistent virulent phages exist across bacterial isolates
Nature Microbiology - The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical...
https://rdcu.be/eWJEp
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Frank Santoriello
3 months ago
The final form of my 2nd postdoc paper with the Bassler Lab! Turns out our favorite quorum-sensing phage isn’t a one-off, but rather a member of a globally dispersed family of phages that sense a universal autoinducer.
#phagesky
#microsky
journals.asm.org/doi/10.1128/...
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A family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial species | mBio
The discovery of quorum-sensing responsive linear plasmid phages has transformed understanding of phage-bacterial interactions by demonstrating inter-domain chemical communication. To date, however, e...
https://journals.asm.org/doi/10.1128/mbio.02320-25
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Sahar Melamed
4 months ago
Do viruses use RNA to rewire bacteria? Yes! In our paper in
@cp-molcell.bsky.social
RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection.
#RNA
#Phage
doi.org/10.1016/j.mo...
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Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle
Using RIL-seq, Silverman et al. map the RNA interactome of E. coli during phage lambda infection and uncover a conserved phage-encoded sRNA that activates host replication machinery. Their findings re...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00936-0
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Alexander Harms
5 months ago
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
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Emmanuele Severi
6 months ago
www.biorxiv.org/content/10.1...
#microsky
#phagesky
#phage
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Phages communicate across species to shape microbial ecosystems
Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...
https://www.biorxiv.org/content/10.1101/2025.10.13.681337v1
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Tung Le
6 months ago
Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!
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Lingchen He 何灵尘
7 months ago
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria.
@jonaszpatkowski.bsky.social
@tcostalab.bsky.social
@jrpenades.bsky.social
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José R Penadés
7 months ago
Thrilled to share our two latest papers with the
@tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
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Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900974-2
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Tiago Costa
7 months ago
Thrilled to share that two of our papers with
@jrpenades.bsky.social
& GoogleDeepMind are now out in
@cellpress.bsky.social
1️⃣Microbial piracy:
tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science:
tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
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Itai Yanai
7 months ago
New review 🔥 Single-cell RNA-Seq has been revolutionary for studying eukaryotic cells and now it's time for it to do the same for microbes! We describe the technology for single-bacterium RNA-Seq & the questions now studied using it.🧵⬇️
science.org/doi/10.1126/...
@andrewpountain.bsky.social
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Aisling Brady
7 months ago
What is everyone's favourite review on anti-phage/defence systems? Ideally as an introduction to the concept/key systems for undergraduate level without expertise in phage biology
#MicroSky
#PhageSky
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Alvaro San Millan
8 months ago
New paper in collaboration with the
@asantoslopez.bsky.social
lab!
www.biorxiv.org/content/10.1...
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ASM
8 months ago
Why do some people age more healthily than others? The answer may come, in part, from our guts and the massive community of microbes living in them. Discover how aging shapes—and is shaped by—the gut microbiota:
asm.org/Articles/202...
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Aging and the Gut: The Microbiome's Second Act | ASM.org
Why do some people age more healthily than others? The answer may come, in part, from our guts and the massive community of microbes living in them.
https://asm.org/Articles/2025/July/Aging-Gut-The-Microbiome-Second-Act
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Microbiology Society
9 months ago
Today, Professor Donal Wall,
@uofglasgow.bsky.social
attended a pitch session as part of the Science, Innovation and Technology Committee's 'Under the Microscope' inquiry to explain why they should be interested in microbiomes.
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Xu Kuang
11 months ago
Let’s talk about/with/to phage!
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Sebastian S. Cocioba
11 months ago
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚
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Nature Portfolio
12 months ago
Gene editing and many other useful biotechnology tools came from studies of bacteria fighting off viral invaders, but scientists have only begun to unlock the secrets of this microbial warfare. Read the Nature feature on what breakthroughs could be next. 🧪
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Microbial warfare brought us CRISPR. What big breakthroughs could be next?
Gene editing and many other useful biotechnology tools came from studies of bacteria fighting off viral invaders. But scientists have only begun to unlock the secrets of this ancient arms race.
https://go.nature.com/4juyrLr
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Alf Soler-Bistué 🦠🔬🧫
12 months ago
I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!).
www.science.org/doi/10.1126/...
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Most bacterial gene families are biased toward specific chromosomal positions
The arrangement of genes along bacterial chromosomes influences their expression through growth rate–dependent gene copy number changes during DNA replication. Although translation- and transcription-...
https://www.science.org/doi/10.1126/science.adm9928#tab-contributors
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PLOS Biology
12 months ago
The BASEL collection of E. coli
#phages
is limited by its host strain.
