@mspielmann.bsky.social
📤 250
📥 224
📝 5
reposted by
Raquel Fueyo
3 days ago
Thrilled to start my Group Leader adventure with these and other great scientists!
add a skeleton here at some point
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reposted by
Max Planck Institute for Molecular Genetics
3 days ago
We are excited to welcome
@fueyoraquel.bsky.social
,
@sedonamurphy.bsky.social
, and
@jmstein.bsky.social
as new group leaders at our institute! Read more about their work: -->
www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call! -->
www.molgen.mpg.de/IMPRSPhDproj...
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Three new research groups joining the MPIMG
https://www.molgen.mpg.de/2025-10-31-new-research-groups
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reposted by
Max Planck Institute for Molecular Genetics
4 days ago
🧬📢 We look forward to welcoming Jacob Hanna from the Weizmann Institute of Science as part of our speaker lineup for the
#Embryo2026
meeting! More information 👇
www.molgen.mpg.de/embryo2026
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reposted by
Nature Reviews Genetics
23 days ago
New online! Redefining cellular reprogramming with advanced genomic technologies
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Redefining cellular reprogramming with advanced genomic technologies
Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.
https://www.nature.com/articles/s41576-025-00899-y?utm_source=dlvr.it&utm_medium=bluesky
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1
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reposted by
Atlas of Variant Effects Alliance
6 days ago
🗓️Abstract Deadline Extended to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org
0
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reposted by
Max Planck Institute for Molecular Genetics
12 days ago
The IMPRS-BAC call is open until January! Interested in applying to the graduate school? Here are ten tips for a successfull application! ⬇ Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
#IMPRS
#IMPRSBAC
@freieuniversitaet.bsky.social
@maxplanck.de
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reposted by
Nature Reviews Genetics
16 days ago
ICYMI: New online! Redefining cellular reprogramming with advanced genomic technologies
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Redefining cellular reprogramming with advanced genomic technologies
Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.
https://www.nature.com/articles/s41576-025-00899-y?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Max Planck Institute for Molecular Genetics
16 days ago
📢🧬 Next in the speaker line-up for
#Embryo2026
is
@eileen-furlong.bsky.social
from
@embl.org
who will present her research on "Genome regulation during embryogenesis: Going loopy about enhancer regulation" Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute
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reposted by
Matt Jones
19 days ago
Delighted to share our new study in
@natcellbio.nature.com
showing that the unique epigenetic landscape of ecDNA can enable the oncogenic enhancer activation of transposable elements! This was a great collaboration with
@katerinakraft.bsky.social
and
@sedonamurphy.bsky.social
.
tinyurl.com/mwfbu4w4
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Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
https://tinyurl.com/mwfbu4w4
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3
reposted by
Max Planck Institute for Molecular Genetics
23 days ago
📢Speaker showcase for our 2nd Meeting
#Embryo2026
🧬
@jamesbriscoe.bsky.social
from
@crick.ac.uk
will speak on The Dynamics of Neural Tube Formation More information on
www.molgen.mpg.de/embryo2026
0
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reposted by
Nature Reviews Genetics
25 days ago
Our featured article: Structural variants in the 3D genome as drivers of disease - Review by Varun K. A. Sreenivasan, Verónica Yumiceba & Malte Spielmann
go.nature.com/4oiPdPQ
Free to read here:
rdcu.be/eu0KR
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Structural variants in the 3D genome as drivers of disease
Nature Reviews Genetics - Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical...
https://rdcu.be/eu0KR
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reposted by
Nature Reviews Genetics
25 days ago
Our November 2025 issue is now live:
go.nature.com/4hlXnVx
Topics include: the impact of structural variation on the 3D genome in disease; single-cell DNA sequencing of somatic mutations; the role of transcription compartments in gene regulation; synonymous mutations and their consequences
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reposted by
Jay Shendure
26 days ago
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) &
@greenahn.bsky.social
on the work! Preprint here:
www.biorxiv.org/content/10.1...
