This is fucking insanity www.insidehighered.com/news/quick-t...

Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...

Watching SNL I think @peterhotezmdphd.bsky.social could be Jack Black!

Some totally awesome updates from grant-witness.us All of my funding curves and more in an easily useful form! grant-witness.us/funding_curv... 🧵 1/7

Not so marvelous news. ~95,000 scientists have left the federal government since the Trump regime took over.

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...

Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T, U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of early Earth. http://dlvr.it/TRWtVp ☄️

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

New TrakLab Picture for 2026. Great eager young scientists poised for discoveries this year.

The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 ! www2.rnasociety.org

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...

We are excited to host the first WOW Symposium for the 'Mutagenesis and Mechanistic Assessment" Special Interest Group @emgsus.bsky.social. Hosting Drs. Graham Walker (MIT), Mikhael Kashlev (NCI), and Julian Sale (MRC). Please join us on March 6th at 11 am. Register at emgs-us.org/event/MolMec...

Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Watched Stranger Things S5E5 tonight with the fam. They was a pretty good representation of the DNA replication fork in Henry’s journal. No one else was impressed but me. 🧬

Live thread of the NSF biology virtual office hour: 🧵

Horrifying news being confirmed about the state of NSF at the NSF IOS/BIO webinar

Grads.. Start building your network now. It is so essential for life after graduation. www.nature.com/articles/d41...

All the centers they’re cutting add up to less than $7 million in spending. UNC athletics budget is $185.4 million for the 2025-26 fiscal year.

Adam Luthman says: it depends. Some answers here: rdcu.be/eUVBj

Make sure to gift something to you administrative staff that keeps the Department running all year long. For me, the best gift to give is Frangos! Originally from Chicago!

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

I prefer Arial

Everyone shut thefuck up in that they discovered ribose and, for the first time in any extraterrestrialsample, glucose on Bennu. This adds to earlier this yr 14 of the 20 amino acids thatlife on Earth uses to make proteinsand all five nucleobases that lifeon Earth uses www.nasa.gov/missions/osi...

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...

Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org Expertise in structure refinement and model-building are required. Please share.

Wynton Marsalis and the Jazz at Lincoln Center Orchestra blew me away tonight. Thanks Baylor and A&S for sponsoring.

Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...

Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social www.science.org/doi/10.1126/...

Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...

Happy to share a new publication on Mechanistic Coupling of Enzyme Activities at the Replisome in JBC. We #Traklab compare and contrast strategies used across organisms to coordinate the many enzymatic processes that occur during DNA replication. Hope it is helpful. doi.org/10.1016/j.jb...

For ASBMB 2026, each meeting day will have a "theme" organized by session chairs. This theme "Racing the clock: Molecular Mechanisms of Aging" will feature Meng Wang as the keynote and is co-organized by Dan Jarosz @jaroszlab.bsky.social (?) and Roz Anderson.

New #Traklab publication in @narjournal.bsky.social "Residues in the little finger domain of the Y-family Dpo4 DNA polymerase communicate to restrict synthesis past 8-oxoguanine lesions" academic.oup.com/nar/article/...

Things are at a standstill with the govt shutdown, the year has been one of 'constant chaos' at the NIH — & the worst may be yet to come folks said on my panel Read a recap of our talk w/ @jeremymberg.bsky.social @malar0ne.bsky.social & Eric Green here www.statnews.com/2025/10/16/f...

My scientific grandfather. What a gentleman scientist. RIP

I feel like this photo of masked, armed men pepper spraying a pastor protecting his community is going to be a defining picture of this moment in America for a long, long time.

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

"You couldn’t stop me from pursuing science. . . . It was just part of who I am." - Mona Minkara. cen.acs.org/physical-che... #chemsky 🧪

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

Continuing efforts to hurt the research pipeline, the very late NSF GFRP solicitation no longer allows 2nd year PhD students to apply. Lots of these students chose not to apply last year because they were told they would have a better change once in their thesis lab www.nsf.gov/funding/oppo...

Frequent user of epitope tags? Try ours! IPI epitope tag antibodies & plasmids are now available through our partner @addgene.bsky.social! buff.ly/YEuZDIp

A frenzy of grantmaking in August has the NIH seemingly on pace to spend its entire $47 billion budget by the end of the fiscal year on Sept. 30 www.statnews.com/2025/09/12/n...

shocking to read over and over the stories of close colleagues who can't run their lab anymore. I know Karen well and it's heartbreaking. Also #PIinthelab! www.washingtonpost.com/education/20...

Heading to #FallACS2025. Check out the #TOXI program. Some great talks and award sessions. See you soon! @sturlalab.bsky.social @laurakiessling.bsky.social @acs.org