@humollidorentina.bsky.social
@damienpiel.bsky.social
@aharms485.bsky.social
&co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity
@plosbiology.org
🧪
plos.io/4jirGvX
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PhD opportunity in a fantastic topic with great supervisors. Check it out!
add a skeleton here at some point
about 1 year ago
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José R Penadés
about 1 year ago
If you are interested in phage satellites, we hope you'll enjoy this. Fun collaboration with the Rocha, Seed, Bikard, and Chen labs!
rdcu.be/efkvG
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Genetics, ecology and evolution of phage satellites
Nature Reviews Microbiology - In this Review, Penadés et al. explore the genetics, potential origins and life cycle of phage satellites, and they discuss the impact of these elements on the...
https://rdcu.be/efkvG
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Nuria Quiles
I2SysBio
about 1 year ago
We welcome on BlueSky Alfred Fillol Salom
@alfredfisa.bsky.social
, the leader of the The Ecology of Mobile Genetic Elements group at our research institute
#microsky
🧫🦠🧪
#phages
#virology
#viruses
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Vivek Mutalik
about 1 year ago
Made a feed for phage papers/discussions/friends! Please feel free to pin this feed to your bluesky profile and if you wish to add to the feed, simply add the
#phage
hashtag (NOT case sensitive) and the feed will aggregate the posts. See you there! Please repost🙏🏽
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Kirsty Wan
about 1 year ago
Re-posts appreciated! We have an open PhD position w/ Prof Harold Auradou on
#microswimmers/#protists
in complex media! Students get to spend at least 12 months in Paris, and will receive their PhD from both Exeter and Paris-Saclay! Apply by 31st Mar. More details:
adum.fr/as/ed/voirpr...
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Kevin Forsberg
about 1 year ago
My lab’s first preprint! We used functional metagenomics to identify phage defenses in human and soil microbiomes. We scaled these selections while maintaining accuracy, enabling us to examine 9 habitats for defense elements against 7 phages.
www.biorxiv.org/content/10.1...
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bioRxiv Microbiology
about 1 year ago
A prophage-encoded anti-phage defense system that prevents phage DNA packaging by targeting the terminase complex
https://www.biorxiv.org/content/10.1101/2025.02.27.640495v1
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Ben Adler
about 1 year ago
It is finally out! Muntathar Al-Shimary,
@doudna-lab.bsky.social
,
@cresslab.bsky.social
and I present a gene knockdown tool that works in diverse bacteriophages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check it out
@naturemicrobiol.bsky.social
www.nature.com/articles/s41...
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CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d - Nature Microbiology
Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.
https://www.nature.com/articles/s41564-025-01935-7
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Fernando Rossine
about 1 year ago
I'm so happy that I can finally share the results of my first postdoc paper with
@baym.lol
!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! (1/n)
www.biorxiv.org/content/earl...
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Intracellular competition shapes plasmid population dynamics
Conflicts between levels of biological organization are central to evolution, from populations of multicellular organisms to selfish genetic elements in microbes. Plasmids are extrachromosomal, self-r...
https://www.biorxiv.org/content/early/2025/02/21/2025.02.19.639193
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bioRxiv Microbiology
about 1 year ago
Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization
https://www.biorxiv.org/content/10.1101/2025.02.11.637232v1
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Richard Lenski
about 1 year ago
Many of us, and especially early-career scientists, are facing huge challenges now. However, one of the joys of science is to delve into thinking about research. In that spirit, I offer this blog post on starting a microbial evolution experiment.
telliamedrevisited.wordpress.com/2025/02/08/h...
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Michael Brockhurst
about 1 year ago
☎️ Calling
#MEvoSky
☎️ 2x 5-year research associate / research assistant positions in experimental evolution ERC-funded project: How do mobile genetic elements and defence systems shape bacterial genome evolution? Join the friendly and exciting
@mermanchester.bsky.social
community in Manchester!
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Alexander Harms
about 1 year ago
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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Mike Inouye
about 1 year ago
Headline click bait but this is an excellent bit size interview. Sometimes Guardian science hits the mark.
www.theguardian.com/science/2025...
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Virologist Wendy Barclay: ‘Wild avian viruses are mixing up their genetics all the time. It’s like viral sex on steroids’
The British scientist on the risk of humans contracting bird flu, how people would cope with new lockdowns and being asked to pour the tea because she is a woman
https://www.theguardian.com/science/2025/feb/01/virologist-wendy-barclay-wild-avian-viruses-are-mixing-up-their-genetics-all-the-time-its-like-viral-sex-on-steroids
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Saloni
over 1 year ago
Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!
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Ákos T Kovács
about 1 year ago
Happy to see this multi country collaboration published in
@cp-cellreports.bsky.social
led by Polonca and Anna Ecology of prophage-like elements in Bacillus subtilis at global and local geographical scales
www.cell.com/cell-reports...
#Phage
#Bacillussubtilis
#MicrobiomeEcology
at
#LeidenBiology
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Nuria Quiles
bioRxiv Microbiology
over 1 year ago
The mycomembrane differentially and heterogeneously restricts antibiotic permeation
https://www.biorxiv.org/content/10.1101/2024.12.31.630956v1
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bioRxiv Microbiology
over 1 year ago
Persistent virulent phages exist in bacterial isolates
https://www.biorxiv.org/content/10.1101/2024.12.31.630880v1
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Alvaro San Millan
over 1 year ago
www.nature.com/articles/s41...
New paper out!!
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A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
https://www.nature.com/articles/s41467-024-55169-y
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