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reposted by
Greg Findlay
25 days ago
Hello Boston! The lab is delighted to be at
#ASHG25🧬
Check out our talks over the next few days - all unpublished stories. Kicking things off is
@michaelherger.bsky.social
presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc Also 👇
1
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5
reposted by
Max Planck Institute for Molecular Genetics
26 days ago
Interested in handling big data and developing efficient algorithms for omics data? Apply by 07.01.2026 for a PhD position in the lab of Knut Reinert
#IMPRS
#IMPRSBAC
@freieuniversitaet.bsky.social
#gradschool
👉
www.molgen.mpg.de/4775929/Rein...
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reposted by
James Briscoe
about 1 month ago
The
@crick.ac.uk
is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov
www.crick.ac.uk/careers-stud...
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Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
https://www.crick.ac.uk/careers-study/faculty/early-career-group-leaders
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reposted by
Raquel Fueyo
about 1 month ago
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (
@molgen.mpg.de
) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work. 🔬🦠I'm hiring at all levels! 🔬🦠Check:
www.molgen.mpg.de/fueyo-lab
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reposted by
Raquel Fueyo
about 1 month ago
Today in
@nature.com
, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot!
rdcu.be/eI3tD
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A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
https://rdcu.be/eI3tD
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reposted by
Jacob (Yaqub) Hanna - يعقوب حنا
about 1 month ago
EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026. Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026
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reposted by
Benoit Bruneau
about 1 month ago
awesome new work by my
@gladstoneinst.bsky.social
and
@ucsanfrancisco.bsky.social
colleagues incl
@vram142.bsky.social
on how chromatin remodelers affect mesoscale chromatin organization
www.science.org/doi/10.1126/...
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ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
https://www.science.org/doi/10.1126/science.adr0018
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reposted by
Deutsche Forschungsgemeinschaft
about 1 month ago
#ResearchCareers
: Just finishing your
#PhD
and wondering if the DFG’s Walter Benjamin Programme is a
#funding
option for your next step in academia? Come and find out in our digital info talk on 14 October. No registration, the meeting link will be published here: ➡️
www.dfg.de/en/research-...
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reposted by
Alex Hoischen
about 1 month ago
0
2
1
reposted by
Max Planck Institute for Molecular Genetics
about 1 month ago
Great to see our Alumni Hossein and Uirá named among the 100 most influential scientists in Berlin by
@tagesspiegel.de
! They are co-founders of Lucid Genomics, a startup that develops algorithms to analyze the non-coding genome for potential use in precision medicine. Congratulations!
0
4
1
reposted by
Nobu Hamazaki
about 1 month ago
New paper from my lab and
@jshendure.bsky.social
lab! Led by the brilliant
@zukailiu.bsky.social
and
@cxqiu.bsky.social
. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n)
www.biorxiv.org/content/10.1...
3
54
22
reposted by
Max Planck Institute for Molecular Genetics
about 1 month ago
2nd Meeting on Early Embryogenesis and Epigenetics 16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin with support by the Weizmann Institute for Science. Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
0
10
10
reposted by
Alex Hoischen
about 2 months ago
Wow! Amazing - and first glimpses of hope for patients and families with this devastating rare disease.
www.bbc.com/news/article...
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Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
https://www.bbc.com/news/articles/cevz13xkxpro
1
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4
reposted by
Stefan Barakat
about 2 months ago
Join us today at Sept 23rd2025 from 5pm to 6.30 pm (Central European Time) for our ERN ITHACA webinar on the non-coding genome and human disease by
@svergult.bsky.social
,
@mspielmann.bsky.social
, Florence Petit and
@stefanbarakat.bsky.social
ern-ithaca.eu/events-news/...
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ERN-ITHACA WEBINAR: NON-CODING GENOME AND HUMAN DISEASE - ERN ITHACA
Recent developments in genomic technologies have enabled the genome-wide identification of regulatory elements and chromatin interactions, controlling the spatiotemporal gene expression. In this webin...
https://ern-ithaca.eu/events-news/upcoming-events/ern-ithaca-webinar-non-coding-genome-and-human-disease/
0
2
2
reposted by
Adam Phillippy
about 2 months ago
Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy:
www.biorxiv.org/content/10.1...
