1/12 A very special moment for me! 🎉 My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes. rupress.org/jcb/article/... #cellbio #devbio #science 🧵for details

New perspective by @maikbischoff.bsky.social & @mayorlab.bsky.social about how mesenchymal cells use contact-dependent rules to generate swarm-like behaviors, patterns & organ forms. rupress.org/jcb/article/... #CellBio #CellMigration #Morphogenesis #Development #Science

We’re excited to announce the launch of our new website at angelman.org! 🎉 Our updated site features easy navigation and filters that help you find the resources, clinics, research, and support you need on any device. Check it out!➡️ angelman.org

A Boa Constrictor brain-derived cell expressing a viral glycoprotein (magenta) and stained for actin (yellow) and DNA (white). #FluorescenceFriday

FINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy

For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social

Stunning images!

1) Branching morphogenesis is fundamental to animal development, shaping complex organs like lungs, kidneys, and vascular networks. Gills are another highly branched organ. Yet, the developmental processes behind gill formation in zebrafish remain poorly understood. #zebrafish #gills #microscopy

Gills just wanna have #FluorescenceFriday 🎵 Phalloidin reveals the beauty of the filament's distal tip in cleared gills of adult 🦓🐟 #microscopy #devbio #sciart

I know, it's a bit late for #FluorescenceFriday but I want to share my new banner :D #cellmigration #cellbio #devbio #sciart #microcosm #science

I begrudgingly admit that actin is pretty cool 🤩 🎥 Primary mouse myotubes labeled with Lifeact-mScarlet-I3 (cyan) and H2B-mStayGreen (red). #FluorescenceFriday

2/4 I chose this picture because I am interested in an old question: How do fly testes obtain their specific shape? In my previous research I learned that muscle precursors shape it, using collective cell migration and alignement to achieve the pattern visible in this picture.

Stand up for science Raleigh!! Let’s keep this energy going!!

Mesonephric glomeruli of #zebrafish for #FluorescenceFriday 🔬 kdrl-mCherry nicely reveals the capillary tuft of the glomerulus. The zebrafish kidney stops developing at the mesonephros stage! It serves as their main kidney structure, and they don't develop a metanephros like humans do.

For today's #fluorescencefriday I have a riddle 😊. Can anyone who is knowledgeable in #Drosophila #neuroscience tell my what these are? I honestly don't know! Overview picture in the comments-they are from the brain🧠🪰. The marker is lifeact::GFP, depth-coded... #sciart #microscopy #cellbio #cellfy🔬

An ancient unpublished picture from my PhD #FluorescenceFriday! Drosophila sperm pump depth-coded with muscles (phalloidin=cyan/green) + Dapi (yellow/red). Not confocal but an old Zeiss Apotome - which is still an awesome scope! #sciart #microscopy #bioart #sciart #microscopyart #cellbio #devbio

Wow! We got the cover! #MBOC #ASCB #CellBio So proud of #TeamTestis. Screening <270 lines for shape defects was a huge team effort! I created this collage from the team’s images from the past 2 years! Depth-color-coded with Fiji. Inspired by late 19th century lithographic animal illustrations.

🔬My first try on #FluorescenceFriday Nice detail of a tissue-cleared kidney from neonatal mice. -GFP is expressed in podocytes and pericytes. -CD31 antibody highlights the branched blood vessels and glomeruli in red

How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling. www.biorxiv.org/content/10.1... Special thanks to @aliceyting.bsky.social for discussions

Muscles growth by sarcomere divisions - how your muscles add new sarcomeres during developmental growth: they divide! Cool collaboration @friedrich-group.bsky.social @raunser-lab.bsky.social @Dirk Görlich @univ-amu.fr @cnrs.bsky.social sciencecast.org/casts/aspy9l... www.biorxiv.org/content/10.1...

For those interested in "Genome editing and CRISPR technologies": (if you are new here at Bluesky), here are the two starter packs... bsky.app/starter-pack... bsky.app/starter-pack...

Excited to give my 1st talk on an #ASCB meeting about collective #cellmigration in #Drosophila! #cellbio2024 12/16 4pm Room 33B, more info below👇! Next, I'll post about our 2 posters!🪰 Thank you @allysonsgro.bsky.social & Daniel Cohen for this opportunity! #cellbio #devbio @ascbiology.bsky.social

1/2 #TeamTestis postbac Sarah Clark presents a really cool poster: A large reverse-genetic screen identifies numerous regulators of testis nascent myotube collective #cellmigration and collective organ sculpting Tuesday, Dec 17 1:30 PM P2783, B400 #cellbio #devbio #cellbio2024 #Drosophila

Next to my talk (12/16 4 pm room 33B), I will present a poster: "Semaphorin/Plexin Antagonism Orchestrates Collective Cell Migration in vivo". Tuesday, Dec 17 11:15 AM. P2780/Board No. B397 I am so excited. I just love ASCB meetings! #cellbio2024 #cellbio #devcell @ascbiology.bsky.social #ASCB

Super recent publication: AAV vector-derived elements integrate into Cas9-generated double-strand breaks and disrupt gene transcription #AngelmanSyndrome doi.org/10.1016/j.ym...

