David Cortez
@dkcortez.bsky.social
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📥 147
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Professor and Chair, Department of Biochemistry
reposted by
David Cortez
Zha Lab
7 days ago
Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at
www.cancer.columbia.edu/research/pro...
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reposted by
David Cortez
Chris Carnie
7 days ago
Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with
@drjhujh.bsky.social
and
@profstewartlab.bsky.social
alongside
@sorenhough.bsky.social
and friends in
@spjacksongroup.bsky.social
.
add a skeleton here at some point
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reposted by
David Cortez
Lopes_Lab
7 days ago
Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by
@vcherdy.bsky.social
, with key collaborative contributions from
@nitikataneja.bsky.social
.
rdcu.be/eVrxX
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Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...
https://rdcu.be/eVrxX
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reposted by
David Cortez
Ernst Schmid
about 1 month ago
Thrilled to share that the final piece of my PhD work is now on bioRxiv!
biorxiv.org/content/10.1...
With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at
predictomes.org/hp
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Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
http://biorxiv.org/content/10.1101/2025.11.10.687652v1
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reposted by
David Cortez
Arnab Ray Chaudhuri
about 2 months ago
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
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FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...
https://www.science.org/doi/10.1126/science.adt1210
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Less than two weeks left to apply for our TWO tenure track assistant professor positions in Department of Biochemistry at Vanderbilt University School of Medicine. Basic Sciences
nam04.safelinks.protection.outlook.com?url=https%3A...
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Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515
Department of Biochemistry, School of Medicine—Basic Sciences
https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nature.com%2Fnaturecareers%2Fjob%2F12843515%2Fassistant-professor-of-biochemistry-at-vanderbilt-university%3Futm_source%3DEmailAFriend%26amp%3Butm_medium%3Demail%26amp%3Butm_campaign%3D12843515&data=05%7C02%7Cdavid.cortez%40Vanderbilt.Edu%7C57abd31a41b84f78f0ba08de012174a3%7Cba5a7f39e3be4ab3b45067fa80faecad%7C0%7C0%7C638949440355355650%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=7ymr%2B0fEYIbdhKdXksznqfzTpHTFtZI0ohWlshdRNn0%3D&reserved=0
3 months ago
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reposted by
David Cortez
Vanderbilt School of Medicine Basic Sciences
3 months ago
🧪 Vanderbilt researchers are on a mission to “smooth out the bumps” in medicinal chemistry. Their new work addresses key inefficiencies that slow discovery and could accelerate the path from lab to clinic. Learn more 👉
medschool.vanderbilt.edu/basic-scienc...
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Vanderbilt research looks to smooth out bumps in medicinal chemistry processes
Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.
https://medschool.vanderbilt.edu/basic-sciences/2025/09/23/vanderbilt-research-looks-to-smooth-out-bumps-in-medicinal-chemistry-processes/
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reposted by
David Cortez
Kavi Mehta
3 months ago
Does anyone have another source besides BD for the B44 anti-brdu antibody or one that reacts with Idu and limited with Cldu. It’s badly back ordered.
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reposted by
David Cortez
Daniel Durocher
4 months ago
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at
@sinaihealth.bsky.social
. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
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reposted by
David Cortez
JStark lab
4 months ago
We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details.
www.imgs-coh.edu/postdoctoral...
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Postdoctoral Training Programs
Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc
https://www.imgs-coh.edu/postdoctoral-training-office/postdoctoral-training-programs
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Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
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Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515
Department of Biochemistry, School of Medicine—Basic Sciences
https://www.nature.com/naturecareers/job/12843515/assistant-professor-of-biochemistry-at-vanderbilt-university/
4 months ago
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The Department of Biochemistry at Vanderbilt University (
medschool.vanderbilt.edu/biochemistry/
) is searching for TWO new Assistant Professors this year. Apply by October 15!
apply.interfolio.com/171767
5 months ago
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reposted by
David Cortez
Rosado lab
9 months ago
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to MarĂa JosĂ© and coauthors HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances
www.science.org/doi/10.1126/...
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HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells
HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.
https://www.science.org/doi/10.1126/sciadv.ads3227
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reposted by
David Cortez
Kavi Mehta
about 1 year ago
Very proud of this. It’s both the end and beginning of something new for me. My last paper in
@dkcortez.bsky.social
lab and my first co-corresponding author. Also truly a great supergroup including
@freudlab.bsky.social
@tmweaver.bsky.social
and Roberts lab
www.nature.com/articles/s41...
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Contributing factors to the oxidation-induced mutational landscape in human cells - Nature Communications
8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...
https://www.nature.com/articles/s41467-024-55497-z?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20241223&utm_content=10.1038/s41467-024-55497-z
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