September 21 is #WorldAlzheimersDay Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

🚨New preprint alert! The thalamus has long been seen as a relay of sensory signals to cortex. But could it also generate its own structured activity? Our study explores this question in the head-direction (HD) system. Some explanation 🧵👇 1/13 www.biorxiv.org/content/10.1...

*New preprint from the lab* – “Granularity of thalamic head direction cells” doi.org/10.1101/2025... 🧠📈 🧪 1/11

15 Sep is the deadline to submit your abstract for a poster or data blitz talk at #iSCAN 2025. Don't miss this opportunity and join us for an exciting meeting on spatial cognition in aging and neurodegeneration! Abstract submission: tinyurl.com/2r7f8dup Meeting website: tinyurl.com/mry28bfc

(buried in a reply, but) This is mind-blowing & deserves a post. Scroll to "video" in this article to watch what happens when the human hypothalamus is stimulated: it's a combo of embarrassment/shame and intense body sensations emanating from the heart. WOW. www.brainstimjrnl.com/article/S193...

NEW: An Oxford study has found that a vaccine against respiratory syncytial virus (RSV) is associated with a 29% reduction in dementia risk over the following 18 months. The findings suggest a novel explanation for how vaccines produce this effect. Read more ⬇️

NEW: Eight exceptional individuals whose achievements have made lasting contributions to the world were recognised today with honorary degrees at Oxford University’s Encaenia. More information ⬇️ www.ox.ac.uk/news/2025-06...

Exeter College was honoured to host Lord Crewe’s Benefaction this morning in the Fellows’ Garden, part of @ox.ac.uk Encaenia ceremony. The Chancellor, Vice-Chancellor, and honorands gathered with other University dignitaries, before processing to the Sheldonian Theatre.

Whew, what a day! Today we revealed the preview of NSF–DOE Rubin Observatory's epic cosmic movie🎬 #RubinFirstLook From wide-field and deep views of the Universe, to the dynamic and changing sky, Rubin is already bringing the night sky to life! 🔭🧪 rubinobservatory.org/news/first-i...

If you are in London a week today and are free early evening, please come along to my talk at @royalsociety.org (free!). If you can’t make it, it will be live-streamed and subsequently available online…

I've been writing a textbook on computational cognitive neuroscience, which has prompted me to assess the evidence supporting various theoretical ideas. It's striking to me how some ideas have an extraordinary shelf life despite weak evidence.

Interesting discussion tonight on How to Hack your Brain to improve learning at Oxford Biohacking Society with my neuroscience colleagues bstaresina.bsky.social‬ and vineytj.bsky.social

Love seeing the beautiful butterfly at #Tau2025 where 1000+ scientists and clinicians are gathering to share ideas to accelerate biomedical discoveries. Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody go.bsky.app/KHno2VG @millermb.bsky.social

Excited to share the sequel to our 2022 paper! In this follow-up, we show that the stable head direction (HD) signals we reported in blind mice rely on stereo olfaction—that is, the comparison of odor info. between the two nostrils. Link: www.nature.com/articles/s41... 🧵highlights below

Wow! www.science.org/doi/10.1126/...

One of my favourite markers: vimentin (tested in post-mortem human cortex)

We now have a blood biomarker that is even more strongly associated with tau PET and cognitive symptoms than even p-tau217! Plasma eMTBR-tau243 will help us to understand whether cognitive impairment is likely to be related to Alzheimer's pathology. #ENDALZ www.nature.com/articles/s41...

Check out the new preprint by Manfredi @vitorlds.bsky.social et al., who find that hippocampal replays can be classified by their sinks in Radiatum or LM! Radsink -> recent waking motifs LMsink -> prior coactivity motifs www.biorxiv.org/content/10.1...

“essentially closing research operations in my group” = no new experiments save 1 recently funded grant. Spending freezes limit our ability to order supplies and reagents. We need to focus remaining funding on maintaining personnel + analyzing existing samples w whatever’s left in the cabinet

Excited to share our latest paper: “Phase Precession Relative to Turning Angle in Theta-Modulated Head Direction Cells” together with Dr. Eleonora Lomi (co-first author) Prof. @katejj.bsky.social Prof. Anna Mitchell and Prof. @neilburgess10.bsky.social doi.org/10.1002/hipo...

Congratulations to winners of The Brain Prize 2025! Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience. Learn more: brainprize.org/winners/canc...

Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.

😱 They "‘toad-napped’ 62 cane toads" and they found their way home! Seriously, this is a cool behavioral study, and it provides intriguing evidence of the conserved role of pallial brain regions in spatial navigation.

