1/ 🚨 New preprint! 🚨 Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇 📄 www.biorxiv.org/content/10.1... 💻 code + data 🔗 below 🤩 #neuroskyence

🚨New preprint alert! The thalamus has long been seen as a relay of sensory signals to cortex. But could it also generate its own structured activity? Our study explores this question in the head-direction (HD) system. Some explanation 🧵👇 1/13 www.biorxiv.org/content/10.1...

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

Check our new preprint where we examine how enriched experiences alter synaptic connectivity and coding sparsity across the neocortex.

My PhD journey has officially come to end with a Summa Cum Laude, thanks to all the amazing people who’ve supported me along the way, especially my advisors Anna Levina and @engeltatiana.bsky.social! Which apparently coincided with graduation from a witchcraft and wizardry school 😉 #neuroskyence

This is a super interesting paper from Bruce McNaughton’s lab, showing why we should study behavior in the context of natural/ecological environments. They show that living in enriched complex environments, prior to task performance, affects both behavior and the underlying neural activity.

When neurons change, but behavior doesn’t: Excitability changes driving representational drift New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...

In many brain areas, neuronal tuning is heterogeneous. But how does this diversity help behavior? We show how tuning diversity shapes representational geometry and boosts coding efficiency for perception in our new preprint: www.biorxiv.org/content/10.1... (w/ @sueyeonchung.bsky.social&Tony Movshon)

A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently. Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries. www.biorxiv.org/content/10.1...

I'm pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, out in @cp-cellreports.bsky.social ! With Demi Brizee & David Dupret, we track how oscillations and spiking behaviour map onto hippocampal layers using an LFP-based embedding. (1/13)

Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in @natcomms.nature.com 🔬🧠 rdcu.be/evWtz

Super excited to see this paper from Armin Lak & colleagues out! (I've seen @saxelab.bsky.social present it before.) www.cell.com/cell/fulltex... tl;dr: The learning trajectories that individual mice take correspond to different saddle points in a deep net's loss landscape. 🧠📈 🧪 #NeuroAI

Our study is out in Nature! Using wireless Neuropixels we recorded hippocampal activity in freely flying bats and uncovered replay and theta(less) sweeps, revealing striking differences from classic rodent models. 👉 www.nature.com/articles/s41...

Do you do Neuropixel recordings and are you struggling with preprocessing? The Power Pixels pipeline is an easy-to-use pipeline from raw data to neural activity of single neurons in specified brain regions 🧠 Now on bioRxiv! www.biorxiv.org/content/10.1...

Our work with Maxim Bazhenov's group showing interleaved replay of new and old memories within individual Up states using a combination of biophysical modeling and electrophysiology experiments.

Your brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...

Our new paper out now in Science explores how neural activity in the lateral entorhinal cortex (LEC) *drifts* over time - and *jumps* at key boundaries - to help organize events in memory. 🔗 www.science.org/doi/10.1126/... Here's a quick summary of what we found 🧵👇

Your brain learns for you even when you're not actively learning. Maybe. (in mice).

Kilosort4 detects a LOT of neurons, I recorded 15k neurons in one year 🤯 Traditionally, one would curate these detected units to see if they are well isolated single neurons. This is not feasible anymore, so today let's look at three options that are out there to automate this process! 🤖👇

Over the past few years, I’ve shared my personal journey as a sleep scientist living with sleep apnea with other scientists and students to raise awareness and reduce stigma. I’m excited to reach an even broader audience in my recent interview with Parade 🎉 parade.com/health/i-fel...

As I transition over to Bluesky I have to plug our new #book. If you haven't already, check out the 2nd edition of The #Hippocampus Book! academic.oup.com/book/59509?s...

New opinion paper in @cp-trendsneuro.bsky.social with Dan Bendor, where we argue that rodent studies provide only marginal support for the idea that replay supports real-time decisions (e.g. planning). Fictive learning and memory tagging are more consistent w/evidence. www.cell.com/trends/neuro...

Excited to share the sequel to our 2022 paper! In this follow-up, we show that the stable head direction (HD) signals we reported in blind mice rely on stereo olfaction—that is, the comparison of odor info. between the two nostrils. Link: www.nature.com/articles/s41... 🧵highlights below

We're bringing together leading researchers from top institutions worldwide to Split, Croatia this summer. If you're passionate about brain-inspired AI, computational neuroscience, or fundamental mathematical principles driving intelligence, this conference is the place to be!

Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D! Suite3D: Volumetric cell detection for two-photon microscopy by @haydari.bsky.social & team. www.biorxiv.org/content/10.1...