🧵[1/14]
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A complete diploid human genome benchmark for personalized genomics
Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...
https://www.biorxiv.org/content/10.1101/2025.09.21.677443v1
4
96
61
reposted by
Yun S. Song
about 2 months ago
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
4
174
95
reposted by
Neil Shubin
about 2 months ago
Congrats to Aurelie Hinterman
aurhin.bsky.social
, Chase Bolt
chasebolt.bsky.social
, and Brent Hawkins
@homeobox.bsky.social
! Coverage in NYTimes by
@carlzimmer.com
:
www.nytimes.com/2025/09/17/s...
add a skeleton here at some point
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Congratulations Nadav and team! Amazing work, so much potential for out patients… thank you!
add a skeleton here at some point
about 2 months ago
0
2
0
reposted by
Alex Hoischen
about 2 months ago
Day one
#nvhg2025
kicked of by the great Hans Clevers - amazing how organoids help basic scientific understanding all the way to therapies!
0
1
1
reposted by
Stein Aerts
about 2 months ago
@niklaskemp.bsky.social
will present our new CREsted framework at the next scverse community meeting! CREsted allows you to train sequence-to-function models tailored to cell type-specific enhancers (including synthetic enhancer design)
www.biorxiv.org/content/10.1...
github.com/aertslab/cre...
add a skeleton here at some point
0
20
5
reposted by
Shicheng Guo
about 2 months ago
Explore genomic newborn screening! Early Check program in NC shows feasibility of 198 gene sequencing with electronic consent. PMID:40913169, Nat Med 2025,
@NatureMedicine
https://doi.org/10.1038/s41591-025-03945-8
#Medsky
#Pharmsky
#RNA
#ASHG
#ESHG
🧪
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Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program | Nature Medicine
Although genomic sequencing presents groundbreaking newborn screening (NBS) opportunities, critical feasibility and utility questions remain. Here we present initial results from the Early Check program—an observational study assessing the feasibility and clinical utility of genomic NBS in North Carolina. Recruitment was statewide through mailed letters with electronic consent. Genome sequencing with analysis of 169 high actionability genes (plus 29 optional lower actionability genes) was performed using residual NBS dried blood spots. In 8 months, 1,979 newborns were screened, with 50 (2.5%) screen positives. Negative results were returned electronically, positive results by genetic counselors. Twenty-eight results (55%) were true positives, all received anticipatory guidance, surveillance and management recommendations, and referral to specialists as appropriate. We report technical feasibility and preliminary clinical utility finding, along with interpretation and follow-up challeng
https://doi.org/10.1038/s41591-025-03945-8
0
1
1
reposted by
Max-Planck-Gesellschaft
2 months ago
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for
#MaxPlanckResearchGroups
launched; applications are possible until October 14, 2025
www.mpg.de/max-planck-r...
#ScienceCareer
2
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63
reposted by
Nature Reviews Genetics
2 months ago
And follow it up with
@natrevcardiol.nature.com
's review on the application of MAVEs in cardiology by
@amglazer.bsky.social
et al. Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine
go.nature.com/3JOJYc3
rdcu.be/eFmoe
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Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine - Nature Reviews Cardiology
In this Review, Roden and co-workers describe how multiplexed assays of variant effects can be used for high-throughput functional assessment of nearly all coding variants in a target sequence to impr...
https://go.nature.com/3JOJYc3
0
5
3
reposted by
Nature Reviews Genetics
2 months ago
Interested in using MAVEs for variant classification? Read our review by Abbye E. McEwen, Malvika Tejura,
@shawnfayer.bsky.social
,
@leastarita.bsky.social
&
@dougfowler.bsky.social
: Multiplexed assays of variant effect for clinical variant interpretation
go.nature.com/3IdCfUb
rdcu.be/eFmll
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Multiplexed assays of variant effect for clinical variant interpretation - Nature Reviews Genetics
Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et al. discuss the advances in MA...
https://go.nature.com/3IdCfUb
1
14
4
reposted by
Max Planck Institute for Molecular Genetics
2 months ago
Congratulations to Claudia Giesecke-Thiel on her ERC Starting Grant! Her project will focus on how the site of infection influences immune responses. She will be moving from the MPIMG to Charité, where she will launch her own research group in Jan 2026. Read more:
www.molgen.mpg.de/news-2025-er...