@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6

Exciting new work from the Dominantly Inherited Alzheimer Network describing a PSEN2 mutation carrier who has “escaped” disease. Importantly lessons to learn for AD resilience!

I am delighted to share that our latest research has been published in Acta Neuropathologica. Please have a read: doi.org/10.1007/s004... #Neuropathology #AlzheimersDisease #Neurodegeneration #Glia #HumanBrain #Immunity

Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78) I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine 1/n

Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social #KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com @kavlifoundation.bsky.social www.nature.com/articles/s41...

Launch of the Centre for Global Epilepsy www.oxfordmartin.ox.ac.uk/news/oxford-...

Don’t miss this upcoming #LMBSeminar by Maria Grazia Spillantini, Professor of Molecular Neurology at the University of Cambridge. At 11am (GMT) Monday 10th Feb, Maria will discuss ‘Alpha-Synuclein and its Aggregation: Past, Present and Future’ More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...

Synaptic Targets and Cellular Sources of CB1 Receptor and VGLUT3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex doi.org/10.1111/ejn.... Delighted that this paper is out - includes n=120 tested interneurons that were recorded and labelled in human cortex

Emails can be very distracting. The only way I manage is to have no notifications on devices and try to check only at specific times of the day. Anything important I assign to a space in my calendar. MS Teams is used for the lab

Here is the MIT Tech Review article covering the data collection linked to this new Phd Opportunity at our new International Centre for NeuroArchitecture and NeuroDesign: www.technologyreview.com/2024/09/13/1...

I'm delighted to share this special issue on scientific histories of hippocampal research in the journal Hippocampus - lots of interesting stories and a great resource for trainees. Huge thanks to Mike Hasselmo and Lynn Nadel for their vision and leadership! onlinelibrary.wiley.com/doi/toc/10.1...

A must-read article for anyone working on #tau and #dementia. I remember Linde Jacobs' important and moving talk at the Tau2024 conference in Washington DC. Her presence at the meeting underscored how important it is to fund and conduct research on tauopathies

A striking example of similar patterns but at massively different scales. Left, a star orbited by exoplanets taken by ESO’s Very Large Telescope (Bohn et al. www.eso.org/public/irela...). Right, β-amyloid42 immunoreactivity in human cerebral cortex (B. Sarkany and T. Viney, University of Oxford)

Fantastic journey through the history of hippocampal extra cellular recording techniques and the search for cell assemblies by Bruce McNaughton. onlinelibrary.wiley.com/doi/10.1002/...

Neurobiotin, drawn by Dr Lizzie Burns. This synthetic #molecule is a derivative of biotin (vitamin B7). It can be delivered into single #brain cells in order to study their architecture and trace the fine processes within and across brain regions, revealing hidden details of the nervous system.

I got to meet Horace Barlow in 2005 just before starting my PhD. We met in his office and he showed me some movies of black dots moving across a grey background. I didn't fully understand the significance until later. I have always recorded single neurons and still listen to them via loudspeaker

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn

“The coexistence of multiple astrocyte phenotypes suggests that we should address astrocyte heterogeneity, stratify astrocyte subtypes, and consider multiple astrocyte targets for developing biomarkers.” I had the honor of commenting on the paper of the year by @sdas617.bsky.social et al.👇

Ants integrate proprioception as well as visual context and efference copies to make robust predictions #sensorimotor www.nature.com/articles/s41...

Publishing requires constant innovation and renewal to remain relevant. We are concerned by the action that Clarivate is taking in regard to @elife.bsky.social but not because eLife may not be eligible for an Impact Factor but because of the chilling effect on innovation. sfdora.org/2024/11/25/c...

🧠 130 people now in this UK Dementia Starter Pack! 🧠 📈 (50 more than 2 days ago!) 📈 A great mix of Profs/PIs/Post-docs/PhDs/Technicians. Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋 go.bsky.app/S6FfsTp

Postmortem evidence that higher brain GFAP levels are associated with higher brain amyloid burden 👇👇👇👇 link.springer.com/article/10.1...

Pleased to say our study led by James Street showing a requirement for the LGN pathway for visual landmark control of head direction cells is now published! physoc.onlinelibrary.wiley.com/doi/10.1113/...

Some precious mouse brain sections currently being processed with diaminobenzidine to follow axons of juxtacellularly labelled cells.

How the #brain talks to the #gut and vice versa! 🧪🧠💩 Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici 👇👇👇 www.cell.com/current-biol...

The main output of the hippocampus is subcortical. Today, for the last class on the neurophys of navigation & mem, we will discuss this fantastic paper by @davidtingley.bsky.social (Buzsaki Lab) showing a link btw hippocampal sharp wave-ripples & glucose release. www.nature.com/articles/s41... 1/n