I am thrilled to announce that the completely redesigned TmDet algorithm by @ProtBioinfRG has just been published in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem!

Structural basis of oligomerization-modulated activation and autoinhibition of orphan receptor GPR3. @CellReports Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9lyb

#CryoEM #Structure of the Flagellar Motor Complex from Paenibacillus sp. TCA20. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9lu9

Structural insights into the selective recognition of RF-amide peptides by neuropeptide FF receptor 2. @EMBOReports. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jfy

Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ee8

Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib. @CellReports Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zbs

Mycobacterium tuberculosis CrgA Forms a Dimeric Structure with Its Transmembrane Domain Sandwiched between Cytoplasmic and Periplasmic β-Sheets... https://pdbtm.unitmp.org/entry/9nm2

Structural basis for catalytic mechanism of human phosphatidylserine synthase 1. @CellDiscovery Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kqf

Structural basis for cholesterol sensing of LYCHOS and its interaction with indoxyl sulfate. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9j3x

A structural and mechanistic model for BSEP dysfunction in PFIC2 cholestatic disease. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/

#CryoEM #structure of a phosphotransferase system glucose transporter stalled in an intermediate conformation. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hnp

Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P2. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9do0

The completely redesigned TmDet algorithm by @ProtBioinfRG has just been accepted in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem! Check it here: https://tmdet.unitmp.org.

The structural diversity of psychedelic drug actions revealed. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9arx

Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters. @JBiolChem Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zoj

Structural basis for the substrate recognition and transport mechanism of the human y+LAT1-4F2hc transporter complex. @ScienceAdvances Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kh5

Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jdm

#CryoEM #structure of the human monocarboxylate transporter 10. @Structure Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hhq

Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel. @BJP Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ex6

#CryoEM #structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9b3j

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9dhp

Structure of the CD33 Receptor and Implications for the Siglec Family. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9bet

Architecture and rearrangements of a sperm-specific Na+/H+ exchanger. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8u6z

#CryoEM #structures of mouse bestrophin 1 channel in closed and partially open conformations. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kc9

Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. @Science Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jhj

Transport and inhibition mechanism for human TauT-mediated taurine uptake. @CellResearch Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jvc

Structure and mechanism of the plastid/parasite ATP/ADP translocator. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9j3j

Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus. @Structure Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9ilt

The ABC transporter MsbA in a dozen environments. @Structure Check the #cryoEM #structure all of these #membrane #proteins in the UniTmp database: https://pdbtm.unitmp.org/entry/9fuq

Narrowed pore conformations of aquaglyceroporins AQP3 and GlpF. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8y8n

In-cell architecture of the mitochondrial respiratory chain. @Science Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9fy5

Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1. Check them in the UniTmp database: https://pdbtm.unitmp.org/entry/9l3w

#CryoEM #structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation. @NatureComms Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9f1r

Structure of human PINK1 at a mitochondrial TOM-VDAC array. @Science Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9eii

Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters. @biorxiv_preprint Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9bgy

Structural basis for malate-driven, pore lipid-regulated activation of the Arabidopsis vacuolar anion channel ALMT9. @NatureComms Check #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zte

Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1. @PlantComms Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zpx

The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis. @AdvancedScience Check the this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zb0

#CryoEM #structure of apo human mitochondrial pyruvate carrier in the IMS-open conformation at pH 8.0. Check this #membrane #protein in the UniTmp database.

Structural and molecular dynamics simulations reveal the mechanotransduction mechanism of FtsEX. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database.

Structure of mitochondrial pyruvate carrier and its inhibition mechanism. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9mnx

#CryoEM #structure of the bacterial intramembrane metalloprotease RseP in the substrate-bound state. @ScienceAdvances Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9j82

Structural insights into the diverse actions of magnesium on NMDA receptors. @Neuron Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9iyp

Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3. @NatureChemBiol Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ii2

Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9gsj

#CryoEM #structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics. @NatureSMB Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ft7

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9eri

Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9czh

A cryptic pocket in CB1 drives peripheral and functional selectivity. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9b65

Structural basis of CXCR4 assembly and regulation. @CellReports Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8yu7