Finally a new textbook for theoretical neuroscience. Xiao-Jing Wang wrote a nice book with very broad coverage of the field. Highly recommend. www.amazon.com/Theoretical-...

"How are memories formed and stored in the brain?...Long-term memory acquisition was found to be associated with a selective increase in multisynaptic boutons..". Groundbreaking new study from my friend and colleague Anton Maximov's lab: www.science.org/doi/10.1126/... Bonus: My son Luca's first pub

Applications are open for the summer school 𝗠𝗮𝘁𝗵𝗲𝗺𝗮𝘁𝗶𝗰𝗮𝗹 𝗠𝗲𝘁𝗵𝗼𝗱𝘀 𝗶𝗻 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲. compneuronrsn.org Application deadline: March 31, 2025 Located in beautiful Eresfjord, Norway 🇳🇴 #Neuroscience #ComputationalNeuroscience #KavliNeuro @kavlintnu.bsky.social

Exciting new paper from David Dupret's lab, showing that hippocampal CA1 ripples can be categorized in 2 types, either driven by CA3 or entorhinal inputs, & are associated with different replay content. The categorization only requires pyramidal layer recording. www.biorxiv.org/content/10.1...

At Reviewer Zero, we're passionate about helping early career researchers navigate the challenges of the peer review system. If you're an early career researcher in psych & neuro and feel stuck & need advice for a manuscript, check out this opportunity!

Ji et al, Burgess lab: phase precession, theta skipping & theta modulation of head direction cells in the anteroventral thalamic nucleus (AVN). Explained using a ring attractor model with theta input and firing rate adaptation: onlinelibrary.wiley.com/doi/10.1002/... #Neuroscience #Neurons

Check out the new preprint by Manfredi @vitorlds.bsky.social et al., who find that hippocampal replays can be classified by their sinks in Radiatum or LM! Radsink -> recent waking motifs LMsink -> prior coactivity motifs www.biorxiv.org/content/10.1...

Excited to share our latest preprint with @camillopadoasch.bsky.social and Xiao-Jing Wang! We present a biologically plausible framework showing how neural circuits compute & compare value to drive flexible economic decision making. www.biorxiv.org/content/10.1...

New manuscript published! ✍️👀 Concept neurons evolve from index neurons through overlapping memories. Check it out here: www.cell.com/trends/cogni... 1/15

We always see that 1) neural responses are very diverse 2) the shattering dimensionality is as high as it can be. Now also in an extensive analysis of the IBL dataset. Wonderful collaboration with @lorenzoposani.com, Shuqi Wang, Samuel Muscinelli, Liam Paninski. Many new analyses in this new version

Neuropixels and Optogenetics are delighted to announce the birth of Neuropixels Opto Combining high-resolution electrophysiology and optogenetics Today in bioRxiv 960 sites, 28 emitters, 2 colors By Lakunina, @karolinazsocha.bsky.social, Ladd, et al www.biorxiv.org/content/10.1... (1/2)

Kudos to the team for such an interesting finding.

What's the right way to think about modularity in the brain? This devilish 😈 question is a big part of my research now, and it started with this paper with @solarpunkgabs.bsky.social, finally published after the first preprint in 2021! 🤖🧠🧪 www.nature.com/articles/s41...

What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...

It’s an incredible feeling to see something you’ve poured your heart into come to life. This work was born from my curiosity about hippocampal “cognitive tuning.” Our interpretation of the environment depends on our actions, constantly evolving as we pursue our goals www.nature.com/articles/s41...

I think a major gap between ANNs and animals is the deeply impoverished stimuli that ANNs receive, which implies we should get better data for ANNs. But these folks had a diff idea: what if we instead impoverish the animals? Better alignment with models! journals.plos.org/ploscompbiol... 🧠📈 🧪

SEEING THROUGH YOUR EYES 👁️: Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus nature.com/articles/s41... 🧵 1/12👇

Attention my fellow spiking neural network python nerds, there is a new version of Brian (2.8) just in time for Xmas. Particularly recommended if you use random numbers in standalone mode, big speed improvements. brian2.readthedocs.io/en/2.8.0/int... Brian will make his way to Bluesky soon. 🤖🧠🧪

The geometry of adaptation! My first excursion in the V1 territory. Great collaboration with @mariodipoppa.bsky.social @matteocarandini.bsky.social and many others

Delighted to highlight our new paper in @natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵

Here are some things that neuroscientists don't like to call "correlation": 1990s: "reverse correlation" 2000s: "granger causality" 2010s: "functional connectivity" 2020s: "subspace communication"