The best cover🥰, paired cats & paired helical filaments.

In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.

Ever wondered how stable your ADCs are and how their stability is influenced by their drug-load? Variable-temperature electrospray ionization can help with that! Jan Fiala’s and my postdoc work in the lab of @hecklab.bsky.social was just published! 🥳🥳🥳 pubs.acs.org/doi/10.1021/... 1/3

I am delighted to share our findings on the binding mode of tetanus neurotoxin and the anti-epileptic drug Levetiracetam to SV2A, an essential synaptic vesicle membrane protein of unknown function, now online in @NatComms.bsky.social   www.nature.com/articles/s41...

#CryoEM #structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation. @NatureComms Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9f1r

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Delighted to share #AuthorInterview with @biopatrika.bsky.social were we discuss on recent findings on Botox. biopatrika.com/academia/res...

Coot 1.1.14 has been released! Coming to homebrew and flatpak soon! - Clark & Labute comes to Coot 1, Moorhen & chapi! (svg, 2D ligand environment view) - Solid Symmetry (symmetry that you can see!) - PAE plot for AlphaFold models #coot #molmatinf

Happy to share our latest publication on @naturesmb.bsky.social Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W. thanks @sjorsscheres.bsky.social and Michel Goedert's support. 🥳 rdcu.be/edqzW rdcu.be/edoGv

Very proud of our new review article on the Beta 1-Adrenergic GPCR now available on bioRxiv: www.biorxiv.org/content/10.1.... With @saureli.bsky.social @valeriorizzi.bsky.social and Nicola we used OneOPES to fully converge the free energy landscapes associated with B1AR apo/holo activation.

Nature research paper: Natural behaviour is learned through dopamine-mediated reinforcement https://go.nature.com/3XMKATn

Male blue-lined octopuses inject females with venom during mating to avoid being eaten by their partners https://go.nature.com/3FqtOU4

Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.

Well said!!. I totally support this. As a collaborator or teamate and co coauthor, it's also our responsibility to ensure quality of Science in every publication we publish as coauthor. #SaveScienceFromJunk

Hey kiddos. Don’t forget to filter your buffers and samples (any cut off is better than no cutoff) or use an inline filter on your systems!

We have deposited the following mice (all B6/J backcrossed) to @mmrrc.bsky.social Adgrf5-EGFP-CT-IRES-CRE GPR123- EGFP-CT-IRES-CRE GPR124- EGFP-CT-IRES-CRE GPR125- EGFP-CT-IRES-CRE Gpr133-EGFP-CT-IRES-CRE GPR156-IRES-Cre GPR156-mGL-IRES-Cre GPR75-IRES-Cre

The paper by @BasurajSK, Oneda Leka, Pal Sushant, @KorkhovLab, and Richard Kammerer (@psich_en), published in @NatureComms provides molecular insights in botulinum neurotoxin recognition and pH-dependent conformational transitions relevant to its mechanism of action. biol.ethz.ch/en/news-and-...

Symbiotic #bacteria ride along with single-celled #protists in ocean's upper layer phys.org/news/2025-02... #Symbionts of predatory protists are widespread in the oceans and related to animal pathogens www.cell.com/cell-host-mi...

Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation pubmed.ncbi.nlm.nih.gov/39934119/ #cryoem

Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation www.nature.com/articles/s41...

Want to know “How does #Botox enter cells at the right time & place to exert its #therapeutic effect?” Check out our latest paper @naturecomms.bsky.social @psich_en @KorkhovLab @ethzurich.bsky.social www.nature.com/articles/s41...

Love this.. 👏 MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony www.biorxiv.org/content/10.1...

Looking for a primer on why the contrast transfer function matters in #cryoEM? Have a look at our updated #CryoSPARC Guide pages on CTF estimation! We cover intuition, theory, job types and practical considerations: guide.cryosparc.com/processing-d...

How can medicines be directed to the precise location within the body where they need to act? Research lead by ETH Zurich have now unveiled a special class of effective particles. They appear visually striking under a microscope too, resembling tiny paper flowers or desert roses.