Super proud and honored to give my first #GRC talk at the Directed Cell Migration #GordonConference in Italy January 12-17 www.grc.org/directed-cel... Thank you so much Sally Horne Badovinac and @robinsall.bsky.social for giving me this fantastic opportunity! #cellbio #devbio #cellmigration

Still can't believe that I will give a talk on #cellbio2024! And I'm also in the session with the coolest title by far😀 WELCOME TO THE ZELLENSTAAT! Thank you so much to the organizers Daniel J Cohen & @allysonsgro.bsky.social and to @ascbiology.bsky.social #ascb #cellbio #cellmigration #devbio

Quite a few new entries on the CRISPR list incl. @nevillesanjana.bsky.social @grunewald.bsky.social @sdomcke.bsky.social @rosswilsonlab.bsky.social @leopoldparts.bsky.social @bkleinstiver.bsky.social @mgdurrant.bsky.social go.bsky.app/DEwe6ZD

New starter pack for all people interested in Gene Editing & Gene Therapy 🧬✂️ including Tools & Delivery|CRISPR-Cas|Zinc finger nucleases|Viral vectors|Non-viral delivery methods go.bsky.app/8R4dVez

Thank you for creating this one! Hopefully I can be added too 😉 #genetherapy

Super recent publication: AAV vector-derived elements integrate into Cas9-generated double-strand breaks and disrupt gene transcription #AngelmanSyndrome doi.org/10.1016/j.ym...

Here’s a #neurosky starter pack (part 1 because I hope there will be more!). #medsky go.bsky.app/B7Sr8VJ

We have created a starter pack with all other Max Planck Institutes we could find on Bluesky! Share, follow and help us build this community! go.bsky.app/DzTMXRy

There are articles about the #science migration now! 😄 That makes it official ❤🦋 #Xodus #eXit #nature #bluesky #bsky #sciencetwitter #sciencebsky www.nature.com/articles/d41...

Nominations and self-nominations sought for the position of Director at MPI CBS! The future Director’s research programme should focus on understanding the neural bases of human cognitive functions, using modern #neuroimaging methods. #science #maxplanck Please share: tinyurl.com/mu43uds6

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...

New starter pack for all people interested in Gene Editing & Gene Therapy 🧬✂️ including Tools & Delivery|CRISPR-Cas|Zinc finger nucleases|Viral vectors|Non-viral delivery methods go.bsky.app/8R4dVez

Neuroscience is exploding on Bluesky! Make sure to follow some Women In Neuroscience here :) go.bsky.app/SCFmKoC

I made a starter pack for neuroscience folks but I just saw that it’s capped at 150 people. Sorry if I missed anyone! Maybe #neuroscience folks should start making subfield starter packs? 🧪 go.bsky.app/Q69XurQ

New preclinical data on a first-in-class gene therapy for Angelman syndrome: encoded.com/press-releas...

Here is a link to my developmental biology starter pack. Please add and follow. go.bsky.app/M5AgJhn

100 scientists in our "Behavioral & Preclinical Neuroscience" starter pack ! Thank you for your enthusiasm! It also means, there are still 50 spots left, so ✋ raise your hand and 📢 nominate your colleagues! go.bsky.app/7cNykut

Information on development and outcomes in Angelman Syndrome has been largely based on decades-old observational studies which don't show the benefits of modern interventions. It's great to now see robust data coming out of Natural History Studies #angelmansyndrome pubmed.ncbi.nlm.nih.gov/38879552/

A nice weekend read. www.cell.com/cell/fulltex... Small and long non-coding RNAs: Past, present, and future #RNA, #RNASky

New to medical science: 3 unrelated children w/ deletions of CHASERR—a stretch of long non-coding RNA—had a neurological disorder not previously identified. Doctors say the cases mark the 1st instances of a new syndrome. It's marked by severe intellectual delays www.medpagetoday.com/neurology/ge...

My starter pack is growing! Please reach out if you use animal models (flies, worms, mice, fish, etc) to study disease mechanisms and want to be added. go.bsky.app/MhUwjSx

My first Starter Pack is almost full - check it out for a very diverse collection of scientists interested in disease models across many species. go.bsky.app/MhUwjSx

Let's build a rare disease starter pack! go.bsky.app/LExn7SZ