1
17
3
reposted by
Wolfgang Huber
2 months ago
Join EMBL as a research group leader in AI in biology. EMBL AI is our new initiative aiming to exploit the full potential of ML/AI-based approaches to advance our understanding of the most complex system in the known universe - life on Earth.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
(1/3)
1
33
24
reposted by
Myllia Biotechnology
2 months ago
We’re thrilled to announce that the "High-Content CRISPR Screening" conference will take place on March 18–19, 2026, in Vienna, Austria. The registration is now open via the conference website:
lnkd.in/d8KACZy5
Meet the Speaker: Christoph Bock
@bocklab.bsky.social
0
6
3
reposted by
The New York Times
2 months ago
A new research lab backed by the UAE said Tuesday that it was freely sharing an A.I. model meant to compete with systems released by companies in the U.S. and China.
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United Arab Emirates Joins U.S. and China in Giving Away A.I. Technology
The Persian Gulf nation has “open sourced” technology meant to compete with OpenAI and China’s DeepSeek.
https://nyti.ms/487YN3i
6
47
14
reposted by
Greg Findlay
2 months ago
We now have an open post-doc position in the lab:
crick.wd3.myworkdayjobs.com/External/job..
. Please apply if you have a background in functional genomics or a related field and are eager to develop methods to map variant effects at scale.
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https://crick.wd3.myworkdayjobs.com/External/job..
0
5
8
reposted by
European Society of Human Genetics
2 months ago
Nominations are open for the Leena Peltonen Prize 2026 (€10,000). candidates: outstanding young researchers, Early career stage, no age or graduation limit Awardee will give the Leena Peltonen Lecture at
#eshg2026
in Gothenburg. 📅 Deadline: 31 Oct 2025 🔗
forms.eshg.org/leena-pelton...
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Leena Peltonen Prize 2026 – Submission of Nomination
https://forms.eshg.org/leena-peltonen-prize-2026-submission-of-nomination/
0
7
6
reposted by
Luca Giorgetti lab @FMI
2 months ago
Become our colleague at
@fmiscience.bsky.social
! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!
add a skeleton here at some point
0
20
12
reposted by
Greg Findlay
2 months ago
Hugely thankful for this 🙏. We will do our best to make the most of it.
@erc.europa.eu
!
add a skeleton here at some point
2
23
3
reposted by
Science Magazine
2 months ago
A new
#MachineLearning
approach is helping to estimate the disease risk of rare genetic variants, researchers report in Science.
https://scim.ag/3K3oyYs
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Machine learning–based penetrance of genetic variants
Accurate variant penetrance estimation is crucial for precision medicine. We constructed machine learning (ML) models for 10 diseases using 1,347,298 participants with electronic health records, then ...
https://scim.ag/3K3oyYs
0
23
6
reposted by
European Society of Human Genetics
2 months ago
📢 Episode 6 of the
#ESHG
Webinar Series: September 24 at 16:00 CEST 🧬 Speaker: Serena Nik-Zainal: "Recent advances in mutational signatures and clinical applications" 💻 Registration is free but required:
buff.ly/P6WD5jB
📩 Past registrants will receive the Zoom link automatically.
0
5
3
reposted by
European Society of Human Genetics
2 months ago
The ESHG calls for caution regarding the proposed use of the SRY gene test in sport. Eligibility rules must acknowledge biological complexity, allow for exceptions, and ensure proper athlete support. Read the full statement:
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Proposed SRY test to determine athletes’ sex should be treated with caution
In the light of recent controversy about eligibility for male and female categories in sport, the International Olympic Committee has decided to set up a working group to look at gender eligibility…
https://www.eshg.org/news/news-details?tx_news_pi1%5Baction%5D=detail&tx_news_pi1%5Bcontroller%5D=News&tx_news_pi1%5Bnews%5D=81&cHash=4623c0a023cac2fdadac3ab05861c2cd
0
4
3
reposted by
Albert Henry
2 months ago
1. 🚨New preprint:
tinyurl.com/tenk10k-causal
. We explored causal effects of gene expression in immune cell types on complex traits and diseases by combining single-cell expression quantitative trait loci (sc-eQTL) mapping in 5M+ cells from 1,925 donors in TenK10K study and GWAS. 🧵
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Single-cell genetics identifies cell type-specific causal mechanisms in complex traits and diseases
Genome-wide association studies (GWAS) have been instrumental in uncovering the genetic basis of complex traits. When integrated with expression quantitative trait loci (eQTL) mapping, they can elucid...
https://tinyurl.com/tenk10k-causal
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